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tirapazamine (322) 322
science & technology (201) 201
life sciences & biomedicine (175) 175
animals (158) 158
humans (140) 140
biological and medical sciences (126) 126
medical sciences (119) 119
oncology (116) 116
mice (109) 109
hypoxia (93) 93
antineoplastic agents (91) 91
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female (72) 72
tumors (64) 64
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triazines - therapeutic use (55) 55
chemotherapy (53) 53
antineoplastic agents - therapeutic use (50) 50
cell hypoxia (50) 50
mice, inbred c3h (47) 47
triazines - administration & dosage (42) 42
male (41) 41
oxidation-reduction (40) 40
cell hypoxia - drug effects (37) 37
tumor cells, cultured (37) 37
combined modality therapy (35) 35
triazines - metabolism (35) 35
radiation-sensitizing agents - pharmacology (34) 34
cisplatin (33) 33
radiology, nuclear medicine & medical imaging (33) 33
cell survival - drug effects (32) 32
radiation-sensitizing agents - therapeutic use (31) 31
cancer (30) 30
antineoplastic combined chemotherapy protocols - therapeutic use (29) 29
dna damage (29) 29
sr 4233 (29) 29
chemistry (28) 28
dose-response relationship, drug (28) 28
triazines - toxicity (28) 28
triazines - chemistry (27) 27
general aspects (26) 26
physical sciences (26) 26
neoplasms - drug therapy (25) 25
neoplasm transplantation (24) 24
bioreductive drugs (23) 23
antineoplastic agents - metabolism (22) 22
cell line, tumor (22) 22
cisplatin - administration & dosage (22) 22
biochemistry & molecular biology (21) 21
research article (21) 21
antineoplastic agents - administration & dosage (20) 20
cell hypoxia - physiology (20) 20
quiescent cell (20) 20
triazines - pharmacokinetics (19) 19
antineoplastic agents - chemistry (18) 18
antineoplastic agents - toxicity (18) 18
toxicity (18) 18
triazines - adverse effects (18) 18
analysis (17) 17
carcinoma, squamous cell - drug therapy (17) 17
cricetinae (17) 17
mice, inbred balb c (17) 17
oxygen - metabolism (17) 17
rats (17) 17
tumor hypoxia (17) 17
antineoplastic agents - pharmacokinetics (16) 16
carcinoma, squamous cell - pathology (16) 16
cytotoxicity (16) 16
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mice, nude (16) 16
treatment. general aspects (16) 16
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combined treatments (15) 15
drug synergism (15) 15
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radiation (15) 15
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aged (14) 14
carcinoma, squamous cell - radiotherapy (14) 14
chemistry, multidisciplinary (14) 14
drug screening assays, antitumor (14) 14
neoplasms - metabolism (14) 14
neoplasms, experimental - drug therapy (14) 14
oxygen (14) 14
research (14) 14
time factors (14) 14
toxicology (14) 14
apoptosis (13) 13
carcinoma, squamous cell - therapy (13) 13
cell line (13) 13
cell survival - radiation effects (13) 13
dose-response relationship, radiation (13) 13
drug administration schedule (13) 13
misonidazole - analogs & derivatives (13) 13
prodrugs - pharmacology (13) 13
radiotherapy dosage (13) 13
science & technology - other topics (13) 13
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1. Full Text Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy
by Wang, Yazhe and Xie, Ying and Li, Jing and Peng, Zheng-Hong and Sheinin, Yuri and Zhou, Jianping and Oupický, David
ACS nano, ISSN 1936-0851, 02/2017, Volume 11, Issue 2, pp. 2227 - 2238
hypoxia | cancer | nanoparticles | tumor penetration | iRGD | photodynamic therapy | Physical Sciences | Chemistry | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology - Other Topics | Chemistry, Multidisciplinary | Chemistry, Physical | Science & Technology | Prodrugs - administration & dosage | Hypoxia - drug therapy | Injections, Intravenous | Photosensitizing Agents - chemistry | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Indocyanine Green - pharmacology | Photochemotherapy | Drug Delivery Systems | Tirapazamine - chemistry | Photosensitizing Agents - administration & dosage | Tissue Distribution | Indocyanine Green - chemistry | Photosensitizing Agents - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | Indocyanine Green - administration & dosage | Tirapazamine - administration & dosage | Tirapazamine - pharmacology | Antineoplastic Agents - chemistry | Reactive Oxygen Species - analysis | Animals | Cell Proliferation - drug effects | Mice | Nanoparticles - administration & dosage | Prodrugs - pharmacology | Drug Screening Assays, Antitumor | Index Medicus | Nanoparticles | Drugs | Therapy | Drug delivery systems | Photodynamic therapy | Penetration | Tumors | Anticancer properties | Hypoxia | Tumor Penetration | Photodynamic Therapy | Cancer
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2. Full Text Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity
by Nemeikaite-Ceniene, Ausra and Sarlauskas, Jonas and Jonusiene, Violeta and Maroziene, Audrone and Miseviciene, Lina and Yantsevich, Aliaksei V and Cenas, Narimantas
International journal of molecular sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4602
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Oxidants - pharmacology | Oxidants - chemistry | Reactive Oxygen Species | Humans | Tirapazamine - analogs & derivatives | Tirapazamine - pharmacology | Antineoplastic Agents - chemistry | Tirapazamine - chemistry | Oxidation-Reduction - drug effects | Biomarkers | NAD(P)H Dehydrogenase (Quinone) - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | NADP - metabolism | Cytochrome | Cell proliferation | Adenocarcinoma | Oxidative stress | Rate constants | Toxicity | Electron transfer | Cytotoxicity | Oxides | Hepatoma | Reduction | Reaction kinetics | Oxidation | NADP | Colon | Tirapazamine | Redox properties | Single electrons | N-Oxides | Deoxyribonucleic acid--DNA | Free radicals | Cell survival | Superoxide | Regeneration | Foreign exchange rates | Reagents | Hypoxia | Index Medicus | reductive activation | oxidative stress | cytotoxicity | tirapazamine
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3. Full Text Usefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential
by Masunaga, Shin-ichiro and Sakurai, Yoshinori and Tanaka, Hiroki and Takata, Takushi and Suzuki, Minoru and Sanada, Yu and Tano, Keizo and Maruhashi, Akira and Ono, Koji
International journal of radiation biology, ISSN 0955-3002, 12/2019, Volume 95, Issue 12, pp. 1708 - 1717
B-carrier | Boron neutron capture therapy | tirapazamine | nicotinamide | mild temperature hyperthermia | quiescent tumor cell | Life Sciences & Biomedicine | Technology | Radiology, Nuclear Medicine & Medical Imaging | Nuclear Science & Technology | Biology | Life Sciences & Biomedicine - Other Topics | Science & Technology | Tirapazamine - therapeutic use | Cell Survival - drug effects | Boron Neutron Capture Therapy | Melanoma - radiotherapy | Tumor Hypoxia - drug effects | Tirapazamine - administration & dosage | Tirapazamine - pharmacology | Treatment Outcome | Combined Modality Therapy | Melanoma - pathology | Cell Survival - radiation effects | Tumor Hypoxia - radiation effects | Animals | Lung Neoplasms - secondary | Melanoma - drug therapy | Hyperthermia, Induced | Cell Line, Tumor | Mice | Index Medicus | Space life sciences
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4. Full Text Multifunctional Theranostic Liposomes Loaded with a Hypoxia-Activated Prodrug for Cascade-Activated Tumor Selective Combination Therapy
by Dai, Yeneng and Wang, Bing and Sun, Zhiquan and Cheng, Juan and Zhao, Honghai and Wu, Kun and Sun, Pengfei and Shen, Qingming and Li, Meixing and Fan, Quli
ACS applied materials & interfaces, ISSN 1944-8244, 10/2019, Volume 11, Issue 43, pp. 39410 - 39423
Research | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Neoplasms - metabolism | Gadolinium - pharmacology | Theranostic Nanomedicine | Antineoplastic Combined Chemotherapy Protocols - chemistry | Gadolinium - pharmacokinetics | Humans | Porphyrins - chemistry | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Prodrugs - chemistry | Indocyanine Green - pharmacology | Porphyrins - pharmacokinetics | Photochemotherapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Tirapazamine - chemistry | Cell Hypoxia | Indocyanine Green - chemistry | Tirapazamine - pharmacokinetics | A549 Cells | Tirapazamine - pharmacology | Porphyrins - pharmacology | Gadolinium - chemistry | Neoplasms - drug therapy | Prodrugs - pharmacokinetics | Liposomes | Prodrugs - pharmacology | Indocyanine Green - pharmacokinetics | Index Medicus
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5. Full Text Effect of tirapazamine on selected kidney parameters in rats treated with cisplatin
by Sysa, Marcin and Pawlowski, Kamil and Slabczynski, Piotr and Burdan, Franciszek and Dudka, Jaroslaw
Current issues in pharmacy and medical sciences, ISSN 2084-980X, 03/2019, Volume 32, Issue 1, pp. 18 - 22
Tirapazamine | Nephrotoxicity | Cisplatin
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6. Full Text Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
by Wang, Wenguang and Cheng, Yuhao and Yu, Peng and Wang, Haoran and Zhang, Yue and Xu, Haiheng and Ye, Qingsong and Yuan, Ahu and Hu, Yiqiao and Wu, Jinhui
Nature communications, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1580 - 1580
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fluorocarbons - chemistry | Prodrugs - administration & dosage | Nanoparticles - chemistry | Tirapazamine - administration & dosage | Tumor Microenvironment | Tirapazamine - pharmacology | Fluorocarbons - pharmacology | Antineoplastic Agents - administration & dosage | Cell Hypoxia | Tumor Hypoxia | Animals | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Drug Delivery Systems - methods | Prodrugs - pharmacology | Nanoparticles | Drugs | Anaerobic bacteria | Perfluorocarbons | Perfluoro compounds | Prodrugs | Reperfusion | Hypoxia | Permeability | Chemical compounds | Tumors | Index Medicus
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7. Full Text Janus Gold Triangle-Mesoporous Silica Nanoplatforms for Hypoxia-Activated Radio-Chemo-Photothermal Therapy of Liver Cancer
by Wang, Zheng and Chang, Zhi-min and Shao, Dan and Zhang, Fan and Chen, Fangman and Li, Li and Ge, Ming-feng and Hu, Rui and Zheng, Xiao and Wang, Yingshuai and Dong, Wen-fei
ACS applied materials & interfaces, ISSN 1944-8244, 09/2019, Volume 11, Issue 38, pp. 34755 - 34765
Research | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Nanoparticles - chemistry | Humans | Prodrugs - chemistry | Liver Neoplasms, Experimental - therapy | Chemoradiotherapy | Drug Delivery Systems | Tirapazamine - chemistry | Cell Hypoxia | Liver Neoplasms, Experimental - metabolism | Nanoparticles - therapeutic use | Hyperthermia, Induced | Liver Neoplasms, Experimental - pathology | Gold - chemistry | Silicon Dioxide - pharmacology | Silicon Dioxide - chemistry | Tirapazamine - pharmacology | Gold - pharmacology | Phototherapy | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Mice | Porosity | Prodrugs - pharmacology | Index Medicus
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8. Full Text Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs)
by Elsaidi, Hassan RH and Yang, Xiao-Hong and Ahmadi, Fatemeh and Weinfeld, Michael and Wiebe, Leonard I and Kumar, Piyush
European journal of medicinal chemistry, ISSN 0223-5234, 03/2019, Volume 165, pp. 216 - 224
Benzotriazine-1-monoxides (BTMOs) | Tumor hypoxia | Benzotriazine-1,4-dioxides (BTDOs) | Radiosensitization | Tirapazamine | Hypoxia-selective benzotriazines | Index Medicus
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9. Full Text Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism
by Bagati, Archis and Hutcherson, Timothy C and Koch, Zethan and Pechette, Joseph and Dianat, Hossein and Higley, Cory and Chiu, Lisa and Song, Yesul and Shah, Jay and Chazen, Elana and Nicolais, Andrew and Casey, Peter and Thompson, Kyle and Burke, Kevin and Nikiforov, Mikhail A and Zirnheld, Jennifer and Zucker, Shoshanna N
Oncotarget, ISSN 1949-2553, 09/2020, Volume 11, Issue 18, pp. 3443 - 3458
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10. Full Text Hypoxia-activated prodrugs: Paths forward in the era of personalised medicine
by Hunter, Francis W and Wouters, Bradly G and Wilson, William R
British journal of cancer, ISSN 0007-0920, 05/2016, Volume 114, Issue 10, pp. 1071 - 1077
evofosfamide | prodrug | hypoxia | tarloxotinib | P450 oxidoreductase | PR-104 | tirapazamine | biomarker | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Hypoxia | Neoplasms - metabolism | Oxidoreductases - metabolism | Humans | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Prodrugs - therapeutic use | Prodrugs - pharmacology | Neoplasms - drug therapy | Precision Medicine | Index Medicus | Minireview
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11. Full Text Combined Cancer Chemo-Photodynamic and Photothermal Therapy Based on ICG/PDA/TPZ-Loaded Nanoparticles
by Huang, Xiaqin and Wu, Junru and He, Muye and Hou, Xinyu and Wang, Yan and Cai, Xiaoran and Xin, Hongliang and Gao, Feng and Chen, Yanzuo
Molecular pharmaceutics, ISSN 1543-8384, 05/2019, Volume 16, Issue 5, pp. 2172 - 2183
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Reactive Oxygen Species - radiation effects | Apoptosis - drug effects | Photochemotherapy - methods | Humans | Prodrugs - metabolism | Drug Delivery Systems | Nanoparticles | Radiation-Sensitizing Agents - therapeutic use | Tissue Distribution | Polymers - therapeutic use | Indoles - metabolism | Hyperthermia, Induced - methods | Tirapazamine - therapeutic use | Cell Survival - drug effects | Photochemotherapy - adverse effects | Mice, Inbred C57BL | Indocyanine Green - therapeutic use | Tirapazamine - metabolism | Treatment Outcome | Indocyanine Green - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Radiation-Sensitizing Agents - metabolism | Cell Line, Tumor | Indoles - therapeutic use | Mice | Mice, Inbred BALB C | Prodrugs - therapeutic use | Polymers - metabolism | Index Medicus
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12. Full Text Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis
by Shi, Yunzhou and Oeh, Jason and Hitz, Anna and Hedehus, Maj and Eastham-Anderson, Jeffrey and Peale, Franklin V and Hamilton, Patricia and O'Brien, Thomas and Sampath, Deepak and Carano, Richard A.D
Neoplasia (New York, N.Y.), ISSN 1476-5586, 11/2017, Volume 19, Issue 11, pp. 950 - 959
Angiogenesis | Prodrugs | Magnetic resonance imaging | Xenografts | Clinical trials | Hypoxia | Tirapazamine | Oxygenation | Vascular endothelial growth factor | Tumors | Structure-function relationships | Cancer | Index Medicus
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13. Full Text Development of [131 I]I-EOE-TPZ and [131 I]I-EOE-TPZMO: Novel tirapazamine (TPZ)-based radioiodinated pharmaceuticals for application in theranostic management of hypoxia
by Elsaidi, Hassan and Ahmadi, Fatemeh and Wiebe, Leonard I and Kumar, Piyush
Pharmaceuticals (Basel, Switzerland), ISSN 1424-8247, 03/2019, Volume 12, Issue 1, p. 3
Benzotriazine-1-monoxide (BTMO) | Tirapazamine (TPZ) | Benzotriazine-1,4-dioxide (BTDO) | Hypoxia | Radiosensitizer | Radioiodination | SR 4317 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | radioiodination | hypoxia | benzotriazine-1,4-dioxide (BTDO), benzotriazine-1-monoxide (BTMO), tirapazamine (TPZ), SR 4317 | radiosensitizer
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