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Nature immunology, ISSN 1529-2916, 2015, Volume 16, Issue 8, pp. 838 - 849
.... We found that IFN-gamma regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E... 
BACTERIAL PATHOGENS | DENDRITIC CELLS | PATHWAY | IMMUNE-RESPONSES | KINASE | IMMUNOLOGY | POLARIZATION | EXPRESSION | TRYPTOPHAN CATABOLISM | MTOR | I INTERFERON | Toll-Like Receptor 2 - genetics | TOR Serine-Threonine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | Protein Biosynthesis - immunology | Eukaryotic Initiation Factor-4E - metabolism | Multiprotein Complexes - genetics | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | RNA Interference | Base Sequence | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Macrophage Activation - immunology | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - metabolism | Signal Transduction - drug effects | Toll-Like Receptor 2 - immunology | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Multiprotein Complexes - immunology | RNA, Messenger - immunology | Transcription Factor HES-1 | Macrophage Activation - genetics | Intracellular Signaling Peptides and Proteins - immunology | Homeodomain Proteins - immunology | Mechanistic Target of Rapamycin Complex 1 | Signal Transduction - immunology | Eukaryotic Initiation Factor-4E - immunology | Protein Biosynthesis - genetics | Eukaryotic Initiation Factor-4E - genetics | Macrophages - immunology | RNA, Messenger - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Homeodomain Proteins - genetics | TOR Serine-Threonine Kinases - immunology | Interferon-gamma - immunology | Basic Helix-Loop-Helix Transcription Factors - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Microscopy, Fluorescence
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 468, Issue 7324, pp. 653 - 658
.... We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth... 
MAINTENANCE | ACTIVATED PROTEIN-KINASE | DROSOPHILA LKB1 | GENE | SERINE-THREONINE KINASE | PATHWAY | PEUTZ-JEGHERS-SYNDROME | MULTIDISCIPLINARY SCIENCES | MICE | TRANSCRIPTION FACTOR | DEFICIENCY | Protein-Serine-Threonine Kinases - deficiency | AMP-Activated Protein Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Hematopoietic Stem Cells - pathology | Aneuploidy | Male | AMP-Activated Protein Kinases - deficiency | Mechanistic Target of Rapamycin Complex 1 | Cell Division | Gene Deletion | Cell Death | Female | Energy Metabolism - physiology | Protein-Serine-Threonine Kinases - metabolism | Hematopoietic Stem Cells - drug effects | Signal Transduction | Cell Survival | Mice, Inbred C57BL | Catalytic Domain - genetics | Protein-Serine-Threonine Kinases - genetics | Spindle Apparatus - pathology | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Sirolimus - pharmacology | AMP-Activated Protein Kinases - chemistry | Regeneration | Animals | Proteins - metabolism | Centrosome - pathology | Hematopoietic Stem Cells - cytology | Cell Cycle - physiology | Mice | Enzyme Activation | Pancytopenia - genetics | AMP-Activated Protein Kinases - genetics | Energy metabolism | Bioenergetics | Cell cycle | Tumor suppressor genes | Research | Properties | Hematopoietic stem cells | Kinases | Metabolism | Stem cells | Tumors
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 9, pp. 1205 - 1217
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 18, pp. 12467 - 12484
.... IRS1 and IRS2 are key substrates of the insulin receptor tyrosine kinase. Mass spectrometry reveals more than 50 phosphorylated IRS1 serine and threonine residues (Ser(P)/Thr(P) residues... 
PROTEIN-KINASE-C | Metabolic Stress | Signal Transduction | IRS1 | PLECKSTRIN-HOMOLOGY-DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Insulin Resistance | Insulin Signaling | PHOSPHOPROTEOME REVEALS | Monoclonal Antibodies | Protein Phosphorylation | DIET-INDUCED OBESITY | MTOR | IRS-1 SERINE PHOSPHORYLATION | SKELETAL-MUSCLE | IN-VITRO | Cell Signaling | RESISTANCE | Phosphotyrosine Signaling | REGULATORY ROLE | CHO Cells | Cricetulus | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Threonine - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Receptor, Insulin - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Insulin - pharmacology | Cricetinae | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Serine - metabolism | Blotting, Western | Hypoglycemic Agents - pharmacology | Tyrosine - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Thapsigargin - pharmacology | Anisomycin - pharmacology | Receptor, Insulin - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Metabolism
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2014, Volume 85, Issue 3, pp. 441 - 450
Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like kinases (CLKs... 
TARGET | PIKFYVE | PROTEIN-KINASE | AMYLOID-BETA | SPLICEOSOME | PHARMACOLOGY & PHARMACY | PTDINS(3,5)P-2 | POTENT INHIBITORS | SELECTIVITY | CYCLIN | FAMILY | Osteosarcoma - drug therapy | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Autophagy - immunology | Phosphorylation - genetics | Protein-Tyrosine Kinases - genetics | TOR Serine-Threonine Kinases - genetics | Dioxoles - pharmacology | Phosphorylation - immunology | Autophagy - genetics | Phosphorylation - drug effects | Osteosarcoma - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Alzheimer Disease - drug therapy | Imidazoles - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Tyrosine - metabolism | Animals | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Alzheimer Disease - genetics | Tyrosine - genetics | Tyrosine | Enzyme Inhibitors | Phosphorylation | Protein-Serine-Threonine Kinases | Microtubule-Associated Proteins | Alzheimer Disease | Autophagy | Phosphatidylinositol 3-Kinases | Dioxoles | Chemical Sciences | Imidazoles | Osteosarcoma | TOR Serine-Threonine Kinases | Protein-Tyrosine Kinases
Journal Article