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Scientific reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 21772
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e92099
MicroRNAs (miRNAs) play an important role in human tumorigenesis as oncogenes or tumor suppressors. miR-99a has been reported as a tumor suppressor gene in... 
LUNG-CANCER | APOPTOSIS | HEPATOCELLULAR-CARCINOMA | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | DOWN-REGULATION | AKT | S6 KINASE | TRANSLATION | MICRORNA | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Molecular Sequence Data | Apoptosis - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Phosphoproteins - metabolism | Antineoplastic Agents - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Base Sequence | Female | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Down-Regulation | Up-Regulation - genetics | Signal Transduction - genetics | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | MicroRNA | Analysis | Genes | Luciferase | Cancer cells | Development and progression | Breast cancer | Genetic aspects | Research | Cancer | TOR protein | Biotechnology | Insulin-like growth factors | Kinases | Cancer therapies | Anticancer properties | Proteins | Liver cancer | Signal transduction | Cell growth | Restoration | Surgery | Cell cycle | miRNA | Tumorigenesis | Inhibition | G1 phase | Rapamycin | Tumorigenicity | Tumor cell lines | Gene expression | Suppressors | Esophagus | Studies | Hospitals | Medical prognosis | Tumor suppressor genes | Antitumor activity | Prostate | Apoptosis
Journal Article
PLoS pathogens, ISSN 1553-7374, 2018, Volume 14, Issue 8, p. e1007264
Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within... 
RAPAMYCIN | IMMUNE-RESPONSE | MESSENGER-RNA TRANSLATION | MYXOMA-VIRUS | ACTIVATION | INITIATION | ONCOLYTIC VIROTHERAPY | MICROBIOLOGY | RESISTANT | HERPES-SIMPLEX-VIRUS | INTERFERON | VIROLOGY | PARASITOLOGY | Catalytic Domain - drug effects | Humans | Cercopithecus aethiops | Eukaryotic Initiation Factor-4E - metabolism | Phosphoproteins - metabolism | Herpes Simplex - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplasms - complications | Neoplasms - virology | Neoplasms - genetics | HEK293 Cells | Immediate-Early Proteins - deficiency | Gene Expression Regulation, Neoplastic - drug effects | Organisms, Genetically Modified | Eukaryotic Initiation Factor-4E - genetics | Vero Cells | Cells, Cultured | Signal Transduction - genetics | Phosphoproteins - genetics | Herpesvirus 1, Human - drug effects | Animals | Immediate-Early Proteins - genetics | TOR Serine-Threonine Kinases - chemistry | Herpes Simplex - pathology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Herpes Simplex - complications | Herpesvirus 1, Human - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Physiological aspects | Genetic aspects | Research | Genetic regulation | Herpes simplex virus | Cancer cells | TOR protein | Transplants & implants | Funding | Xenotransplantation | Herpes simplex | Viruses | Genomes | mRNA | Infections | Biochemistry | Kinases | Proteins | Immunology | Repressors | Transformed cells | Immunotherapy | Xenografts | Oncolysis | Inhibition | Supervision | Medical research | Protein biosynthesis | Rapamycin | Pharmacology | Children & youth | Infectious diseases | Inhibitors | Protein synthesis | Herpes viruses | Replication | Initiation factor eIF-4E | Tumors | Cancer | TOR Serine-Threonine Kinases/antagonists & inhibitiors | Herpes Simplex/genetics | Herpes Simplex/pathology | Neoplasms/pathology | Eukaryotic Initiation Factor-4E/genetics | Ubiquitin-Protein Ligases/deficiency | Immediate-Early Proteins/genetics | Neoplasms/genetics | Herpes Simplex/complications | Life Sciences | Eukaryotic Initiation Factor-4E/metabolism | Neoplasms/complications | Herpesvirus 1, Human/genetics | Catalytic Domain/drug effects | Signal Transduction/genetics | Adaptator Proteins, Signal Transducing/genetics | Gene Expression Regulation, Neoplastic/drug effects | Phosphoproteins/genetics | Adaptator Proteins, Signal Transducing/metabolism | Immediate-Early Proteins/deficiency | Phosphoproteins/metabolims | TOR Serine-Threonine Kinases/chemistry | Protein Kinase Inhibitors/pharmacology | Herpesvirus 1, Human/drug effects | Ubiquitin-Protein Ligases/genetics | Neoplasms/virology
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2014, Volume 207, Issue 3, pp. 365 - 374
Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood,... 
INSULIN | TRANSPORT | ACTIVATED PROTEIN-KINASE | ADIPOCYTES | STIMULATION | NOREPINEPHRINE | MAMMALIAN PROTEIN | KNOCKOUT | BETA-ADRENOCEPTORS | ADIPOSE-TISSUE | CELL BIOLOGY | Phosphorylation | Adipocytes, Brown - metabolism | Insulin - physiology | TOR Serine-Threonine Kinases - metabolism | Humans | Multipotent Stem Cells - metabolism | Glucose Transporter Type 1 - metabolism | Male | Adrenergic beta-3 Receptor Agonists - pharmacology | Mechanistic Target of Rapamycin Complex 2 | TOR Serine-Threonine Kinases - antagonists & inhibitors | Female | TOR Serine-Threonine Kinases - physiology | Insulin - pharmacology | Cells, Cultured | Morpholines - pharmacology | Pyrimidines - pharmacology | Receptors, Adrenergic, beta-3 - metabolism | Sirolimus - pharmacology | Multiprotein Complexes - physiology | Protein Transport | Animals | Isoproterenol - pharmacology | Glucose - metabolism | Mice | Protein Processing, Post-Translational | Primary Cell Culture | Adipose tissues | Glucose metabolism | Translocation (Genetics) | Genetic research | Genetic aspects | Research | Health aspects | Sirolimus | Multiprotein Complexes | Adipocytes, Brown | Glucose | Isoproterenol | Multipotent Stem Cells | Life Sciences | Pyrimidines | Receptors, Adrenergic, beta-3 | Glucose Transporter Type 1 | Morpholines | Insulin | TOR Serine-Threonine Kinases | Development Biology | Adrenergic beta-3 Receptor Agonists
Journal Article
Clinical cancer research, ISSN 1557-3265, 2018, Volume 24, Issue 13, pp. 3108 - 3118
Journal Article
PloS one, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e83908
Objective: Hepatic stellate cells (HSCs) transdifferentiation and subsequent inflammation are important pathological processes involved in the formation of... 
PATHWAYS | SURVIVAL | GROWTH-FACTOR RECEPTOR | ACTIVATION | HEPATOCYTE PROLIFERATION | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | LIVER FIBROSIS | KINASE | HEPATIC STELLATE CELL | EXPRESSION | Inflammation - pathology | Liver - pathology | TOR Serine-Threonine Kinases - metabolism | Extracellular Matrix - metabolism | Male | Splenomegaly - pathology | Mechanistic Target of Rapamycin Complex 2 | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Portal Pressure - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Inflammation - metabolism | Liver - drug effects | Liver Cirrhosis - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Liver Function Tests | Liver Cirrhosis - drug therapy | Liver Cirrhosis - complications | Liver - metabolism | Rats | Sirolimus - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fibrosis | Inflammation - genetics | Liver Cirrhosis - pathology | Hemodynamics | Mitogen-Activated Protein Kinase 1 - metabolism | Immunohistochemistry | Interleukins | Liver | Portal hypertension | Inflammation | Rapamycin | Muscle proteins | Liver cirrhosis | TOR protein | Interleukin | Smooth muscle | AKT protein | Kinases | Proteins | Signal transduction | Actin | Rodents | Interleukin 1 | Inhibition | Hypertension | Stellate cells | Muscles | Extracellular signal-regulated kinase | Histology | Ribosomal protein S6 | Bile duct | Polymerase chain reaction | Ribosomal protein S6 kinase | Signaling | Morphometry | Bile
Journal Article