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Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors and is frequently deregulated in cancer... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/2012, Volume 32, Issue 1, pp. 2 - 11
Journal Article
Nature immunology, ISSN 1529-2916, 2015, Volume 16, Issue 8, pp. 838 - 849
.... We found that IFN-gamma regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E... 
BACTERIAL PATHOGENS | DENDRITIC CELLS | PATHWAY | IMMUNE-RESPONSES | KINASE | IMMUNOLOGY | POLARIZATION | EXPRESSION | TRYPTOPHAN CATABOLISM | MTOR | I INTERFERON | Toll-Like Receptor 2 - genetics | TOR Serine-Threonine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | Protein Biosynthesis - immunology | Eukaryotic Initiation Factor-4E - metabolism | Multiprotein Complexes - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Base Sequence | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Macrophage Activation - immunology | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - metabolism | Signal Transduction - drug effects | Toll-Like Receptor 2 - immunology | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Multiprotein Complexes - immunology | RNA, Messenger - immunology | Transcription Factor HES-1 | Macrophage Activation - genetics | Intracellular Signaling Peptides and Proteins - immunology | Homeodomain Proteins - immunology | Mechanistic Target of Rapamycin Complex 1 | Signal Transduction - immunology | Eukaryotic Initiation Factor-4E - immunology | Protein Biosynthesis - genetics | Eukaryotic Initiation Factor-4E - genetics | Macrophages - immunology | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Homeodomain Proteins - genetics | TOR Serine-Threonine Kinases - immunology | Interferon-gamma - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Microscopy, Fluorescence
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 12/2009, Volume 297, Issue 6, pp. 1313 - 1323
...), AMP-activated protein kinase (AMPK), and general control nondepressible kinase 2 (GCN2). However, no study has investigated the involvement of these signaling pathways in hepatic AA sensing... 
Transduction pathways | Translation | Adenosine 5′-monophosphate-activated protein kinase | General control nondepressible kinase 2 | High-protein diet | Mammalian target of rapamycin | MAMMALIAN TARGET | SIGNALING PATHWAYS | ACTIVATION | PHYSIOLOGY | PHOSPHORYLATION | general control nondepressible kinase 2 | KINASE LEADS | high-protein diet | SKELETAL-MUSCLE | mammalian target of rapamycin | transduction pathways | RAPAMYCIN MTOR | DIETARY-PROTEIN | AMINO-ACIDS | LIVER | ENDOCRINOLOGY & METABOLISM | translation | adenosine 5 '-monophosphate-activated protein kinase | Protein Kinases - metabolism | Dietary Proteins - administration & dosage | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Liver - enzymology | Rats, Wistar | Male | Hepatocytes - metabolism | RNA - genetics | Amino Acids - metabolism | Dietary Proteins - metabolism | Energy Metabolism - physiology | Cell Survival - physiology | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Liver - metabolism | Protein-Serine-Threonine Kinases - genetics | Rats | RNA - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Insulin - metabolism | Animals | Glucose - metabolism | TOR Serine-Threonine Kinases | AMP-Activated Protein Kinases - genetics | Hepatocytes - enzymology | Energy metabolism | Bioenergetics | Physiological aspects | Cellular signal transduction | Research | Health aspects | Protein kinases | RNA | Liver | Protein-Serine-Threonine Kinases | Glucose | Cellular Biology | AMP-Activated Protein Kinases | Tissues and Organs | Life Sciences | Dietary Proteins | Food and Nutrition | Endocrinology and metabolism | Subcellular Processes | Cell Behavior | Cell Survival | Biochemistry, Molecular Biology | Insulin | Amino Acids | Human health and pathology | Energy Metabolism | Hepatocytes | Protein Kinases | Molecular biology | Molecular Networks
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, pp. 27071 - 27071
Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel... 
SESQUITERPENE AMINOQUINONE | OXIDATIVE STRESS | THERAPY | INHIBITION | MECHANISM | MULTIDISCIPLINARY SCIENCES | ISOMALABARICANE TRITERPENES | SMENOSPONGINE | PROGRESSION | AAPTAMINE | MARINE SPONGE | Cyclin D1 - metabolism | RNA-Binding Proteins - genetics | Reactive Oxygen Species | Triterpenes - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Cyclin-Dependent Kinase Inhibitor p27 - agonists | Gene Expression Regulation, Neoplastic | Autophagy-Related Protein 5 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Porifera - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | A549 Cells | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Phosphatidylinositol 3-Kinases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cyclin D1 - genetics | Autophagy-Related Protein 5 - metabolism | Triterpenes - isolation & purification | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus
Journal Article
Cancer discovery, ISSN 2159-8274, 11/2015, Volume 5, Issue 11, pp. 1194 - 11209
Journal Article
PLoS pathogens, ISSN 1553-7374, 2018, Volume 14, Issue 8, p. e1007264
Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within... 
RAPAMYCIN | IMMUNE-RESPONSE | MESSENGER-RNA TRANSLATION | MYXOMA-VIRUS | ACTIVATION | INITIATION | ONCOLYTIC VIROTHERAPY | MICROBIOLOGY | RESISTANT | HERPES-SIMPLEX-VIRUS | INTERFERON | VIROLOGY | PARASITOLOGY | Catalytic Domain - drug effects | Humans | Cercopithecus aethiops | Eukaryotic Initiation Factor-4E - metabolism | Phosphoproteins - metabolism | Herpes Simplex - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplasms - complications | Neoplasms - virology | Neoplasms - genetics | HEK293 Cells | Immediate-Early Proteins - deficiency | Gene Expression Regulation, Neoplastic - drug effects | Organisms, Genetically Modified | Eukaryotic Initiation Factor-4E - genetics | Vero Cells | Cells, Cultured | Signal Transduction - genetics | Phosphoproteins - genetics | Herpesvirus 1, Human - drug effects | Animals | Immediate-Early Proteins - genetics | TOR Serine-Threonine Kinases - chemistry | Herpes Simplex - pathology | Adaptor Proteins, Signal Transducing - genetics | Ubiquitin-Protein Ligases - deficiency | Herpes Simplex - complications | Herpesvirus 1, Human - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Physiological aspects | Genetic aspects | Research | Genetic regulation | Herpes simplex virus | Cancer cells | TOR protein | Transplants & implants | Funding | Xenotransplantation | Herpes simplex | Viruses | Genomes | mRNA | Infections | Biochemistry | Kinases | Proteins | Immunology | Repressors | Transformed cells | Immunotherapy | Xenografts | Oncolysis | Inhibition | Supervision | Medical research | Protein biosynthesis | Rapamycin | Pharmacology | Children & youth | Infectious diseases | Inhibitors | Protein synthesis | Herpes viruses | Replication | Initiation factor eIF-4E | Tumors | Cancer | TOR Serine-Threonine Kinases/antagonists & inhibitiors | Herpes Simplex/genetics | Herpes Simplex/pathology | Neoplasms/pathology | Eukaryotic Initiation Factor-4E/genetics | Ubiquitin-Protein Ligases/deficiency | Immediate-Early Proteins/genetics | Neoplasms/genetics | Herpes Simplex/complications | Life Sciences | Eukaryotic Initiation Factor-4E/metabolism | Neoplasms/complications | Herpesvirus 1, Human/genetics | Catalytic Domain/drug effects | Signal Transduction/genetics | Adaptator Proteins, Signal Transducing/genetics | Gene Expression Regulation, Neoplastic/drug effects | Phosphoproteins/genetics | Adaptator Proteins, Signal Transducing/metabolism | Immediate-Early Proteins/deficiency | Phosphoproteins/metabolims | TOR Serine-Threonine Kinases/chemistry | Protein Kinase Inhibitors/pharmacology | Herpesvirus 1, Human/drug effects | Ubiquitin-Protein Ligases/genetics | Neoplasms/virology
Journal Article