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1. Full Text Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd 2 (CO 3 ) 3 @PDA nanoparticles via TLR-2/NF-κB/Akt signaling
by Ouyang, Zhengxiao and Tan, Tingting and Liu, Chunfeng and Duan, Juan and Wang, Wanchun and Guo, Xiaoning and Zhang, Qing and Li, Zhihong and Huang, Qianli and Dou, Pengcheng and Liu, Tang
Biomaterials, ISSN 0142-9612, 06/2019, Volume 205, pp. 50 - 63
The progressive degeneration of cartilage marks the advancement of osteoarthritis (OA), which requires specific targeted treatment for effective cartilage... 
Cartilage | Hesperetin | CO | TLR-2 | Osteoarthritis
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2. Full Text Assessment of TLR-2 concentration in tick-borne encephalitis and neuroborreliosis
by Moniuszko-Malinowska, Anna and Penza, Paweł and Czupryna, Piotr and Zajkowska, Olga and Pancewicz, Sławomir and Król, Monika and Świerzbińska, Renata and Dunaj, Justyna and Zajkowska, Joanna
Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, 10/2019, Volume 79, Issue 7, pp. 502 - 506
The aim of the study was to check whether measurement of TLR-2 in serum or cerebrospinal fluid (CSF) can help differentiate between neuroborreliosis (NB) and... 
neuroborreliosis | TLR-2 | biomarker | TBE
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3. Full Text Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd2(CO3)3@PDA nanoparticles via TLR-2/NF-κB/Akt signaling
by Ouyang, Zhengxiao and Tan, Tingting and Liu, Chunfeng and Duan, Juan and Wang, Wanchun and Guo, Xiaoning and Zhang, Qing and Li, Zhihong and Huang, Qianli and Dou, Pengcheng and Liu, Tang
Biomaterials, ISSN 0142-9612, 06/2019, Volume 205, pp. 50 - 63
The progressive degeneration of cartilage marks the advancement of osteoarthritis (OA), which requires specific targeted treatment for effective cartilage... 
Gd2(CO3)3 | Cartilage | Hesperetin | TLR-2 | Osteoarthritis
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4. Full Text Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: An in vivo and in vitro study
by Liu, Yi-Xun and Wang, Guo-Dong and Wang, Xiao and Zhang, Yong-Le and Zhang, Tian-Lun
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 24, pp. 38602 - 38617
The study aims to explore the effects of TLR-2/NF-kappa B signaling pathway on the occurrence of degenerative knee osteoarthritis (OA). Degenerative knee OA... 
Matrix metalloprotease-13 | Degenerative osteoarthritis | Toll-like receptor 2 | TLR-2/NF-κB signaling pathway | Nuclear transcription factor-kappa B | TLR-2/NF-kappa B signaling pathway | RHEUMATOID-ARTHRITIS | nuclear transcription factor-kappa B | NF-KB | degenerative osteoarthritis | matrix metalloprotease-13 | FACTOR-KAPPA-B | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | SYNOVIAL FIBROBLASTS | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | TNF-ALPHA | UP-REGULATION | toll-like receptor 2 | Cell Proliferation | Prevalence | Prognosis | Toll-Like Receptor 2 - genetics | Follow-Up Studies | Humans | Middle Aged | Male | NF-kappa B - metabolism | Osteoarthritis, Knee - epidemiology | Case-Control Studies | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Signal Transduction | Matrix Metalloproteinase 13 - genetics | Cells, Cultured | China - epidemiology | Toll-Like Receptor 2 - metabolism | Matrix Metalloproteinase 13 - metabolism | NF-kappa B - genetics | Osteoarthritis, Knee - pathology | Chondrocytes | Aged | Biomarkers, Tumor - genetics | In Vitro Techniques | Osteoarthritis, Knee - metabolism
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5. Full Text AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production
by Mahil, Satveer K and Twelves, Sophie and Farkas, Katalin and Setta-Kaffetzi, Niovi and Burden, A. David and Gach, Joanna E and Irvine, Alan D and Képíró, László and Mockenhaupt, Maja and Oon, Hazel H and Pinner, Jason and Ranki, Annamari and Seyger, Marieke M.B and Soler-Palacin, Pere and Storan, Eoin R and Tan, Eugene S and Valeyrie-Allanore, Laurence and Young, Helen S and Trembath, Richard C and Choon, Siew-Eng and Szell, Marta and Bata-Csorgo, Zsuzsanna and Smith, Catherine H and Di Meglio, Paola and Barker, Jonathan N and Capon, Francesca
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2016, Volume 136, Issue 11, pp. 2251 - 2259
Prominent skin involvement is a defining characteristic of autoinflammatory disorders caused by abnormal IL-1 signaling. However, the pathways and cell types... 
GENERALIZED PUSTULAR PSORIASIS | RESPONSES | ACTIVATION | DISEASES | INFLAMMATION | GENERATION | INFLAMMASOMES | DERMATOLOGY | Cell Line | Interleukin-1 - genetics | Up-Regulation | Signal Transduction | Humans | Middle Aged | Transcriptional Activation | Autophagy | Interleukin-1 - biosynthesis | DNA - genetics | Keratinocytes - pathology | Psoriasis - genetics | Psoriasis - pathology | DNA Mutational Analysis | Keratinocytes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Psoriasis - metabolism | Female | Aged | Mutation | Adaptor Proteins, Signal Transducing - metabolism | 3-MA, 3-methyladenine | GFP, green fluorescent protein | MALP-2, macrophage-activating lipopeptide 2 | Cas9, CRISPR-associated endonuclease 9 | AID, autoinflammatory disorder | CRISPR, clustered regularly-interspaced short palindromic repeats | TLR-2 | Original | 6, Toll-like receptor 2 | siRNA, small interfering RNA
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6. Full Text TLR-2 independent recognition of M. tuberculosis by CD11c+ pulmonary cells from old mice
by Rottinghaus, Erin K and Vesosky, Bridget and Turner, Joanne
Mechanisms of ageing and development, ISSN 0047-6374, 6/2010, Volume 131, Issue 6, pp. 405 - 414
The elderly are particularly susceptible to infectious diseases such as influenza, bacterial pneumonia, and tuberculosis. Current vaccines are only partially... 
TLR-2 | tuberculosis | Macrophage
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7. Full Text Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice1
by You-Jee Jang and Jae-Il Park and Won-Jin Moon and Phuong T.M. Dam and Moon-Kyoung Cho and Sang-Young Chun
Biology of Reproduction, ISSN 0006-3363, 2015, Volume 92, Issue 1
ABSTRACT Ovulation resembles the inflammatory response. The purpose of the present study was to examine the expression and role of type I interferons (IFNs)... 
TLR-2/4 | cumulus expansion | gonadotropins | ovulation | type I interferons
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8. Full Text Coxiella burnetii lipopolysaccharide blocks p38a- MAPK activation through the disruption of TLR-2 and TLR-4 association
by Conti, Filippo and Conti, Filippo and Boucherit, Nicolas and Boucherit, Nicolas and Baldassarre, Veronica and Baldassarre, Veronica and Trouplin, Virginie and Trouplin, Virginie and Toman, Rudolf and Toman, Rudolf and Mottola, Giovanna and Mottola, Giovanna and Mege, Jean-Louis and Mege, Jean-Louis and Ghigo, Eric and Ghigo, Eric
Frontiers in Cellular and Infection Microbiology, 2014, Volume 4, p. 182
Cytoskeleton | TLR-4 | Macrophages | TLR-2 | Coxiella burnetii
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9. Full Text Micronized and Heat-Treated Lactobacillus plantarum LM1004 Stimulates Host Immune Responses Via the TLR-2/MAPK/NF-κB Signalling Pathway In Vitro and In Vivo
by Jisun Lee and and Ilseon Jung and Ji Won Choi and Chang Won Lee and Sarang Cho and Tae Gyu Choi and Minn Sohn and Yong Il Park
Journal of Microbiology and Biotechnology, ISSN 1017-7825, 2019, Volume 29, Issue 5, p. 704
Although nanometric dead Lactobacillus plantarum has emerged as a potentially important modulator of immune responses, its underlying mechanism of action has... 
MAPK-NF-κB signalling pathway | immunostimulating activity | action mechanism | TLR-2 | Nanometric heat-killed Lactobacillus plantarum
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10. Full Text The Toll-Like Receptor 2 agonist PEG-Pam2Cys as an immunochemoprophylactic and immunochemotherapeutic against the liver and transmission stages of malaria parasites
by Ernest, Medard and Hunja, Carol and Arakura, Yuka and Haraga, Yohei and Abkallo, Hussein M and Zeng, Weiguang and Jackson, David C and Chua, Brendon and Culleton, Richard
International Journal for Parasitology: Drugs and Drug Resistance, ISSN 2211-3207, 12/2018, Volume 8, Issue 3, pp. 451 - 458
Both vaccine and therapeutic approaches to malaria are based on conventional paradigms; whole organism or single antigen epitope-based vaccines administered... 
Plasmodium | Malaria | TLR-2 | Pam2Cys | Cys | Pam
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11. Full Text Defective MyD88 and IRAK4 but not TLR-2 expression in HIV+ individuals with latent tuberculosis infection
by Devalraju, Kamakshi Prudhula and Neela, Venkata Sanjeev Kumar and Gaddam, Ramulu and Chaudhury, Arunabala and Van, Abhinav and Krovvidi, Siva Sai and Vankayalapati, Ramakrishna and Valluri, Vijaya Lakshmi
Cytokine, ISSN 1043-4666, 10/2018, Volume 110, pp. 213 - 221
•Production of IL-1 β, TNF-a and IL-10 is independent of TLR2 expression on monocytes.•MyD88 and IRAK4, not NF-kB mediate production of IL-1β, MCP-1 and IP-10... 
Human | Monocytes | Tuberculosis | HIV | Cytokines | TLR-2 | Interleukins | Fluorescein | HIV patients | Interferon | Biological response modifiers | HIV (Viruses) | Health aspects | HIV infection | monocytes | cytokines | tuberculosis
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12. Full Text HMGB1 induces an inflammatory response in the chorioamniotic membranes that is partially mediated by the inflammasome
by Plazyo, Olesya and Romero, Roberto and Unkel, Ronald and Balancio, Amapola and Mial, Tara N and Xu, Yi and Dong, Zhong and Hassan, Sonia S and Gomez-Lopez, Nardhy
Biology of Reproduction, ISSN 0006-3363, 12/2016, Volume 95, Issue 6, pp. 1 - 14
Spontaneous preterm labor occurs in two subsets of patients with sterile intra-amniotic inflammation, a process induced by alarmins such as high-mobility group... 
Parturition | Preterm birth | Preterm labor | Sterile intra-amniotic inflammation | NOD2 | RAGE | Caspase-1 | DAMPs | Interleukin-6 | Alarmins | Pregnancy | AIM2 | Interleukin-1b | NLRP3 | Sterile inflammation | TLR-2 | MMP-9 | preterm birth | sterile inflammation | TOLL-LIKE RECEPTOR | interleukin-6 | parturition | HUMAN FETAL MEMBRANES | alarmins | REPRODUCTIVE BIOLOGY | NOD-LIKE RECEPTORS | PRETERM PREMATURE RUPTURE | END-PRODUCTS RAGE | caspase-1 | pregnancy | preterm labor | NECROSIS-FACTOR-ALPHA | INNATE IMMUNE-SYSTEM | NLRP3 INFLAMMASOME | CLINICAL CHORIOAMNIONITIS | sterile intra-amniotic inflammation | MATRIX METALLOPROTEINASES | interleukin-1 beta | Inflammation - chemically induced | Phosphorylation | Inflammasomes - metabolism | Humans | Premature Birth - metabolism | Caspase 1 - metabolism | Up-Regulation - drug effects | Young Adult | Inflammation - metabolism | Amnion - metabolism | HMGB1 Protein - pharmacology | Inflammation Mediators - metabolism | Adult | Female | Amnion - drug effects | Chorion - drug effects | Chorion - metabolism
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13. Full Text New antimicrobial peptide kills drug-resistant pathogens without detectable resistance
by Lee, Jong-Kook and Luchian, Tudor and Park, Yoonkyung
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 21, pp. 15616 - 15634
Clavaspirin peptide (CSP) is derived from the pharyngeal tissues of the tunicate . The 23-amino acid peptide is histidine-rich and amidated at the N-terminus.... 
Nuclear factor-kappa B (NF-κB) | Toll-like receptor-2 (TLR-2) | Proinflammatory cytokine | Staphylococcus aureus | Clavaspirin peptide (CSP)
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14. Full Text Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF-α expression in mice
by Taghavi, Mehdi and Mortaz, Esmaeil|info:eu-repo/dai/nl/29141320X and Khosravi, Alireza and Vahedi, Ghasem and Folkerts, Gert|info:eu-repo/dai/nl/087131811 and Varahram, Mohammad and Kazempour-Dizaji, Mehdi and Garssen, Johan|info:eu-repo/dai/nl/086369962 and Adcock, Ian M
Journal of Inflammation, ISSN 1476-9255, 03/2018, Volume 15, Issue 5, pp. 5 - 10
Background: Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel... 
Zymosan | TLR-4 | TNF-α | TLR-2 | BETA-GLUCANS | CELLS | ACTIVATION | TNF-alpha | INNATE | RECEPTOR | IMMUNOLOGY | CYTOKINE PRODUCTION | CANCER-TREATMENT | IMMUNE-RESPONSES | PARTICULATE | SKIN
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15. Full Text Regulation of B-Cell-Activating Factor Expression on the Basophil Membrane of Allergic Patients
by Boita, Monica and Heffler, Enrico and Pizzimenti, Stefano and Raie, Alberto and Saraci, Elona and Omedè, Paola and Bussolino, Claudia and Bucca, Caterina and Rolla, Giovanni
International Archives of Allergy and Immunology, ISSN 1018-2438, 05/2015, Volume 166, Issue 3, pp. 208 - 212
Background: To investigate the modulation of B-cell-activating factor (BAFF) expression on the basophil membrane of allergic patients. BAFF is an important... 
Original Paper | IgE | B-cell-activating factor | Fungal sensitization | Basophil activation test | Severe asthma | Allergic bronchopulmonary aspergillosis | Aspergillus fumigatus | TLR-2 | Basophil | BAFF | NASAL POLYPS | LYMPHOCYTE STIMULATOR | RELEASE | IMMUNOLOGY | FAMILY | ALLERGY | Up-Regulation | B-Cell Activating Factor - biosynthesis | Rhinitis, Allergic - immunology | Humans | Middle Aged | Male | Lipopolysaccharides | Lymphocyte Activation - immunology | Membrane Proteins - biosynthesis | B-Lymphocytes - immunology | Immunoglobulin E - immunology | Aspergillosis, Allergic Bronchopulmonary - immunology | Aspergillus fumigatus - immunology | Asthma - immunology | Basophils - immunology | Tetraspanin 30 - biosynthesis | Toll-Like Receptor 2 - immunology | Adult | B-Cell Activating Factor - immunology | Female | beta-Glucans - immunology | Fungi | Immunoglobulins | Allergies | Asthma
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16. Full Text Cottonseed protein concentrate (CPC) suppresses immune function in different intestinal segments of hybrid grouper ♀Epinephelus fuscoguttatus×♂Epinephelus lanceolatu via TLR-2/MyD88 signaling pathways
by Yin, Bin and Liu, Hongyu and Tan, Beiping and Dong, Xiaohui and Chi, Shuyan and Yang, Qihui and Zhang, Shuang and Chen, Liqiao
Fish and Shellfish Immunology, ISSN 1050-4648, 10/2018, Volume 81, pp. 318 - 328
Cottonseed protein concentrate (CPC) has similar amino acid composition compared with fish meal, and has the characteristics of low gossypol and low toxicity.... 
Antioxidant capacity | Cottonseed protein concentrate | Intestinal segments | Epinephelus fuscoguttatus×♂Epinephelus lanceolatu | Fish meal | TLR-2/MyD88 signaling | Intestines - drug effects | Fish Proteins - immunology | Plant Preparations - administration & dosage | Perciformes - immunology | Cottonseed Oil | Intestines - immunology | Animals | Signal Transduction - drug effects | Malondialdehyde - blood | Myeloid Differentiation Factor 88 - immunology | Perciformes - blood | Plant Proteins - administration & dosage | Toll-Like Receptor 2 - immunology | Female | Cytokines - genetics | Animal Feed | Index Medicus
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17. Full Text HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome1
by Plazyo, Olesya and Romero, Roberto and Unkel, Ronald and Balancio, Amapola and Mial, Tara N and Xu, Yi and Dong, Zhong and Hassan, Sonia S and Gomez-Lopez, Nardhy
Biology of Reproduction, ISSN 0006-3363, 12/2016, Volume 95, Issue 6
Spontaneous preterm labor occurs in two subsets of patients with sterile intra-amniotic inflammation, a process induced by alarmins such as high-mobility group... 
preterm birth | sterile inflammation | pregnancy | preterm labor | NOD2 | RAGE | interleukin-6 | parturition | alarmins | DAMPs | interleukin-1β | sterile intra-amniotic inflammation | AIM2 | NLRP3 | TLR-2 | caspase-1 | MMP-9
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18. Full Text Plasmodium–Salmonella Coinfection Induces Intense Inflammatory Response, Oxidative Stress, and Liver Damage: A Mice Model Study for Therapeutic Strategy
by Patel, Dinesh K and Mittal, Sandeep and Tiwari, Nimisha and Maurya, Anil K and Singh, Dhirendra and Pandey, Alok K and Pal, Anirban
SHOCK, ISSN 1073-2322, 12/2018, Volume 50, Issue 6, pp. 741 - 749
ABSTRACTImpairment of host immune response in malaria favors bacteremia caused by typhoidal or nontyphoidal serovars of Salmonella enterica. Ofloxacin and... 
hemeoxygenase-1 | Th1/Th2 | SURGERY | ASSAY | RECOGNITION | CONCURRENT MALARIA | nontyphoidal Salmonella | malaria-typhoid | Plasmodium | HEME | GLUTATHIONE | TLR-2/TLR-4 | SYSTEMS | PERIPHERAL VASCULAR DISEASE | Bacterial load | HEMATOLOGY | NF-KAPPA-B | oxidative stress | PARADIGM | CRITICAL CARE MEDICINE | Oxidative stress | Care and treatment | Rats as laboratory animals | Malaria | Salmonellosis | Models | Research | Risk factors
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19. Full Text Characterization of Calcined Jade and its immunomodulatory effect on macrophage isolated from Swiss albino mice
by Elahi, Asif and Jairajpuri, Deeba S and Khan, Farah
Journal of Traditional and Complementary Medicine, ISSN 2225-4110, 10/2017, Volume 7, Issue 4, pp. 487 - 493
Calcined Jade (CJ) is a metasilicate frequently used in traditional system of medicine as tonic to vital organs with several other pharmacological activities.... 
Calcined Jade | AAS | TLR-2 | TEM | XRPD | Macrophage
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20. Full Text Tet38 of Staphylococcus aureus Binds to Host Cell Receptor Complex CD36-Toll-Like Receptor 2 and Protects from Teichoic Acid Synthesis Inhibitors Tunicamycin and Congo Red
by Truong-Bolduc, QC and Wang, Y and Hooper, DC
INFECTION AND IMMUNITY, ISSN 0019-9567, 07/2019, Volume 87, Issue 7
Using an affinity column retention assay, we showed that the purified Tet38 membrane transporter of Staphylococcus aureus bound specifically to host cell CD36... 
INFECTIOUS DISEASES | PHAGOCYTOSIS | ACTIVATION | LIPOTEICHOIC ACID | Tet38 | teichoic acids | IMMUNOLOGY | MGRA | ADHERENCE | INTERNALIZATION | S. aureus | Congo red | EFFLUX PUMPS | RESISTANCE | CD36 | TLR-2 | EXPRESSION | tunicamycin | Staphylococcus aureus - genetics | Staphylococcal Infections - genetics | CD36 Antigens - genetics | Toll-Like Receptor 2 - genetics | Congo Red - pharmacology | Humans | Bacterial Proteins - genetics | Lipopolysaccharides - metabolism | Toll-Like Receptor 2 - metabolism | Teichoic Acids - biosynthesis | CD36 Antigens - metabolism | Tunicamycin - pharmacology | Teichoic Acids - metabolism | Protein Binding | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Staphylococcal Infections - microbiology | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Staphylococcal Infections - metabolism | Staphylococcus aureus - metabolism
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