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BMB reports, ISSN 1976-6696, 12/2019, Volume 52, Issue 12, pp. 712 - 717
Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be... 
Mitochondria | EMT | TOMM20 | Cell cycle | Colorectal cancer
Journal Article
ISSN 0264-6021, 2016
Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with... 
PARK15 | Gsk3β | E3 ubiquitin-ligase | Fbxo7 | ubiquitin | Tomm20
Journal Article
Autophagy, ISSN 1554-8627, 04/2015, Volume 11, Issue 4, pp. 595 - 606
The selective degradation of mitochondria by the process of autophagy, termed mitophagy, is one of the major mechanisms of mitochondrial quality control. The... 
USP35 | l-USP35, long form of ubiquitin specific peptidase 35 | s-USP35, short form of ubiquitin specific peptidase 35 | TOMM20, translocase of outer mitochondrial membrane 20 homolog (yeast) | USP, ubiquitin specific peptidase | MTS | PARK2 | SYNJ2BP, synaptojanin 2 binding protein | DUB | neurodegenerative diseases | CCCP | Cer, cerulean | PARK2, parkin RBR E3 ubiquitin protein ligase | USP30 | MFN2, mitofusin 2 | OMM, outer mitochondrial membrane | GFP, green fluorescent protein | autophagy | DsRed, Discosoma sp. red fluorescent protein | deubiquitinating enzyme | PINK1, PTEN-induced putative kinase 1 | deubiquitinating enzymes | carbonyl cyanide m-chlorophenylhydrazone | ubiquitin | mitochondrial dynamics | mitophagy | DMSO, dimethyl sulfoxide | GAPDH, glyceraldehyde 3-phosphate dehydrogenase | HA, human influenza hemagglutinin | mitochondrial targeting sequence | Deubiquitinating enzymes | Neurodegenerative diseases | Mitochondrial dynamics | Mitophagy | Autophagy | Ubiqui tin | FUSION | P62/SQSTM1 | RECEPTOR | MITOCHONDRIAL FISSION | CELL BIOLOGY | PARKIN | DEGRADATION | PROMOTES | Endopeptidases - metabolism | Mitochondrial Proteins - metabolism | Humans | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Cytosol - metabolism | Autophagy - physiology | Mitochondria - metabolism | Thiolester Hydrolases - metabolism | Ubiquitination - physiology | Mitochondrial Degradation - physiology
Journal Article
Redox Biology, ISSN 2213-2317, 04/2015, Volume 4, Issue C, pp. 6 - 13
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2012, Volume 11, Issue 7, pp. 1445 - 1454
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2013, Volume 12, Issue 9, pp. 1371 - 1384
Here, we interrogated head and neck cancer (HNSCC) specimens (n = 12) to examine if different metabolic compartments (oxidative vs. glycolytic) co-exist in... 
stem cells | head and neck cancer | mitochondria | glycolysis | OXPHOS | TOMM20 | tumor recurrence | monocarboxylate transporters (MCT) | MCT4 | MCT1 | tumor stroma | metabolic symbiosis | oxidative stress | Oxidative stress | Tumor stroma | Monocarboxylate transporters (MCT) | Metabolic symbiosis | Mitochondria | Tumor recurrence | Stem cells | Glycolysis | Head and neck cancer | FDG-PET | MITOCHONDRIAL METABOLISM | CELL BIOLOGY | BREAST-CANCER | CYTOCHROME-C-OXIDASE | POSITRON-EMISSION-TOMOGRAPHY | PROGNOSTIC-FACTOR | AEROBIC GLYCOLYSIS | SQUAMOUS-CELL CARCINOMA | HYDROGEN-PEROXIDE | Cell Proliferation | Epithelial Cells - metabolism | Oxidative Stress | Humans | Ketone Bodies - metabolism | Middle Aged | Male | Head and Neck Neoplasms - metabolism | Neoplasm Recurrence, Local - pathology | Monocarboxylic Acid Transporters - metabolism | Neoplastic Stem Cells - metabolism | Muscle Proteins - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Membrane Transport Proteins - metabolism | Cell Differentiation | Fibroblasts - metabolism | Neoplasm Recurrence, Local - metabolism | Lactic Acid - metabolism | Kaplan-Meier Estimate | Oxidative Phosphorylation | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Mitochondria - metabolism | Fibroblasts - pathology | Symporters - metabolism | Head and Neck Neoplasms - pathology | Aged | Neoplasm Staging | Report
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 833 - 843
Mitochondrial autophagy, also known as mitophagy, is an autophagosome-based mitochondrial degradation process that eliminates unwanted or damaged mitochondria... 
TOMM20, translocase of outer mitochondrial membrane 20 homolog (yeast) | CsA, cyclosporin A | WM, wortmannin | neurodegeneration | CCCP, carbonyl cyanide m-chlorophenyl hydrazone | PARK2, Parkin RBR E3 ubiquitin protein ligase | ΔΨ, mitochondrial membrane potential | Co, control | P, postnatal day | retina | flow cytometry | 3MA, 3-methyladenine | TOMM40, translocase of outer mitochondrial membrane 40 homolog (yeast) | COX4I1, cytochrome c oxidase subunit IV isoform 1 | N+L, ammonium chloride + leupeptin | mitophagic flux | autophagic flux | Atg, autophagy-related | MTOR, mechanistic target of rapamycin | autophagy | PINK1, PTEN-induced putative kinase 1 | mitochondria | LC3, MAP1LC3/LC3 | EBSS, Earle's balanced salt solution | WT, wild type | MTDR, MitoTracker Deep Red | TIMM23, translocase of inner mitochondrial membrane 23 homolog (yeast) | NAM, nicotinamide | FIS, fisetin | mitophagy | E, embryonic day | KO, knockout | HCQ, hydroxychloroquine | PHEN, 1,10-phenanthroline | MEFs, mouse embryonic fibroblasts | Rapa, rapamycin | astrocyte primary culture | Flow cytometry | Mitochondria | Mitophagic flux | Neurodegeneration | Autophagic flux | Astrocyte primary culture | Retina | Mitophagy | Autophagy | PROTEIN | RAT HEPATOCYTES | UBIQUITIN LIGASE | SELECTIVE AUTOPHAGY | MAMMALIAN-CELLS | CELL BIOLOGY | MITOTRACKER GREEN | PARKIN | DEGRADATION | RETINITIS-PIGMENTOSA | Lysosomes - drug effects | Retina - drug effects | Flow Cytometry - methods | Retina - metabolism | Humans | Mice, Inbred C57BL | Mitochondria - metabolism | Amino Acids - deficiency | Mitochondria - drug effects | Down-Regulation - drug effects | Animals | Lysosomes - metabolism | Embryo, Mammalian - cytology | Mitochondrial Degradation - drug effects | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Fibroblasts - drug effects | Fibroblasts - cytology | Flavonoids - pharmacology | HeLa Cells | Niacinamide - pharmacology | Retinitis Pigmentosa - pathology | Disease Models, Animal | Fibroblasts - metabolism
Journal Article
Cell Cycle, ISSN 1538-4101, 08/2013, Volume 12, Issue 16, pp. 2580 - 2597
Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the host microenvironment. A matched set of "normal" and oncogenically... 
wound healing | autophagy | RAS | glycolysis | cancer associated fibroblast | reverse Warburg effect | NFkB | oncogene | TOMM20 | metabolic parasite | senescence | caveolin-1 | MCT4 | field cancerization | inflammation | oncogenic stress | MCT1 | tumor microenvironment | response to injury | stromal biomarkers | oxidative stress | HaCaT | mitochondrial metabolism | Caveolin-1 | Oxidative stress | Reverse Warburg effect | Senescence | Wound healing | Tumor microenvironment | Oncogene | Stromal biomarkers | Inflammation | Cancer associated fibroblast | Autophagy | Oncogenic stress | Mitochondrial metabolism | Metabolic parasite | Response to injury | Glycolysis | Field cancerization | CELL BIOLOGY | BREAST-CANCER | SOIL HYPOTHESIS | FIBROTIC FOCUS | HYDROGEN-PEROXIDE | PROGNOSTIC-SIGNIFICANCE | CANCER-ASSOCIATED FIBROBLASTS | INVASIVE DUCTAL CARCINOMA | OXIDATIVE MITOCHONDRIAL METABOLISM | CAVEOLIN-1 EXPRESSION | PROTEIN EXPRESSION | Oncogenes - genetics | Reactive Oxygen Species - metabolism | Humans | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Epithelial Cells | Tumor Microenvironment - physiology | Oncogenes - physiology | Drug Discovery | Caveolin 1 - metabolism | Stromal Cells | Mitochondrial Turnover - drug effects | Monocarboxylic Acid Transporters - metabolism | Flow Cytometry | Models, Biological | Acetylcysteine - pharmacology | Muscle Proteins - metabolism | Cell Line, Tumor | Glucose - metabolism | Antineoplastic Agents - pharmacology | Energy Metabolism - physiology | Gene Expression Regulation, Neoplastic - physiology | Report
Journal Article
Biochemical Journal, ISSN 0264-6021, 2016, Volume 473, Issue 20, pp. 3563 - 3580
Journal Article
Redox Biology, ISSN 2213-2317, 01/2020, Volume 28, p. 101365
Though succinate accumulation is associated with reactive oxygen species (ROS) production and neuronal injury, which play critical roles in epilepsy, it is... 
Reactive oxygen species | Mitophagy | Neurodegeneration | Status epilepticus | Succinate | SUPEROXIDE-PRODUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURINE NUCLEOTIDE CYCLE | REPERFUSION INJURY | DNA-DAMAGE | DEHYDROGENASE | INDUCED SEIZURES | INHIBITION | BASE EXCISION-REPAIR | COMPLEX-I | MALATE-ASPARTATE SHUTTLE
Journal Article
Journal of thyroid disorders & therapy, ISSN 2167-7948, 02/2016, Volume 5, Issue 1
Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of tumorigenesis in various cancer types. Thyrocyte metabolism in... 
Journal Article
Diabetology and Metabolic Syndrome, ISSN 1758-5996, 07/2016, Volume 8, Issue 1, p. 55
Background: The TOMM20 gene was previously identified as differentially expressed and methylated between severely obese subjects with and without metabolic... 
Lipid profile | Obesity | Visceral adipose tissue | TOMM20 | meQTL | DNA METHYLATION | MITOCHONDRIAL BIOGENESIS | PROTEIN IMPORT | ENDOCRINOLOGY & METABOLISM | SNPS | FAT | SEX-DIFFERENCES | TRANSCRIPTION FACTOR | EXPRESSION | ADIPOSE-TISSUE | BLOOD | Type 2 diabetes | Quantitative genetics | Analysis | Genetic aspects | DNA binding proteins | Risk factors
Journal Article