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1. Full Text Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors
by Grouthier, Virginie and Lebrun-Vignes, Benedicte and Glazer, Andrew M and Touraine, Philippe and Funck-Brentano, Christian and Pariente, Antoine and Courtillot, Carine and Bachelot, Anne and Roden, Dan M and Moslehi, Javid J and Salem, Joe-Elie
Heart (British Cardiac Society), ISSN 1355-6037, 11/2018, Volume 104, Issue 22, pp. 1859 - 1863
selective estrogen receptor modulators | Long QT syndrome | torsade de pointes | aromatase inhibitors | ventricular arrhythmias | sex steroid hormones | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Prognosis | Humans | Middle Aged | Selective Estrogen Receptor Modulators - adverse effects | Long QT Syndrome - chemically induced | Long QT Syndrome - physiopathology | Young Adult | Heart Rate - drug effects | Aromatase Inhibitors - adverse effects | Long QT Syndrome - diagnosis | Aged, 80 and over | Adult | Female | Torsades de Pointes - diagnosis | Torsades de Pointes - physiopathology | Action Potentials - drug effects | Databases, Factual | Long QT Syndrome - mortality | Risk Assessment | Torsades de Pointes - mortality | Adverse Drug Reaction Reporting Systems | Risk Factors | Torsades de Pointes - chemically induced | Europe - epidemiology | Heart Conduction System - drug effects | Cardiotoxicity | Heart Conduction System - physiopathology | Adolescent | Aged | Tamoxifen - adverse effects | Heart | Testosterone | Cardiac arrhythmia | Dictionaries | Databases | Classification | Electrocardiography | Pharmacology | Breast cancer | Cancer therapies | Drug dosages | Index Medicus | Abridged Index Medicus | Life Sciences
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2. Full Text The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin
by Chorin, Ehud and Dai, Matthew and Shulman, Eric and Wadhwani, Lalit and Bar-Cohen, Roi and Barbhaiya, Chirag and Aizer, Anthony and Holmes, Douglas and Bernstein, Scott and Spinelli, Michael and Park, David S and Chinitz, Larry A and Jankelson, Lior
Nature medicine, ISSN 1078-8956, 06/2020, Volume 26, Issue 6, pp. 808 - 809
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Betacoronavirus - pathogenicity | Arrhythmias, Cardiac - chemically induced | Coronavirus Infections - drug therapy | Humans | Pandemics - prevention & control | Pneumonia, Viral - drug therapy | Coronavirus Infections - physiopathology | Azithromycin - administration & dosage | Hydroxychloroquine - adverse effects | Arrhythmias, Cardiac - physiopathology | COVID-19 | SARS-CoV-2 | Pneumonia, Viral - complications | Coronavirus Infections - complications | Torsades de Pointes - diagnosis | Torsades de Pointes - physiopathology | Electrocardiography - methods | Betacoronavirus - drug effects | Torsades de Pointes - chemically induced | Electrocardiography - drug effects | Arrhythmias, Cardiac - virology | Hydroxychloroquine - administration & dosage | Pneumonia, Viral - physiopathology | Azithromycin - adverse effects | Oxygen - administration & dosage | Coronavirus Infections - virology | Arrhythmias, Cardiac - diagnosis | Viral Load - drug effects | Pneumonia, Viral - virology | Complications and side effects | Usage | Heart beat | Hydroxychloroquine | Arrhythmia | Azithromycin | Cardiac arrest | Dosage and administration | Drug therapy, Combination | Drug therapy | Health aspects | Risk factors | Index Medicus
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3. Full Text A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes
by Ando, Hiroyuki and Yoshinaga, Takashi and Yamamoto, Wataru and Asakura, Keiichi and Uda, Takaaki and Taniguchi, Tomohiko and Ojima, Atsuko and Shinkyo, Raku and Kikuchi, Kiyomi and Osada, Tomoharu and Hayashi, Seiji and Kasai, Chieko and Miyamoto, Norimasa and Tashibu, Hiroyuki and Yamazaki, Daiju and Sugiyama, Atsushi and Kanda, Yasunari and Sawada, Kohei and Sekino, Yuko
Journal of pharmacological and toxicological methods, ISSN 1056-8719, 03/2017, Volume 84, pp. 111 - 127
Concordance | Field potential duration | Risk categorisation | Early afterdepolarization | Proarrhythmia | Multi-electrode array | Torsade de pointes | Human induced pluripotent stem cell-derived cardiomyocytes | Free concentration | Torsadogenic risk | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Cardiotoxins - toxicity | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Risk Assessment | Humans | Cells, Cultured | Torsades de Pointes - chemically induced | Action Potentials - physiology | Torsades de Pointes - pathology | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Torsades de Pointes - physiopathology | Action Potentials - drug effects | Risk assessment | Stem cells | Heart cells | Index Medicus
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4. Full Text Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
by Mirams, Gary R and Cui, Yi and Sher, Anna and Fink, Martin and Cooper, Jonathan and Heath, Bronagh M and McMahon, Nick C and Gavaghan, David J and Noble, Denis
Cardiovascular research, ISSN 0008-6363, 7/2011, Volume 91, Issue 1, pp. 53 - 61
Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Cardiac dysrhythmias | Calcium Channel Blockers - adverse effects | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Ion Channels - genetics | ERG1 Potassium Channel | Potassium Channel Blockers - adverse effects | Action Potentials | Dose-Response Relationship, Drug | Transfection | Sodium Channel Blockers - adverse effects | Computer Simulation | HEK293 Cells | Sodium Channels - metabolism | Torsades de Pointes - physiopathology | NAV1.5 Voltage-Gated Sodium Channel | Rabbits | Guinea Pigs | Risk Assessment | Models, Cardiovascular | Risk Factors | Torsades de Pointes - chemically induced | Torsades de Pointes - metabolism | Sodium Channels - drug effects | Ion Channels - antagonists & inhibitors | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Patch-Clamp Techniques | Animals | Ion Channels - metabolism | Calcium Channels, L-Type - drug effects | Dogs | Calcium Channels, L-Type - metabolism | Kinetics | Index Medicus | Computer modelling | Risk prediction | Torsade-de-pointes | Pharmacology | Drug development | Original
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5. Full Text Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure-response simulator
by Sahli Costabal, Francisco and Yao, Jiang and Sher, Anna and Kuhl, Ellen
Progress in biophysics and molecular biology, ISSN 0079-6107, 07/2019, Volume 144, pp. 61 - 76
Electrophysiology | Pharmacology | Finite element analysis | Computational modeling | Early afterdepolarizations | Torsades de pointes | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Heart - physiopathology | Potassium - metabolism | Risk Assessment | Models, Cardiovascular | Humans | Pericardium - drug effects | Torsades de Pointes - chemically induced | Electrocardiography - drug effects | Torsades de Pointes - metabolism | Endocardium - pathology | Dose-Response Relationship, Drug | Heart Rate - drug effects | Torsades de Pointes - pathology | Pericardium - pathology | Phenethylamines - adverse effects | Heart - drug effects | Sulfonamides - adverse effects | Torsades de Pointes - physiopathology | Purkinje Cells - drug effects | Single-Cell Analysis | Purkinje Cells - pathology | Action Potentials - drug effects | Endocardium - drug effects | Drugs | Heart | Heart beat | Arrhythmia | Mandatory drug testing | Cardiac patients | Electrocardiogram | Electrocardiography | Dofetilide | Mechanical engineering | Index Medicus | early afterdepolarizations | torsades de pointes | electrophysiology | computational modeling | finite element analysis | pharmacology
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6. Full Text Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19)
by Giudicessi, John R and Noseworthy, Peter A and Friedman, Paul A and Ackerman, Michael J
Mayo Clinic proceedings, ISSN 0025-6196, 06/2020, Volume 95, Issue 6, pp. 1213 - 1221
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Pandemics | Coronavirus Infections - drug therapy | Humans | Pneumonia, Viral - drug therapy | Death, Sudden, Cardiac - prevention & control | Long QT Syndrome - chemically induced | Death, Sudden, Cardiac - etiology | Drug Monitoring - methods | Hydroxychloroquine - adverse effects | Risk Adjustment - methods | Torsades de Pointes - therapy | COVID-19 | SARS-CoV-2 | Ritonavir - adverse effects | Coronavirus Infections - epidemiology | Pneumonia, Viral - epidemiology | Drug Repositioning - ethics | Electrocardiography - methods | Long QT Syndrome - mortality | Anti-Infective Agents - adverse effects | Betacoronavirus - isolation & purification | Ritonavir - administration & dosage | Torsades de Pointes - mortality | Betacoronavirus - drug effects | Torsades de Pointes - chemically induced | Long QT Syndrome - therapy | Hydroxychloroquine - administration & dosage | Anti-Infective Agents - administration & dosage | Drug Repositioning - methods | Lopinavir - administration & dosage | Drug Combinations | Lopinavir - adverse effects | Personal protective equipment | Electrocardiography | Coronaviruses | Drug therapy | Index Medicus | Abridged Index Medicus
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7. Full Text QT interval prolongation and the risk of torsades de pointes: essentials for clinicians
by Trinkley, Katy E and Lee Page, Robert and Lien, Hoang and Yamanouye, Kevin and Tisdale, James E
Current medical research and opinion, ISSN 0300-7995, 12/2013, Volume 29, Issue 12, pp. 1719 - 1726
Mitigation | Prevention | QT interval prolongation | Torsades de pointes | Drug-induced | Risk factors | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | Cardiac dysrhythmias | Pharmacology. Drug treatments | Long QT Syndrome - complications | Torsades de Pointes - etiology | Humans | Risk Factors | Male | PubMed | Long QT Syndrome - therapy | Long QT Syndrome - physiopathology | Sex Factors | Electrocardiography | Female | Torsades de Pointes - physiopathology | Torsades de Pointes - prevention & control | Index Medicus
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8. Full Text Efavirenz Inhibits the Human Ether‐A‐Go‐Go Related Current (hERG) and Induces QT Interval Prolongation in CYP2B666 Allele Carriers
by ABDELHADY, AHMED M and SHUGG, TYLER and THONG, NANCY and LU, JESSICA BO LI and KREUTZ, YVONNE and JAYNES, HEATHER A and ROBARGE, JASON D and TISDALE, JAMES E and DESTA, ZERUESENAY and OVERHOLSER, BRIAN R
Journal of cardiovascular electrophysiology, ISSN 1045-3873, 10/2016, Volume 27, Issue 10, pp. 1206 - 1213
QTc interval prolongation | QTc | torsade de pointes | hERG | efavirenz | HERG | Efavirenz | Torsade de pointes | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Reverse Transcriptase Inhibitors - blood | Humans | Torsades de Pointes - genetics | Male | Healthy Volunteers | Cytochrome P-450 CYP2B6 - metabolism | Potassium Channel Blockers - adverse effects | Action Potentials | Dose-Response Relationship, Drug | Reverse Transcriptase Inhibitors - adverse effects | Young Adult | Heart Rate - drug effects | Transfection | Time Factors | HEK293 Cells | Electrocardiography | Pharmacogenomic Variants | Adult | Benzoxazines - blood | Female | Torsades de Pointes - physiopathology | Potassium Channel Blockers - blood | Pharmacogenetics | Risk Assessment | Cytochrome P-450 CYP2B6 - genetics | Gene Frequency | Risk Factors | Torsades de Pointes - chemically induced | Benzoxazines - adverse effects | Genotype | Torsades de Pointes - metabolism | ERG1 Potassium Channel - metabolism | Homozygote | Phenotype | Adolescent | ERG1 Potassium Channel - antagonists & inhibitors | Antiviral agents | Cytochrome P-450 | Index Medicus
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9. Full Text Assessing QT Interval Prolongation and its Associated Risks with Antipsychotics
by Nielsen, Jimmi and Graff, Claus and Kanters, Jørgen K and Toft, Egon and Taylor, David and Meyer, Jonathan M
CNS drugs, ISSN 1172-7047, 6/2011, Volume 25, Issue 6, pp. 473 - 490
Pharmacotherapy | Neurology | Neurosciences | Medicine & Public Health | Psychiatry | Psychopharmacology | Antipsychotics | Torsade-de-pointes | Sudden-death | QT-interval-prolongation | Pharmacology & Pharmacy | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cardiology. Vascular system | Heart | Psycholeptics: tranquillizer, neuroleptic | Psychology. Psychoanalysis. Psychiatry | Cardiac dysrhythmias | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Neuropharmacology | Drug toxicity and drugs side effects treatment | Toxicity: cardiovascular system | Torsades de Pointes - epidemiology | Antipsychotic Agents - adverse effects | Death, Sudden, Cardiac - epidemiology | Humans | Risk Factors | Torsades de Pointes - chemically induced | Death, Sudden, Cardiac - etiology | Torsades de Pointes - physiopathology | Electrophysiologic Techniques, Cardiac - methods | Torsades de Pointes - complications | Complications and side effects | Tachycardia | Antipsychotic drugs | Prognosis | Cardiac arrest | Research | Health aspects | Risk factors | Index Medicus
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