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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 03/2009, Volume 23, Issue 3, pp. 477 - 485
The detailed molecular mechanism of action of second-generation BCR-ABL tyrosine kinase inhibitors, including perturbed targets and pathways, should contribute... 
BCR-ABL INHIBITORS | SRC | TYROSINE KINASE | MECHANISMS | NILOTINIB | BREAST-CANCER CELLS | dasatinib | ONCOLOGY | IMATINIB | kinase profiling | RESISTANCE | chronic myeloid leukemia | chemical proteomics | SKI-606 | HEMATOLOGY | bosutinib | Nitriles - pharmacology | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Substrate Specificity | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | K562 Cells - drug effects | Quinolines - pharmacology | Drug Delivery Systems | Leukemia, Myeloid, Accelerated Phase - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Dasatinib | Nerve Tissue Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Leukocytes, Mononuclear - drug effects | Quinolines - chemistry | src-Family Kinases - antagonists & inhibitors | Pyrimidines - pharmacology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | K562 Cells - enzymology | Leukemia, Myeloid, Accelerated Phase - enzymology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Leukocytes, Mononuclear - enzymology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Enzyme inhibitors | Physiological aspects | Chronic myeloid leukemia | Research | Drug therapy | Health aspects | Protein kinases | Index Medicus
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 3, pp. 203 - 216
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2005, Volume 288, Issue 2, pp. 461 - 468
The balance between matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), plays a critical role... 
Matrix metalloproteinase | Proliferation | Apoptosis | Phenotypic differentiation | DEATH DOMAIN | CELLS | phenotypic differentiation | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | proliferation | RAT | apoptosis | FAILING HUMAN HEART | GROWTH-FACTOR-BETA | matrix metalloproteinase | RECOMBINANT ADENOVIRUSES | MYOFIBROBLASTS | PERIPHERAL VASCULAR DISEASE | MOLECULAR-CLONING | EXPRESSION | Humans | Actins - metabolism | Culture Media, Conditioned - pharmacology | Tissue Inhibitor of Metalloproteinase-3 - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinases - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Myocardium - metabolism | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Adenoviridae - genetics | Fibroblasts - metabolism | Tissue Inhibitor of Metalloproteinase-3 - genetics | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Tissue Inhibitor of Metalloproteinases - antagonists & inhibitors | Cells, Cultured | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinases - metabolism | Myocardium - cytology | Cell Division - physiology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Fibroblasts - cytology | Mice | Apoptosis - physiology | Tissue Inhibitor of Metalloproteinase-2 - antagonists & inhibitors | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2009, Volume 5, Issue 5, pp. 491 - 503
Journal Article
American Journal of Psychiatry, ISSN 0002-953X, 05/2004, Volume 161, Issue 5, pp. 826 - 835
OBJECTIVE: Minimum therapeutic doses of paroxetine and citalopram produce 80% occupancy for the serotonin (5-HT) transporter (5-HTT). The authors used... 
H-3 PAROXETINE BINDING | ANTIDEPRESSANTS | DASB | 5-HT2 RECEPTORS | PSYCHIATRY | IN-VIVO | HIGH-AFFINITY | HUMAN-BRAIN | MAJOR DEPRESSION | UPTAKE SITES | PET | Paroxetine - pharmacokinetics | Serotonin Uptake Inhibitors - pharmacokinetics | Cyclohexanols - pharmacokinetics | Fluoxetine - pharmacokinetics | Membrane Glycoproteins - metabolism | Humans | Middle Aged | Male | Paroxetine - therapeutic use | Serotonin Plasma Membrane Transport Proteins | Carrier Proteins - drug effects | Corpus Striatum - metabolism | Dose-Response Relationship, Drug | Sertraline - pharmacokinetics | Sertraline - therapeutic use | Adult | Female | Fluoxetine - therapeutic use | Serotonin Uptake Inhibitors - therapeutic use | Nerve Tissue Proteins | Venlafaxine Hydrochloride | Carrier Proteins - metabolism | Membrane Transport Proteins | Serotonin - metabolism | Benzylamines | Corpus Striatum - drug effects | Cyclohexanols - therapeutic use | Membrane Glycoproteins - drug effects | Citalopram - pharmacokinetics | Citalopram - therapeutic use | Tomography, Emission-Computed | Corpus Striatum - diagnostic imaging | Delayed-Action Preparations | Carbon Radioisotopes | Dosage and administration | Serotonin agents | Drug therapy | Mental illness | Tomography | Mental disorders | Antidepressants | Psychiatry | Clinical outcomes | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166268 - e0166268
Journal Article