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Publication DateFrontiers in Immunology, ISSN 1664-3224, 2014, Volume 5, p. 461
Toll-like receptors < TLRs > play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various...
NF-ΚB | Signal transduction | IRFs | Adaptors | TLRs | STERILE INFLAMMATION | signal transduction | NUCLEIC-ACID | adaptors | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | ANTIVIRAL RESPONSE | DEPENDENT IMMUNE-RESPONSES | NF-kappa B | NEGATIVE REGULATION | GENE INDUCTION-PROGRAM | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | I INTERFERON-PRODUCTION | Signal Transduction | NF-B
NF-ΚB | Signal transduction | IRFs | Adaptors | TLRs | STERILE INFLAMMATION | signal transduction | NUCLEIC-ACID | adaptors | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | ANTIVIRAL RESPONSE | DEPENDENT IMMUNE-RESPONSES | NF-kappa B | NEGATIVE REGULATION | GENE INDUCTION-PROGRAM | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | I INTERFERON-PRODUCTION | Signal Transduction | NF-B
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 43, pp. 31268 - 31279
Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns that mediate well established cytokine-driven pathways, activating...
HOMOTYPIC INTERACTION MOTIF | CELL-DEATH PATHWAY | TNF-INDUCED NECROSIS | INTERACTING PROTEIN | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADAPTER TRIF | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | DOMAIN-LIKE | NF-KAPPA-B | Glycoproteins - genetics | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | NIH 3T3 Cells | Protein Kinases - genetics | Signal Transduction | Adaptor Proteins, Vesicular Transport - genetics | Glycoproteins - metabolism | Multiprotein Complexes - genetics | Necrosis - metabolism | Toll-Like Receptor 3 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Necrosis - pathology | Mice, Knockout | Multiprotein Complexes - antagonists & inhibitors | Multiprotein Complexes - metabolism | Protein Kinase Inhibitors - chemistry | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Mice | Necrosis - genetics | Protein Kinase Inhibitors - pharmacology | Toll-Like Receptor 3 - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Toll-like Receptors (TLR) | Immunology | RIPK3 | Serine | Caspase | Necrosis (Necrotic Death) | Threonine Protein Kinase | Apoptosis
HOMOTYPIC INTERACTION MOTIF | CELL-DEATH PATHWAY | TNF-INDUCED NECROSIS | INTERACTING PROTEIN | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADAPTER TRIF | MIXED LINEAGE KINASE | PROGRAMMED NECROSIS | DOMAIN-LIKE | NF-KAPPA-B | Glycoproteins - genetics | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | NIH 3T3 Cells | Protein Kinases - genetics | Signal Transduction | Adaptor Proteins, Vesicular Transport - genetics | Glycoproteins - metabolism | Multiprotein Complexes - genetics | Necrosis - metabolism | Toll-Like Receptor 3 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Necrosis - pathology | Mice, Knockout | Multiprotein Complexes - antagonists & inhibitors | Multiprotein Complexes - metabolism | Protein Kinase Inhibitors - chemistry | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Mice | Necrosis - genetics | Protein Kinase Inhibitors - pharmacology | Toll-Like Receptor 3 - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Toll-like Receptors (TLR) | Immunology | RIPK3 | Serine | Caspase | Necrosis (Necrotic Death) | Threonine Protein Kinase | Apoptosis
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Loading RightsVeterinary Immunology and Immunopathology, ISSN 0165-2427, 2010, Volume 134, Issue 3, pp. 139 - 150
The innate immune system constitutes an efficient defense against invading microbial pathogens. Toll-like receptors (TLRs) eventually alert vertebrates about...
Teleost | TLR signaling | NF-κB | Innate immunity | MyD88 | SOLE CYNOGLOSSUS-SEMILAEVIS | DOUBLE-STRANDED-RNA | FACTOR 88 MYD88 | RAINBOW-TROUT | EXPRESSION ANALYSIS | MINNOW GOBIOCYPRIS-RARUS | IMMUNOLOGY | NF-kappa B | VETERINARY SCIENCES | FULL-LENGTH SEQUENCE | NF-KAPPA-B | TROUT ONCORHYNCHUS-MYKISS | VIRULENT EDWARDSIELLA-ICTALURI | Amino Acid Sequence | Fishes - genetics | Promoter Regions, Genetic | Fish Proteins - immunology | Humans | Toll-Like Receptors - immunology | Toll-Like Receptors - classification | Molecular Sequence Data | Phylogeny | Immunity, Innate | Fish Proteins - classification | Fishes - immunology | DNA - genetics | Sequence Homology, Amino Acid | Fish Proteins - genetics | Signal Transduction - immunology | Animals | Models, Biological | Base Sequence | Toll-Like Receptors - genetics
Teleost | TLR signaling | NF-κB | Innate immunity | MyD88 | SOLE CYNOGLOSSUS-SEMILAEVIS | DOUBLE-STRANDED-RNA | FACTOR 88 MYD88 | RAINBOW-TROUT | EXPRESSION ANALYSIS | MINNOW GOBIOCYPRIS-RARUS | IMMUNOLOGY | NF-kappa B | VETERINARY SCIENCES | FULL-LENGTH SEQUENCE | NF-KAPPA-B | TROUT ONCORHYNCHUS-MYKISS | VIRULENT EDWARDSIELLA-ICTALURI | Amino Acid Sequence | Fishes - genetics | Promoter Regions, Genetic | Fish Proteins - immunology | Humans | Toll-Like Receptors - immunology | Toll-Like Receptors - classification | Molecular Sequence Data | Phylogeny | Immunity, Innate | Fish Proteins - classification | Fishes - immunology | DNA - genetics | Sequence Homology, Amino Acid | Fish Proteins - genetics | Signal Transduction - immunology | Animals | Models, Biological | Base Sequence | Toll-Like Receptors - genetics
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Loading RightsCytokine and Growth Factor Reviews, ISSN 1359-6101, 2014, Volume 25, Issue 5, pp. 533 - 541
Abstract There is a wealth of knowledge about how different Ser/Thr protein kinases participate in Toll-like receptor (TLR) signaling. In many cases, we know...
Advanced Basic Science | TLR | Protein tyrosine kinases | Tyrosine phosphorylation | Src | EGFR | KAPPA-B ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TIR-DOMAIN | LPS | I INTERFERON | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | ADAPTER | TRIF | LYN KINASE | TLR4 | Phosphorylation | Tyrosine - metabolism | Animals | Signal Transduction | Models, Biological | Humans | Toll-Like Receptors - physiology | Proteins | Tyrosine | Phenols | Phosphotransferases | Analysis | Protein Tyrosine kinases | PI3K | IRFs | Btk | MyD88
Advanced Basic Science | TLR | Protein tyrosine kinases | Tyrosine phosphorylation | Src | EGFR | KAPPA-B ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TIR-DOMAIN | LPS | I INTERFERON | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | ADAPTER | TRIF | LYN KINASE | TLR4 | Phosphorylation | Tyrosine - metabolism | Animals | Signal Transduction | Models, Biological | Humans | Toll-Like Receptors - physiology | Proteins | Tyrosine | Phenols | Phosphotransferases | Analysis | Protein Tyrosine kinases | PI3K | IRFs | Btk | MyD88
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Loading RightsArthritis Research and Therapy, ISSN 1478-6354, 02/2005, Volume 7, Issue 1, pp. 12 - 19
The family of Toll-like receptors (TLRs) senses conserved structures found in a broad range of pathogens, causing innate immune responses that include the...
Innate immunity | TIR-domain containing adapter | Inflammatory cytokines | TLR | Interferons | TRANSCRIPTION FACTORS | RHEUMATOID-ARTHRITIS | IMMUNE-RESPONSE | inflammatory cytokines | RHEUMATOLOGY | IFN-REGULATORY FACTOR-3 | CUTTING EDGE | DOMAIN-CONTAINING ADAPTER | interferons | innate immunity | CELL ACTIVATION | GENE-EXPRESSION | NF-KAPPA-B | BACTERIAL-DNA | Protein Structure, Tertiary | Signal Transduction | Infection - immunology | Humans | Gene Expression Regulation | Toll-Like Receptors - chemistry | Inflammation - immunology | Myeloid Differentiation Factor 88 | I-kappa B Kinase - physiology | Mice, Knockout | Arthritis, Rheumatoid - metabolism | Adaptor Proteins, Signal Transducing - physiology | Drosophila Proteins - physiology | Infection - genetics | Infection - metabolism | Inflammation - metabolism | Animals | Inflammation - genetics | Toll-Like Receptors - physiology | Ligands | Receptors, Interleukin-1 - physiology | Mice | Arthritis, Rheumatoid - immunology | Review
Innate immunity | TIR-domain containing adapter | Inflammatory cytokines | TLR | Interferons | TRANSCRIPTION FACTORS | RHEUMATOID-ARTHRITIS | IMMUNE-RESPONSE | inflammatory cytokines | RHEUMATOLOGY | IFN-REGULATORY FACTOR-3 | CUTTING EDGE | DOMAIN-CONTAINING ADAPTER | interferons | innate immunity | CELL ACTIVATION | GENE-EXPRESSION | NF-KAPPA-B | BACTERIAL-DNA | Protein Structure, Tertiary | Signal Transduction | Infection - immunology | Humans | Gene Expression Regulation | Toll-Like Receptors - chemistry | Inflammation - immunology | Myeloid Differentiation Factor 88 | I-kappa B Kinase - physiology | Mice, Knockout | Arthritis, Rheumatoid - metabolism | Adaptor Proteins, Signal Transducing - physiology | Drosophila Proteins - physiology | Infection - genetics | Infection - metabolism | Inflammation - metabolism | Animals | Inflammation - genetics | Toll-Like Receptors - physiology | Ligands | Receptors, Interleukin-1 - physiology | Mice | Arthritis, Rheumatoid - immunology | Review
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Loading RightsCytokine, ISSN 1043-4666, 08/2015, Volume 74, Issue 2, pp. 181 - 189
Families of innate immune receptors serve as the bodies primary defence system by recognising and rapidly responding to infection by microorganisms or to...
Innate immunity | Toll-like receptors (TLRs) | Signalling | Myddosome | ATF3 | IRAK-M | STERILE INFLAMMATION | PRION-LIKE POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRP3 INFLAMMASOME ACTIVATION | IMMUNOLOGY | CHOLESTEROL EFFLUX CAPACITY | HIGH-DENSITY-LIPOPROTEIN | CUTTING EDGE | CELL BIOLOGY | DOMAIN-CONTAINING ADAPTER | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | Transcription, Genetic - immunology | Signal Transduction - immunology | Animals | Activating Transcription Factor 3 - immunology | Humans | Toll-Like Receptors - immunology | Genetic aspects | Genetic transcription
Innate immunity | Toll-like receptors (TLRs) | Signalling | Myddosome | ATF3 | IRAK-M | STERILE INFLAMMATION | PRION-LIKE POLYMERIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRP3 INFLAMMASOME ACTIVATION | IMMUNOLOGY | CHOLESTEROL EFFLUX CAPACITY | HIGH-DENSITY-LIPOPROTEIN | CUTTING EDGE | CELL BIOLOGY | DOMAIN-CONTAINING ADAPTER | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | Transcription, Genetic - immunology | Signal Transduction - immunology | Animals | Activating Transcription Factor 3 - immunology | Humans | Toll-Like Receptors - immunology | Genetic aspects | Genetic transcription
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Loading RightsThe EMBO Journal, ISSN 0261-4189, 04/2008, Volume 27, Issue 7, pp. 1110 - 1121
Autophagy is a newly recognized innate defense mechanism, acting as a cell‐autonomous system for elimination of intracellular pathogens. The signals and...
autophagy | TLR | HIV | LC3 | tuberculosis | Tuberculosis | Autophagy | MYCOBACTERIUM-TUBERCULOSIS | KINASE-ACTIVITY | NADPH OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFENSE-MECHANISM | CUTTING EDGE | CELL BIOLOGY | PLASMACYTOID DENDRITIC CELLS | ADAPTIVE IMMUNITY | CROSS-TALK | TOXOPLASMA-GONDII | MATURATION STEP | Macrophages - ultrastructure | Toll-Like Receptor 7 - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Mice, Inbred C57BL | Immunoblotting | Autophagy - physiology | Macrophages - cytology | Animals | Intracellular Space - microbiology | Mycobacterium tuberculosis | Ligands | Mice | Protein Processing, Post-Translational | HeLa Cells | Toll-Like Receptors - metabolism | Myeloid Differentiation Factor 88 - metabolism | Cytoplasmic Structures - metabolism | RNA, Small Interfering - metabolism | Pathogens | Signal transduction | Immunology | Cellular biology
autophagy | TLR | HIV | LC3 | tuberculosis | Tuberculosis | Autophagy | MYCOBACTERIUM-TUBERCULOSIS | KINASE-ACTIVITY | NADPH OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFENSE-MECHANISM | CUTTING EDGE | CELL BIOLOGY | PLASMACYTOID DENDRITIC CELLS | ADAPTIVE IMMUNITY | CROSS-TALK | TOXOPLASMA-GONDII | MATURATION STEP | Macrophages - ultrastructure | Toll-Like Receptor 7 - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Mice, Inbred C57BL | Immunoblotting | Autophagy - physiology | Macrophages - cytology | Animals | Intracellular Space - microbiology | Mycobacterium tuberculosis | Ligands | Mice | Protein Processing, Post-Translational | HeLa Cells | Toll-Like Receptors - metabolism | Myeloid Differentiation Factor 88 - metabolism | Cytoplasmic Structures - metabolism | RNA, Small Interfering - metabolism | Pathogens | Signal transduction | Immunology | Cellular biology
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Loading RightsJournal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 6, pp. 4517 - 4524
Toll-like receptors (TLRs) are the key molecular sensors used by the mammalian innate immune system to detect various types of pathogens. Tlr13 is a novel and...
ANTIVIRAL RESPONSE | ADAPTIVE IMMUNITY | SIGNALING PATHWAYS | STRANDED-RNA | ACTIVATION | PATTERN-RECOGNITION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | INNATE IMMUNE-SYSTEM | INFECTION | NIH 3T3 Cells | NF-kappa B - immunology | Vesiculovirus - immunology | NF-kappa B - metabolism | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Gene Knockdown Techniques | Signal Transduction - immunology | Cloning, Molecular | Myeloid Differentiation Factor 88 - immunology | Interferon Type I - metabolism | Toll-Like Receptors - metabolism | Rhabdoviridae Infections - metabolism | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Interferon Regulatory Factor-7 - immunology | MAP Kinase Kinase Kinases - metabolism | Interferon Regulatory Factor-7 - metabolism | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Animals | NF-kappa B - genetics | Rhabdoviridae Infections - immunology | Toll-Like Receptors - genetics | Rhabdoviridae Infections - genetics | Vesiculovirus - metabolism | Interferon Type I - genetics | Mice | Myeloid Differentiation Factor 88 - metabolism | Toll-like Receptors (TLR) | NF-κB | Interferon | Viral Immunology | Immunology | Innate Immunity
ANTIVIRAL RESPONSE | ADAPTIVE IMMUNITY | SIGNALING PATHWAYS | STRANDED-RNA | ACTIVATION | PATTERN-RECOGNITION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | INNATE IMMUNE-SYSTEM | INFECTION | NIH 3T3 Cells | NF-kappa B - immunology | Vesiculovirus - immunology | NF-kappa B - metabolism | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Gene Knockdown Techniques | Signal Transduction - immunology | Cloning, Molecular | Myeloid Differentiation Factor 88 - immunology | Interferon Type I - metabolism | Toll-Like Receptors - metabolism | Rhabdoviridae Infections - metabolism | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Interferon Regulatory Factor-7 - immunology | MAP Kinase Kinase Kinases - metabolism | Interferon Regulatory Factor-7 - metabolism | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Animals | NF-kappa B - genetics | Rhabdoviridae Infections - immunology | Toll-Like Receptors - genetics | Rhabdoviridae Infections - genetics | Vesiculovirus - metabolism | Interferon Type I - genetics | Mice | Myeloid Differentiation Factor 88 - metabolism | Toll-like Receptors (TLR) | NF-κB | Interferon | Viral Immunology | Immunology | Innate Immunity
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Loading RightsFree Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 48, Issue 9, pp. 1121 - 1132
Injury caused by oxidative stress occurs in many clinical scenarios involving ischemia and reperfusion such as organ transplantation, hemorrhagic shock (HS),...
Hemorrhagic shock | Free radicals | NADPH oxidase | HMGB1 | Redox stress | Ischemia/reperfusion | Toll-like receptor | DAMPs | MEDIATES ISCHEMIA/REPERFUSION INJURY | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | ENDOTOXIN-RESISTANT MICE | ACUTE LUNG INJURY | GROUP BOX-1 PROTEIN | ISCHEMIA-REPERFUSION INJURY | HEMORRHAGIC-SHOCK | TUMOR-NECROSIS-FACTOR | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | Inflammation - immunology | Animals | Humans | Reperfusion Injury - immunology | Toll-Like Receptors - immunology | Oxidative Stress - immunology | Oxidases | Transplantation of organs, tissues, etc | Oxidative stress | Inflammation | Chromosomal proteins | Analysis | inflammation | hemorrhagic shock | damage associated molecular pattern (DAMP) | toll-like receptor (TLR) | ischemia-reperfusion | oxidative stress | redox
Hemorrhagic shock | Free radicals | NADPH oxidase | HMGB1 | Redox stress | Ischemia/reperfusion | Toll-like receptor | DAMPs | MEDIATES ISCHEMIA/REPERFUSION INJURY | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | ENDOTOXIN-RESISTANT MICE | ACUTE LUNG INJURY | GROUP BOX-1 PROTEIN | ISCHEMIA-REPERFUSION INJURY | HEMORRHAGIC-SHOCK | TUMOR-NECROSIS-FACTOR | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | Inflammation - immunology | Animals | Humans | Reperfusion Injury - immunology | Toll-Like Receptors - immunology | Oxidative Stress - immunology | Oxidases | Transplantation of organs, tissues, etc | Oxidative stress | Inflammation | Chromosomal proteins | Analysis | inflammation | hemorrhagic shock | damage associated molecular pattern (DAMP) | toll-like receptor (TLR) | ischemia-reperfusion | oxidative stress | redox
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Loading RightsClinical Science, ISSN 0143-5221, 03/2008, Volume 114, Issue 5-6, pp. 347 - 360
Although several lines of evidence suggest that variation in human inflammation is genetically controlled, the genes which regulate these responses are largely...
Innate immunity | Inflammation | Genetic variation | Toll-like receptor (TLR) | Immunodeficiency | Polymorphism | RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CROHNS-DISEASE | genetic variation | ARG753GLN POLYMORPHISM | polymorphism | GENE POLYMORPHISMS | INFLAMMATORY-BOWEL-DISEASE | innate immunity | inflammation | HUMAN INFECTIOUS-DISEASE | immunodeficiency | SINGLE-NUCLEOTIDE POLYMORPHISMS | Signal Transduction - immunology | Genetic Predisposition to Disease |
Innate immunity | Inflammation | Genetic variation | Toll-like receptor (TLR) | Immunodeficiency | Polymorphism | RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CROHNS-DISEASE | genetic variation | ARG753GLN POLYMORPHISM | polymorphism | GENE POLYMORPHISMS | INFLAMMATORY-BOWEL-DISEASE | innate immunity | inflammation | HUMAN INFECTIOUS-DISEASE | immunodeficiency | SINGLE-NUCLEOTIDE POLYMORPHISMS | Signal Transduction - immunology | Genetic Predisposition to Disease |