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Nature, ISSN 0028-0836, 03/2002, Volume 416, Issue 6877, pp. 194 - 199
The immune system consists of two evolutionarily different but closely related responses, innate immunity and adaptive immunity. Each of these responses has... 
PATHWAYS | APOPTOSIS | DOMAIN | PROTEIN | RECOGNITION | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | INHIBITOR | NF-KAPPA-B | EXPRESSION | Protein-Serine-Threonine Kinases - deficiency | Toll-Like Receptor 2 | Membrane Glycoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases | NF-kappa B - metabolism | Listeria monocytogenes - immunology | Receptors, Interleukin - metabolism | Toll-Like Receptors | T-Lymphocytes - metabolism | Gene Deletion | Interleukins - immunology | Listeriosis - immunology | Tumor Necrosis Factor-alpha - immunology | Killer Cells, Natural - immunology | Receptors, Antigen, T-Cell - immunology | Cell Differentiation | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Interleukins - biosynthesis | Listeria monocytogenes - physiology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | Drosophila Proteins | Listeriosis - metabolism | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Lymphocyte Activation | Receptors, Cytokine - biosynthesis | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Receptors, Cell Surface - metabolism | Nod2 Signaling Adaptor Protein | Mice, Knockout | Immunity, Innate - immunology | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | T-Lymphocytes - cytology | Listeriosis - pathology | T-Lymphocytes - immunology | Mice | Nod1 Signaling Adaptor Protein | Killer Cells, Natural - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Molecules | Bacteria | Genes | Cells | Immune system | Rip2 protein | TLR2 protein | Toll-like receptors | TLR4 protein | TLR3 protein | TLR9 protein | CARDIAK protein | RICK protein | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e101503 - e101503
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 09/2012, Volume 19, Issue 9, pp. 1482 - 1494
Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA).... 
apoptosis | caspase-8 | cancer cells | ubiquitination | Toll-like receptor 3 | RIP1 | HOMOTYPIC INTERACTION MOTIF | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | IFN-BETA | NECROSIS | TOLL-LIKE RECEPTORS | C-FLIP | TRIF | NF-KAPPA-B | RNA-Binding Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | TNF Receptor-Associated Factor 2 - genetics | Caspase 8 - metabolism | Apoptosis - genetics | Baculoviral IAP Repeat-Containing 3 Protein | TNF Receptor-Associated Death Domain Protein - genetics | Caspase 8 - genetics | Nuclear Pore Complex Proteins - genetics | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Toll-Like Receptor 3 - genetics | TNF Receptor-Associated Death Domain Protein - metabolism | Nuclear Pore Complex Proteins - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Signal Transduction - genetics | Toll-Like Receptor 3 - metabolism | Ubiquitin-Protein Ligases | Signal Transduction - drug effects | RNA, Double-Stranded - pharmacology | Cell Line, Tumor | RNA-Binding Proteins - metabolism | Ubiquitination - genetics | Index Medicus | Tumor necrosis factor receptors | Immune response | Lung cancer | Double-stranded RNA | TLR3 protein | death receptors | Caspase-8 | FADD protein | Molecular modelling | Toll-like receptors | alpha -Interferon | Ubiquitin-protein ligase | Apoptosis | Original Paper
Journal Article
by Yang, Q and Liu, TT and Lin, H and Zhang, M and Wei, J and Luo, WW and Hu, YH and Zhong, B and Hu, MM and Shu, HB
PLOS PATHOGENS, ISSN 1553-7366, 09/2017, Volume 13, Issue 9, pp. e1006600 - e1006600
Toll-like receptor (TLR)-mediated signaling are critical for host defense against pathogen invasion. However, excessive responses would cause harmful damages... 
ACTIVATION | DNA VIRUS | RECOGNITION | I INTERFERON INDUCTION | CELLULAR ANTIVIRAL RESPONSE | MICROBIOLOGY | FAMILY PROTEINS | VIROLOGY | IRF3 | ADAPTER | K63-LINKED UBIQUITINATION | NF-KAPPA-B | PARASITOLOGY | Cytokines - metabolism | Immunity, Innate - drug effects | Humans | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | Toll-Like Receptor 3 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Autophagy | Toll-Like Receptor 4 - metabolism | Transcription Factors - metabolism | Immunity, Innate - immunology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 3 - genetics | Tripartite Motif Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Autophagy (Cytology) | Immune response | Research | Binding proteins | Health aspects | TLR4 | Ubiquitin | Salmonella | Transcription factors | Transcription | Body weight | Biology | Kinases | Lipopolysaccharides | Degradation | Proteins | Rodents | Toll-like receptors | Life sciences | Research centers | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Medical research | Cytokines | Inflammation | Poly (I:C) | TLR3 protein | Immune systems | Mice | Interferon | Adapter proteins | Phagocytosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2011, Volume 108, Issue 50, pp. 20054 - 20059
We report here that mouse macrophages undergo receptor-interacting kinase-3 (RIP3)-dependent but TNF-α—independent necrosis when Toll-like receptors (TLR) 3... 
Reactive oxygen species | Receptors | Cytokines | Cell death | Toll like receptors | Mice | Macrophages | Viability | Necrosis | Apoptosis | Necroptosis | Bone marrow-derived macrophage | INDUCED CELL-DEATH | APOPTOSIS | DOMAIN | PROTEIN | RECOGNITION | MULTIDISCIPLINARY SCIENCES | INHIBITION | LIPOPOLYSACCHARIDE | MICE | TNF-ALPHA | bone marrow-derived macrophage | NF-KAPPA-B | necroptosis | Protein Structure, Tertiary | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Reactive Oxygen Species - metabolism | Macrophages - pathology | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | NF-kappa B - metabolism | Enzyme Activation - drug effects | Toll-Like Receptor 3 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Signal Transduction - immunology | Models, Immunological | Animals | Signal Transduction - drug effects | Protein Binding - drug effects | Inflammation Mediators - metabolism | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Macrophages - drug effects | Cytokines - biosynthesis | Macrophages - immunology | Cell receptors | Genetic aspects | Properties | Gangrene | Signal transduction | TNF inhibitors | Kinases | Rodents | Index Medicus | Tumor necrosis factor receptors | Immune response | Data processing | Inflammation | Interleukin 1 receptors | TLR4 protein | adaptor proteins | TLR3 protein | Lipopolysaccharides | Infection | beta -Interferon | Toll-like receptors | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63793 - e63793
Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis in developing nations and occurs in sporadic and epidemic forms. The... 
PATHWAYS | CYTOKINE PRODUCTION | ORF3 PROTEIN | UBIQUITIN LIGASE | INNATE IMMUNE RECEPTORS | MULTIDISCIPLINARY SCIENCES | HEV | HEPATOMA-CELLS | C VIRUS | PATTERN-RECOGNITION RECEPTORS | EXPRESSION | Epithelial Cells - metabolism | Hepatitis E - genetics | Humans | Adaptor Proteins, Vesicular Transport - genetics | NF-kappa B - immunology | NF-kappa B - metabolism | Hepatitis E - metabolism | Transcriptome - immunology | Adaptor Proteins, Vesicular Transport - metabolism | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | Hepatitis E virus - immunology | RNA Interference | Hepatitis E - immunology | Myeloid Differentiation Factor 88 - immunology | Capsid Proteins - immunology | Cytokines - genetics | Chemokines - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Myeloid Differentiation Factor 88 - genetics | Virus Replication - immunology | Transcriptome - genetics | Adaptor Proteins, Vesicular Transport - immunology | Reverse Transcriptase Polymerase Chain Reaction | Chemokines - genetics | Blotting, Western | Hepatitis E virus - physiology | NF-kappa B - genetics | Epithelial Cells - immunology | Epithelial Cells - virology | Cell Line, Tumor | Interferon Regulatory Factor-3 - metabolism | Chemokines - metabolism | Myeloid Differentiation Factor 88 - metabolism | Medical research | Hepatitis E | Genes | Development and progression | DNA binding proteins | Genetic transcription | Biological response modifiers | Infection | Disease transmission | Viral proteins | Tumor necrosis factor | Medicine, Experimental | Interferon | Health aspects | Cell culture | Post-transcription | Epidemics | Transcription factors | Capsid protein | Pathogenesis | Epithelial cells | RANTES | Lung | Gene regulation | Developing countries | Inflammatory response | Viruses | Genomes | Infections | Developing nations | Interleukin 6 | Proteins | DNA helicase | Hepatitis | Reporter gene | Rodents | Toll-like receptors | Interleukin 8 | Adaptor proteins | NF-κB protein | Immune response | Cytokines | Inflammation | Adaptors | Gene expression | TLR3 protein | Virology | Pregnancy | Immune systems | Molecular modelling | Interferon regulatory factor 3 | TLR2 protein | Influenza | MyD88 protein | Human behavior | Protein structure | Chemokines | Viral infections | Index Medicus
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 04/2018, Volume 86, Issue 4, pp. 475 - 490
The Toll‐like receptors (TLRs) are critical components of the innate immune system due to their ability to detect conserved pathogen‐associated molecular... 
mutation | BB loop | TLR3A795P | signaling adaptor | TLR2P618H | Lps | PPCheck | TIR domain | TLR2 | LOCALIZATION | Lps(d) mutation | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | B-CELL ADAPTER | TIR-DOMAIN | DIMERIZATION | IDENTIFICATION | SIGNAL-TRANSDUCTION | BIOPHYSICS | SITES | NF-KAPPA-B | BINDING | Toll-Like Receptor 2 - genetics | Humans | Protein Multimerization | Toll-Like Receptors - chemistry | Protein Interaction Maps | Protein Interaction Domains and Motifs | Toll-Like Receptor 3 - genetics | Protein Stability | Toll-Like Receptors - metabolism | Toll-Like Receptor 1 - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - chemistry | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Molecular Dynamics Simulation | Toll-Like Receptor 1 - genetics | Point Mutation | Toll-Like Receptors - genetics | Hydrophobic and Hydrophilic Interactions | Protein Conformation | Toll-Like Receptor 3 - chemistry | Molecular Docking Simulation | Toll-Like Receptor 1 - chemistry | Toll-Like Receptor 2 - chemistry | Case studies | Proteins | Molecular dynamics | Genetic aspects | Protein-protein interactions | Molecular structure | Downstream effects | Viruses | Critical components | Receptors | Microorganisms | Toll-like receptors | Immune system | Adaptor proteins | Dynamic structural analysis | TLR4 protein | Adaptors | TLR3 protein | Interfaces | Immune systems | Studies | Signaling | Cognition & reasoning | TLR2 protein | Dimers | Mutation | Protein structure | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0118010 - e0118010
Journal Article
Journal Article