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Clinical Pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 3, pp. 203 - 216
Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2009, Volume 5, Issue 5, pp. 491 - 503
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2018, Volume 175, Issue 22, pp. 4239 - 4252
BACKGROUND AND PURPOSE Angiotensin-converting enzyme (ACE), an important part of the renin-angiotensin system, is implicated in stimulating the fibrotic... 
IN-VITRO | COLLAGEN | CONCISE GUIDE | WOUND-HEALING DEFECT | HUMAN DERMAL FIBROBLASTS | TISSUE FIBROSIS | PHARMACOLOGY & PHARMACY | MECHANISMS | SKIN | EXPERIMENTAL-DESIGN | EXPRESSION
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2015, Volume 42, Issue 10, pp. 780 - 787
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2005, Volume 288, Issue 2, pp. 461 - 468
The balance between matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), plays a critical role... 
Matrix metalloproteinase | Proliferation | Apoptosis | Phenotypic differentiation | DEATH DOMAIN | CELLS | phenotypic differentiation | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | proliferation | RAT | apoptosis | FAILING HUMAN HEART | GROWTH-FACTOR-BETA | matrix metalloproteinase | RECOMBINANT ADENOVIRUSES | MYOFIBROBLASTS | PERIPHERAL VASCULAR DISEASE | MOLECULAR-CLONING | EXPRESSION | Humans | Actins - metabolism | Culture Media, Conditioned - pharmacology | Tissue Inhibitor of Metalloproteinase-3 - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinases - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Myocardium - metabolism | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Adenoviridae - genetics | Fibroblasts - metabolism | Tissue Inhibitor of Metalloproteinase-3 - genetics | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Tissue Inhibitor of Metalloproteinases - antagonists & inhibitors | Cells, Cultured | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinases - metabolism | Myocardium - cytology | Cell Division - physiology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Fibroblasts - cytology | Mice | Apoptosis - physiology | Tissue Inhibitor of Metalloproteinase-2 - antagonists & inhibitors | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 2014, Volume 134, Issue 6, pp. 1484 - 1494
Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase... 
brain accumulation | crizotinib | P‐glycoprotein | ALK inhibitor | elacridar | P-glycoprotein | LUNG | EML4-ALK FUSION GENE | METASTASES | PENETRATION | GF120918 | COMBINATION | ANAPLASTIC LYMPHOMA KINASE | PHARMACOKINETICS | ONCOLOGY | MULTIDRUG-RESISTANCE | PHASE-I | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pyridines - pharmacokinetics | Biological Availability | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | ATP-Binding Cassette Transporters - physiology | Brain - metabolism | Tissue Distribution | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Drug Therapy, Combination | Neoplasm Proteins - genetics | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Tetrahydroisoquinolines - pharmacology | Administration, Oral | Cells, Cultured | Mice, Knockout | Brain - drug effects | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Acridines - pharmacology | ATP Binding Cassette Transporter, Sub-Family B | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Plasma | Chemotherapy | Brain cancer | Rodents | Lymphomas | Glycoproteins | Metastasis | Index Medicus
Journal Article