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1. Full Text Tumor necrosis factor receptor‐ associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system
by Walsh, Matthew C and Lee, JangEun and Choi, Yongwon
Immunological reviews, ISSN 0105-2896, 07/2015, Volume 266, Issue 1, pp. 72 - 92
K63‐linked | TRAF‐6 | TAK1 | TRAFs | signal transduction | mir‐146a | K63-linked | Signal transduction | TRAF-6 | Mir-146a | Life Sciences & Biomedicine | Immunology | Science & Technology | Animals | Signal Transduction | Immune System - metabolism | Lymphocyte Activation | Humans | TNF Receptor-Associated Factor 6 - metabolism | Homeostasis | Immune Tolerance | Immune System - growth & development | Toll-Like Receptors - metabolism | Tumor necrosis factor | Cellular signal transduction | B cells | Protein-protein interactions | Immune system | Tumors | Necrosis | Index Medicus | mir-146a
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2. Full Text Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
by Lutgens, Esther and Lievens, Dirk and Beckers, Linda and Wijnands, Erwin and Soehnlein, Oliver and Zernecke, Alma and Seijkens, Tom and Engel, David and Cleutjens, Jack and Keller, Anna M and Naik, Shalin H and Boon, Louis and Oufella, Hafid Ait and Mallat, Ziad and Ahonen, Cory L and Noelle, Randolph J and de Winther, Menno P and Daemen, Mat J and Biessen, Erik A and Weber, Christian
The Journal of experimental medicine, ISSN 0022-1007, 2010, Volume 207, Issue 2, pp. 391 - 404
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Inflammation - pathology | Leukocytes - pathology | Apolipoproteins E - deficiency | TNF Receptor-Associated Factor 2 - genetics | Anti-Inflammatory Agents - immunology | TNF Receptor-Associated Factor 5 - immunology | TNF Receptor-Associated Factor 6 - immunology | CD40 Ligand - immunology | Leukocytes - immunology | Signal Transduction - immunology | CD40 Antigens - metabolism | CD40 Ligand - metabolism | TNF Receptor-Associated Factor 3 - genetics | Inflammation Mediators - metabolism | TNF Receptor-Associated Factor 6 - genetics | Inflammation Mediators - immunology | Atherosclerosis - pathology | Atherosclerosis - immunology | TNF Receptor-Associated Factor 2 - metabolism | TNF Receptor-Associated Factor 3 - metabolism | Inflammation - immunology | TNF Receptor-Associated Factor 5 - metabolism | Atherosclerosis - metabolism | Disease Progression | TNF Receptor-Associated Factor 5 - genetics | Animals | TNF Receptor-Associated Factor 2 - immunology | TNF Receptor-Associated Factor 3 - immunology | TNF Receptor-Associated Factor 6 - metabolism | Mice | Leukocytes - metabolism | CD40 Antigens - immunology | Index Medicus
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3. Full Text TNF receptor?associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation
by Semmler, Sabrina and Gagne, Myriam and Garg, Pranav and Pickles, Sarah R and Baudouin, Charlotte and Hamon-Keromen, Emeline and Destroismaisons, Laurie and Khalfallah, Yousra and Chaineau, Mathilde and Caron, Elise and Bayne, Andrew N and Trempe, Jean-Francois and Cashman, Neil R and Star, Alexandra T and Haqqani, Arsalan S and Durcan, Thomas M and Meiering, Elizabeth M and Robertson, Janice and Grandvaux, Nathalie and Plotkin, Steven S and McBride, Heidi M and Vande Velde, Christine
The Journal of biological chemistry, ISSN 0021-9258, 03/2020, Volume 295, Issue 12, pp. 3808 - 3825
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Aggregates | Cell Line | Superoxide Dismutase-1 - immunology | Mutagenesis, Site-Directed | Rats, Transgenic | Rats | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Mitochondria - metabolism | Protein Folding | Superoxide Dismutase-1 - chemistry | Amyotrophic Lateral Sclerosis - pathology | Ubiquitination | Animals | RNA Interference | Superoxide Dismutase-1 - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Superoxide Dismutase-1 - genetics | TNF Receptor-Associated Factor 6 - metabolism | Antibodies - immunology | TNF Receptor-Associated Factor 6 - genetics | Disease Models, Animal | RNA, Small Interfering - metabolism | Index Medicus
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4. Full Text Trim13 potentiates toll-like receptor 2-mediated nuclear factor κb activation via K29-linked polyubiquitination of tumor necrosis factor receptor-associated factor 6
by Huang, Bin and Baek, Suk-Hwan
Molecular pharmacology, ISSN 0026-895X, 04/2017, Volume 91, Issue 4, pp. 307 - 316
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Polyubiquitin - metabolism | Chemokines - biosynthesis | Toll-Like Receptor 2 - agonists | Oligonucleotide Array Sequence Analysis | Humans | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | Male | NF-kappa B - metabolism | Up-Regulation - genetics | Toll-Like Receptor 2 - metabolism | Macrophage Activation | DNA-Binding Proteins - metabolism | Ubiquitination | Animals | HEK293 Cells | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | RAW 264.7 Cells | Lysine - metabolism | Mice | Tripartite Motif Proteins - metabolism | Index Medicus
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5. Full Text TNF Receptor‐Associated Factor 6 Mediates TNFα‐Induced Skeletal Muscle Atrophy in Mice During Aging
by Li, Jinbo and Yi, Xiangjiao and Yao, Zhenqiang and Chakkalakal, Joe V and Xing, Lianping and Boyce, Brendan F
Journal of bone and mineral research, ISSN 0884-0431, 08/2020, Volume 35, Issue 8, pp. 1535 - 1548
TNFα | MUSCLE ENVIRONMENTAL CELLS | NF‐κB | INFLAMMAGING | MUSCLE ATROPHY | TRAF6 | RHEUMATOID ARTHRITIS | SARCOPENIA | NF-κB | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Ubiquitin | Tumor necrosis factor receptors | Phenotypes | TRAF6 protein | Transcription | Transgenic mice | Satellite cells | Tumor necrosis factor-α | Cell differentiation | Macrophages | Skeletal muscle | Myoblasts | Serum levels | Atrophy | Sarcopenia | Regeneration | Proteolysis | Rheumatoid arthritis | Rodents | Myosin | Aging | Leukocytes (granulocytic) | Ubiquitin-protein ligase | Index Medicus
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6. Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock
by Rim, Hong-Kun and Cho, Woong and Sung, Sang Hyun and Lee, Kyung-Tae
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 09/2012, Volume 342, Issue 3, pp. 654 - 664
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Interleukin-1beta - genetics | Promoter Regions, Genetic - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Drug Interactions | Ubiquitination - drug effects | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Dinoprostone - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Down-Regulation - genetics | Coumarins - pharmacology | Dinoprostone - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Nitric Oxide - genetics | Lipopolysaccharides - pharmacology | Mice | Transcription, Genetic - genetics | Dinoprostone - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Shock, Septic - prevention & control | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Shock, Septic - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Inflammation - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Inflammation - genetics | Macrophages - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Ubiquitination - genetics
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7. Full Text Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation
by Lamothe, Betty and Besse, Arnaud and Campos, Alejandro D and Webster, William K and Wu, Hao and Darnay, Bryant G
The Journal of biological chemistry, ISSN 0021-9258, 01/2007, Volume 282, Issue 6, pp. 4102 - 4112
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | TNF Receptor-Associated Factor 6 - physiology | Transcription Factors - physiology | Ubiquitin-Conjugating Enzymes - physiology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Protein Structure, Tertiary - genetics | TNF Receptor-Associated Factor 6 - deficiency | Mice, Knockout | Transcription Factors - metabolism | Animals | I-kappa B Kinase - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Signal Transduction - physiology | Lysine - metabolism | Mice | Catalysis | Enzyme Activation | Index Medicus
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