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1. Full Text HIV and HIV‐Tat inhibit LPS‐induced IL‐27 production in human macrophages by distinct intracellular signaling pathways
by Gajanayaka, Niranjala and O’Hara, Shifawn and Konarski, Yulia and Fernandes, Jason and Muthumani, Kar and Kozlowski, Maya and Angel, Jonathan B and Kumar, Ashok
Journal of Leukocyte Biology, ISSN 0741-5400, 09/2017, Volume 102, Issue 3, pp. 925 - 939
HIV inhibition of LPS‐induced IL‐27 production in human macrophages affects cIAP‐1‐TRAF‐6, PI3K, and p38 MAPKs. Monocyte‐derived Mϕs (MDMs) from HIV‐infected... 
TLR signaling | IL‐27 regulation | HIV infection | IL‐27 expression | IL-27 expression | IL-27 regulation | HUMAN MONOCYTIC CELLS | DENDRITIC CELLS | BINDING PROTEIN BETA | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | CELL BIOLOGY | SINGLE-STRANDED RNA | 2ND CODING EXON | PERIPHERAL-BLOOD MONOCYTES | HEMATOLOGY | NF-KAPPA-B | T-CELLS | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Humans | TNF Receptor-Associated Factor 6 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | MAP Kinase Signaling System - immunology | Phosphatidylinositol 3-Kinases - immunology | HIV Infections - immunology | HIV-1 - immunology | MAP Kinase Signaling System - drug effects | Interleukins - immunology | Lipopolysaccharides - pharmacology | Inhibitor of Apoptosis Proteins - immunology | tat Gene Products, Human Immunodeficiency Virus - immunology | Macrophages - immunology | Tumor necrosis factor receptors | Phosphorylation | SHP-1 protein | Peptides | Homology | Intracellular signalling | Infections | Activation | Kinases | Macrophages | Interleukin 27 | Lipopolysaccharides | Signal transduction | Cell activation | Pathways | Human immunodeficiency virus--HIV | Toll-like receptors | Inhibition | Tyrosine | Cytokines | MAP kinase | Interleukin 12 | TLR4 protein | Src protein | 1-Phosphatidylinositol 3-kinase | Tat protein | Monocytes | Intracellular | Protein-tyrosine-phosphatase | Apoptosis
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2. Full Text Response of human pulmonary epithelial cells to lipopolysaccharide involves toll-like receptor 4 (TLR4)-dependent signaling pathways: Evidence for an intracellular compartmentalization of TLR4
by Guillott, Loïc and Medjane, Samir and Le-Barillec, Karine and Balloy, Viviane and Danel, Claire and Chignard, Michel and Si-Tahar, Mustapha
Journal of Biological Chemistry, ISSN 0021-9258, 01/2004, Volume 279, Issue 4, pp. 2712 - 2718
Pulmonary epithelial cells are continuously exposed to microbial challenges as a result of breathing. It is recognized that immune myeloid cells express... 
BACTERIAL LIPOPOLYSACCHARIDE | INTESTINAL EPITHELIUM | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN | INVASIVE SHIGELLA-FLEXNERI | GOLGI-APPARATUS | GENE-EXPRESSION | TRANSDUCTION | NF-KAPPA-B | LPS | Cell Line | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Gram-Negative Bacteria | Humans | Receptors, Cell Surface - metabolism | Gram-Negative Bacterial Infections - metabolism | Respiratory Mucosa - ultrastructure | Membrane Glycoproteins - genetics | Cell Compartmentation | Toll-Like Receptors | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Respiratory Mucosa - metabolism | Receptors, Cell Surface - genetics | lipopolysaccharides | TLR4 protein
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3. Full Text Retracted: Anti‐inflammatory properties of tianeptine on lipopolysaccharide‐induced changes in microglial cells involve toll‐like receptor‐related pathways
by Slusarczyk, Joanna and Trojan, Ewa and Glombik, Katarzyna and Piotrowska, Anna and Budziszewska, Boguslawa and Kubera, Marta and Popiolek‐Barczyk, Katarzyna and Lason, Wladyslaw and Mika, Joanna and Basta‐Kaim, Agnieszka
Journal of Neurochemistry, ISSN 0022-3042, 03/2016, Volume 136, Issue 5, pp. 958 - 970
Accumulating evidence suggests that activation of microglia plays a key role in the pathogenesis of depression. Activated microglia produce a wide range of... 
cytokines | tianeptine | antidepressant drugs | inflammation | microglia | intracellular pathways | Brain | Phosphorylation | Reactive oxygen species | Protein kinase C | Transient ischemic attack | Pathogenesis | Medical services | Disorders | Stimulation | Activation | Mental depression | Kinases | Caspase-3 | Lipopolysaccharides | Degradation | Interleukin 6 | Proteins | Pathways | Antidepressants | Interleukin 1 | Toll-like receptors | Microglial cells | Tumor necrosis factor-TNF | Inhibition | Activation analysis | Immune system | NF-κB protein | Antiinflammatory agents | Cytokines | Extracellular signal-regulated kinase | Caspase | Cultures | Inflammation | TLR4 protein | Nitric-oxide synthase | Microglia | Interleukin 18 | Lymphocytes B | Tumor necrosis factor | Nitric oxide | Tianeptine
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4. Full Text Targeting the NLRP3 inflammasome-related pathways via tianeptine treatment-suppressed microglia polarization to the M1 phenotype in lipopolysaccharide-stimulated cultures
by Ślusarczyk, Joanna and Trojan, Ewa and Głombik, Katarzyna and Piotrowska, Anna and Budziszewska, Bogusława and Kubera, Marta and Popiołek-Barczyk, Katarzyna and Lasoń, Władysław and Mika, Joanna and Basta-Kaim, Agnieszka
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2018, Volume 19, Issue 7, p. 1965
An increasing body of evidence postulates that microglia are the main mediators of inflammation-related disorders, including depression. Since activated... 
M1/M2 microglia activation | Cytokines | NLRP3 inflammasome | Tianeptine | TLR4 intracellular pathways | CANCER-CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCHIZOPHRENIA | KAPPA-B-ALPHA | tianeptine | NEUROTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | NITRIC-OXIDE | cytokines | CENTRAL-NERVOUS-SYSTEM | STRESS | EXPRESSION | HYPOTHALAMUS | Cell Survival - drug effects | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytokines - metabolism | Microglia - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Rats | Thiazepines - pharmacology | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Animals | Antidepressive Agents, Tricyclic - pharmacology | Lipopolysaccharides - pharmacology | Cell Polarity - drug effects | Cell Death - drug effects | Primary Cell Culture | Nitric Oxide - metabolism | Polarization | Reactive oxygen species | Phosphorylation | CD40 antigen | Insulin-like growth factor I | Interleukin | Activation | Insulin-like growth factors | Mental depression | Kinases | Caspase-1 | Lipopolysaccharides | Interleukin 6 | Interleukin 4 | Antidepressants | Toll-like receptors | Tumor necrosis factor-TNF | Growth factors | Phenotypes | Oligomerization | Extracellular signal-regulated kinase | Caspase | Inflammation | Insulin | Microglia | Interleukin 18 | Beta cells | Molecular modelling | Major histocompatibility complex | Nitric oxide | Interleukin 10 | Histocompatibility | Viability | Monocyte chemoattractant protein 1
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5. Full Text β-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages
by Valerio, M.S and Minderman, H and Mace, T and Awad, A.B
Cellular Immunology, ISSN 0008-8749, 09/2013, Volume 285, Issue 1-2, pp. 76 - 83
Recent evidence has shown that dietary phytosterols (PS) possess anti-inflammatory properties both and . Our previous work shows that PS β-Sitosterol (SIT),... 
IRAK | Lipid rafts | SOCS | TLR4 | MyD88 | Phytosterols | PHOSPHATASE SHP-1 | CANCER CELLS | CHOLESTEROL | TOLL-LIKE RECEPTOR | IMMUNOLOGY | CELL BIOLOGY | INHIBITION | METABOLISM | GENE-EXPRESSION | OLIGOMERIZATION | Cell Line | Interleukin-1 Receptor-Associated Kinases - metabolism | Toll-Like Receptor 4 - biosynthesis | Interleukin-1 Receptor-Associated Kinases - biosynthesis | Sitosterols - pharmacology | Enzyme Activation - drug effects | Toll-Like Receptor 4 - metabolism | Lipopolysaccharides | Signal Transduction - immunology | Suppressor of Cytokine Signaling 3 Protein | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Membrane Microdomains - drug effects | Mice | Myeloid Differentiation Factor 88 - metabolism | Suppressor of Cytokine Signaling Proteins - biosynthesis | Anticholesteremic Agents - pharmacology | Macrophages - immunology
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6. Full Text Mathematical modeling and parameter estimation of intracellular signaling pathway: Application to LPS-induced NFκB activation and TNFα production in macrophages
by Lee, Dongheon and Ding, Yufang and Jayaraman, Arul and Kwon, Joseph S
Processes, ISSN 2227-9717, 03/2018, Volume 6, Issue 3, p. 21
Due to the intrinsic stochasticity, the signaling dynamics in a clonal population of cells exhibit cell-to-cell variability at the single-cell level, which is... 
Lipopolysaccharide | Flow cytometry | Parameter estimation | Sensitivity analysis | NFκB signaling pathway | Systems biology | systems biology | CANCER-CELLS | APOPTOSIS | KINETIC-MODELS | sensitivity analysis | TEMPORAL CONTROL | IDENTIFIABILITY ANALYSIS | RECEPTOR | ENDOCYTOSIS | NF kappa B signaling pathway | INHIBITS PROTEIN-SYNTHESIS | ENGINEERING, CHEMICAL | parameter estimation | flow cytometry | BREFELDIN-A | lipopolysaccharide | TLR4 | Secretion | Intracellular signalling | Tumor necrosis factor-α | Macrophages | Model accuracy | Lipopolysaccharides | Cytometry | Signal transduction | Cell activation | Dynamics | Reagents | Mathematical models | Stochasticity
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7. Full Text Astragaloside IV protects neurons from microglia-mediated cell damage through promoting microglia polarization
by Yu, JW and Guo, MF and Li, YH and Zhang, HY and Zhi, C and Qing, W and Yan, YQ and Yu, JZ and Liu, CY and Zhang, GX and Ma, CG
FOLIA NEUROPATHOLOGICA, ISSN 1641-4640, 2019, Volume 57, Issue 2, pp. 170 - 181
Astragaloside IV (AST-IV) is a major active ingredient of astragalus, with a neuroprotective effect. The current study is aimed to investigate the impact of... 
ACTIVATION | neuroinflammatory | ISCHEMIA | MECHANISMS | PATHOLOGY | neurons | NEUROSCIENCES | TLR4 intracellular pathways | microglia polarization | STRATEGIES | astragaloside IV | MICE | INFLAMMATORY CYTOKINES | Neuroprotection | NF-κB protein | Phenotypes | Cell survival | Arginase | Inflammation | TLR4 protein | Tumor necrosis factor-α | Microglia | Lipopolysaccharides | Interleukin 6 | Signal transduction | Molecular modelling | Cell death | Nitric oxide | Interleukin 10 | Toll-like receptors | MyD88 protein | Tumor necrosis factor-TNF | Tumors
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8. Full Text Intracellular networks of the PI3K/AKT and MAPK pathways for regulating Toxoplasma gondii-induced IL-23 and IL-12 production in human THP-1 cells
by Quan, Juan-Hua and Chu, Jia-Qi and Kwon, Jaeyul and Choi, In-Wook and Ismail, Hassan Ahmed Hassan Ahmed and Zhou, Wei and Cha, Guang-Ho and Zhou, Yu and Yuk, Jae-Min and Jo, Eun-Kyeong and Lee, Young-Ha
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0141550
Interleukin (IL)-23 and IL-12 are closely related in structure, and these cytokines regulate both innate and adaptive immunity. However, the precise signaling... 
IMMUNE-RESPONSE | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | RESISTANCE | INNATE | INFECTION | CYTOKINE | MICE | EXPRESSION | Up-Regulation | Humans | Enzyme Inhibitors - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Signaling System | Toxoplasma | Toxoplasmosis - pathology | Toxoplasmosis - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Interleukin-23 - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Interleukin-12 - biosynthesis | Care and treatment | Interleukins | Patient outcomes | Physiological aspects | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Health aspects | Networks | Adaptive structures | Phosphorylation | Interleukin | Intracellular signalling | AKT protein | Interleukin 23 | Biology | Infections | Activation | Tachyzoites | Parasites | Kinases | Immunity | Proteins | Signal transduction | Transfection | Pathways | Cascades | Gastroenterology | Toll-like receptors | Inhibition | Pretreatment | Immunoglobulins | Cytokines | Dendritic cells | Secretion | Neutrophils | Extracellular signal-regulated kinase | MAP kinase | Interleukin 12 | JNK protein | siRNA | Adaptive immunity | TLR4 protein | Gene expression | 1-Phosphatidylinositol 3-kinase | Medicine | Monocytes | Hospitals | Inhibitors | TLR2 protein | Wortmannin | Ligands | Intracellular
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9. Full Text Intracellular bacteria interfere with dendritic cell functions: Role of the type I interferon pathway
by Gorvel, Laurent and Textoris, Julien and Banchereau, Romain and Amara, Amira Ben and Tantibhedhyangkul, Wiwit and Von Bargen, Kristin and Ka, Mignane B and Capo, Christian and Ghigo, Eric and Gorve, Jean-Pierre and Mege, Jean-Louis
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99420
Dendritic cells (DCs) orchestrate host defenses against microorganisms. In infectious diseases due to intracellular bacteria, the inefficiency of the immune... 
BRUCELLA | SCRUB TYPHUS | HUMAN MACROPHAGES | DC-SIGN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | TROPHERYMA-WHIPPLEI | ENDOPLASMIC-RETICULUM | ACTIVATED PROTEIN-KINASES | COXIELLA-BURNETII | ORIENTIA-TSUTSUGAMUSHI | Phosphorylation | Oligonucleotide Array Sequence Analysis | Signal Transduction | Brucella abortus - physiology | Monocytes - cytology | Dendritic Cells - immunology | Humans | Gene Expression Profiling | Coxiella burnetii - physiology | Phenotype | Animals | Interferon-beta - metabolism | Intracellular Space - microbiology | Transcription, Genetic | Cell Differentiation | Mice, Inbred BALB C | p38 Mitogen-Activated Protein Kinases - metabolism | Bacteria | Interferon | Dendritic cells | Biological response modifiers | Analysis | Scrub typhus | Transcription | Genes | Infections | Activation | Kinases | Cytosol | Typhus | Defects | Proteins | Microorganisms | Endocytosis | Immunology | Listeria | Compartments | Toll-like receptors | Trends | Stat1 protein | Immune system | Pathogens | Antigen presentation | Immune response | Bacterial infections | Maturation | TLR4 protein | Gene expression | Fever | TLR3 protein | Monocytes | Infectious diseases | Tuberculosis | DNA microarrays | Q fever | Biomarkers | Brucellosis | Intracellular
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10. Full Text High Mobility Group Box-1 Promotes the Proliferation and Migration of Hepatic Stellate Cells via TLR4-Dependent Signal Pathways of PI3K/Akt and JNK
by Wang, Fu-ping and Li, Lei and Li, Jing and Wang, Ji-yao and Wang, Ling-yan and Jiang, Wei
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64373
Background: The migration of hepatic stellate cells (HSCs) is essential to the hepatic fibrotic response, and recently High-mobility group box 1 (HMGB1) has... 
APOPTOSIS | PROTEIN | RAT | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | LIVER FIBROSIS | KAPPA-B | HMGB1 | RECEPTOR 4 | EXPRESSION | GLYCATION END-PRODUCTS | Cell Survival - drug effects | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Hepatic Stellate Cells - cytology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Cell Movement - drug effects | HMGB1 Protein - pharmacology | Signal Transduction - drug effects | Cell Proliferation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Hepatic Stellate Cells - drug effects | Viral antibodies | Chromosomal proteins | Liver diseases | Collagen | Analysis | Liver | Antibodies | Enzyme-linked immunosorbent assay | Cell proliferation | Phosphorylation | Motility | Mobility | Intracellular signalling | AKT protein | Smooth muscle | Kinases | HMGB1 protein | Cell adhesion & migration | Proteins | Signal transduction | Cell growth | Pathways | Rodents | Gastroenterology | Toll-like receptors | Fibroblasts | Extracellular matrix | Inhibition | Recombinant | Stellate cells | NF-κB protein | Cytokines | JNK protein | TLR4 protein | 1-Phosphatidylinositol 3-kinase | Inhibitors | Neutralizing | Fibrosis | Hypoxia | Intracellular | Cell migration
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11. Full Text Toll‐like receptor signalling cross‐activates the autophagic pathway to restrict Salmonella Typhimurium growth in macrophages
by Liu, Wei and Zhuang, Jing and Jiang, Yuanyuan and Sun, Jing and Prinz, Richard A and Sun, Jun and Jiao, Xinan and Xu, Xiulong
Cellular Microbiology, ISSN 1462-5814, 12/2019, Volume 21, Issue 12, pp. e13095 - n/a
It has been long recognised that activation of toll‐like receptors (TLRs) induces autophagy to restrict intracellular bacterial growth. However, the mechanisms... 
AMP‐activated protein kinase | mTOR | toll‐like receptors | ULK1 | autophagy | Salmonella Typhimurium | TARGET | toll-like receptors | PHOSPHORYLATION | MICROBIOLOGY | AMP-activated protein kinase | CELL BIOLOGY | INVASION | EPITHELIAL-CELLS | TAK1 | HOST-DEFENSE | AMPK | INFECTION | TOR protein | Phosphates | Salmonella | Phosphorylation | Gastroenteritis | Food contamination | Flagellin | Intracellular signalling | Activation | Kinases | Macrophages | Autophagy | Lipopolysaccharides | Signal transduction | Receptors | Cell activation | Xenografts | Bone marrow | Toll-like receptors | Bacteria | CpG islands | TLR5 protein | AMP | TAK1 protein | TLR4 protein | TLR9 protein | Signaling | Protein kinase | Food poisoning | Intracellular | Phagocytosis | Index Medicus
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12. Full Text Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways
by Sakai, Atsushi and Takasu, Kumiko and Sawada, Makoto and Suzuki, Hidenori
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e32268
The mammalian tachykinins, substance P (SP) and hemokinin-1 (HK-1), are widely distributed throughout the nervous system and/or peripheral organs, and function... 
SUPRASPINAL LEVEL | CELLS | PAIN | MESSENGER-RNA | KINASE | BIOLOGY | RAT/MOUSE HEMOKININ-1 | NK1 RECEPTOR | MICE | MAMMALIAN TACHYKININ PEPTIDE | SUBSTANCE-P | Microglia - metabolism | Up-Regulation | Signal Transduction | Tachykinins - metabolism | Gene Expression Regulation | Neurotransmitter Agents - metabolism | Lipopolysaccharides - metabolism | Rats | NF-kappa B - metabolism | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Tachykinins - biosynthesis | Animals | Immune System | Substance P - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Brain | Tachykinin receptors | Peptides | Laboratories | Central nervous system | Intracellular signalling | Nervous system | Neuropeptides | Activation | Kinases | Neuromodulation | Modulators | Medical schools | Proteins | Signal transduction | Pathways | Rodents | Toll-like receptors | Trends | Immune system | NF-κB protein | Substance P | Organs | MAP kinase | Pharmacology | Inflammation | TLR4 protein | Gene expression | Microglia | Neurotransmitters | Brain-derived neurotrophic factor | Protein kinase | Tachykinin
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