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Genes and Development, ISSN 0890-9369, 07/2004, Volume 18, Issue 14, pp. 1649 - 1654
Journal Article
Chinese Journal of Cancer Prevention and Treatment, ISSN 1673-5269, 05/2017, Volume 24, Issue 10, pp. 692 - 702
Journal Article
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 471 - 9
Occupational exposure to silica has been observed to cause pulmonary fibrosis and lung cancer through complex mechanisms. Telomeres, the nucleoprotein... 
PROTECTION | MULTIDISCIPLINARY SCIENCES | POT1 | ATM | CRYSTALLINE SILICA | PROTEINS | BINDING | EXPRESSION | TRF1 | TIN2 | TELOMERE LENGTH
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 11/2019, Volume 39, Issue 21
TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encoding TIN2, cause short-telomere syndromes. While the genetics... 
shelterin | LOCALIZATION | COMPLEX | alternative splicing | PROTECTION | PROTEIN TPP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | telomere | processivity | TRF1 | CELL BIOLOGY | LENGTH REGULATOR | telomerase | DYSKERATOSIS-CONGENITA | POT1 | TPP1 | MUTATIONS | TIN2
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 08/2019, Volume 431, Issue 17, pp. 3289 - 3301
Human telomeric repeat binding factors TRF1 and TRF2 along with TIN2 form the core of the shelterin complex that protects chromosome ends against unwanted... 
assembly | shelterin | single-molecule | TIN2 | telomere | COMPLEX | DOMAIN | PROTECTION | PROTEIN TPP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | LENGTH REGULATOR | STRUCTURAL BASIS | DNA | TEL-PATCH | POT1 | Fluorescence | Telomeres | Telomerase | Analysis
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 512, Issue 2, pp. 230 - 235
The shelterin protein complex protects natural chromosome ends from being recognized as DNA damage sites and also regulates the synthesis of telomeric repeats... 
Telomere length maintenance | Telomerase function | Telomeric binding protein TPP1 | Shelterin complex | RECRUITMENT | COMPLEX | PROTECTION | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LENGTH | BIOPHYSICS | INTERACTS | POT1 | REQUIRES | TIN2 | ATR | Proteins | Telomeres | Telomerase | Analysis | Antigenic determinants | Protein binding
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 06/2018, Volume 38, Issue 12
TIN2 is central to the shelterin complex, linking the telomeric proteins TRF1 and TRF2 with TPP1/POT1. Mutations in T1NF2, which encodes TIN2, that are found... 
shelterin | CASEIN KINASE-2 | COMPLEX | PROTECTION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | telomere | PROTEIN-KINASE CK2 | TRF2 | casein kinase 2 | TRF1 | PREDICTION | CELL BIOLOGY | MAINTENANCE | REGULATOR | dyskeratosis congenita | SEQUENCE | TPP1 | TIN2 | TELOMERE LENGTH
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2005, Volume 7, Issue 7, pp. 712 - 718
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5866, pp. 1092 - 1096
Mammalian telomeres are protected by a six-protein complex: shelterin. Shelterin contains two closely related proteins (TRF1 and TRF2), which recruit various... 
Proteins | Telomeres | Colors | Atomic interactions | Amino acids | Reports | Grants | Electrostatics | Binding sites | Crystal structure | COMPLEX | DNA | INTERACTS | MULTIDISCIPLINARY SCIENCES | POLYMERASE | APOLLO | TIN2 | Humans | Molecular Sequence Data | Telomeric Repeat Binding Protein 1 - metabolism | Crystallography, X-Ray | TATA Box Binding Protein-Like Proteins - metabolism | Telomeric Repeat Binding Protein 1 - chemistry | Telomere-Binding Proteins - genetics | Inhibitor of Apoptosis Proteins - chemistry | TATA Box Binding Protein-Like Proteins - genetics | Tumor Suppressor Proteins - chemistry | TATA Box Binding Protein-Like Proteins - chemistry | Inhibitor of Apoptosis Proteins - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Telomeric Repeat Binding Protein 2 | Models, Molecular | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Amino Acid Motifs | Hydrogen Bonding | Mutant Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Telomere-Binding Proteins - chemistry | Cellular proteins | Evaluation | Thyrotropin releasing factor | Influence | Properties | Protein binding | Protons | Biochemistry
Journal Article