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by Weinstein, John N and Akbani, Rehan and Broom, Bradley M and Wang, Wenyi and Verhaak, Roeland G. W and McConkey, David and Lerner, Seth and Morgan, Margaret and Creighton, Chad J and Smith, Carolyn and Cherniack, Andrew D and Kim, Jaegil and Pedamallu, Chandra Sekhar and Noble, Michael S and Al-Ahmadie, Hikmat A and Reuter, Victor E and Rosenberg, Jonathan E and F.Bajorin, Dean and Bochner, Bernard H and Solit, David B and Koppie, Theresa and Robinson, Brian and Gordenin, Dmitry A and Fargo, David and Klimczak, Leszek J and Roberts, Steven A and Au, Jessie and Laird, Peter W and Hinoue, Toshinori and Schultz, Nikolaus and Ramirez, Ricardo and Hansel, Donna and Hoadley, Katherine A and Kim, William Y and Damrauer, Jeffrey S and Baylin, Stephen B and Mungall, Andrew J and Robertson, A. Gordon and Chu, Andy and Kwiatkowski, David J and Sougnez, Carrie and Cibulskis, Kristian and Lichtenstein, Lee and Sivachenko, Andrey and Stewart, Chip and Lawrence, Michael S and Getz, Gad and Lander, Eric and Gabrie, Stacey B and Donehower, Lawrence and Carter, Scott L and Saksena, Gordon and Schumacher, Steven E and Freeman, Samuel S and Jung, Joonil and Bhatt, Ami S and Pugh, Trevor and Beroukhim, Rameen and Meyerson, Matthew and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Dhalla, Noreen and Hirst, Carrie and Holt, Robert A and Jones, Steven J. M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Wong, Tina and Wye, Natasja and Bowlby, Reanne and Chuah, Eric and Guin, Ranabir and Shen, Hui and Bootwalla, Moiz S and Triche Jr, Timothy and Lai, Phillip H and Van Den Berg, David J and Weisenberger, Daniel J and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Meng, Shaowu and Mose, Lisle E and Simons, Janae V and Soloway, Mathew G and Wu, Junyuan and Parker, Joel S and Hayes, D. Neil and Roach, Jeffrey and Buda, Elizabeth and Jones, Corbin D and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 315 - 322
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 741 - 750
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1761, Volume 289, Issue 18, pp. 12467 - 12484
Background: Metabolic stresses, including hyperinsulinemia, promote insulin resistance. Results: Monoclonal antibodies raised against Ser(P)/Thr(P) residues in... 
PROTEIN-KINASE-C | SIGNALING PATHWAYS | Metabolic Stress | Signal Transduction | IRS1 | PLECKSTRIN-HOMOLOGY-DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Insulin Resistance | Insulin Signaling | PHOSPHOPROTEOME REVEALS | Monoclonal Antibodies | Protein Phosphorylation | DIET-INDUCED OBESITY | MASS-SPECTROMETRY | IRS-1 SERINE PHOSPHORYLATION | SKELETAL-MUSCLE CELLS | IN-VIVO | Cell Signaling | Phosphotyrosine Signaling | REGULATORY ROLE | CHO Cells | Cricetulus | TOR Serine-Threonine Kinases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Threonine - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Receptor, Insulin - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Insulin - pharmacology | Cricetinae | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Serine - metabolism | Blotting, Western | Hypoglycemic Agents - pharmacology | Tyrosine - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Thapsigargin - pharmacology | Anisomycin - pharmacology | Receptor, Insulin - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Metabolism
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPTOR | BINDING PARTNER | RAG GTPASES | TOS MOTIF | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PIK-RELATED KINASES | CELL-GROWTH | P70 S6 KINASE | RAPAMYCIN COMPLEX-1 | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure | Index Medicus
Journal Article
Science, ISSN 0036-8075, 09/2014, Volume 345, Issue 6204, pp. 1579 - +
Journal Article
Science, ISSN 0036-8075, 05/2017, Volume 356, Issue 6337, pp. 513 - 519
Journal Article