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toll-like receptors (272) 272
tlr1 protein (251) 251
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single-nucleotide polymorphism (39) 39
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myd88 protein (30) 30
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toll-like receptor (30) 30
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genetic predisposition to disease (24) 24
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PLoS ONE, ISSN 1932-6203, 08/2011, Volume 6, Issue 8, p. e23989
Toll-like receptors (TLRs) activate a potent immunostimulatory response. There is clear evidence that overactivation of TLRs leads to infectious and... 
STRUCTURAL BASIS | CRYSTAL-STRUCTURE | PROTEIN-DOCKING | MULTIDISCIPLINARY SCIENCES | ENDOTOXIN TOLERANCE | TIR-DOMAIN | INTERLEUKIN-1 RECEPTOR | IL-1 RECEPTOR | MYD88 ADAPTER-LIKE | QUALITY ASSESSMENT | INNATE IMMUNITY | Interleukin-1 Receptor-Like 1 Protein | Humans | Protein Multimerization | Proteolipids - metabolism | Molecular Sequence Data | Myeloid Differentiation Factor 88 - chemistry | Myelin and Lymphocyte-Associated Proteolipid Proteins | Protein Structure, Quaternary | Membrane Transport Proteins - metabolism | Receptors, Cell Surface - chemistry | Protein Stability | Protein Structure, Tertiary | Toll-Like Receptor 6 - metabolism | Amino Acid Sequence | Toll-Like Receptor 6 - chemistry | Signal Transduction | Computational Biology | Receptors, Cell Surface - metabolism | Toll-Like Receptor 4 - chemistry | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Molecular Dynamics Simulation | Membrane Transport Proteins - chemistry | Myelin Proteins - chemistry | Sequence Alignment | Myelin Proteins - metabolism | Myeloid Differentiation Factor 88 - metabolism | Toll-Like Receptor 2 - chemistry | Proteolipids - chemistry | Molecular dynamics | Medicine, Experimental | Medical research | Structure | Analysis | Crystals | Nuclear magnetic resonance--NMR | Genes | Science | Homology | Innate immunity | Interleukin 1 receptors | Kinases | Immunity | Inflammatory diseases | Molecular docking | Proteins | Signal transduction | Receptors | Pathways | Hydrogen bonds | Rodents | Interleukin 1 | Toll-like receptors | Trends | Inhibition | Crystal structure | Immune system | Immunostimulation | Cytokines | Computer simulation | Adapters | TLR4 protein | Signaling | Molecular modelling | TLR1 protein | TLR2 protein | MyD88 protein | Ligands | In vivo methods and tests | Regulation | Mutation | Three dimensional models | Nuclear magnetic resonance | NMR
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2007, Volume 127, Issue 2, pp. 331 - 341
Keratinocytes are continuously in contact with external stimuli and have the capacity to produce several soluble mediators. Pathogen-associated molecular... 
TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | SKIN-ASSOCIATED CHEMOKINE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INNATE IMMUNE-RESPONSE | INFLAMMATORY PROTEIN 3-ALPHA | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | HUMAN EPIDERMAL-KERATINOCYTES | DERMATOLOGY | Oligonucleotides - genetics | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Toll-Like Receptor 9 - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Flagellin - pharmacology | Tissue Distribution | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Biological Transport | Oligonucleotides - pharmacology | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Chemokine CXCL9 | Toll-Like Receptor 5 - metabolism | Poly I-C - pharmacology | Cytokines - metabolism | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Chemokine CXCL10 | Transcription Factor RelA - metabolism | Keratinocytes - metabolism | Toll-Like Receptors - genetics | Chemokines, CXC - metabolism | Lipopolysaccharides - pharmacology | CpG Islands | Ligands | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | CD40 antigen | Oligonucleotides | Flagellin | mRNA | intercellular adhesion molecule 1 | Immunity | Lipopolysaccharides | CXC chemokines | CCL20 protein | Toll-like receptors | CpG islands | TLR7 protein | Dermatology | Keratinocytes | Nuclear transport | Stress | TLR3 protein | TLR9 protein | TLR1 protein | External stimuli | CXCL10 protein | Histocompatibility antigen HLA | Interferon | Internet | Monocyte chemoattractant protein 1 | Tumor necrosis factor- alpha
Journal Article
American Journal of Physiology, ISSN 0363-6143, 07/2018, Volume 315, Issue 1, p. C62
Chitin particles have been used to understand host response to chitin-containing pathogens and allergens and are known to induce a wide range of polarized... 
Chitinase | TOR protein | Allergens | Genes | Interleukin 1 receptors | Macrophages | CD14 antigen | Microparticles | Proteins | Tissue | Cell growth | Cell activation | Actin | Interleukin 1 | Toll-like receptors | Protein-tyrosine kinase | Adaptor proteins | Tyrosine | Pathogens | MAP kinase | Chitin | Rapamycin | TLR1 protein | TLR2 protein | Lck protein | MyD88 protein | Lyn protein | Chitosan | Phagocytosis
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, p. e0161931
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, encoding the transcription... 
Bronchi - microbiology | RNA, Small Interfering - genetics | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | I-kappa B Proteins - immunology | Epithelial Cells - drug effects | Humans | NF-kappa B - immunology | Monocytes - immunology | Bronchi - immunology | I-kappa B Proteins - genetics | Bronchi - drug effects | RNA, Small Interfering - immunology | I-kappa B Proteins - antagonists & inhibitors | Toll-Like Receptor 4 - antagonists & inhibitors | Nuclear Proteins - genetics | Streptococcus pneumoniae - physiology | Monocytes - microbiology | Benzocycloheptenes - pharmacology | Streptococcus pneumoniae - drug effects | Interleukin-6 - genetics | Signal Transduction | Gene Expression Regulation | Toll-Like Receptor 4 - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Nuclear Proteins - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Host-Pathogen Interactions | Monocytes - drug effects | Toll-Like Receptor 1 - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Toll-Like Receptor 1 - antagonists & inhibitors | NF-kappa B - genetics | Epithelial Cells - immunology | Epithelial Cells - microbiology | Nuclear Proteins - antagonists & inhibitors | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Primary Cell Culture | Toll-Like Receptor 1 - immunology | Pneumonia | Epithelial cells | Pathogenesis | Genes | Critical care | Biology | Infections | Single-nucleotide polymorphism | Streptococcus infections | Interleukin 6 | Proteins | Toll-like receptors | Inhibition | Cytokines | Internal medicine | MAP kinase | Inflammation | TLR4 protein | Children & youth | Medicine | Pneumolysin | Monocytes | Sleep | Streptococcus | TLR1 protein | Lungs | Pharmacy | TLR2 protein | Human behavior
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54586
The innate immune response plays a critical role in the host defense against invading pathogens, and TLR2, a member of the Toll-like receptor (TLR) family, has... 
PROTEIN | RECOGNITION | CELL ACTIVATION | MULTIDISCIPLINARY SCIENCES | INNATE | HEPARAN-SULFATE | CYTOKINE | CD14 | BINDING | CUTTING EDGE | TLR2 | Toll-Like Receptor 6 - metabolism | Cell Line | Cytokines - metabolism | Herpesvirus 1, Human - metabolism | Signal Transduction | Humans | Solubility | Monocytes - metabolism | NF-kappa B - metabolism | Monocytes - immunology | Recombinant Proteins | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Lipopolysaccharide Receptors - metabolism | Viral Envelope Proteins - chemistry | Inflammation Mediators - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Viral Envelope Proteins - metabolism | Protein Binding | Herpesvirus 1, Human - genetics | Herpesvirus 1, Human - immunology | Myeloid Differentiation Factor 88 - metabolism | Cell culture | Target recognition | Blocking antibodies | Herpes simplex | CD14 antigen | Recruitment | Proteins | Signal transduction | Coding | Virions | Pathogens | NF-κB protein | Glycoprotein B | Cytokines | Glycoprotein | Glycoproteins | Pattern recognition | TLR2 protein | Herpes viruses | MyD88 protein | Ligands | Kinetics | Kidney transplantation | Biotechnology | Laboratories | Interleukin | Antibodies | Viruses | Biology | Infections | Activation | Biological effects | Immunology | Toll-like receptors | Interleukin 8 | Immune system | Encephalitis | Cytomegalovirus | Immune response | TRAF6 protein | Incubation | Secretion | Inflammation | Virology | Signaling | Monocytes | TLR1 protein | Plasmids | Phenols | Chemokines
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 07/2018, Volume 12, Issue 7, p. e0006589
Chronic chagasic cardiomyopathy (CCC) is observed in 30% to 50% of the individuals infected by Trypanosoma cruzi and heart failure is the important cause of... 
C-REACTIVE PROTEIN | CLINICAL FORMS | VENTRICULAR-ARRHYTHMIAS | HEART-DISEASE | NUCLEAR-FACTOR | IFN-GAMMA | TRYPANOSOMA-CRUZI INFECTION | T-CELLS | PARASITOLOGY | TROPICAL MEDICINE | NALP3 INFLAMMASOME | CUTTING EDGE | Chagas Cardiomyopathy - immunology | Chagas Cardiomyopathy - parasitology | Chagas Cardiomyopathy - genetics | Interleukin-12 - genetics | Humans | Middle Aged | NLR Proteins - genetics | Interleukin-1beta - immunology | Male | Caspase 1 - immunology | Interleukin-1beta - genetics | NLR Proteins - immunology | Digestive System Diseases - genetics | Trypanosoma cruzi - physiology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Caspase 1 - genetics | Interleukin-12 - immunology | Digestive System Diseases - immunology | Adult | Female | Aged | Digestive System Diseases - parasitology | Immune response | Cardiomyopathy | Cardiac patients | Patient outcomes | Genetic aspects | Research | Gene expression | Health aspects | Heart diseases | Risk factors | Protein binding | Heart | Pathogenesis | Funding | Leukocytes (mononuclear) | Interleukin 23 | Nucleotides | Immunity | Caspase-1 | Proteins | Signal transduction | Receptors | Pathogens | Antigens | Parasitology | Cytokines | Adapters | Interleukin 12 | Tumor necrosis factor-α | Patients | Interleukin 18 | TLR2 protein | Rectum | MyD88 protein | Chagas' disease | Ejection | Correlation | β-Interferon | Innate immunity | Lymphocytes T | Infections | Parasites | Interleukin 6 | Molecules | Lymphocytes | Toll-like receptors | Peripheral blood mononuclear cells | Supervision | Immune system | Vector-borne diseases | Protozoa | Caspase | Population decline | TLR1 protein | Lymphocytes B | Levels | Ventricle
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, p. e0153823
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma with a still undefined etiology. Several lines of evidence are consistent with the... 
PATHWAYS | BORRELIA-BURGDORFERI | ACTIVATION | CD40 | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | TUMOR | NON-HODGKIN-LYMPHOMA | INFECTION | NF-KAPPA-B | HUMAN MONOCYTES | Cyclin D1 - metabolism | Toll-Like Receptor 5 - metabolism | Humans | Interleukin-4 - metabolism | Toll-Like Receptor 1 - metabolism | Cell Proliferation - physiology | NF-kappa B - metabolism | Glycogen Synthase Kinase 3 - metabolism | Toll-Like Receptor 4 - metabolism | CD40 Ligand - metabolism | Lymphoma, Non-Hodgkin - metabolism | Cell Line, Tumor | Ligands | Signal Transduction - physiology | Proto-Oncogene Proteins c-akt - metabolism | Lymphoma, Mantle-Cell - metabolism | Cyclin D3 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Toll-like receptors | Cyclin D proteins | Research | Analysis | Mantle cell lymphoma | Immunoglobulin M | Biotechnology | CD40 antigen | Authorship | Pathogenesis | AKT protein | Infections | Activation | Kinases | Cyclin D1 | Drug resistance | CD40L protein | Cyclin D3 | Interleukin 6 | Proteins | Receptors | Interleukin 4 | Cell growth | Lymphocytes | Etiology | Immunotherapy | Cascades | Cell cycle | Post-translation | Mantle | Immune system | NF-κB protein | Cell survival | TLR5 protein | MAP kinase | Cultures | Gene expression | Lymphoma | Signaling | Overexpression | TLR1 protein | Lymphocytes B | Medical prognosis | TLR2 protein | Cell lines | Lymphomas | Stimuli | Cancer | Apoptosis
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0202408
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and danger associated molecular patterns to initiate an innate... 
SIGNAL-TRANSDUCTION | TRANSFER BRET | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INDUCTION | IDENTIFICATION | ADAPTER PROTEIN | BINDING | FAMILY | Gene Expression | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Humans | Receptors, Interleukin-1 - genetics | Myeloid Differentiation Factor 88 - genetics | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Membrane Glycoproteins - genetics | Receptors, Interleukin-1 - metabolism | Microscopy, Confocal | Signal Transduction - drug effects | HEK293 Cells | Fluorescence Resonance Energy Transfer | Myeloid Differentiation Factor 88 - metabolism | Cytokines | Gene expression | Research | Bioluminescence | Transcription factors | Immunoprecipitation | Confocal microscopy | Biology | Activation | Kinases | Recruitment | Proteins | Signal transduction | Receptors | Immunology | Transcription activation | Toll-like receptors | Artefacts | Immune system | Binding | Adaptor proteins | CRISPR | Medical research | NF-κB protein | Immune response | Cell walls | Hazards | Pattern recognition | Adaptors | Real time | Artifacts | TLR1 protein | Microscopy | TLR2 protein | Tagging | MyD88 protein | Ligands | Resonance | Dimers | Kinetics | Receptor mechanisms | Protein interaction | Lipopeptides | Energy transfer
Journal Article