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1. Full Text Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: A systematic review and meta-analysis
by Vasilakou, Despoina and Karagiannis, Thomas and Athanasiadou, Eleni and Mainou, Maria and Liakos, Aris and Bekiari, Eleni and Sarigianni, Maria and Matthews, David R and Tsapas, Apostolos
Annals of internal medicine, ISSN 0003-4819, 08/2013, Volume 159, Issue 4, pp. 262 - 274
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Hypoglycemic Agents - therapeutic use | Sodium-Glucose Transporter 2 - adverse effects | Risk Assessment | Glycated Hemoglobin A - metabolism | Humans | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Weight Loss | Selection Bias | Blood Pressure - drug effects | Sodium-Glucose Transporter 2 - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Health aspects | Patient outcomes | Membrane proteins | Meta-analysis | Studies | Inhibitor drugs | Glucose | Bias | Index Medicus | Abridged Index Medicus
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2. Full Text Tissue inhibitors of metalloproteinases
by Murphy, Gillian
Genome Biology, ISSN 1474-7596, 2011, Volume 12, Issue 11, pp. 233 - 233
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Catalytic Domain | Disintegrins - metabolism | Signal Transduction | Humans | Models, Molecular | Phylogeny | Mammals | Tissue Inhibitor of Metalloproteinases - chemistry | Disintegrins - genetics | Tissue Inhibitor of Metalloproteinases - metabolism | Tissue Inhibitor of Metalloproteinases - genetics | Biological Evolution | Animals | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Matrix Metalloproteinase Inhibitors | Protein Binding | Matrix Metalloproteinases - metabolism | Disintegrins - chemistry | Drosophila melanogaster | Protein Isoforms - genetics | Index Medicus | Protein Family Review
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3. Full Text Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
by Liu, Jiwen and Lee, TaeWeon and DeFronzo, Ralph A
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2012, Volume 61, Issue 9, pp. 2199 - 2204
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Glucosides - pharmacology | Hypoglycemic Agents - pharmacokinetics | Benzhydryl Compounds | Humans | Glucosides - pharmacokinetics | Permeability | Glucose - antagonists & inhibitors | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Animals | Models, Biological | Kidney Tubules, Proximal - metabolism | Blood Glucose - metabolism | Physiological aspects | Research | Blood sugar | Analysis | Membrane proteins | Index Medicus | Abridged Index Medicus | s in Diabetes
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4. Full Text Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages
by Williams, Lynn and Bradley, Laura and Smith, Alexandra and Foxwell, Brian
The Journal of immunology (1950), ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
Life Sciences & Biomedicine | Immunology | Science & Technology | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
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5. Full Text Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors
by Romero, F. Anthony and Taylor, Alexander M and Crawford, Terry D and Tsui, Vickie and Côté, Alexandre and Magnuson, Steven
Journal of medicinal chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism | Index Medicus
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6. Full Text The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
by Drucker, Daniel J and Nauck, Michael A
The Lancet (British edition), ISSN 0140-6736, 2006, Volume 368, Issue 9548, pp. 1696 - 1705
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Triazoles - administration & dosage | Triazoles - adverse effects | Glucagon-Like Peptide 1 - administration & dosage | Humans | Pyrazines - administration & dosage | Glucagon-Like Peptide 1 - biosynthesis | Dipeptidyl Peptidase 4 | Glucagon-Like Peptide 1 - physiology | Pyrazines - therapeutic use | Adenosine Deaminase Inhibitors | Peptides - administration & dosage | Hypoglycemic Agents - administration & dosage | Adamantane - therapeutic use | Pyrrolidines | Venoms - administration & dosage | Nitriles | Sitagliptin Phosphate | Adamantane - administration & dosage | Adamantane - adverse effects | Adamantane - analogs & derivatives | Triazoles - therapeutic use | Glucagon-Like Peptide 1 - classification | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Drug Administration Schedule | Glucagon-Like Peptide 1 - analogs & derivatives | Venoms - adverse effects | Glycoproteins - antagonists & inhibitors | Clinical Trials as Topic | Glucagon-Like Peptide-1 Receptor | Dipeptidyl-Peptidase IV Inhibitors | Pyrazines - adverse effects | Venoms - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Glucagon-Like Peptide 1 - adverse effects | Hypoglycemic Agents - adverse effects | Liraglutide | Peptides - adverse effects | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Type 2 diabetes | Care and treatment | Diagnosis | Glucagon | Analysis | Dosage and administration | Research | Protease inhibitors | Drug therapy | Proteins | Diabetes | Kinases | Insulin | Rodents | Index Medicus | Abridged Index Medicus
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7. Full Text Chelation: A fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications
by Nagai, Ryoji and Murray, David B and Metz, Thomas O and Baynes, John W and Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Diabetes (New York, N.Y.), ISSN 0012-1797, 03/2012, Volume 61, Issue 3, pp. 549 - 559
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Glycation End Products, Advanced - physiology | Aldehyde Reductase - antagonists & inhibitors | Animals | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Humans | Glycation End Products, Advanced - antagonists & inhibitors | Diabetes Complications - drug therapy | Antihypertensive Agents - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Chelating Agents - therapeutic use | Advanced glycation end products | Usage | Care and treatment | Physiological aspects | Research | Chelating agents | Diabetes | Index Medicus | Abridged Index Medicus | OXIDATION | CARBONYLS | AGE breaker | BASIC BIOLOGICAL SCIENCES | ENZYME INHIBITORS | TRAPPING | HYDROLYSIS | 60 APPLIED LIFE SCIENCES | ANGIOTENSIN | advanced glycation end-product (AGE) | MODIFICATIONS | DISEASES | THERAPY | metal-catalyzed oxidation | INFLAMMATION | chelation | Environmental Molecular Sciences Laboratory | REACTION INTERMEDIATES | PROTEINS | FUNCTIONALS | oxidative stress | s in Diabetes
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