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PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0151967
Highly purified outer membrane vesicles (OMVs) of the periodontal pathogens, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia were... 
PROTEINASE-ADHESIN COMPLEXES | BACTEROIDES-GINGIVALIS | BACTERIA | TREPONEMA-DENTICOLA | EPITHELIAL-CELLS | SOLUBLE PEPTIDOGLYCAN | PORPHYROMONAS-GINGIVALIS | DNA | MULTIDISCIPLINARY SCIENCES | RELEASE | VIRULENCE | Cell Line | Receptors, Pattern Recognition - isolation & purification | Bacterial Outer Membrane Proteins - immunology | Bacteroides - chemistry | Receptors, Pattern Recognition - immunology | Receptors, Pattern Recognition - chemistry | Bacteroides - immunology | Humans | Treponema denticola - immunology | Bacterial Outer Membrane Proteins - chemistry | Nod2 Signaling Adaptor Protein - immunology | Porphyromonas gingivalis - chemistry | Toll-Like Receptor 4 - immunology | Nod1 Signaling Adaptor Protein - immunology | Bacterial Outer Membrane Proteins - isolation & purification | Treponema denticola - chemistry | Chronic Periodontitis - microbiology | Lipopolysaccharides - analysis | Chronic Periodontitis - immunology | Toll-Like Receptor 2 - immunology | Peptidoglycan - analysis | Porphyromonas gingivalis - immunology | Virulence (Microbiology) | Periodontitis | Analysis | Risk factors | Pattern recognition receptors | Cell culture | Dental schools | Disease | Lipids | Ultracentrifugation | Nanoparticles | Proteins | Signal transduction | Receptors | Vesicles | Ultrafiltration | Rodents | Toll-like receptors | Bacteria | Nod1 protein | Deoxyribonucleic acid--DNA | NOD2 protein | Pathogens | Enzymes | Enumeration | TLR7 protein | Light scattering | Peptidoglycans | Membrane vesicles | Inflammation | Nucleic acids | Pattern recognition | TLR4 protein | Fatty acids | TLR9 protein | Cytometry | Biofilms | Oral hygiene | TLR2 protein | Deoxyribonucleic acid
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1530 - 1534
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor KB (NF-KB)-dependent... 
T lymphocytes | Molecules | Cytokines | Microscopy | Genes | REPORTS | Toll like receptors | Agonists | Macrophages | Cells | Endosomes | LOCALIZATION | ACTIVATION | DENDRITIC CELLS | TRAF3 | MULTIDISCIPLINARY SCIENCES | TLR9 | TOLL-LIKE-RECEPTOR-9 | INDUCTION | INTERFERON-ALPHA PRODUCTION | I INTERFERON | AP-3 ADAPTER | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Transcriptional Activation | Interferon Type I - immunology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - immunology | Cytoplasmic Vesicles - metabolism | Interferon Type I - metabolism | Membrane Transport Proteins - metabolism | Cytokines - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Signal Transduction | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 3 - metabolism | Adaptor Protein Complex beta Subunits | Interferon Regulatory Factor-7 - metabolism | Adaptor Protein Complex 3 - metabolism | Protein Transport | Animals | Adaptor Protein Complex 3 - genetics | Interferon Type I - genetics | Mice | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Cellular control mechanisms | Physiological aspects | TLR7 | Research | Health aspects | Immune system | Proteins | Signal transduction | Interferon | Cellular biology | Receptors | Compartments | Bifurcations | Activation
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0121371
CpG-ODNs activate dendritic cells (DCs) to produce interferon alpha (IFN alpha) and beta (IFN beta). Previous studies demonstrated that Toll-like receptor 9... 
OLIGODEOXYNUCLEOTIDES | INTERFERON | ACTIVATION | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTOR | TLR9 | DEPENDENT PROTEIN-KINASE | ALPHA | INDUCTION | Interleukin-1 Receptor-Associated Kinases - metabolism | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Antigens, Nuclear - metabolism | Dendritic Cells - immunology | Toll-Like Receptor 9 - genetics | Mechanistic Target of Rapamycin Complex 1 | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | STAT1 Transcription Factor - metabolism | Interferon Type I - pharmacology | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Dendritic Cells - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Interleukin-12 - pharmacology | DNA-Binding Proteins - immunology | TNF Receptor-Associated Factor 3 - metabolism | Interleukin-12 - metabolism | Mice, Knockout | Animals | Interleukin-6 - pharmacology | Ku Autoantigen | Signal Transduction - drug effects | Protein Binding | Mice | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Antigens, Nuclear - immunology | Interferon | Systemic lupus erythematosus | B cells | Dendritic cells | Biological response modifiers | DNA | Protein kinase C | Downstream effects | Oligonucleotides | Antibodies | AKT protein | Biology | Kinases | Interleukin 6 | Proteins | α-Interferon | Immunology | Toll-like receptors | Bone marrow | Catalysis | Deoxyribonucleic acid--DNA | CpG islands | Immune system | IRAK protein | Immunoglobulins | Interleukin 12 | Biological assays | Gene expression | Molecular chains | TLR9 protein | DNA-dependent protein kinase | MyD88 protein | Cancer | Deoxyribonucleic acid
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 49, pp. E11523 - E11531
The SMCR8-WDR41-C9ORF72 complex is a regulator of autophagy and lysosomal function. Autoimmunity and inflammatory disease have been ascribed to... 
Inflammatory bowel disease | Inflammation | Vesicle trafficking | Toll-like receptor | CELLS | ACTIVATION | RECOGNITION | MULTIDISCIPLINARY SCIENCES | MACROPHAGE | AMYOTROPHIC-LATERAL-SCLEROSIS | C9ORF72 | inflammatory bowel disease | PROTECTS | COLITIS | inflammation | MYASTHENIA-GRAVIS | RECEPTORS | vesicle trafficking | C9orf72 Protein - genetics | Dextran Sulfate | Gene Expression Regulation | Hematopoiesis - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mice, Knockout | Autoimmune Diseases - genetics | Carrier Proteins - genetics | Signal Transduction - immunology | Inflammation - metabolism | Animals | Carrier Proteins - metabolism | Colitis - chemically induced | Toll-Like Receptors - genetics | C9orf72 Protein - metabolism | Mice | Mutation | Toll-Like Receptors - metabolism | Autoimmune Diseases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Toll-like receptors | Physiological aspects | Cellular signal transduction | Health aspects | Splenomegaly | Lymphocytes T | Sodium sulfates | Macrophages | Autophagy | Proteins | Receptors | Lymphocytes | Rodents | Sodium sulfate | Immune system | Myeloid cells | TLR7 protein | Cytokines | Medical immunity | Amyotrophic lateral sclerosis | TLR4 protein | TLR3 protein | TLR9 protein | Dextran | Lymphadenopathy | Signaling | Molecular modelling | Sodium | TLR2 protein | Ligands | Colitis | Autoimmune diseases | Phagocytosis | Biological Sciences | PNAS Plus
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2007, Volume 127, Issue 2, pp. 331 - 341
Keratinocytes are continuously in contact with external stimuli and have the capacity to produce several soluble mediators. Pathogen-associated molecular... 
TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | SKIN-ASSOCIATED CHEMOKINE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INNATE IMMUNE-RESPONSE | INFLAMMATORY PROTEIN 3-ALPHA | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | HUMAN EPIDERMAL-KERATINOCYTES | DERMATOLOGY | Oligonucleotides - genetics | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Toll-Like Receptor 9 - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Flagellin - pharmacology | Tissue Distribution | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Biological Transport | Oligonucleotides - pharmacology | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Chemokine CXCL9 | Toll-Like Receptor 5 - metabolism | Poly I-C - pharmacology | Cytokines - metabolism | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Chemokine CXCL10 | Transcription Factor RelA - metabolism | Keratinocytes - metabolism | Toll-Like Receptors - genetics | Chemokines, CXC - metabolism | Lipopolysaccharides - pharmacology | CpG Islands | Ligands | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | CD40 antigen | Oligonucleotides | Flagellin | mRNA | intercellular adhesion molecule 1 | Immunity | Lipopolysaccharides | CXC chemokines | CCL20 protein | Toll-like receptors | CpG islands | TLR7 protein | Dermatology | Keratinocytes | Nuclear transport | Stress | TLR3 protein | TLR9 protein | TLR1 protein | External stimuli | CXCL10 protein | Histocompatibility antigen HLA | Interferon | Internet | Monocyte chemoattractant protein 1 | Tumor necrosis factor- alpha
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2018, Volume 48, Issue 9, pp. 1506 - 1521
The production of IL‐10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN‐γ, a key cytokine in... 
interferon‐gamma | mitogen‐activated protein kinases | B cells | Toll‐like receptor 9 | interleukin‐10 | Toll-like receptor 9 | interferon-gamma | interleukin-10 | mitogen-activated protein kinases | Cell Proliferation - genetics | Humans | Mice, Inbred C57BL | Cells, Cultured | JNK Mitogen-Activated Protein Kinases - metabolism | Interferon-gamma - metabolism | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Signal Transduction - immunology | Lymphocyte Activation - genetics | Animals | B-Lymphocytes - immunology | MAP Kinase Signaling System - genetics | CpG Islands - genetics | Interleukin-10 - biosynthesis | Mice | Mice, Inbred BALB C | Receptor, Interferon alpha-beta - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Interferon-gamma - genetics | Dual Specificity Phosphatase 1 - biosynthesis | Toll-Like Receptor 9 - metabolism | Macrophages - immunology | Cell proliferation | Oligonucleotides | Leukocytes (mononuclear) | Lymphocytes T | Kinases | Macrophages | MAP kinase phosphatase | Proteins | Signal transduction | Lymphocytes | Toll-like receptors | Peripheral blood mononuclear cells | Inhibition | CpG islands | Immune system | Spleen | Immune response | TLR7 protein | Cytokines | Immunoregulation | T cell receptors | TLR4 protein | TLR3 protein | TLR9 protein | CD4 antigen | Monocytes | Immunosuppression | Inhibitors | Lymphocytes B | TLR2 protein | Interferon | Peritoneum
Journal Article
Journal of Internal Medicine, ISSN 0954-6820, 11/2014, Volume 276, Issue 5, pp. 425 - 443
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2011, Volume 6, Issue 1, p. e15324
textabstractChronic hepatitis B virus (HBV) infection is caused by inadequate anti-viral immunity. Activation of plasmacytoid dendritic cells (pDC) leading to... 
NATURAL-KILLER | BIOLOGY | GENE-EXPRESSION | RECEPTOR | C VIRUS | IMMUNOLOGY | NONPARENCHYMAL LIVER-CELLS | HBV | IFN-ALPHA PRODUCTION | VIRAL-INFECTION | I INTERFERON | Cell Communication - immunology | Dendritic Cells - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Cells, Cultured | Viral Proteins - pharmacology | Monocytes - immunology | Dendritic Cells - virology | Hepatitis B virus - immunology | Immunity | Tumor Necrosis Factor-alpha - biosynthesis | Case-Control Studies | Medical research | Antiviral agents | Dendritic cells | Research | Genetic transcription | Proteins | Infection | Killer cells | Medicine, Experimental | Hepatitis B virus | Comparative analysis | Health aspects | Hepatitis B | TOR protein | Animal models | Phosphorylation | Transcription | Liver | Chronic infection | Viruses | Infections | Activation | Interleukin 6 | Hepatitis | Cell activation | Hepatology | Gastroenterology | Toll-like receptors | IP-10 protein | Natural killer cells | Active control | Deoxyribonucleic acid--DNA | CpG islands | Antigens | TLR7 protein | Hepatitis B surface antigen | Cytokines | Tumor necrosis factor-α | Gene expression | Patients | TLR9 protein | Hepatitis B e antigen | Interferon regulatory factor 7 | Immunosuppression | Monocytes | Lymphocytes B | Influenza | Ligands | Interferon | Viral infections | Deoxyribonucleic acid | DNA
Journal Article