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Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here... 
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 749 - 757
Journal Article
Immunity, ISSN 1074-7613, 09/2016, Volume 45, Issue 3, pp. 540 - 554
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2013, Volume 14, Issue 2, pp. 162 - 171
Signaling through the G protein-coupled receptors for the complement fragments C3a and C5a (C3aR and C5aR, respectively) by dendritic cells and CD4(+) cells... 
Forkhead Transcription Factors - immunology | Cell Communication - immunology | T-Lymphocytes, Regulatory - metabolism | TOR Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta1 - metabolism | Complement C5a - metabolism | Receptors, Complement - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Transforming Growth Factor beta1 - immunology | Forkhead Transcription Factors - metabolism | Class Ib Phosphatidylinositol 3-Kinase - metabolism | T-Lymphocytes, Regulatory - cytology | Interleukin-10 - metabolism | Receptor, Anaphylatoxin C5a - immunology | Cell Differentiation | Proto-Oncogene Proteins c-akt - metabolism | Complement C3a - metabolism | Interleukin-6 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Chemokine - metabolism | Gene Expression Regulation | Mice, Transgenic | Receptors, Chemokine - immunology | Receptor Cross-Talk - immunology | TOR Serine-Threonine Kinases - immunology | Animals | Proto-Oncogene Proteins c-akt - immunology | Receptors, Complement - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Interleukin-6 - immunology | Mice | Complement C3a - immunology | Complement C5a - immunology | Class Ib Phosphatidylinositol 3-Kinase - immunology | Interleukin-10 - immunology | Receptor, Anaphylatoxin C5a - metabolism | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 8, pp. 838 - 849
Interferon-gamma (IFN-gamma) primes macrophages for enhanced microbial killing and inflammatory activation by Toll-like receptors (TLRs), but little is known... 
BACTERIAL PATHOGENS | DENDRITIC CELLS | PATHWAY | IMMUNE-RESPONSES | KINASE | IMMUNOLOGY | POLARIZATION | EXPRESSION | TRYPTOPHAN CATABOLISM | MTOR | I INTERFERON | Toll-Like Receptor 2 - genetics | TOR Serine-Threonine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | Protein Biosynthesis - immunology | Eukaryotic Initiation Factor-4E - metabolism | Multiprotein Complexes - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Base Sequence | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Macrophage Activation - immunology | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - metabolism | Signal Transduction - drug effects | Toll-Like Receptor 2 - immunology | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Multiprotein Complexes - immunology | RNA, Messenger - immunology | Transcription Factor HES-1 | Macrophage Activation - genetics | Intracellular Signaling Peptides and Proteins - immunology | Homeodomain Proteins - immunology | Mechanistic Target of Rapamycin Complex 1 | Signal Transduction - immunology | Eukaryotic Initiation Factor-4E - immunology | Protein Biosynthesis - genetics | Eukaryotic Initiation Factor-4E - genetics | Macrophages - immunology | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Homeodomain Proteins - genetics | TOR Serine-Threonine Kinases - immunology | Interferon-gamma - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Index Medicus
Journal Article
Journal Article
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 08/2011, Volume 35, Issue 7, pp. 1774 - 1779
Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling... 
Prefrontal cortex | Translation initiation pathway | Major depressive disorder | Postmortem | PHOSPHORYLATION | INITIATION | PSYCHIATRY | RECEPTOR | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | CLINICAL NEUROLOGY | KETAMINE | PHARMACOLOGY & PHARMACY | EUKARYOTIC TRANSLATION | Ribosomal Protein S6 Kinases, 70-kDa - analysis | TOR Serine-Threonine Kinases - metabolism | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Male | Depressive Disorder, Major - immunology | Prefrontal Cortex - pathology | Ribosomal Protein S6 Kinases - immunology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | Autopsy | Eukaryotic Initiation Factors - immunology | Aged, 80 and over | Ribosomal Protein S6 Kinases - analysis | Adult | Female | Eukaryotic Initiation Factors - genetics | Prefrontal Cortex - immunology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Signal Transduction - genetics | Eukaryotic Initiation Factors - biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - immunology | TOR Serine-Threonine Kinases - immunology | TOR Serine-Threonine Kinases - analysis | Depressive Disorder, Major - genetics | Family | Aged | Eukaryotic Initiation Factors - analysis | Ribosomal Protein S6 Kinases - biosynthesis | Ribosomal Protein S6 Kinases - genetics | Proteins | Methyl aspartate | Glutamate | Antidepressants | Index Medicus | major depressive disorder | prefrontal cortex; translation initiation pathway | postmortem
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1266 - 1276
Highly pathogenic avian influenza viruses pose a continuing global threat. Current vaccines will not protect against newly evolved pandemic viruses. The... 
CELLS | H5N1 | TRANSMISSION | ACTIVATION | PEPTIDE ARRAYS | MEMORY | CONSEQUENCES | IMMUNOLOGY | AID | NEUTRALIZATION | CYTOTOXICITY | Orthomyxoviridae Infections - prevention & control | TOR Serine-Threonine Kinases - metabolism | Influenza A Virus, H5N1 Subtype - physiology | Immunoglobulin Class Switching - immunology | Immunoglobulin M - immunology | Orthomyxoviridae - classification | Host-Pathogen Interactions - immunology | Mechanistic Target of Rapamycin Complex 1 | Orthomyxoviridae - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Flow Cytometry | T-Lymphocytes - metabolism | Female | Immunoglobulin Class Switching - drug effects | Adaptive Immunity - immunology | Immunosuppressive Agents - pharmacology | B-Lymphocytes - metabolism | Cell Line | Antibody Formation - immunology | Mice, Inbred C57BL | Influenza A Virus, H3N2 Subtype - immunology | Sirolimus - pharmacology | Mice, Knockout | TOR Serine-Threonine Kinases - immunology | Animals | B-Lymphocytes - immunology | Influenza A Virus, H5N1 Subtype - immunology | Survival Analysis | Antibodies, Viral - immunology | T-Lymphocytes - immunology | Influenza A Virus, H3N2 Subtype - physiology | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae - physiology | Orthomyxoviridae Infections - immunology | Multiprotein Complexes - immunology | Influenza viruses | Prevention | Immune response | Protein kinases | Health aspects | Testing | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 33, Issue 6, pp. 929 - 941
There is a discrepancy between the in vitro anergic state of CD4 CD25 FoxP3 regulatory T (Treg) cells and their in vivo proliferative capability. The... 
LEPTIN | IMMUNE-RESPONSE | POPULATION | ACTIVATION | INHIBITION |