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Journal of Experimental Medicine, ISSN 0022-1007, 12/2008, Volume 205, Issue 13, pp. 3065 - 3077
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2012, Volume 209, Issue 11, pp. 1937 - 1952
Apoptotic death of alveolar macrophages observed during lung infection with Streptococcus pneumoniae is thought to limit overwhelming lung inflammation in... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | MURINE MODEL | STREPTOCOCCUS-PNEUMONIAE | BACTERIAL CLEARANCE | INFLUENZA-VIRUS-INFECTION | HOST-DEFENSE | ALVEOLAR MACROPHAGE APOPTOSIS | IMMUNOLOGY | PULMONARY INFECTION | NEUTROPHIL APOPTOSIS | T-CELLS | Lung - microbiology | Macrophages, Alveolar - pathology | Apoptosis - drug effects | Caspase 3 - metabolism | Male | Host-Pathogen Interactions - drug effects | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology | Necrosis | Pneumonia, Pneumococcal - genetics | Flow Cytometry | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Female | Lung - metabolism | Neutrophils - metabolism | Antibodies, Monoclonal - immunology | Neutrophils - pathology | Streptococcus pneumoniae - physiology | Lung - pathology | Streptococcus pneumoniae - drug effects | Pneumonia, Pneumococcal - microbiology | Cytokines - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Neutrophils - drug effects | Treatment Outcome | TNF-Related Apoptosis-Inducing Ligand - metabolism | Mice, Knockout | Animals | Macrophages, Alveolar - drug effects | Survival Analysis | Mice | Pneumonia, Pneumococcal - drug therapy | Macrophages, Alveolar - metabolism | TNF-Related Apoptosis-Inducing Ligand - genetics
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2012, Volume 209, Issue 11, pp. 1919 - 1935
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2018, Volume 128, Issue 6, pp. 2325 - 2338
ONC201 is a first-in-class, orally active antitumor agent that upregulates cytotoxic TRAIL pathway signaling in cancer cells. ONC201 has demonstrated safety... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | NATURAL-KILLER-CELLS | EFFECTOR FUNCTIONS | TUMOR-METASTASIS | ANTICANCER AGENT | SMALL-MOLECULE ONC201/TIC10 | LIGAND | INTEGRATED STRESS-RESPONSE | CANCER | CD8(+) T-CELLS | Cell Survival - drug effects | HCT116 Cells | Humans | Cell Death - immunology | Killer Cells, Natural - pathology | TNF-Related Apoptosis-Inducing Ligand - immunology | Cell Survival - immunology | Heterocyclic Compounds, 4 or More Rings - pharmacology | Dose-Response Relationship, Drug | Xenograft Model Antitumor Assays | Signal Transduction - immunology | Neoplasm Metastasis | Animals | Colorectal Neoplasms - immunology | Signal Transduction - drug effects | Mice, Nude | Colorectal Neoplasms - drug therapy | Killer Cells, Natural - immunology | Female | Cell Proliferation - drug effects | Mice | Cell Death - drug effects | Colorectal Neoplasms - pathology | Antimitotic agents | Killer cells | Care and treatment | Ligands (Biochemistry) | Physiological aspects | Dosage and administration | Metastasis | Antineoplastic agents | Drug therapy | Health aspects | Methods | Cancer | Bax protein | PD-1 protein | Clinical trials | Cytotoxicity | T cell receptors | CD3 antigen | Patients | Metastases | Signal transduction | Cell death | Peripheral blood | Degranulation | Antitumor activity | Tumor necrosis factor-TNF | Natural killer cells | Cell migration | Apoptosis
Journal Article
Journal Article
Journal Article
Journal Article