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Chinese Journal of Lung Cancer, ISSN 1009-3419, 2018, Volume 21, Issue 1, pp. 63 - 66
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance... 
Molecular markers | Resistance to cancer therapy | AKT/m-TOR signaling pathway | AKT | Mini-Review | m-TOR signaling pathway
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112186
We previously showed that [Pt(O,O'-acac)(gamma-acac)(DMS)] ([Pt(acac)(2)(DMS)]) exerted substantial cytotoxic effects in SH-SY5Y neuroblastoma cells, and... 
BREAST-CANCER CELLS | TUMOR INVASION | ACTIVATION | NHE1 | PLATINUM(II) COMPLEXES | CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | GROWTH | INTRACELLULAR PH | S6 KINASE | INDEPENDENT PATHWAY | TOR Serine-Threonine Kinases - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Neoplasm Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Sodium-Hydrogen Exchangers - metabolism | MAP Kinase Signaling System - genetics | Protein Isoforms - metabolism | TOR Serine-Threonine Kinases - genetics | Cation Transport Proteins - metabolism | Neoplasm Invasiveness - pathology | Cation Transport Proteins - genetics | Sodium-Hydrogen Exchangers - genetics | Neoplasm Proteins - genetics | Neuroblastoma - pathology | Neuroblastoma - genetics | Protein Kinase C-epsilon - genetics | Cell Movement - drug effects | MAP Kinase Signaling System - drug effects | Protein Kinase C-epsilon - metabolism | Cell Line, Tumor | Neuroblastoma - metabolism | Neoplasm Invasiveness - genetics | Platinum Compounds - pharmacology | Sodium-Hydrogen Exchanger 1 | Protein Isoforms - genetics | TOR protein | Protein kinase C | Hydrogen | Cytotoxicity | Activation | mRNA | Metastasis | Neuroblastoma | Kinases | pH effects | NAD(P)H oxidase | Neuroblastoma cells | Cell adhesion & migration | Proteins | Gelatin | Platinum | Cell cycle | Physiology | Inhibition | Sulfur | Secretion | Na+/H+-exchanging ATPase | Extracellular signal-regulated kinase | MAP kinase | Breast cancer | Gene expression | Gelatinase A | Wounding | Sodium | Inorganic chemistry | Ligands | Solid tumors | Cell migration | Tumors | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64434
Recent studies suggest that microRNAs play important roles in dermal wound healing and microRNA deregulation has been linked with impaired wound repair. Here,... 
MIR-100 | PATHOGENESIS | MULTIDISCIPLINARY SCIENCES | PLK1 | SQUAMOUS-CELL CARCINOMA | DOWN-REGULATION | PROLIFERATION | SKIN | EXPRESSION | CANCER | PROGRESSION | Receptor, IGF Type 1 - metabolism | Phosphorylation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Gene Expression Profiling | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Cell Movement - genetics | Base Sequence | Female | Wound Healing - genetics | Proto-Oncogene Proteins c-akt - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | RNA, Messenger - genetics | Signal Transduction - genetics | Keratinocytes - pathology | Animals | Carrier Proteins - metabolism | Keratinocytes - metabolism | Dermis - pathology | Mice | MicroRNAs - genetics | Genetic research | Care and treatment | Wound healing | MicroRNA | Wounds and injuries | Luciferase | TOR protein | Cell proliferation | Deregulation | Genes | AKT protein | mRNA | Insulin-like growth factors | Cell adhesion & migration | Recruitment | Signal transduction | Physiology | Bioinformatics | AKT1 protein | Tissue engineering | RNA-mediated interference | MiRNA | Principal components analysis | Dentistry | Gene expression | Ribonucleic acid--RNA | Insulin | Signaling | Oral diseases | 3' Untranslated regions | Biopsy | MicroRNAs | Healing | Skin | Molecular biology | Prostate | Cell migration | Cancer | RNA | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63799
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e106155
A characteristic of dysregulated wound healing in IPF is fibroblastic-mediated damage to lung epithelial cells within fibroblastic foci. In these foci,... 
APOPTOSIS | COMPLEX | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TORC1/2 INHIBITOR | HYDROGEN-PEROXIDE | RICTOR | AKT | IDIOPATHIC PULMONARY-FIBROSIS | TRIPTOLIDE | Benzoxazoles - pharmacology | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Coculture Techniques | Epithelial Cells - drug effects | Multiprotein Complexes - genetics | Pulmonary Fibrosis - genetics | Mechanistic Target of Rapamycin Complex 2 | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Bleomycin | TOR Serine-Threonine Kinases - genetics | Protective Agents - pharmacology | Epithelial Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Extracellular Matrix Proteins - metabolism | Fibroblasts - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Signal Transduction | Extracellular Matrix Proteins - antagonists & inhibitors | Extracellular Matrix Proteins - genetics | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Pulmonary Fibrosis - pathology | Pyrimidines - pharmacology | Fibroblasts - pathology | Carrier Proteins - genetics | Transforming Growth Factor beta - pharmacology | Animals | Carrier Proteins - metabolism | Fibroblasts - drug effects | Pulmonary Fibrosis - chemically induced | Mice | Pulmonary Fibrosis - drug therapy | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Bone morphogenetic proteins | Transforming growth factors | Lung diseases | Fibrosis | TOR protein | Cell culture | Phosphorylation | Transplants & implants | Pathogenesis | Epithelial cells | Critical care | AKT protein | Activation | Kinases | Cell adhesion & migration | Proteins | Cell cycle | Fibroblasts | Inhibition | Growth factors | Wound healing | Pulmonary arteries | Medical treatment | Metabolism | Medicine | Pulmonary fibrosis | Laboratory animals | Regulatory proteins
Journal Article
Zhongguo Fei Ai Za Zhi, ISSN 1009-3419, 01/2018, Volume 21, Issue 1, pp. 63 - 66
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance... 
Cell growth | Thyroid cancer | Kinases | Cancer therapies | Prostate cancer | Molecular markers | Resistance to cancer therapy | AKT/m-TOR signaling pathway
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e70029
Diabetic nephropathy (DN), a major complication of diabetes, is characterized by hypertrophy, extracellular matrix accumulation, fibrosis and proteinuria... 
KIDNEY-DISEASE | SOLUBLE EPOXIDE HYDROLASE | OXIDATIVE STRESS | IGF-I | ENDOTHELIAL DYSFUNCTION | CYTOCHROME-P450 4A EXPRESSION | MULTIDISCIPLINARY SCIENCES | 20-HYDROXYEICOSATETRAENOIC ACID 20-HETE | HIGH GLUCOSE | ARACHIDONIC-ACID | RENAL INJURY | Diabetic Nephropathies - pathology | Reactive Oxygen Species - metabolism | Oxidative Stress | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | TOR Serine-Threonine Kinases - metabolism | Cytochrome P-450 CYP4A - metabolism | Diabetic Nephropathies - metabolism | Cells, Cultured | Cytochrome P-450 Enzyme System - metabolism | Rats | Glucose - pharmacology | 8,11,14-Eicosatrienoic Acid - metabolism | Hypertrophy - pathology | Hypertrophy - metabolism | Blotting, Western | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Hydroxyeicosatetraenoic Acids - metabolism | Animals | Kidney Tubules, Proximal - metabolism | Hyperglycemia | Metabolites | Diabetic nephropathies | Physiological aspects | Glucose | Arachidonic acid | Dextrose | Cytochrome | TOR protein | Oxidative stress | Nephrology | Renal function | Syngeneic grafts | Epithelial cells | Biosynthesis | Biochemistry | Accumulation | Proteins | Rodents | Extracellular matrix | Physiology | Injuries | Hypertension | Medical research | Diabetes mellitus | Anatomy & physiology | Metabolism | Medicine | Androgens | Nephropathy | Acids | Fibrosis | Kidney diseases | Diabetes | Hypertrophy | Proteinuria | Apoptosis | Reactive oxygen species
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e88891
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 07/2017, Volume 8, p. 1204
Autophagy is a critical process for recycling of cytoplasmic materials during environmental stress, senescence and cellular remodeling. It is upregulated under... 
TOR signaling | Stress responses | Auxin | Arabidopsis | Autophagy | TARGET | ACTIVATION | autophagy | auxin | HOMOLOG | ENDOPLASMIC-RETICULUM STRESS | stress responses | RAPAMYCIN TOR | CELL-DEATH | PLANT SCIENCES | SENESCENCE | S6 KINASE | PROTEINS | PLANT-GROWTH
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e62327
Multi-drug resistance leads to the failure of chemotherapy for cancers. Our previous study showed that overexpression of CA916798 led to multi-drug resistance.... 
APOPTOSIS | INVASION | INHIBITION | PROTEIN | MULTIDISCIPLINARY SCIENCES | KINASE | MECHANISMS | LUNG-CANCER CELLS | DRUG-RESISTANCE | CHEMOTHERAPY | PI3K/AKT | Immunohistochemistry | Lung Neoplasms - drug therapy | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | DNA Primers - genetics | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Chromones - pharmacology | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Drug Resistance, Multiple - physiology | Gene Expression Regulation, Neoplastic - physiology | Real-Time Polymerase Chain Reaction | Drug Resistance, Multiple - genetics | Morpholines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - drug therapy | Blotting, Western | Drug Resistance, Neoplasm - genetics | Animals | Analysis of Variance | Mice, Nude | Fluorescent Antibody Technique | Cell Line, Tumor | Signal Transduction - physiology | Mice | Drug Resistance, Neoplasm - physiology | Drug resistance | Chemotherapy | Cancer | TOR protein | Adenocarcinoma | Phosphorylation | Downstream effects | Genomics | Lung cancer | AKT protein | Kinases | Cancer therapies | Anticancer properties | Proteins | Cell growth | Cell cycle | Inhibition | Medical research | AKT1 protein | Multidrug resistance | Rapamycin | Gene expression | 1-Phosphatidylinositol 3-kinase | Medicine | Plasmids | Cell lines | Laboratory animals | Immunofluorescence | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 8, p. e71349
Journal Article