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1. A suspected case of carbimazole-associated torsades de pointes
by Bagchi, Chiranjib and Sinha, Dhurjati Prasad and Tripathi, Santanu Kumar
12/2010
Torsades de pointes (TdP) or polymorphic ventricular tachycardia owing to drug-induced QT prolongation is a common cause of withdrawal of marketed drugs and... 
torsades de pointes | QT prolongation | Carbimazole
Web Resource
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2. Full Text QT prolongation in opioid poisoning is mostly due to methadone
by Mann, G and Gunja, N
CLINICAL TOXICOLOGY, ISSN 1556-3650, 06/2017, Volume 55, Issue 5, pp. 473 - 473
TORSADES-DE-POINTES | TOXICOLOGY
Conference Proceeding
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3. Full Text Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
by Li, Zhihua and Ridder, Bradley J and Han, Xiaomei and Wu, Wendy W and Sheng, Jiansong and Tran, Phu N and Wu, Min and Randolph, Aaron and Johnstone, Ross H and Mirams, Gary R and Kuryshev, Yuri and Kramer, James and Wu, Caiyun and Crumb, William J and Strauss, David G
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 02/2019, Volume 105, Issue 2, pp. 466 - 475
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs are... 
TORSADES-DE-POINTES | DISOPYRAMIDE | EARLY AFTERDEPOLARIZATIONS | DISPERSION | DRUGS | VALIDATION | PHARMACOLOGY & PHARMACY | REPOLARIZATION | Research
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4. Full Text The incidence, predictors and outcomes of QTc prolongation in critically ill patients
by Russell, Hollie and Churilov, Leonid and Toh, Lisa and Eastwood, Glenn M and Bellomo, Rinaldo
Journal of Critical Care, ISSN 0883-9441, 09/2019
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5. Full Text Concomitant use of levofloxacin and fluconazole leading to possible torsades de pointes
by Tilton, Jessica J and Sadr, Rozhan and Groo, Vicki L
Journal of Oncology Pharmacy Practice, ISSN 1078-1552, 2018, p. 107815521881574
fluconazole | corrected QT | levofloxacin | Torsades de pointes
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6. Full Text Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit
by Barr, Juliana and Fraser, Gilles L and Puntillo, Kathleen and Ely, E. Wesley and Gélinas, Céline and Dasta, Joseph F and Davidson, Judy E and Devlin, John W and Kress, John P and Joffe, Aaron M and Coursin, Douglas B and Herr, Daniel L and Tung, Avery and Robinson, Bryce R. H and Fontaine, Dorrie K and Ramsay, Michael A and Riker, Richard R and Sessler, Curtis N and Pun, Brenda and Skrobik, Yoanna and Jaeschke, Roman and American College of Critical Care Medicine
Critical Care Medicine, ISSN 0090-3493, 01/2013, Volume 41, Issue 1, pp. 263 - 306
Objective: To revise the "Clinical Practice Guidelines for the Sustained Use of Sedatives and Analgesics in the Critically III Adult" published in Critical... 
agitation | critical care medicine | pain | intensive care | outcomes | analgesia | GRADE | guidelines | protocols | sedation | delirium | evidence-based medicine | POSTTRAUMATIC-STRESS-DISORDER | TORSADES-DE-POINTES | RANDOMIZED CONTROLLED-TRIAL | RESPIRATORY-DISTRESS-SYNDROME | MECHANICALLY VENTILATED PATIENTS | PROPOFOL INFUSION SYNDROME | CONFUSION ASSESSMENT METHOD | QUALITY-OF-LIFE | LONG-TERM SEDATION | CRITICALLY-ILL PATIENTS | Psychomotor Agitation - diagnosis | Risk Assessment - methods | Intensive Care Units | Hypnotics and Sedatives - adverse effects | United States | Humans | Clinical Protocols | Pain Management - methods | Critical Illness | Delirium - therapy | Hypnotics and Sedatives - therapeutic use | Pain Measurement - methods | Psychomotor Agitation - therapy | Adult | Hypnotics and Sedatives - pharmacology | Delirium - diagnosis
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7. QT alterations in psychopharmacology: Proven candidates and suspects
by Alvarez, Paulino Antonio and Pahissa, Jaime
Current Drug Safety, ISSN 1574-8863, 01/2010, Volume 5, Issue 1, pp. 97 - 104
Psychotropics are among the most common causes of drug induced acquired long QT syndrome. Blockage of Human ether-ago- go-related gene (HERG) potassium channel... 
Antipsychotics | Psychotropics | Antidepressants | Torsades de pointes | QTc prolongation
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8. Full Text Acute Fluoride Toxicokinetics Modelled Via Electrolyte Disturbance Velocity in a Single Patient
by Blumenberg, A and Girardi, F and Rudy, C and McKeown, N and Hendrickson, RG
CLINICAL TOXICOLOGY, ISSN 1556-3650, 10/2019, Volume 57, Issue 10, pp. 936 - 937
Calcium | Torsades de pointes | Hydrofluoric acid | TOXICOLOGY
Conference Proceeding
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9. Full Text Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens
by Odagiri, Takashi and Inagaki, Hiroaki and Nagamochi, Masatoshi and Kitamura, Takahiro and Komoriya, Satoshi and Takahashi, Hisashi
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 16, pp. 7234 - 7244
Novel 7-[(3aS,7aS)-3a-aminohexahydropyrano[3,4-c]pyrrol-2(3H)-yl]-6-fluoro-1-[(1R,2S)-2- fluorocyclopropyl]-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic... 
TORSADES-DE-POINTES | INFECTIONS | CHEMISTRY, MEDICINAL | INHIBITION | DRUG DISCOVERY | FLUOROQUINOLONES | QUINOLONES | PROLONGATION | RISK-ASSESSMENT | DERIVATIVES | LIPOPHILICITY
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10. Full Text Atrioventricular Block-induced Torsades de Pointes Associated with KCNQ1-G269S
by Nakajima, Tadashi and Sugawara, Takashi and Kaneko, Yoshiaki and Kurabayashi, Masahiko
Internal Medicine, ISSN 0918-2918, 2018
mutation | torsades de pointes | long QT syndrome | atrioventricular block | KCNQ1
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11. Full Text Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem CellDerived Cardiomyocytes to Functional Preclinical Safety Assays
by Harris, K and Aylott, M and Cui, Y and Louttit, JB and McMahon, NC and Sridhar, A
TOXICOLOGICAL SCIENCES, ISSN 1096-6080, 08/2013, Volume 134, Issue 2, pp. 412 - 426
Human-induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are a potential source to develop assays for predictive electrophysiological safety screening.... 
HUMAN PHARMACEUTICALS | TORSADES-DE-POINTES | hiPSC-CM | cardiovascular safety | electrophysiology: ion channel blockers | HUMAN VENTRICULAR CARDIOMYOCYTES | CELL-DERIVED CARDIOMYOCYTES | QT INTERVAL PROLONGATION | BLINDED VALIDATION | CARDIAC NA+ CHANNEL | ANTIARRHYTHMIC DRUGS | IN-VITRO | POTENTIAL RECORDINGS | multielectrode array | preclinical | TOXICOLOGY
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12. Full Text Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?
by Towart, Rob and Linders, Joannes T.M and Hermans, An N and Rohrbacher, Jutta and van der Linde, Henk J and Ercken, Martine and Cik, Miroslav and Roevens, Peter and Teisman, Ard and Gallacher, David J
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 07/2009, Volume 60, Issue 1, pp. 1 - 10
The problem of drug-induced hERG channel blockade, which can lead to acquired long QT syndrome and potentially fatal arrhythmias, has exercised drug developers... 
Kv7.1 | Ligand binding | hERG | HMR1556 | KCNQ1 | Torsades de pointes
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13. Full Text Azithromycin and the Risk of Cardiovascular Death
by Ray, Wayne A and Murray, Katherine T and Hall, Kathi and Arbogast, Patrick G and Stein, C. Michael
The New England Journal of Medicine, ISSN 0028-4793, 05/2012, Volume 366, Issue 20, pp. 1881 - 1890
In a large cohort study, patients who took azithromycin had significantly increased risks of cardiovascular death and death from any cause during a 5-day... 
MEDICINE, GENERAL & INTERNAL | TORSADES-DE-POINTES | QT-INTERVAL PROLONGATION | EVENT REPORTING SYSTEM | DRUGS | MACROLIDE | SUDDEN CARDIAC DEATH | PHARMACOEPIDEMIOLOGY | ORAL ERYTHROMYCIN | ADJUSTMENT | PROPENSITY SCORES | Arrhythmias, Cardiac - chemically induced | United States | Humans | Middle Aged | Male | Risk | Death, Sudden, Cardiac - etiology | Incidence | Anti-Bacterial Agents - therapeutic use | Azithromycin - adverse effects | Azithromycin - therapeutic use | Cardiovascular Diseases - mortality | Adult | Female | Anti-Bacterial Agents - adverse effects | Cardiovascular Diseases - chemically induced | Retrospective Studies | Medicaid | Cohort Studies | Dose-response relationship (Biochemistry) | Causes of | Complications and side effects | Cardiovascular diseases | Azithromycin | Levofloxacin | Hospitals | Antibiotics | Amoxicillin | Macrolide antibiotics | Death | Ciprofloxacin | Index Medicus | Abridged Index Medicus
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14. Full Text Improved Prediction of Drug‐Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms
by Lancaster, M Cummins and Sobie, EA
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 10/2016, Volume 100, Issue 4, pp. 371 - 379
The ventricular arrhythmia Torsades de Pointes (TdP) is a common form of drug‐induced cardiotoxicity, but prediction of this arrhythmia remains an unresolved... 
Algorithms | Machine Learning | Humans | Risk Factors | Torsades de Pointes - chemically induced | Usage | Arrhythmia | Drug therapy | Torsade de pointes | Machine learning | Index Medicus | Abridged Index Medicus
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15. Full Text Electrocardiographic Harbingers of Ventricular Tachycardia Arrest - A Moment of Pause
by Dejong, Colette and Nishtala, Arvind and Goldschlager, Nora
JAMA Internal Medicine, ISSN 2168-6106, 02/2019, Volume 179, Issue 2, pp. 249 - 251
MEDICINE, GENERAL & INTERNAL | TORSADES-DE-POINTES
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16. Full Text Drug therapy: Drug-induced prolongation of the QT interval
by Roden, DM
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 03/2004, Volume 350, Issue 10, pp. 1013 - 1022
  The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic... 
ANTIARRHYTHMIC DRUGS | MEDICINE, GENERAL & INTERNAL | TORSADES-DE-POINTES | TRIGGERED ACTIVITY | CARDIAC-ARRHYTHMIA | M-CELLS | CLINICAL-FEATURES | VENTRICULAR ARRHYTHMIAS | ACUTE PROMYELOCYTIC LEUKEMIA | POTASSIUM CHANNEL | ATRIAL-FIBRILLATION | Side effects | Drug therapy | Health risk assessment | Toxicity | Decision making
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17. Full Text The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias
by Curtis, Michael J and Hancox, Jules C and Farkas, András and Wainwright, Cherry L and Stables, Catherine L and Saint, David A and Clements-Jewery, Hugh and Lambiase, Pier D and Billman, George E and Janse, Michiel J and Pugsley, Michael K and Ng, G. André and Roden, Dan M and Camm, A. John and Walker, Michael J.A
Pharmacology and Therapeutics, ISSN 0163-7258, 08/2013, Volume 139, Issue 2, pp. 213 - 248
The ‘Lambeth Conventions’ is a guidance document, written in 1987 ( ), intended to be of practical value in the investigation of experimental arrhythmias... 
Lambeth Conventions | Ventricular arrhythmia | Antiarrhythmic | Torsades de pointes | Methods | Supraventricular arrhythmia | TORSADES-DE-POINTES | LONG-QT SYNDROME | REPERFUSION-INDUCED ARRHYTHMIAS | PERSISTENT ATRIAL-FIBRILLATION | CORONARY-ARTERY OCCLUSION | ACTION-POTENTIAL DURATION | ACUTE MYOCARDIAL-INFARCTION | SUDDEN CARDIAC DEATH | PHARMACOLOGY & PHARMACY | STRETCH-INDUCED VULNERABILITY | HERG POTASSIUM CHANNEL | Biomedical Research | Arrhythmias, Cardiac | Animals | Research Design | Humans | Arrhythmia | Analysis | Anti-arrhythmia drugs
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