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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 8, pp. 2497 - 2502
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here... 
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors
Journal Article
Expert Review of Respiratory Medicine, ISSN 1747-6348, 11/2015, Volume 9, Issue 6, pp. 739 - 750
Journal Article
Comparative Immunology, Microbiology and Infectious Diseases, ISSN 0147-9571, 10/2019, Volume 66, p. 101339
IL-1R8 is a member of Interleukin-1 receptor family acting as a negative regulator of inflammation reliant on ILRs and TLRs activation. IL-1R8 role has never... 
IL-1R8/TIR8/SIGIRR | Innate immunity | Goat | Intra-mammary infection | Staphylococcus aureus | REFERENCE GENES | MICROBIOLOGY | IMMUNOLOGY | INTESTINAL EPITHELIAL-CELLS | FAMILY | MEMBER | SIGIRR | INNATE IMMUNE-RESPONSES | NEGATIVE REGULATION | INFLAMMATION | TOLL-LIKE RECEPTORS | VETERINARY SCIENCES | TIR8 RECEPTOR
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 30, pp. 49470 - 49483
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e19204
Innate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney... 
CELLS | ISCHEMIA/REPERFUSION INJURY | RECOGNITION | INFLAMMATION | KIDNEY INJURY | BIOLOGY | MICE | TIR8/SIGIRR | TLR4 | NEPHROPATHY | FAILURE | Fibrosis - genetics | Toll-Like Receptor 2 - genetics | Kidney - pathology | Receptors, Interleukin-1 - genetics | Toll-Like Receptor 9 - genetics | Signal Transduction - genetics | Ureteral Obstruction - metabolism | Toll-Like Receptor 2 - metabolism | Fibrosis - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Kidney Diseases - genetics | Receptors, Interleukin-1 - metabolism | Animals | Mice, Mutant Strains | Toll-Like Receptors - genetics | Ureteral Obstruction - genetics | Signal Transduction - physiology | Mice | Toll-Like Receptors - metabolism | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Kidney Diseases - metabolism | Animal experimentation | Chronic kidney failure | Cytokines | RNA | Collagen | Fibrosis | Bone morphogenetic proteins | T cells | Transforming growth factors | Muscle proteins | Nephrology | Syngeneic grafts | Smooth muscle | Intracellular signalling | Infections | Lymphocytes T | Interleukin 1 receptors | Macrophages | Interleukin 6 | Atrophy | Proteins | CD90 antigen | Receptors | Lymphocytes | Actin | Rodents | Toll-like receptors | Fibroblasts | Deoxyribonucleic acid--DNA | Immune system | Kidneys | Neutrophils | Inflammation | Gene expression | TLR9 protein | TLR2 protein | MyD88 protein | Diabetes | Kidney diseases | Chemokines | Monocyte chemoattractant protein 1 | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Minerva Biotecnologica, ISSN 1120-4826, 12/2015, Volume 27, Issue 4, pp. 219 - 223
Inflammation is a fundamental response to tissue injury and invasion of pathogens, but it is detrimental in clinically important inflammatory disorders.... 
Receptors, interleukin | Autoimmune diseases | Inflammation | RHEUMATOID-ARTHRITIS | IL-1 | MONOCYTES | MECHANISMS | Receptors, Interleukin | FAMILY-MEMBER | EPITHELIAL-CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | TIR8/SIGIRR
Journal Article
Journal Article