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ACS Nano, ISSN 1936-0851, 02/2017, Volume 11, Issue 2, pp. 2227 - 2238
Poor tumor penetration is a major challenge for the use of nanoparticles in anticancer therapy. Moreover, the inability to reach hypoxic tumor cells that are... 
hypoxia | cancer | nanoparticles | tumor penetration | iRGD | photodynamic therapy | DRUG-DELIVERY | COMBINATION THERAPY | MATERIALS SCIENCE, MULTIDISCIPLINARY | TISSUE | CHEMISTRY, PHYSICAL | TIRAPAZAMINE | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | PEPTIDE | BREAST-CANCER | MICROENVIRONMENT | EFFICIENT | POLYMER HYBRID NANOPARTICLES | Prodrugs - administration & dosage | Hypoxia - drug therapy | Injections, Intravenous | Photosensitizing Agents - chemistry | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Indocyanine Green - pharmacology | Photochemotherapy | Drug Delivery Systems | Tirapazamine - chemistry | Photosensitizing Agents - administration & dosage | Tissue Distribution | Indocyanine Green - chemistry | Photosensitizing Agents - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | Indocyanine Green - administration & dosage | Tirapazamine - administration & dosage | Tirapazamine - pharmacology | Antineoplastic Agents - chemistry | Reactive Oxygen Species - analysis | Animals | Cell Proliferation - drug effects | Mice | Nanoparticles - administration & dosage | Prodrugs - pharmacology | Drug Screening Assays, Antitumor | Nanoparticles | Drugs | Therapy | Drug delivery systems | Photodynamic therapy | Penetration | Tumors | Anticancer properties | Hypoxia | Tumor Penetration | Photodynamic Therapy | Cancer
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4602
Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN→O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action... 
reductive activation | oxidative stress | cytotoxicity | tirapazamine
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 03/2016, Volume 77, Issue 3, pp. 441 - 457
Journal Article
Analytical Chemistry, ISSN 0003-2700, 10/2018, Volume 90, Issue 20, pp. 11899 - 11907
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2017, Volume 108, pp. S46 - S46
Journal Article
Molecular pharmacology, ISSN 0026-895X, 06/2019, Volume 95, Issue 6, pp. 638 - 651
Evofosfamide (TH-302) is a hypoxia-activated DNA-crosslinking prodrug currently in clinical development for cancer therapy. Oxygen-sensitive activation of... 
PRODRUG EVOFOSFAMIDE | THERAPY | PRECLINICAL MODELS | IN-VIVO | DOXORUBICIN | TIRAPAZAMINE | PHARMACOLOGY & PHARMACY | HYPOXIA | IDENTIFICATION | COMBINATION | TH-302
Journal Article
Pharmaceuticals, ISSN 1424-8247, 03/2019, Volume 12, Issue 1, p. 3
: Benzotriazine-1,4-dioxides (BTDOs) such as tirapazamine (TPZ) and its derivatives act as radiosensitizers of hypoxic tissues. The benzotriazine-1-monoxide... 
Benzotriazine-1-monoxide (BTMO) | Tirapazamine (TPZ) | Benzotriazine-1,4-dioxide (BTDO) | Hypoxia | Radiosensitizer | Radioiodination | SR 4317 | radioiodination | hypoxia | benzotriazine-1,4-dioxide (BTDO), benzotriazine-1-monoxide (BTMO), tirapazamine (TPZ), SR 4317 | radiosensitizer
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 06/2007, Volume 48, Issue 6, pp. 973 - 980
We evaluated the predictive value of PET using the hypoxia tracer F-18-fluoroazomycin arabinoside (F-18-FAZA) for success of radiotherapy in combination with... 
FAZA | tirapazamine | RADIATION ONCOLOGY | tumor hypoxia | PHASE-II | EMT6 | CHEMOTHERAPEUTIC DRUGS | ADVANCED HEAD | NECK-CANCER | CELL LUNG-CANCER | radiochemotherapy | POSITRON-EMISSION-TOMOGRAPHY | RADIOTHERAPY | CONCURRENT TIRAPAZAMINE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Neoplasia, ISSN 1476-5586, 11/2017, Volume 19, Issue 11, pp. 950 - 959
The effect of anti-angiogenic agents on tumor oxygenation has been in question for a number of years, where both increases and decreases in tumor pO have been... 
Angiogenesis | Prodrugs | Magnetic resonance imaging | Xenografts | Clinical trials | Hypoxia | Tirapazamine | Oxygenation | Vascular endothelial growth factor | Tumors | Structure-function relationships | Cancer
Journal Article
Biomaterials, ISSN 0142-9612, 04/2019, Volume 200, pp. 48 - 55
Oxygen is known as an irreplaceable gas in the lives of most eukaryotic cells, yet researchers underestimate its importance, as in the case in many studies of... 
Hypoxia | Cell dormancy | Gaseous microenvironment regulation | Controlled drug release | Anaerobic | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | TIRAPAZAMINE | CANCER | Green chemistry | Ceramics | Ceramic materials | Green technology | Tumors
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2012, Volume 68, Issue 43, pp. 8942 - 8944
Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with O incorporated into the N-oxide... 
HOF·CH | O isotope | N-oxide | Oxygen transfer | Tirapazamine
Journal Article