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The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 18, pp. 12467 - 12484
.... IRS1 and IRS2 are key substrates of the insulin receptor tyrosine kinase. Mass spectrometry reveals more than 50 phosphorylated IRS1 serine and threonine residues (Ser(P)/Thr(P) residues... 
PROTEIN-KINASE-C | Metabolic Stress | Signal Transduction | IRS1 | PLECKSTRIN-HOMOLOGY-DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Insulin Resistance | Insulin Signaling | PHOSPHOPROTEOME REVEALS | Monoclonal Antibodies | Protein Phosphorylation | DIET-INDUCED OBESITY | MTOR | IRS-1 SERINE PHOSPHORYLATION | SKELETAL-MUSCLE | IN-VITRO | Cell Signaling | RESISTANCE | Phosphotyrosine Signaling | REGULATORY ROLE | CHO Cells | Cricetulus | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Threonine - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Receptor, Insulin - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Insulin - pharmacology | Cricetinae | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Serine - metabolism | Blotting, Western | Hypoglycemic Agents - pharmacology | Tyrosine - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Thapsigargin - pharmacology | Anisomycin - pharmacology | Receptor, Insulin - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Metabolism
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | INACTIVATION | SUPPRESSOR | SIGNATURES | ONCOLOGY | SRC | ADENOCARCINOMA | SENSITIVITY | MUTATIONS | LKB1/STK11 | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 534, Issue 7606, pp. 272 - 276
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2010, Volume 120, Issue 8, pp. 2858 - 2866
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, pp. 27071 - 27071
Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel... 
SESQUITERPENE AMINOQUINONE | OXIDATIVE STRESS | THERAPY | INHIBITION | MECHANISM | MULTIDISCIPLINARY SCIENCES | ISOMALABARICANE TRITERPENES | SMENOSPONGINE | PROGRESSION | AAPTAMINE | MARINE SPONGE | Cyclin D1 - metabolism | RNA-Binding Proteins - genetics | Reactive Oxygen Species | Triterpenes - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Cyclin-Dependent Kinase Inhibitor p27 - agonists | Gene Expression Regulation, Neoplastic | Autophagy-Related Protein 5 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Porifera - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | A549 Cells | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Phosphatidylinositol 3-Kinases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cyclin D1 - genetics | Autophagy-Related Protein 5 - metabolism | Triterpenes - isolation & purification | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 08/2013, Volume 122, Issue 9, pp. 1610 - 1620
Journal Article
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2014, Volume 85, Issue 3, pp. 441 - 450
Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like kinases (CLKs... 
TARGET | PIKFYVE | PROTEIN-KINASE | AMYLOID-BETA | SPLICEOSOME | PHARMACOLOGY & PHARMACY | PTDINS(3,5)P-2 | POTENT INHIBITORS | SELECTIVITY | CYCLIN | FAMILY | Osteosarcoma - drug therapy | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Autophagy - immunology | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | TOR Serine-Threonine Kinases - genetics | Dioxoles - pharmacology | Phosphorylation - immunology | Autophagy - genetics | Phosphorylation - drug effects | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Alzheimer Disease - drug therapy | Imidazoles - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Tyrosine - metabolism | Animals | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Alzheimer Disease - genetics | Tyrosine - genetics | Tyrosine | Enzyme Inhibitors | Phosphorylation | Protein-Serine-Threonine Kinases | Microtubule-Associated Proteins | Alzheimer Disease | Autophagy | Phosphatidylinositol 3-Kinases | Dioxoles | Chemical Sciences | Imidazoles | Osteosarcoma | TOR Serine-Threonine Kinases | Protein-Tyrosine Kinases
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 17, pp. 13107 - 13120
Journal Article