X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (209) 209
torc1 (202) 202
cell biology (109) 109
biochemistry & molecular biology (86) 86
humans (83) 83
rapamycin (83) 83
animals (82) 82
signal transduction (78) 78
yeast (71) 71
saccharomyces-cerevisiae (66) 66
saccharomyces cerevisiae proteins - metabolism (64) 64
transcription factors - metabolism (57) 57
phosphorylation (54) 54
saccharomyces cerevisiae - metabolism (53) 53
tor serine-threonine kinases - metabolism (51) 51
autophagy (50) 50
proteins (48) 48
article (47) 47
mechanistic target of rapamycin complex 1 (46) 46
saccharomyces cerevisiae - genetics (42) 42
multiprotein complexes - metabolism (40) 40
transcription factors - genetics (38) 38
saccharomyces cerevisiae proteins - genetics (37) 37
metabolism (36) 36
mtor (36) 36
pathway (36) 36
complex (35) 35
rag gtpases (35) 35
activation (34) 34
amino acids (34) 34
cell-growth (33) 33
saccharomyces cerevisiae (31) 31
mammalian target (29) 29
microbiology (29) 29
transcription (29) 29
growth (28) 28
kinases (28) 28
physiological aspects (28) 28
sirolimus - pharmacology (28) 28
ego complex (27) 27
mice (27) 27
protein (27) 27
analysis (26) 26
biology (26) 26
gene expression regulation, fungal (26) 26
gene-expression (26) 26
genetics & heredity (26) 26
protein binding (25) 25
research (25) 25
tor (25) 25
cancer (24) 24
protein-serine-threonine kinases - metabolism (23) 23
male (22) 22
transfer-rna synthetase (22) 22
amino acids - metabolism (21) 21
gene expression (21) 21
monomeric gtp-binding proteins - metabolism (21) 21
torc2 (21) 21
genetic aspects (20) 20
target of rapamycin complex 1 (20) 20
tor protein (20) 20
budding yeast (19) 19
female (19) 19
kinase (19) 19
mechanistic target of rapamycin complex 1 - metabolism (19) 19
mtorc1 (19) 19
mutation (19) 19
research article (19) 19
biotechnology & applied microbiology (18) 18
controls torc1 (18) 18
nutrients (18) 18
signal transduction - physiology (18) 18
akt (17) 17
hek293 cells (16) 16
signaling (16) 16
tor serine-threonine kinases - antagonists & inhibitors (16) 16
cells (15) 15
life sciences (15) 15
molecular biology (15) 15
oncology (15) 15
protein transport (15) 15
review (15) 15
saccharomyces cerevisiae - drug effects (15) 15
saccharomyces cerevisiae - physiology (15) 15
sch9 (15) 15
signal transduction - drug effects (15) 15
starvation (15) 15
target (15) 15
aging (14) 14
binding (14) 14
homeostasis (14) 14
mitochondria (14) 14
models, biological (14) 14
multidisciplinary sciences (14) 14
signaling pathway (14) 14
apoptosis (13) 13
biophysics (13) 13
expression (13) 13
nuclear-localization (13) 13
p70 s6 kinase (13) 13
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2017, Volume 68, Issue 5, pp. 835 - 846.e3
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 231 - 241
AS 160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MOUSE SKELETAL-MUSCLE | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2017, Volume 67, Issue 2, pp. 266 - 281.e4
Mec1 mediates the DNA damage response (DDR), integrating chromosomal signals and mechanical stimuli. We show that the PP2A phosphatases, ceramide-activated... 
Irc21 | TORC1 | genome stability | Rad53 | DNA damage response | protein phosphatase PP2A | metabolism | Mec1-ATR | GROWTH-CONTROL | FORK RESTART | CHAIN FATTY-ACIDS | CERAMIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALKALINE CERAMIDASE | PROTEIN PHOSPHATASE 2A | YEAST-CELL CYCLE | CYTOCHROME B | SACCHAROMYCES-CEREVISIAE | S-PHASE CHECKPOINT | CELL BIOLOGY | Metabolomics | DNA, Fungal - genetics | Saccharomyces cerevisiae - genetics | Protein Methyltransferases - genetics | Saccharomyces cerevisiae - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Protein Methyltransferases - metabolism | Cytochrome-B Reductase - metabolism | Genomic Instability - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Gene Expression Regulation, Fungal | DNA Repair - drug effects | Ceramides - metabolism | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Sirolimus - pharmacology | Ceramides - pharmacology | Transcription Factors - metabolism | Energy Metabolism | Adaptor Proteins, Signal Transducing - genetics | DNA, Fungal - metabolism | Protein Phosphatase 2 - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Cytochrome-B Reductase - genetics | Protein Kinase Inhibitors - pharmacology | DNA Damage | Enzyme Activation | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Genome, Fungal - drug effects | Phosphatases | DNA damage | Transferases | Genomics | DNA | Physiological aspects | Ceramides | Genetic research | Plant lipids | DNA repair | Genomes
Journal Article
Journal Article
Aging Cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 994 - 1005
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e106155
A characteristic of dysregulated wound healing in IPF is fibroblastic-mediated damage to lung epithelial cells within fibroblastic foci. In these foci,... 
APOPTOSIS | COMPLEX | EFFICACY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TORC1/2 INHIBITOR | HYDROGEN-PEROXIDE | RICTOR | AKT | IDIOPATHIC PULMONARY-FIBROSIS | TRIPTOLIDE | Benzoxazoles - pharmacology | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Coculture Techniques | Epithelial Cells - drug effects | Multiprotein Complexes - genetics | Pulmonary Fibrosis - genetics | Mechanistic Target of Rapamycin Complex 2 | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Bleomycin | TOR Serine-Threonine Kinases - genetics | Protective Agents - pharmacology | Epithelial Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Extracellular Matrix Proteins - metabolism | Fibroblasts - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Signal Transduction | Extracellular Matrix Proteins - antagonists & inhibitors | Extracellular Matrix Proteins - genetics | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Pulmonary Fibrosis - pathology | Pyrimidines - pharmacology | Fibroblasts - pathology | Carrier Proteins - genetics | Transforming Growth Factor beta - pharmacology | Animals | Carrier Proteins - metabolism | Fibroblasts - drug effects | Pulmonary Fibrosis - chemically induced | Mice | Pulmonary Fibrosis - drug therapy | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Bone morphogenetic proteins | Transforming growth factors | Lung diseases | Fibrosis | TOR protein | Cell culture | Phosphorylation | Transplants & implants | Pathogenesis | Epithelial cells | Critical care | AKT protein | Activation | Kinases | Cell adhesion & migration | Proteins | Cell cycle | Fibroblasts | Inhibition | Growth factors | Wound healing | Pulmonary arteries | Medical treatment | Metabolism | Medicine | Pulmonary fibrosis | Laboratory animals | Regulatory proteins
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2017, Volume 118, Issue 8, pp. 2241 - 2249
We investigated the effect of the dual mechanistic target of rapamycin complex 1/2 (mTORC1/2) inhibitor Palomid 529 (P529) on TGF‐β‐dependent signaling and... 
TGF‐β | FIBRONECTIN DEPOSITION | PULMONARY FIBROSIS | MYOFIBROBLAST | mTOR | P529 | Smad | ACTIN CYTOSKELETON | mTORC2 | mTORC1 | TGF-β | TARGET | BINDING PARTNER | TORC1/TORC2 INHIBITOR | STRESS FIBER FORMATION | TGF-BETA | REDUCES TUMOR-GROWTH | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | TGF | PALOMID 529 | IDIOPATHIC PULMONARY-FIBROSIS | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Humans | Actins - metabolism | Cells, Cultured | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Survival of Motor Neuron 1 Protein - metabolism | Myofibroblasts - drug effects | Phosphoproteins - metabolism | Blotting, Western | Fibronectins - metabolism | Mechanistic Target of Rapamycin Complex 1 - metabolism | Myofibroblasts - cytology | Collagen - metabolism | Mechanistic Target of Rapamycin Complex 2 - metabolism | Transforming Growth Factor beta - pharmacology | Receptors, Transforming Growth Factor beta - metabolism | Cell Differentiation - drug effects | Phosphorylation - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Benzopyrans - pharmacology | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Fibronectins | Collagen | Bone morphogenetic proteins | Respiratory tract diseases | Transforming growth factors | Muscle proteins | Genetic translation | Protein binding | TOR protein | Phosphorylation | Smad protein | Matrices (mathematics) | AKT protein | Activation | Biochemistry | Kinases | Matrix methods | Fibronectin | Proteins | Mathematical analysis | Actin | Smad2 protein | Transcription activation | Fibroblasts | Inhibition | Matrix protein | p70 S6 kinase | Deposition | Activation analysis | Binding | Stresses | Translocation | Lung diseases | Dose dependency | Translation initiation | Wounds | Rapamycin | Gene expression | Stress | Inhibitors | Fibrosis | Differentiation | actin cytoskeleton | myofibroblast | pulmonary fibrosis | fibronectin deposition
Journal Article