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Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2017, Volume 65, Issue 12, pp. 1179 - 1184
Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of... 
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2016, Volume 64, Issue 3, pp. 276 - 281
Fourteen compounds were isolated from the flowers of Inula japonica THUNB. (Asteraceae), including two new compounds,... 
Journal Article
Chemical & Pharmaceutical Bulletin, ISSN 0009-2363, 2013, Volume 61, Issue 6, pp. 631 - 636
A novel series of quinolone derivatives (6a-n) were designed and synthesized, and their biological activities were evaluated as potential antitumor... 
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 19, pp. 8613 - 8624
Camptothecin (CPT) has been shown to block disassembly of the topoisomerase-I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic... 
Camptothecin | DNA Topoisomerase I | Sepsis
Journal Article
03/2013
The most important of fluoroquinolones resistance mechanisms is the accumulation of mutations in the bacterial enzymes targeted by fluoroquinolones; DNA gyrase... 
mutation | bacteria | topoisomerase | Nigeria | Quinolones
Web Resource
11/2012
Bloom syndrome is a rare autosomal recessive disorder that is caused by mutations in the BLM gene. BLM associates with TopoIIIα and RMI1 to form a complex that... 
BLM | RMI1 | 0307 | genome integrity | topoisomerase IIIalpha
Dissertation
Heterogeneity in the radiosensitizing effects of the DNA ligand hoechst-33342 in human tumor cell lines, 12/2005
The AT specific minor grove DNA binding ligands bisbenzimidazole derivatives like hoechst-33342 and hoechst-33258 which scavenge free radicals and stabilize... 
Radiosensitization, Topoisomerase inhibitors, DNA ligand, Hoechst-33342, Apoptosi, CyclinB1
Journal
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 99, pp. 37286 - 37288
Journal Article
Mechanisms of Development, ISSN 0925-4773, 07/2017, Volume 145, p. S136
Journal Article
Applied and Environmental Microbiology, ISSN 0099-2240, 07/2010, Volume 76, Issue 13, pp. 4130 - 4135
The stinkbug Parastrachia japonensis (Hemiptera: Parastrachiidae) is known for its prolonged prereproductive nonfeeding period, maternal care of eggs in an... 
DNA topoisomerase
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2016, Volume 213, Issue 6, pp. 601 - 601
Two studies reveal a conserved, noncatalytic role for Topo II's C-terminal domain in recruiting the checkpoint kinase Aurora B. 
DNA TOPOISOMERASE-II | CELL BIOLOGY
Journal Article
Zeitschrift für Kristallographie - New Crystal Structures, ISSN 1433-7266, 05/2018, Volume 233, Issue 3, pp. 365 - 367
, monoclinic, (no. 4), = 8.0094(5) Å, = 6.7689(3) Å, = 29.577(2) Å, = 95.809(6)°, =1595.27(16) Å , = 4, ) = 0.0457, ) = 0.1209, = 293 K. 
1558968 | TOPOISOMERASE-I | CRYSTALLOGRAPHY
Journal Article
by Ma, HG and Wang, LP and Xu, ZH and Zhang, YP and Li, X and Zhu, WM
CHINESE JOURNAL OF ORGANIC CHEMISTRY, ISSN 0253-2786, 08/2016, Volume 36, Issue 8, pp. 1839 - 1846
Nine new N-12-ethyl substituted indolocarbazole derivatives were synthesized. Their structures were identified by NMR, C-13 NMR and HRESIMS. The thiazolyl blue... 
synthesis | PROTEIN-KINASE-C | STAUROSPORINE | CHEMISTRY, ORGANIC | TOPOISOMERASE-I | ENZASTAURIN | ACUTE MYELOID-LEUKEMIA | N-12-ethyl indolocarbazole | MARINE NATURAL-PRODUCTS | TRIAL | ORIGIN | MIDOSTAURIN PKC412 | INHIBITOR | cytotoxicity
Journal Article
Genetics, ISSN 0016-6731, 01/2018, Volume 208, Issue 1, pp. 79 - 88
Modern experimental techniques, such as whole-genome sequencing and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 endogenous genome... 
Topoisomerase | Caenorhabditis elegans | Oogenesis | Meiosis | Spermatogenesis | Primer | spermatogenesis | topoisomerase | meiosis | oogenesis
Journal Article
International Journal of Pharmacy and Pharmaceutical Sciences, 2014, Volume 6, Issue 9, pp. 34 - 41
Journal Article
Cancer Research, ISSN 0008-5472, 08/2000, Volume 60, Issue 16, pp. 4538 - 4543
DNA damage is attended by rapid recruitment of endogenous type I topoisomerase (topo I) into covalent cleavage complexes with genomic DNA in vivo. In contrast,... 
topoisomerase I
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2009, Volume 32, Issue 4, pp. 724 - 727
DNA topoisomerase I (Top1) is a ubiquitous nuclear enzyme that plays essential roles in various cellular processes, such as transcription or replication.... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 6, pp. 2950 - 2973
Spiropyrimidinetriones are a novel class of antibacterial agents that target the bacterial type II topoisomerase via a new mode of action. Compound ETX0914 is... 
CHEMISTRY, MEDICINAL | GENOTOXICITY | METABOLISM | MECHANISM | COMMUNITY | ROLES | AZD0914 | DISCOVERY | TOPOISOMERASE
Journal Article
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