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International Immunology, ISSN 0953-8178, 03/2019, Volume 31, Issue 3, pp. 167 - 173
Toll-like receptor 8 (TLR8), a sensor for pathogen-derived single-stranded RNA (ssRNA), binds to uridine (Uri) and ssRNA to induce defense responses. We here... 
5-azacytidine | CDA | TLR8 | RECOGNITION | RNA | DNA | CDNA | CPG | IMMUNOLOGY
Journal Article
RNA, ISSN 1355-8382, 09/2017, Volume 23, Issue 9, pp. 1344 - 1351
Bacterial RNA serves an important function as activator of the innate immune system. In humans bacterial RNA is sensed by the endosomal receptors TLR7 and... 
RNA modification | ACTIVATION | DENDRITIC CELLS | RECOGNITION | BACTERIAL RNA | IMMUNOSTIMULATORY ACTIVITY | HUMAN TLR8 | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN MONOCYTES | SIGNALING PATHWAY | SINGLE-STRANDED RNA | DEGRADATION-PRODUCTS | 2 '-O-methylation | TLR8 | immune stimulation | TLR7 | inhibitory RNA
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 10/2017, Volume 8, pp. 1243 - 1243
TLR8 is the major endosomal sensor of degraded RNA in human monocytes and macrophages. It has been implicated in the sensing of viruses and more recently also... 
Infection | Inflammation | Primary human phagocytes | Human TLR8 | Pattern recognition receptors | infection | ACTIVATION | INFECTIONS | IFN-BETA PRODUCTION | RNA | RECOGNITION | INNATE | human TLR8 | BACTERIAL | IMMUNOLOGY | primary human phagocytes | I INTERFERON | pattern recognition receptors | inflammation | TLR8 | DIFFERENTIATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 17, pp. 6871 - 6885
Journal Article
OncoImmunology, ISSN 2162-4011, 05/2016, Volume 5, Issue 5, pp. e1126037 - e1126037
A novel approach to immunotherapy is the activation of toll-like receptor 8 (TLR8). Motolimod, a selective TLR8 agonist can act in concert with approved... 
CELLS | TLR8 | IMMUNOLOGY | ONCOLOGY
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 11/2017, Volume 8, Issue 11, pp. 1148 - 1152
A series of N1-modified imidazoquinolines were synthesized and screened for Toll-like receptors (TLR) 7 and 8 activities to identify recognition elements that... 
cytokine | TLR8 | TLR7 | SAR | Toll-like receptor | imidazoquinoline
Journal Article
Infection, Genetics and Evolution, ISSN 1567-1348, 10/2019, Volume 74, pp. 103936 - 103936
Norovirus is known as a major cause of several acute gastroenteritis (AGE) outbreaks each year. A study was conducted to develop a unique multi epitope subunit... 
Capsid protein VP1 | Norovirus | Protein VP2 | TLR8 receptor | Reverse vaccinology | Molecular docking | Index Medicus
Journal Article
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2019, Volume 10, pp. 1209 - 1209
TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously... 
Bacteria | Sensors | Macrophages | Tumor necrosis factor | Staphylococcus aureus | monocytes | human TLR8 | cytokines | bacteria | IRAK-1
Journal Article
ChemMedChem, ISSN 1860-7179, 4/2014, Volume 9, Issue 4, pp. 719 - 723
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that... 
Innate immunity | TLR8 | Adjuvant | Vaccines | Aminoquinolines
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 01/2018, Volume 8, pp. 1972 - 1972
Accumulating evidence suggests important functions for human Toll-like receptor 8 in vivo in tuberculosis and autoimmune diseases. However, these studies are... 
Type I IFN signaling | Adjuvants | TLR8 | Memory T cell | Tuberculosis | Immunologic | memory T cell | T-CELL SUBSETS | DENDRITIC CELLS | RNA | HUMAN TLR8 | tuberculosis | IMMUNOLOGY | immunologic | HUMAN MONOCYTES | I IFN | SUBUNIT VACCINE | type I IFN signaling | IMMUNE-RESPONSES | MICE | adjuvants | SYNTHETIC PROMOTER | Prevention | Immunization | Usage | Toll-like receptors | Cellular signal transduction | Research
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2017, Volume 36, Issue 20, pp. 2998 - 3011
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 11/2017, Volume 8, Issue 11, pp. 1148 - 1152
A series of N1-modified imidazoquinolines were synthesized and screened for Toll-like receptors (TLR) 7 and 8 activities to identify recognition elements that... 
cytokine | CHEMISTRY, MEDICINAL | LIGANDS | SAR | TLR8 | TLR7 | Toll-like receptor | imidazoquinoline | ENHANCED CYTOKINE INDUCTION
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2018, Volume 497, Issue 1, pp. 319 - 325
The recognition of single-stranded RNA by TLR7/8 leads to the production of NF-κB-mediated cytokines and type I IFNs. However, the role of TLR7/8 activation in... 
TLR8 | Monocytes | TLR7 | Macrophages | Immune modulation | THP-1 | DENDRITIC CELLS | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETEROGENEITY | BIOPHYSICS | PATHWAY | INFLAMMATION | INFECTION | Index Medicus
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 06/2019, Volume 105, Issue 6, pp. 1155 - 1165
Human neutrophils contribute to the regulation of inflammation via the generation of a range of cytokines that affect all elements of the immune system. Here,... 
IL‐23 | TLR8 | TNF‐α | neutrophils | Th17 cells | TNF-α | IL-23 | GAMMA | CELLS | CYTOKINES | PROTEIN | TNF-alpha | TRANSCRIPTION | RECEPTOR | IMMUNOLOGY | IL-12 | CELL BIOLOGY | INFLAMMATION | GENE-EXPRESSION | PRIMARY MONOCYTES | HEMATOLOGY
Journal Article