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Seminars in Immunology, ISSN 1044-5323, 2004, Volume 16, Issue 1, pp. 3 - 9
Toll-like receptors (TLRs) have been established to play an essential role in the activation of innate immunity by recognizing specific patterns of microbial... 
Signal transduction | Innate immunity | TLR | TIR domain | DOUBLE-STRANDED-RNA | signal transduction | IL-1 RECEPTOR | IMMUNOLOGY | CUTTING EDGE | DOMAIN-CONTAINING ADAPTER | IFN-BETA | REGULATORY FACTOR-3 | innate immunity | CELL ACTIVATION | TOLL-LIKE RECEPTORS | DEFECTIVE INTERLEUKIN-1 | NF-KAPPA-B | Toll-Like Receptor 2 | Toll-Like Receptor 3 | Receptors, Immunologic - physiology | Toll-Like Receptor 4 | Humans | Interleukin-1 Receptor-Associated Kinases | Interferon Regulatory Factor-3 | Signal Transduction - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Immunity, Innate - physiology | Receptors, Cell Surface - physiology | Membrane Glycoproteins - immunology | Carrier Proteins - physiology | Proteins - physiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Adaptor Proteins, Vesicular Transport - physiology | Protein-Serine-Threonine Kinases - physiology | Intracellular Signaling Peptides and Proteins | Myeloid Differentiation Factor 88 | I-kappa B Kinase | Receptors, Cell Surface - immunology | Antigens, Differentiation - physiology | Ubiquitin-Protein Ligases | Immunity, Innate - immunology | Adaptor Proteins, Signal Transducing | TNF Receptor-Associated Factor 6 | Animals | Models, Biological | Protein Kinases - physiology | Receptors, Interleukin-1 - physiology | Signal Transduction - physiology | Nuclear Proteins - physiology
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 06/2014, Volume 306, Issue 12, pp. E1378 - E1387
Incomplete beta-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that... 
Acylcarnitine | β-oxidation | Inflammation | TLR | Pattern recognition receptors | OXIDATION | PHYSIOLOGY | acylcarnitine | SATURATED FATTY-ACIDS | INDUCED INSULIN-RESISTANCE | pattern recognition receptors | TOLL-LIKE RECEPTOR-2 | OBESITY | inflammation | beta-oxidation | ENDOCRINOLOGY & METABOLISM | EXPRESSION | Phosphorylation | Toll-Like Receptor 2 - agonists | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Humans | Carnitine - metabolism | Diabetes Mellitus, Type 2 - metabolism | MAP Kinase Signaling System | Receptors, Pattern Recognition - antagonists & inhibitors | Receptors, Pattern Recognition - metabolism | Macrophages - secretion | Cyclooxygenase 2 - genetics | Diabetes Mellitus, Type 2 - immunology | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Receptors, Pattern Recognition - agonists | Carnitine - analogs & derivatives | Macrophages - immunology | Recombinant Proteins - metabolism | Myristic Acids - metabolism | Cyclooxygenase 2 - chemistry | Cytokines - secretion | Gene Silencing | Myeloid Differentiation Factor 88 - genetics | Enzyme Induction | Recombinant Proteins - chemistry | Toll-Like Receptor 2 - metabolism | Macrophage Activation | Myeloid Differentiation Factor 88 - agonists | Macrophages - metabolism | Animals | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Receptors, Pattern Recognition - genetics | Mice | Protein Processing, Post-Translational | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Docosahexaenoic Acids - metabolism | Type 2 diabetes | Physiological aspects | Insulin resistance | Cellular signal transduction | Research | Diabetes
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2011, Volume 12, Issue 8, pp. 695 - 708
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47713
Background & Aims: While it is widely accepted that obesity is associated with low-grade systemic inflammation, the molecular origin of the inflammation... 
SYSTEM | ACTIVATION | MULTIDISCIPLINARY SCIENCES | RESISTANCE | ECOLOGY | MODEL | NF-KAPPA-B | ADIPOSE-TISSUE | INFILTRATION | Endotoxins - blood | Diet, High-Fat - adverse effects | Male | Adipose Tissue - metabolism | Inflammation - metabolism | Forkhead Transcription Factors - metabolism | Inflammation Mediators - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cytokines - blood | Endotoxins - metabolism | Cytokines - metabolism | Macrophages - pathology | Signal Transduction | Adipose Tissue - pathology | Inflammation Mediators - blood | Gastrointestinal Tract - microbiology | Toll-Like Receptor 4 - genetics | Adiposity - genetics | Toll-Like Receptor 4 - metabolism | Gastrointestinal Tract - metabolism | Mice, Knockout | Obesity - metabolism | Colitis - etiology | Animals | Mice | Forkhead Box Protein O3 | Metagenome | Obesity | Microbiota (Symbiotic organisms) | Causes of | Physiological aspects | Toll-like receptors | Development and progression | Inflammation | Genetic aspects | Research | Ketogenic diet | Phosphorylation | Adipose tissue | Body weight | AKT protein | Kinases | Macrophages | High fat diet | Proteins | Signal transduction | Microbiota | Intestine | Rodents | Colon | Digestive tract | FOXO3 protein | Immune system | NF-κB protein | Cytokines | Digestive system | Permeability | TLR4 protein | Nitric-oxide synthase | Signaling | Insulin resistance | Infiltration | Cyclooxygenase-2
Journal Article
Journal Article