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Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 242 - 246
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are recognized by members of the TNF... 
PATHWAYS | TOLL-LIKE-RECEPTORS | NECROSIS-FACTOR RECEPTOR | PROTEIN | TRADD | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SUPERFAMILY | BACTERIAL EFFECTOR | FAMILY | NLEB | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Protein Biosynthesis | Humans | Virulence | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Male | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | fas Receptor - metabolism | Multiprotein Complexes - metabolism | Enteropathogenic Escherichia coli - metabolism | Enteropathogenic Escherichia coli - pathogenicity | Receptors, Tumor Necrosis Factor, Type I - chemistry | TNF Receptor-Associated Death Domain Protein - metabolism | Acylation | Disease Models, Animal | Protein Structure, Tertiary | Signal Transduction | Mice, Inbred C57BL | Fas-Associated Death Domain Protein - metabolism | Escherichia coli Infections - microbiology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Fas-Associated Death Domain Protein - chemistry | N-Acetylglucosaminyltransferases - metabolism | Multiprotein Complexes - chemistry | Animals | TNF Receptor-Associated Death Domain Protein - chemistry | Escherichia coli Infections - pathology | Virulence Factors - metabolism | Mice | HeLa Cells | Arginine - metabolism | Apoptosis | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Arginine | Cytokines | Cell death | Tumor necrosis factor | Escherichia coli | Genetic aspects | Research | Properties | Salmonella | Microbiology | Kinases | Bacteriology
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 247 - 251
Successful infection by enteric bacterial pathogens depends on the ability of the bacteria to colonize the gut, replicate in host tissues and disseminate to... 
SYSTEM | INDUCED APOPTOSIS | ROLES | MULTIDISCIPLINARY SCIENCES | DISEASE | CITROBACTER-RODENTIUM | VIRULENCE | PROTEINS | NLEB | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Fas Ligand Protein - metabolism | Humans | fas Receptor - deficiency | Caspase 8 - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Male | Citrobacter rodentium - pathogenicity | fas Receptor - metabolism | Enteropathogenic Escherichia coli - metabolism | Enteropathogenic Escherichia coli - pathogenicity | Cell Death | HEK293 Cells | Female | TNF Receptor-Associated Death Domain Protein - metabolism | Protein Structure, Tertiary | Citrobacter rodentium - physiology | Signal Transduction | Fas-Associated Death Domain Protein - metabolism | Escherichia coli Infections - microbiology | Gastrointestinal Tract - microbiology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | Fas-Associated Death Domain Protein - chemistry | N-Acetylglucosaminyltransferases - metabolism | Fas Ligand Protein - antagonists & inhibitors | Animals | TNF Receptor-Associated Death Domain Protein - chemistry | Escherichia coli Infections - pathology | Virulence Factors - metabolism | Mice | Enzyme Activation | HeLa Cells | Cell receptors | Bacterial infections | Pathogenic microorganisms | Microbiology | Physiological aspects | Research | Stomach diseases | Proteins | Yeast | Microscopy | Rodents | Infections | Kinases | Apoptosis | EPEC | apoptosis | caspase-8 | death domain
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 42, pp. 17337 - 17350
The inhibition of host innate immunity pathways is essential for the persistence of attaching and effacing pathogens such as enteropathogenic Escherichia coli... 
SUBSTRATE-SPECIFICITY | UBIQUITINATION SITES | ENTEROPATHOGENIC ESCHERICHIA-COLI | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENRICHMENT | RECEPTOR | CITROBACTER-RODENTIUM | IDENTIFICATION | MASS-SPECTROMETRY | PROTEOMICS | Fas-Associated Death Domain Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Virulence Factors - genetics | Humans | Enteropathogenic Escherichia coli - enzymology | Fas-Associated Death Domain Protein - metabolism | Citrobacter rodentium - enzymology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | Citrobacter rodentium - pathogenicity | TNF Receptor-Associated Death Domain Protein - genetics | Escherichia coli Infections - genetics | Glycosyltransferases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Enteropathogenic Escherichia coli - pathogenicity | Escherichia coli Infections - pathology | Escherichia coli Proteins - genetics | Virulence Factors - metabolism | Protein Processing, Post-Translational | Glycosyltransferases - genetics | HeLa Cells | Protein Stability | TNF Receptor-Associated Death Domain Protein - metabolism | Apoptosis | post-translational modification (PTM) | pathogenesis | Microbiology | innate immunity | Escherichia coli (E. coli) | glycosylation | bacterial effectors
Journal Article
Immunity, ISSN 1074-7613, 2008, Volume 28, Issue 5, pp. 651 - 661
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 09/2012, Volume 19, Issue 9, pp. 1482 - 1494
Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA).... 
apoptosis | caspase-8 | cancer cells | ubiquitination | Toll-like receptor 3 | RIP1 | HOMOTYPIC INTERACTION MOTIF | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | IFN-BETA | NECROSIS | TOLL-LIKE RECEPTORS | C-FLIP | TRIF | NF-KAPPA-B | RNA-Binding Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | TNF Receptor-Associated Factor 2 - genetics | Caspase 8 - metabolism | Apoptosis - genetics | Baculoviral IAP Repeat-Containing 3 Protein | TNF Receptor-Associated Death Domain Protein - genetics | Caspase 8 - genetics | Nuclear Pore Complex Proteins - genetics | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Toll-Like Receptor 3 - genetics | TNF Receptor-Associated Death Domain Protein - metabolism | Nuclear Pore Complex Proteins - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Signal Transduction - genetics | Toll-Like Receptor 3 - metabolism | Ubiquitin-Protein Ligases | Signal Transduction - drug effects | RNA, Double-Stranded - pharmacology | Cell Line, Tumor | RNA-Binding Proteins - metabolism | Ubiquitination - genetics | Tumor necrosis factor receptors | Immune response | Lung cancer | Double-stranded RNA | TLR3 protein | death receptors | Caspase-8 | FADD protein | Molecular modelling | Toll-like receptors | alpha -Interferon | Ubiquitin-protein ligase | Apoptosis | Original Paper
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 705 - 10
Journal Article
Cell death & disease, ISSN 2041-4889, 2013, Volume 4, Issue 1, pp. e465 - e465
Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent... 
INDUCED CELL-DEATH | TARGET | APOPTOSIS | COMPLEX | MIXED LINEAGE KINASE | DOMAIN-LIKE | IDENTIFICATION | TNF | FACTOR RECEPTOR | NF-KAPPA B | CELL BIOLOGY | receptor-interacting protein kinases | smac-mimetic | inhibitor of apoptosis proteins TNF | INHIBITOR | necroptosis | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Caspase Inhibitors - pharmacology | Apoptosis - drug effects | Tumor Necrosis Factor-alpha - genetics | bcl-2 Homologous Antagonist-Killer Protein - deficiency | Caspase 8 - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Receptors, Tumor Necrosis Factor, Type I - metabolism | Recombinant Proteins - biosynthesis | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Quinolines - pharmacology | Necrosis | TNF Receptor-Associated Death Domain Protein - genetics | Caspase 8 - genetics | TNF Receptor-Associated Death Domain Protein - deficiency | Receptors, Tumor Necrosis Factor, Type I - deficiency | Amino Acid Chloromethyl Ketones - pharmacology | bcl-2-Associated X Protein - deficiency | TNF Receptor-Associated Death Domain Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Cell Line | bcl-2-Associated X Protein - metabolism | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Fibroblasts - pathology | Receptors, Tumor Necrosis Factor, Type I - genetics | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Fibroblasts - drug effects | Mice | Original
Journal Article