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Journal of Leukocyte Biology, ISSN 0741-5400, 09/2017, Volume 102, Issue 3, pp. 925 - 939
HIV inhibition of LPS‐induced IL‐27 production in human macrophages affects cIAP‐1‐TRAF‐6, PI3K, and p38 MAPKs. Monocyte‐derived Mϕs (MDMs) from HIV‐infected... 
TLR signaling | IL‐27 regulation | HIV infection | IL‐27 expression | IL-27 expression | IL-27 regulation | HUMAN MONOCYTIC CELLS | DENDRITIC CELLS | BINDING PROTEIN BETA | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | CELL BIOLOGY | SINGLE-STRANDED RNA | 2ND CODING EXON | PERIPHERAL-BLOOD MONOCYTES | HEMATOLOGY | NF-KAPPA-B | T-CELLS | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Humans | TNF Receptor-Associated Factor 6 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | MAP Kinase Signaling System - immunology | Phosphatidylinositol 3-Kinases - immunology | HIV Infections - immunology | HIV-1 - immunology | MAP Kinase Signaling System - drug effects | Interleukins - immunology | Lipopolysaccharides - pharmacology | Inhibitor of Apoptosis Proteins - immunology | tat Gene Products, Human Immunodeficiency Virus - immunology | Macrophages - immunology | Tumor necrosis factor receptors | Phosphorylation | SHP-1 protein | Peptides | Homology | Intracellular signalling | Infections | Activation | Kinases | Macrophages | Interleukin 27 | Lipopolysaccharides | Signal transduction | Cell activation | Pathways | Human immunodeficiency virus--HIV | Toll-like receptors | Inhibition | Tyrosine | Cytokines | MAP kinase | Interleukin 12 | TLR4 protein | Src protein | 1-Phosphatidylinositol 3-kinase | Tat protein | Monocytes | Intracellular | Protein-tyrosine-phosphatase | Apoptosis
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2018, Volume 19, Issue 7, p. 1965
An increasing body of evidence postulates that microglia are the main mediators of inflammation-related disorders, including depression. Since activated... 
M1/M2 microglia activation | Cytokines | NLRP3 inflammasome | Tianeptine | TLR4 intracellular pathways | CANCER-CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCHIZOPHRENIA | KAPPA-B-ALPHA | tianeptine | NEUROTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | NITRIC-OXIDE | cytokines | CENTRAL-NERVOUS-SYSTEM | STRESS | EXPRESSION | HYPOTHALAMUS | Cell Survival - drug effects | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Cytokines - metabolism | Microglia - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Rats | Thiazepines - pharmacology | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Animals | Antidepressive Agents, Tricyclic - pharmacology | Lipopolysaccharides - pharmacology | Cell Polarity - drug effects | Cell Death - drug effects | Primary Cell Culture | Nitric Oxide - metabolism | Polarization | Reactive oxygen species | Phosphorylation | CD40 antigen | Insulin-like growth factor I | Interleukin | Activation | Insulin-like growth factors | Mental depression | Kinases | Caspase-1 | Lipopolysaccharides | Interleukin 6 | Interleukin 4 | Antidepressants | Toll-like receptors | Tumor necrosis factor-TNF | Growth factors | Phenotypes | Oligomerization | Extracellular signal-regulated kinase | Caspase | Inflammation | Insulin | Microglia | Interleukin 18 | Beta cells | Molecular modelling | Major histocompatibility complex | Nitric oxide | Interleukin 10 | Histocompatibility | Viability | Monocyte chemoattractant protein 1
Journal Article
by Yu, JW and Guo, MF and Li, YH and Zhang, HY and Zhi, C and Qing, W and Yan, YQ and Yu, JZ and Liu, CY and Zhang, GX and Ma, CG
FOLIA NEUROPATHOLOGICA, ISSN 1641-4640, 2019, Volume 57, Issue 2, pp. 170 - 181
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0141550
Interleukin (IL)-23 and IL-12 are closely related in structure, and these cytokines regulate both innate and adaptive immunity. However, the precise signaling... 
IMMUNE-RESPONSE | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | RESISTANCE | INNATE | INFECTION | CYTOKINE | MICE | EXPRESSION | Up-Regulation | Humans | Enzyme Inhibitors - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Signaling System | Toxoplasma | Toxoplasmosis - pathology | Toxoplasmosis - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Interleukin-23 - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Interleukin-12 - biosynthesis | Care and treatment | Interleukins | Patient outcomes | Physiological aspects | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Health aspects | Networks | Adaptive structures | Phosphorylation | Interleukin | Intracellular signalling | AKT protein | Interleukin 23 | Biology | Infections | Activation | Tachyzoites | Parasites | Kinases | Immunity | Proteins | Signal transduction | Transfection | Pathways | Cascades | Gastroenterology | Toll-like receptors | Inhibition | Pretreatment | Immunoglobulins | Cytokines | Dendritic cells | Secretion | Neutrophils | Extracellular signal-regulated kinase | MAP kinase | Interleukin 12 | JNK protein | siRNA | Adaptive immunity | TLR4 protein | Gene expression | 1-Phosphatidylinositol 3-kinase | Medicine | Monocytes | Hospitals | Inhibitors | TLR2 protein | Wortmannin | Ligands | Intracellular
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99420
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64373
Background: The migration of hepatic stellate cells (HSCs) is essential to the hepatic fibrotic response, and recently High-mobility group box 1 (HMGB1) has... 
APOPTOSIS | PROTEIN | RAT | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | LIVER FIBROSIS | KAPPA-B | HMGB1 | RECEPTOR 4 | EXPRESSION | GLYCATION END-PRODUCTS | Cell Survival - drug effects | Apoptosis - drug effects | Humans | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Hepatic Stellate Cells - cytology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Cell Movement - drug effects | HMGB1 Protein - pharmacology | Signal Transduction - drug effects | Cell Proliferation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Hepatic Stellate Cells - drug effects | Viral antibodies | Chromosomal proteins | Liver diseases | Collagen | Analysis | Liver | Antibodies | Enzyme-linked immunosorbent assay | Cell proliferation | Phosphorylation | Motility | Mobility | Intracellular signalling | AKT protein | Smooth muscle | Kinases | HMGB1 protein | Cell adhesion & migration | Proteins | Signal transduction | Cell growth | Pathways | Rodents | Gastroenterology | Toll-like receptors | Fibroblasts | Extracellular matrix | Inhibition | Recombinant | Stellate cells | NF-κB protein | Cytokines | JNK protein | TLR4 protein | 1-Phosphatidylinositol 3-kinase | Inhibitors | Neutralizing | Fibrosis | Hypoxia | Intracellular | Cell migration
Journal Article
Journal Article