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tmem16a (349) 349
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1. Full Text TMEM16A/ANO1 inhibits apoptosis via down-regulation of Bim expression
by Godse, Neal R and Khan, Nayel and Yochum, Zachary A and Gomez-Casal, Roberto and Kemp, Carolyn and Shiwarski, Daniel J and Seethala, Raja S and Kulich, Scott and Seshadri, Mukund and Burns, Timothy F and Duvvuri, Umamaheswar
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 12/2017, Volume 23, Issue 23, pp. 7324 - 7332
ANO1 | apoptosis | TMEM16A | HNSCC | Bim
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2. Full Text EAVK segment “c” sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1
by Strege, Peter R and Gibbons, Simon J and Mazzone, Amelia and Bernard, Cheryl E and Beyder, Arthur and Farrugia, Gianrico
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2017, Volume 312, Issue 6, pp. G572 - G579
Calcium-activated chloride channel anoctamin1 (Ano1) is necessary for normal slow waves in the gastrointestinal interstitial cells of Cajal. Exon “0” encodes... 
Electrophysiology | Ion channels | TMEM16A | electrophysiology | ion channels
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3. Full Text Cell-specific regulation of proliferation by Ano 1/TMEM16A in breast cancer with different ER, PR, and HER2 status
by Wu, Huizhe and Wang, Hui and Guan, Shu and Zhang, Jing and Chen, Qiuchen and Wang, Xiaodong and Ma, Ke and Zhao, Pengfei and Zhao, Haishan and Yao, Weifan and Jin, Feng and Xiao, Qinghuan and Wei, Minjie
Oncotarget, 10/2017, Volume 8, Issue 49, pp. 84996 - 85013
Ano1 | Breast cancer | Proliferation | TMEM16A | Ki67
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4. Full Text Inhibition of Ca 2+ -activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling
by Liu, Zongtao and Zhang, Sushan and Hou, Feng and Zhang, Congxiao and Gao, Jianjun and Wang, KeWei
International Journal of Cancer, ISSN 0020-7136, 05/2019, Volume 144, Issue 9, pp. 2215 - 2226
Most common ovarian cancers are epithelial carcinoma in which the etiology for carcinogenesis remains elusive. ANO1/TMEM16A, a member of Ca -activated Cl... 
ANO1 | TMEM16A | metastasis | ovarian cancer | PBMCs | SKOV3 cells
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5. Full Text Ion Channels: Poring over furrows
by Fisher, SID and Hartzell, HC
ELIFE, ISSN 2050-084X, 05/2017, Volume 6
MEMBRANE | BIOLOGY | INDEPENDENT ACTIVATION | TMEM16A | PORES
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6. Full Text Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
by Britschgi, A and Bill, A and Brinkhaus, H and Rothwell, C and Clay, I and Duss, S and Rebhan, M and Raman, P and Guy, CT and Wetzel, K and George, E and Popa, MO and Lilley, S and Choudhury, H and Gosling, M and Wang, L and Fitzgerald, S and Borawski, J and Baffoe, J and Labow, M and Gaither, LA and Bentires-Alj, M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2013, Volume 110, Issue 11, pp. E1026 - E1034
The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in... 
SURVIVAL | HEAD | CaCCinh-A01 | GROWTH-FACTOR-RECEPTOR | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | ESCC | AMPLIFICATION | ion channel | HNSCC | SQUAMOUS-CELL CARCINOMA | TMEM16A | 11Q13 AMPLICON | EXPRESSION
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7. Full Text A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland
by Marcelo A. Catalán and Yusuke Kondo and Gaspar Peña-Munzenmayer and Yasna Jaramillo and Frances Liu and Sooji Choi and Edward Crandall and Zea Borok and Per Flodby and Gary E. Shull and James E. Melvin
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2015, Volume 112, Issue 7, pp. 2263 - 2268
Activation of an apical Ca2+-activated Cl- channel (CaCC) triggers the secretion of saliva. It was previously demonstrated that CaCC-mediated Cl- current and... 
CL-CURRENT | CELLS | ESSENTIAL COMPONENT | ACTIVATED CHLORIDE CHANNEL | MULTIDISCIPLINARY SCIENCES | Cl- channel | MEMBRANE-PROTEIN | Cftr channel | KNOCKOUT MICE | Tmem16A/Ano1 | secretion | SUBMANDIBULAR-GLAND | REGULATED ANION CHANNEL | CYSTIC-FIBROSIS | acinar cell | CFTR | Anoctamin-1 | Animals | Saliva - secretion | Salivary Glands - secretion | Mice | Acinar Cells - secretion | Chloride Channels - genetics | Receptors, Adrenergic, beta - physiology | Mice, Knockout | Physiological aspects | Chloride channels | Genetic aspects | Salivary glands | Gene expression | Observations | Ano1 | Biological Sciences | Tmem16A | Cl− channel
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8. Full Text Potent vasorelaxant activity of the TMEM16A inhibitor T16A inh-A01
by Davis, Alison J and Shi, Jian and Pritchard, Harry A.T and Chadha, Preet S and Leblanc, Normand and Vasilikostas, Georgios and Yao, Zhen and Verkman, A.S and Albert, Anthony P and Greenwood, Iain A
British Journal of Pharmacology, ISSN 0007-1188, 02/2013, Volume 168, Issue 3, pp. 773 - 784
Ano1 | anti-hypertensive | patch clamp | vascular smooth muscle | calcium-activated chloride channels | TMEM16A | anoctamins
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9. Full Text Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl- Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein
by Junya Ohshiro and Hisao Yamamura and Yoshiaki Suzuki and Yuji Imaizumi and Department of Molecular and Cellular Pharmacology and Graduate School of Pharmaceutical Sciences and Nagoya City University
Journal of Pharmacological Sciences, ISSN 1347-8613, 2014, Volume 125, Issue 1, pp. 107 - 111
Abstract. TMEM16A is a major component of Ca2+ -activated Cl- channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the... 
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10. Full Text Characterization of the effects of Cl − channel modulators on TMEM16A and bestrophin-1 Ca 2+ activated Cl − channels
by Liu, Yani and Zhang, Huiran and Huang, Dongyang and Qi, Jinlong and Xu, Jiaxi and Gao, Haixia and Du, Xiaona and Gamper, Nikita and Zhang, Hailin
Pflugers Archiv European Journal of Physiology, ISSN 0031-6768, 08/2014, Volume 467, Issue 7, pp. 1417 - 1430
Ca 2+ activated Cl − channels (CaCCs) | Bestrophin-1 | Patch clamp | Inhibitor | TMEM16A | CHO cells
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11. Full Text Cl− channels in smooth muscle cells
by Bulley, Simon and Jaggar, Jonathan H
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 5/2014, Volume 466, Issue 5, pp. 861 - 872
In smooth muscle cells (SMCs), the intracellular chloride ion (Cl−) concentration is high due to accumulation by Cl−/HCO3 − exchange and Na+–K+–Cl−... 
ClC-3 | Biomedicine | Human Physiology | Bestrophins | Chloride channel | Smooth muscle | TMEM16A/Ano1 | CFTR | PHYSIOLOGY | NORADRENALINE-INDUCED CONTRACTIONS | VOLUME-SENSITIVE OSMOLYTE | PULMONARY-ARTERY | RECTIFYING ANION CHANNELS | INTERSTITIAL-CELLS | TRANSMEMBRANE CONDUCTANCE REGULATOR | MESENTERIC SMALL ARTERIES | CYSTIC-FIBROSIS | ACTIVATED CHLORIDE CHANNELS | RABBIT PORTAL-VEIN | Chloride Channels - metabolism | Animals | Membrane Potentials | Myocytes, Smooth Muscle - metabolism | Humans | Myocytes, Smooth Muscle - physiology | Cystic fibrosis | Ano1 | TMEM16A
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12. Full Text Targeting ion channels in cystic fibrosis
by Mall, Marcus A and Galietta, Luis J.V
Journal of Cystic Fibrosis, ISSN 1569-1993, 2015, Volume 14, Issue 5, pp. 561 - 570
Abstract Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause a characteristic defect in epithelial ion transport that plays... 
Pulmonary/Respiratory | Pharmacotherapy | TMEM16A | SLC26A9 | ENaC | CFTR modulators | Alternative chloride channels | MUCUS OBSTRUCTION | EPITHELIAL SODIUM-CHANNEL | TMEM16A CHLORIDE CHANNEL | CFTR POTENTIATOR | AIRWAY SURFACE LIQUID | ENAC-OVEREXPRESSING MICE | TRANSMEMBRANE CONDUCTANCE REGULATOR | NA+ CHANNEL | RESPIRATORY SYSTEM | LUNG-DISEASE | RESPIRATORY EPITHELIA | Anoctamin-1 | Chloride Channels - drug effects | Cystic Fibrosis - metabolism | Humans | Antiporters - metabolism | Aminophenols - therapeutic use | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Epithelial Sodium Channels - metabolism | Neoplasm Proteins - metabolism | Neoplasm Proteins - drug effects | Chloride Channels - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - drug effects | Mutation - drug effects | Epithelial Sodium Channels - drug effects | Cystic Fibrosis - genetics | Quinolones - therapeutic use | Antiporters - drug effects | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Cystic Fibrosis - drug therapy | Ion Transport - genetics | Cystic fibrosis | Ion channels | Mortality
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13. Full Text Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole
by Yip, Kay-Pong and Balasubramanian, Lavanya and Kan, Chen and Wang, Lei and Liu, Ruisheng and Ribeiro-Silva, Luisa and Sham, James S. K
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 12/2018, Volume 315, Issue 6, pp. F1592 - F1600
Myogenic contraction of renal arterioles is an important regulatory mechanism for renal blood flow autoregulation. We have previously demonstrated that... 
Confocal fluorescence microscopy | Myogenic response | Integrin | TMEM16A | Afferent arteriole
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14. Full Text Biochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells In Vitro
by Frobom, R and Sellberg, F and Xu, C and Zhao, A and Larsson, C and Lui, WO and Nilsson, IL and Berglund, E and Branstrom, R
ANTICANCER RESEARCH, ISSN 0250-7005, 07/2019, Volume 39, Issue 7, pp. 3433 - 3442
Background/Aim: DOG1 is a calcium-activated chloride channel that has gained attention as a promising drug target due to its involvement in several processes... 
PDGFRA | Gastrointestinal stromal tumors | GIST | TMEM16A EXPRESSION | EGFR | THERAPY | ONCOLOGY | DOG1 | ion channel | GROWTH | cancer | TMEM16A | CONTRIBUTES | Calcium | Tumor cells | Colonies | Chloride currents | Chloride channels (calcium-gated) | Anticancer properties | Calcium chloride | Chloride ions | Cell lines | Cell cycle | Ion channels | Inhibition | Viability | Tumors | Apoptosis | G1 phase
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15. Full Text TMEM16A as a Potential Biomarker in the Diagnosis and Prognosis of Lung Cancer
by Hu, C and Zhang, RG and Jiang, DP
ARCHIVES OF IRANIAN MEDICINE, ISSN 1029-2977, 01/2019, Volume 22, Issue 1, pp. 32 - 38
Background: Transmembrane protein 16A (TMEM16A), also known as ANO1 (anoctamin-1), was reported to be vital in the growth and invasion of several malignancies.... 
STATISTICS | Lung cancer | CELL-PROLIFERATION | Metastasis | Proliferation | IDENTIFICATION | Invasion | MEDICINE, GENERAL & INTERNAL | POOR-PROGNOSIS | ANO1 TMEM16A | RECURRENCE | TMEM16A | CA2+-ACTIVATED CL-CHANNEL | EXPRESSION | CONTRIBUTES | CHLORIDE
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16. Full Text Expression of ANO1/DOG1 is associated with shorter survival and progression of breast carcinomas
by Bae, Jun Sang and Park, Jeong Yeol and Park, See-Hyoung and Ha, Sang Hoon and An, Ae Ri and Noh, Sang Jae and Kwon, Keun Sang and Jung, Sung Hoo and Park, Ho Sung and Kang, Myoung Jae and Jang, Kyu Yun
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 1, pp. 607 - 621
The expression of ANO1 is considered to have diagnostic specificity for gastrointestinal stromal tumors. However, its function as a calcium-activated chloride... 
Breast | ANO1 | Carcinoma | Prognosis | DOG1 | ACTIVATED CHLORIDE CHANNEL | prognosis | TMEM16A EXPRESSION | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | carcinoma | GASTRIC-CANCER | SQUAMOUS-CELL CARCINOMA | ANO1 TMEM16A | GROWTH-FACTOR | CANCER PROGRESSION | breast | CA2+-ACTIVATED CL-CHANNEL | TUMOR-GROWTH
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17. Full Text Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl− Channel Regulation in Cerebrovascular Cells
by Lin, Cai-Xia and Lv, Xiao-Fei and Yuan, Feng and Li, Xiang-Yu and Ma, Ming-Ming and Liu, Can-Zhao and Zhou, Jia-Guo and Wang, Guan-Lei and Guan, Yong-Yuan
Circulation Journal, ISSN 1346-9843, 2017
Background:TMEM16A is a critical component of Ca2+-activated chloride channels (CaCCs) and mediates basilar arterial smooth muscle cell (BASMC) proliferation... 
CaMKIIγ | Serine phosphorylation | Chloride channels | TMEM16A | Cerebrovascular remodeling
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18. Full Text Calcium-activated Cl − channel: Insights on the molecular identity in epithelial tissues
by Rottgen, Trey S and Nickerson, Andrew J and Rajendran, Vazhaikkurichi M
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2018, Volume 19, Issue 5, p. 1432
Calcium-activated chloride secretion in epithelial tissues has been described for many years. However, the molecular identity of the channel responsible for... 
activated Cl | CLCA1 | TMEM16A | channels | Epithelium | CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL-CHARACTERIZATION | MUCIN SECRETION | CHEMISTRY, MULTIDISCIPLINARY | AGE-DEPENDENT DIARRHEA | Ca2+-activated Cl- channels | Ca2 | Cl- channels | ANO1 TMEM16A | epithelium | CHLORIDE CHANNEL | EXTRACELLULAR NUCLEOTIDES | INDEPENDENT ACTIVATION | EXPRESSION | Reviews | Secretion | Calcium channels (voltage-gated) | Localization | Mucous membrane | Molecular chains | Calcium ions | Calcium chloride | Ca2+-activated Cl− channels | Cl− channels
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19. Full Text The Natural Compound Cinnamaldehyde is a Novel Activator of Calcium-Activated Chloride Channel
by Huang, Yayue and Guo, Shuai and Ren, Shuxi and Chen, Yafei and Zhan, Yong and An, Hailong
The Journal of Membrane Biology, ISSN 0022-2631, 12/2018, Volume 251, Issue 5, pp. 747 - 756
Calcium-activated chloride channels (CaCCs) play important roles in a multitude of physiological processes, and in many cells types, TMEM16A was identified as... 
Life Sciences | Biochemistry, general | Cinnamaldehyde | Activator of CaCC/TMEM16A | Human Physiology | Electrophysiology | Drug discovery | Fluorescent imaging | PHYSIOLOGY | MARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CINNAMON | INTERSTITIAL-CELLS | CELL BIOLOGY | INHIBITION | CAJAL | TMEM16A | SECRETION | EXPRESSION | TRANSMEMBRANE PROTEIN | Electrical engineering | Electrical equipment and supplies | Fluorescence | Molecular biology | Electrical machinery | Aldehydes | Calcium channels | Calcium (intracellular) | Deactivation | Calcium | Traditional Chinese medicine | Calcium compounds | Clamping | Ileum | Modulators | Chloride channels (calcium-gated) | Calcium chloride | Chloride ions | Herbal medicine | Microscopy | Guinea pigs | Ion channels | Intracellular | Scanning microscopy | Calcium ions
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20. Full Text Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria
by Schenk, Laura K and Buchholz, Bjoern and Henke, Sebastian F and Michgehl, Ulf and Daniel, Christoph and Amann, Kerstin and Kunzelmann, Karl and Pavenstädt, Hermann
American journal of physiology. Renal physiology, ISSN 1931-857X, 12/2018, Volume 315, Issue 6, pp. F1777 - F1786
TMEM16A is a transmembrane protein from a conserved family of calcium-activated proteins that is highly expressed in the kidney. TMEM16A confers... 
Ano1 | albuminuria | kidney | TMEM16A | nephron number | PHYSIOLOGY | CHLORIDE CHANNELS | FORM | PROLIFERATION | HYPOXIA | GUDMAP | UROLOGY & NEPHROLOGY | MICE
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