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1. Full Text Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3
by Miwa Sasai and Melissa M. Linehan and Akiko Iwasaki
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1530 - 1534
T lymphocytes | Molecules | Cytokines | Microscopy | Genes | REPORTS | Toll like receptors | Agonists | Macrophages | Cells | Endosomes | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Signal transduction | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Transcriptional Activation | Interferon Type I - immunology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - immunology | Cytoplasmic Vesicles - metabolism | Interferon Type I - metabolism | Membrane Transport Proteins - metabolism | Cytokines - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Signal Transduction | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 3 - metabolism | Adaptor Protein Complex beta Subunits | Interferon Regulatory Factor-7 - metabolism | Adaptor Protein Complex 3 - metabolism | Protein Transport | Animals | Adaptor Protein Complex 3 - genetics | Interferon Type I - genetics | Mice | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Cellular control mechanisms | Physiological aspects | TLR9 | TLR7 | Research | Health aspects | Immune system | Proteins | Interferon | Cellular biology | Index Medicus | Receptors | Compartments | Bifurcations | Activation
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2. Full Text Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
by Uehara, Akiko and Fujimoto, Yukari and Fukase, Koichi and Takada, Haruhiko
Molecular immunology, ISSN 0161-5890, 2007, Volume 44, Issue 12, pp. 3100 - 3111
NODs | Epithelial cells | β-Defensin 2 | TLRs | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Science & Technology | beta-Defensins - genetics | Epithelial Cells - metabolism | Carrier Proteins - biosynthesis | Humans | Gene Expression Regulation | Nod2 Signaling Adaptor Protein - genetics | Inflammation | Immunity | Bacteria - immunology | Epithelial Cells - immunology | Toll-Like Receptors - genetics | Cytokines - biosynthesis | Nod1 Signaling Adaptor Protein - genetics | Microbiology | Peptides | Index Medicus | Tongue | RNA | Lung | Kidney | Lipid A | Mimicry | Interleukin 6 | peptidoglycan recognition proteins | Intestine | Antimicrobial peptides | Toll-like receptors | Nod1 protein | Interleukin 8 | NOD2 protein | TLR7 protein | Cytokines | lipopeptides | Salivary gland | Poly (I:C) | TLR4 protein | Pharynx | TLR3 protein | Esophagus | Defensins | TLR2 protein | Monocyte chemoattractant protein 1
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3. Full Text Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans
by Ochi, Atsuo and Graffeo, Christopher S and Zambirinis, Constantinos P and Rehman, Adeel and Hackman, Michael and Fallon, Nina and Barilla, Rocky M and Henning, Justin R and Jamal, Mohsin and Rao, Raghavendra and Greco, Stephanie and Deutsch, Michael and Medina-Zea, Marco V and Saeed, Usama Bin and Ego-Osuala, Melvin O and Hajdu, Cristina and Miller, George
The Journal of clinical investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 4118 - 4129
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Inflammation - pathology | Pancreatic Neoplasms - metabolism | Membrane Glycoproteins - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Immunity, Innate - genetics | Neoplasm Proteins - immunology | Neoplasm Proteins - metabolism | MAP Kinase Signaling System - immunology | Carcinoma, Pancreatic Ductal - genetics | Inflammation - metabolism | MAP Kinase Signaling System - genetics | Cell Transformation, Neoplastic - genetics | Mice, Mutant Strains | Toll-Like Receptor 7 - immunology | Membrane Glycoproteins - immunology | Neoplasm Proteins - genetics | Carcinoma, Pancreatic Ductal - immunology | Gene Expression Regulation, Neoplastic - genetics | Toll-Like Receptor 7 - genetics | Toll-Like Receptor 7 - metabolism | Pancreatic Neoplasms - pathology | Gene Expression Regulation, Neoplastic - immunology | Pancreatic Neoplasms - genetics | Inflammation - immunology | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Membrane Glycoproteins - genetics | Cell Transformation, Neoplastic - immunology | Animals | Pancreatic Neoplasms - immunology | Inflammation - genetics | Mice | Cell Transformation, Neoplastic - pathology | Care and treatment | Pancreatic cancer | Cancer cells | Development and progression | Genetic aspects | Research | Genetic regulation | Carcinogenesis | Adenocarcinoma | Animal models | c-Myc protein | Transforming growth factor- beta | Immunity | Cyclin B1 | Signal transduction | Toll-like receptors | Tumorigenesis | TLR7 protein | Invasiveness | Stat3 protein | Data processing | MAP kinase | Inflammation | Environmental effects | p53 protein | NF- Kappa B protein | stromal cells | Microenvironments | Notch protein | cyclin D1 | Peroxisome proliferator-activated receptors | Neoplasia | PTEN protein | Index Medicus | Abridged Index Medicus
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4. Full Text UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity
by Majer, Olivia and Liu, Bo and Kreuk, Lieselotte S. M and Krogan, Nevan and Barton, Gregory M
Nature (London), ISSN 0028-0836, 11/2019, Volume 575, Issue 7782, pp. 366 - 370
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Autoimmunity | Cell Line | Phosphorylation | Toll-Like Receptor 7 - metabolism | Membrane Glycoproteins - metabolism | Signal Transduction | Humans | Syntenins - metabolism | Animals | Membrane Transport Proteins - genetics | Membrane Transport Proteins - metabolism | Mice | Polymorphism, Single Nucleotide | Prevention | Control | Analysis | Influence | TLR7 | Protein-protein interactions | Membrane proteins | Binding | Lupus | Animal models | TLR7 protein | Activation | Genomes | Ribonucleic acid--RNA | Exosomes | TLR9 protein | Proteins | Signaling | Receptors | Chronic conditions | Systemic lupus erythematosus | Acids | Toll-like receptors | Evolution | Regulation | Mutation | Autoimmune diseases | Deoxyribonucleic acid--DNA | Structure-function relationships | Index Medicus
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5. Full Text Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle
by Perkins, Ryan K and Lavin, Kaleen M and Raue, Ulrika and Jemiolo, Bozena and Trappe, Scott W and Trappe, Todd A
Journal of applied physiology (1985), ISSN 8750-7587, 12/2020, Volume 129, Issue 6, pp. 1483 - 1492
Adaptor proteins | NF-κB protein | TLR7 protein | Muscles | TLR4 protein | Adaptors | Gene expression | Aerobics | TLR3 protein | Skeletal muscle | Musculoskeletal system | Physical fitness | Exercise | TLR1 protein | Quadriceps muscle | Toll-like receptors | Aging | MyD88 protein | Immune system | Index Medicus
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6. Full Text Screening of toll-like receptor signaling pathway-related genes and the response of recombinant glutathione S-transferase A3 protein to thiram induced apoptosis in chicken erythrocytes
by Jahejo, Ali Raza and Jia, Fa-jie and Raza, Sayed Haidar Abbas and Shah, Mujahid Ali and Yin, Jiao-jiao and Ahsan, Anam and Waqas, Muhammad and Niu, Sheng and Ning, Guan-bao and Zhang, Ding and Khan, Ajab and Tian, Wen-xia
Developmental and comparative immunology, ISSN 0145-305X, 01/2021, Volume 114, pp. 103831 - 103831
Erythrocyte | Immunity | Tibial dyschondroplasia | Broiler | Protein | Apoptosis | Fisheries | Immunology | Life Sciences & Biomedicine | Zoology | Science & Technology | TRAF6 protein | TLR7 protein | TLR5 protein | Genes | Erythrocytes | Thiram | Gene expression | TLR3 protein | Proteins | Interleukin 7 | Signaling | Signal transduction | Receptors | Red blood cells | Diet | Glutathione transferase | TLR2 protein | Chondrocytes | Toll-like receptors | MyD88 protein | Glutathione | Index Medicus
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7. Full Text Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response
by Ubil, Eric and Caskey, Laura and Holtzhausen, Alisha and Hunter, Debra and Story, Charlotte and Earp, H. Shelton
The Journal of clinical investigation, ISSN 0021-9738, 06/2018, Volume 128, Issue 6, pp. 2356 - 2369
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Humans | Neoplasms, Experimental - pathology | Toll-Like Receptor 8 - immunology | Neoplasms, Experimental - immunology | Toll-Like Receptor 7 - immunology | Neoplasms, Experimental - genetics | Membrane Glycoproteins - immunology | Cytokines - genetics | Carrier Proteins - immunology | Macrophages - immunology | Cytokines - immunology | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Macrophages - pathology | Membrane Glycoproteins - agonists | Imidazoles - pharmacology | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Toll-Like Receptor 8 - genetics | Mice | Polarization | Transcription | Metastasis | Gene deletion | Kinases | Macrophages | Phosphatase | Metastases | Axl protein | Lipopolysaccharides | Proteins | Clonal deletion | Lymphocytes | Rodents | Toll-like receptors | Bone marrow | Protein-tyrosine kinase receptors | Tumorigenesis | Tyrosine | CRISPR | Immune response | TLR7 protein | Cytokines | Tumor cells | Melanoma | Breast cancer | Inflammation | Tumor cell lines | Gene expression | γ-Interferon | PD-L1 protein | Antitumor activity | Protein S | Ligands | Tumors | Apoptosis | Index Medicus | Abridged Index Medicus
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8. Full Text UNC93B1 mediates differential trafficking of endosomal TLRs
by Lee, Bettina L and Moon, Joanne E and Shu, Jeffrey H and Yuan, Lin and Newman, Zachary R and Schekman, Randy and Barton, Gregory M
eLife, ISSN 2050-084X, 02/2013, Volume 2013, Issue 2, pp. e00291 - e00291
Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Humans | Mice, Inbred C57BL | COP-Coated Vesicles - metabolism | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Mice, Transgenic | Endosomes - metabolism | Protein Transport | Adaptor Protein Complex 2 - metabolism | Animals | Transfection | RNA Interference | Membrane Transport Proteins - genetics | Toll-Like Receptors - genetics | HEK293 Cells | Golgi Apparatus - metabolism | Membrane Transport Proteins - metabolism | Mutation | Toll-Like Receptors - metabolism | COS Cells | TLR7 protein | Yeast | TLR3 protein | TLR9 protein | Golgi apparatus | Recruitment | Proteins | Toll-like receptors | Ligands | Localization | Autoimmune diseases | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Index Medicus
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9. Full Text Human Keratinocytes Express Functional Toll-Like Receptor 3, 4, 5, and 9
by Lebre, Maria C and van der Aar, Angelic M.G and van Baarsen, Lisa and van Capel, Toni M.M and Schuitemaker, Joost H.N and Kapsenberg, Martien L and de Jong, Esther C
Journal of investigative dermatology, ISSN 0022-202X, 02/2007, Volume 127, Issue 2, pp. 331 - 341
Life Sciences & Biomedicine | Dermatology | Science & Technology | Oligonucleotides - genetics | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Toll-Like Receptor 9 - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Flagellin - pharmacology | Tissue Distribution | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Biological Transport | Oligonucleotides - pharmacology | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Chemokine CXCL9 | Toll-Like Receptor 5 - metabolism | Poly I-C - pharmacology | Cytokines - metabolism | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Chemokine CXCL10 | Transcription Factor RelA - metabolism | Keratinocytes - metabolism | Toll-Like Receptors - genetics | Chemokines, CXC - metabolism | Lipopolysaccharides - pharmacology | CpG Islands | Ligands | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | CD40 antigen | Oligonucleotides | Flagellin | mRNA | intercellular adhesion molecule 1 | Immunity | Lipopolysaccharides | CXC chemokines | CCL20 protein | Toll-like receptors | CpG islands | TLR7 protein | Keratinocytes | Nuclear transport | Stress | TLR3 protein | TLR9 protein | TLR1 protein | External stimuli | CXCL10 protein | Histocompatibility antigen HLA | Interferon | Internet | Monocyte chemoattractant protein 1 | Tumor necrosis factor- alpha | Index Medicus
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10. Full Text TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
by Heinz, Leonhard X and Lee, JangEun and Kapoor, Utkarsh and Kartnig, Felix and Sedlyarov, Vitaly and Papakostas, Konstantinos and Cesar-Razquin, Adrian and Essletzbichler, Patrick and Goldmann, Ulrich and Stefanovic, Adrijana and Bigenzahn, Johannes W and Scorzoni, Stefania and Pizzagalli, Mattia D and Bensimon, Ariel and Mueller, Andre C and King, F. James and Li Jun and Girardi, Enrico and Mbow, M. Lamine and Whitehurst, Charles E and Rebsamen, Manuele and Superti-Furga, Giulio
Nature (London), ISSN 0028-0836, 05/2020, Volume 581, Issue 7808, pp. 316 - 322
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Carrier proteins | Analysis | Toll-like receptors | Mechanical properties | Causes of | Lysosomes | Influence | Lupus erythematosus | Interferon | Plasma | Interferon-inducible protein | Residues | Amino acids | Activation | Defects | Proteins | Signal transduction | Clonal deletion | Localization | Immune system | Lupus | Adaptor proteins | Pathogens | NF-κB protein | TLR7 protein | MAP kinase | Adaptors | Gene expression | TLR9 protein | Signaling | Mutagenesis | Ligands | Autoimmune diseases | Transporter | Recognition | Index Medicus
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