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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2019, Volume 27, Issue 13, pp. 2784 - 2800
Toll-like receptor 2 (TLR2) is a bridge between innate immunity and adaptive immunity. TLR2 agonists have been exploited as potential vaccine adjuvants and... 
TLR2 agonists | Pam3CSK4 | TLR2/6 | Structure optimization | TLR2/1
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 2012, Volume 3
Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with... 
TLR1 | TLR2 ligands | TLR6 | IMMUNOLOGY | polymorphisms | co-receptors | TLR2
Journal Article
10/2011
Toll-like receptors (TLRs) recognise pathogen-derived molecules and influence immunity to control parasite infections. This study aimed to evaluate the mRNA... 
Leishmania chagasi | cytokines | TLR4 | TLR2
Web Resource
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2008, Volume 83, Issue 6, pp. 1467 - 1475
Journal Article
06/2012
Kawasaki disease (KD) is a childhood vasculitis with a predilection for the coronary arteries (CA). The etiology of KD is unknown; however, superantigens (SAg)... 
0982 | Kawasaki Disease | Endothelial cells | TLR2
Dissertation
by Du, XM and Qian, JW and Wang, YJ and Zhang, MM and Chu, YW and Li, YX
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 07/2019, Volume 27, Issue 13, pp. 2784 - 2800
Toll-like receptor 2 (TLR2) is a bridge between innate immunity and adaptive immunity. TLR2 agonists have been exploited as potential vaccine adjuvants and... 
LIPOPEPTIDE | DESIGN | CHEMISTRY, MEDICINAL | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | TLR2 agonists | Structure optimization | BACTERIAL LIPOPROTEIN | DISCOVERY | PamCSK | TLR2/6 | TLR2/1 | ADJUVANTS | TOLL-LIKE RECEPTORS | PATTERN-RECOGNITION RECEPTORS | INNATE IMMUNITY
Journal Article
Frontiers in Immunology, 2012, Volume 3
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2016, Volume 300, pp. 13 - 24
Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated. We showed... 
Aryl hydrocarbon receptor | Obesity | TLR2/TGFβ/PI3K/NF-κB/IDO1/AHR axis | α-Naphthoflavone and CH-223191 | Liver steatosis | TOLL-LIKE-RECEPTORS | METABOLIC SYNDROME | DENDRITIC CELLS | INDOLEAMINE 2,3-DIOXYGENASE | LOW-DENSITY-LIPOPROTEIN | DIOXIN RECEPTOR | TLR2/TGF beta/PI3K/NF-kappa B/IDO1/AHR axis | alpha-Naphthoflavone and CH-223191 | REGULATORY T-CELLS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NF-KAPPA-B | ADIPOSE-TISSUE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Signal Transduction | Kynurenine - biosynthesis | Mice, Inbred C57BL | Fatty Liver - prevention & control | Male | Toll-Like Receptor 2 - metabolism | Animals | Adiposity | Benzoflavones - pharmacology | Lipids - blood | Obesity - prevention & control | Intra-Abdominal Fat - drug effects | Mice | Azo Compounds - pharmacology | Diet, Western | Transforming Growth Factor beta - metabolism | Hepatocytes - drug effects | Lipoproteins, LDL | Pyrazoles - pharmacology | Index Medicus | KYNURENINE | TRYPTOPHAN | METABOLITES | QUINOLINES | 60 APPLIED LIFE SCIENCES | LUCIFERASE | GROWTH FACTORS | HYDROXY COMPOUNDS | INHIBITION | DIET | LIGANDS | METABOLISM | LIVER | LIVER CELLS | MICE | METABOLIC DISEASES | RECEPTORS | LIPOPROTEINS | Aryl Hydrocarbon Receptor | NF-κB | PI3K | TGFβ | AHR axis | TLR2 | IDO1
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 04/2018, Volume 9, pp. 712 - 712
Trichomoniasis, caused by Trichomonas vaginalis infection, is the most prevalent sexually transmitted disease in female and male globally. However, the... 
Trichomonas vaginalis | NF-κB | TLR | Cytokines | MAPK | TLR2 | CELLS | SIGNALING PATHWAYS | RECOGNITION | INVOLVEMENT | INNATE | TLR2(-/-) | NEUTROPHILS | MICROBIOLOGY | IL-6 PRODUCTION | TOLL-LIKE RECEPTOR-2 | NF-kappa B | TOXOPLASMA-GONDII | cytokines | EXPRESSION | TLR2-
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 02/2019, Volume 202, Issue 4, pp. 1219 - 1228
The appropriate inflammatory response is essential for normal wound repair, and skin commensal Staphylococcus epidermidis has been shown to regulate... 
CELLS | IMMUNITY | DEFENSE | MICROBIOTA | IMMUNOLOGY | NF-KAPPA-B | TLR2
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, pp. E8698 - E8706
Successful cancer immunotherapy entails activation of innate immune receptors to promote dendritic cell (DC) maturation, antigen presentation, up-regulation of... 
PD-L1 antibody | Agonist | Cancer immunotherapy | Melanoma | TLR1/TLR2 | MULTIDISCIPLINARY SCIENCES | melanoma | RECEPTOR | agonist | MEMBER | IMMUNOGENICITY | cancer immunotherapy | B7 FAMILY | RESISTANCE | BLOCKADE | T-CELLS | INNATE IMMUNITY | Immunotherapy - methods | Adjuvants, Immunologic - pharmacology | Toll-Like Receptor 2 - agonists | Toll-Like Receptor 2 - genetics | Ovalbumin - immunology | Humans | Melanoma, Experimental - immunology | Toll-Like Receptor 1 - agonists | Antibodies, Monoclonal - immunology | Antibodies, Monoclonal - pharmacology | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Toll-Like Receptor 1 - metabolism | Cells, Cultured | Kaplan-Meier Estimate | THP-1 Cells | Toll-Like Receptor 2 - metabolism | B7-H1 Antigen - immunology | Mice, Knockout | Drug Synergism | Toll-Like Receptor 1 - genetics | Animals | B7-H1 Antigen - antagonists & inhibitors | Melanoma, Experimental - genetics | Cell Line, Tumor | Usage | Care and treatment | Immunotherapy | Toll-like receptors | Physiological aspects | Health aspects | Methods | Agonists (Biochemistry) | Cancer | CD8 antigen | Aluminum sulfate | Cytotoxicity | Activation | Lymphocytes T | Leukocytes | Macrophages | Anticancer properties | Proteins | Receptors | Cell activation | Lymphocytes | Antigen presentation | Ovalbumin | Immunoglobulins | Immunization | Secretion | Costimulator | White blood cells | Immune systems | TLR1 protein | Tumor necrosis factor | TLR2 protein | PD-L1 protein | Antitumor activity | Mice | Alum | Tumors | Peritoneum | Index Medicus | TLR1 | Biological Sciences | PNAS Plus | TLR2
Journal Article
Life Sciences, ISSN 0024-3205, 10/2019, Volume 234, pp. 116793 - 116793
Environmental factors have a key role in the control of gut microbiota and obesity. TLR2 knockout (TLR2 ) mice in some housing conditions are protected from... 
Gut microbiota | Genetic protection | Insulin resistance | LPS | TLR2 | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 05/2018, Volume 9, Issue 33, pp. 23237 - 23252
Recent studies have reported important roles for chloride intracellular channel 1 (CLIC1) in various cancers; however, its involvement in esophageal squamous... 
Esophageal squamous cell carcinoma | TLR2/JNK pathway | CLIC1 | Cellular movement | Tumor survival
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2008, Volume 83, Issue 6, pp. 1467 - 1475
Human G‐protein‐coupled formyl peptide receptor‐like 1 and its mouse homologue formyl peptide receptor 2 (mFPR2) mediate the chemotactic activity of a variety... 
TLR2 | chemotaxis
Journal Article