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1. Full Text Divalent toxoids loaded stable chitosan–glucomannan nanoassemblies for efficient systemic, mucosal and cellular immunostimulatory response following oral administration
by Harde, Harshad and Siddhapura, Krupa and Agrawal, Ashish Kumar and Jain, Sanyog
International Journal of Pharmaceutics, ISSN 0378-5173, 06/2015, Volume 487, Issue 1-2, pp. 292 - 304
The present study reports dual tetanus and diphtheria toxoids loaded stable chitosan–glucomannan nanoassemblies (sCh–GM-NAs) formulated using tandem ionic... 
Vaccine | Stability | Mucosal immunity | Chitosan-glucomannan nanoassemblies | Glucomannosylation | DRUG | GENE DELIVERY | VACCINE DELIVERY | INSULIN | IMMUNIZATION | IN-VITRO | IMPROVED STABILITY | IMMUNE-RESPONSES | PHARMACOLOGY & PHARMACY | HEPATITIS-B | PLGA NANOPARTICLES | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Humans | Diphtheria Toxoid - immunology | Nanostructures | Intestinal Absorption | Toxoids - administration & dosage | Immunity, Mucosal - drug effects | Toxoids - pharmacology | Immunity, Cellular - drug effects | Mannans - chemistry | Adjuvants, Immunologic - chemistry | Toxoids - chemistry | Drug Compounding | Tetanus Toxoid - pharmacology | Caco-2 Cells | Administration, Oral | Immunization - methods | Freeze Drying | Rats | Rats, Sprague-Dawley | Tetanus Toxoid - administration & dosage | Particle Size | Diphtheria Toxoid - administration & dosage | Animals | Chitosan - chemistry | Diphtheria Toxoid - pharmacology | Mice | Mice, Inbred BALB C | Tetanus Toxoid - immunology
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2. Development of dual toxoid-loaded layersomes for complete immunostimulatory response following peroral administration
by Harde, Harshad and Siddhapura, Krupa and Agrawal, Ashish Kumar and Jain, Sanyog
Nanomedicine, ISSN 1743-5889, 04/2015, Volume 10, Issue 7, pp. 1077 - 1091
Aim: Present study reports the development of divalent vaccine with enhanced protection, permeation and presentation following peroral immunization. Materials... 
layersomes | vaccine | toxoids | oral delivery | mucosal immunity | DRUG | CHITOSAN | VACCINATION | TETANUS TOXOIDS | NANOSCIENCE & NANOTECHNOLOGY | MICROPARTICLES | INSULIN | NANOPARTICLES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMPROVED STABILITY | LIPOSOMES | Immunoglobulin G - blood | Humans | Diphtheria Toxoid - immunology | Interleukin-2 - immunology | Immunoglobulin G - immunology | Tetanus - immunology | Diphtheria - prevention & control | Female | Caco-2 Cells | Cell Line | Immunization | Diphtheria - immunology | Administration, Oral | Diphtheria Toxoid - pharmacokinetics | Tetanus - prevention & control | Tetanus Toxoid - administration & dosage | Diphtheria Toxoid - administration & dosage | Liposomes - chemistry | Animals | Immunoglobulin A - immunology | Interferon-gamma - immunology | Mice | Mice, Inbred BALB C | Tetanus Toxoid - immunology | Tetanus Toxoid - pharmacokinetics | Immunoglobulin A - analysis | Interferon-gamma - blood | Interleukin-2 - blood
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3. Full Text Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds
by Grandjean, Philippe and Andersen, Elisabeth Wreford and Budtz-Jørgensen, Esben and Nielsen, Flemming and Mølbak, Kåre and Weihe, Pal and Heilmann, Carsten
JAMA, ISSN 0098-7484, 01/2012, Volume 307, Issue 4, pp. 391 - 397
CONTEXT Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent model at serum concentrations... 
PATHWAYS | MEDICINE, GENERAL & INTERNAL | TOXIN | NATIONAL-HEALTH | PERFLUOROOCTANE SULFONATE | MICE | POLYFLUOROALKYL COMPOUNDS | ANTITOXIN | Fluorocarbons - toxicity | Prenatal Exposure Delayed Effects | Prospective Studies | Food Contamination | Humans | Child, Preschool | Polychlorinated Biphenyls - blood | Seafood | Male | Diphtheria Toxoid - immunology | Milk, Human - chemistry | Maternal Exposure | Fluorocarbons - blood | Immunity, Humoral | Female | Odds Ratio | Child | Immunization | Immune Tolerance | Tetanus Toxoid - administration & dosage | Environmental Exposure - adverse effects | Pregnancy | Diphtheria Toxoid - administration & dosage | Antibody Formation - drug effects | Denmark | Tetanus Toxoid - immunology | Perfluorocarbons | Care and treatment | Immune response | Vaccination | Food poisoning | Causes of | Research | Health aspects | Methods
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4. Full Text Binding and cleavage (BINACLE) assay for the functional in vitro detection of tetanus toxin: Applicability as alternative method for the safety testing of tetanus toxoids during vaccine production
by Behrensdorf-Nicol, Heike A and Bonifas, Ursula and Hanschmann, Kay-Martin and Krämer, Beate and Weißer, Karin
Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 52, pp. 6247 - 6253
Highlights • BINACLE (combined BINding And CLEavage) assay detects active tetanus neurotoxin. • BINACLE represents an alternative method for safety testing of... 
Allergy and Immunology | Synaptobrevin | In vitro toxicity assay | Ganglioside GT1b | Toxoids | Tetanus neurotoxin | MEDICINE, RESEARCH & EXPERIMENTAL | NEUROTRANSMITTER RELEASE | IMMUNOLOGY | Tetanus Toxoid - isolation & purification | Toxoids - toxicity | Tetanus Toxoid - standards | Toxoids - metabolism | Sensitivity and Specificity | Tetanus Toxin - toxicity | Technology, Pharmaceutical - methods | Tetanus Toxin - metabolism | Tetanus Toxoid - adverse effects | Safety and security measures | Vaccines | Tetanus | Methods | Index Medicus
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5. Full Text A Conformational Change of C Fragment of Tetanus Neurotoxin Reduces Its Ganglioside-Binding Activity but Does Not Destroy Its Immunogenicity
by Rui Yu and Shaoqiong Yi and Changming Yu and Ting Fang and Shuling Liu and Ting Yu and Xiaohong Song and Ling Fu and Lihua Hou and Wei Chen
Clinical and Vaccine Immunology, ISSN 1556-6811, 10/2011, Volume 18, Issue 10, pp. 1668 - 1672
Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
INFECTIOUS DISEASES | TOXIN | RECEPTOR | MICROBIOLOGY | IMMUNOLOGY | PROTEINS | H-C | Antitoxins - blood | Immunoglobulin G - blood | Toxoids - toxicity | Toxoids - metabolism | Disulfides | Tetanus Toxin - toxicity | Metalloendopeptidases - metabolism | Toxoids - immunology | Tetanus Toxoid - chemistry | Gangliosides - metabolism | Toxoids - chemistry | Tetanus Toxin - immunology | Cell Line | Tetanus Toxoid - metabolism | Tetanus Toxin - chemistry | Rats | Tetanus - prevention & control | Metalloendopeptidases - immunology | Tetanus Toxoid - adverse effects | Metalloendopeptidases - toxicity | Animals | Metalloendopeptidases - chemistry | Survival Analysis | Protein Conformation | Mice | Mice, Inbred BALB C | Tetanus Toxin - metabolism | Tetanus Toxoid - immunology | Index Medicus | Vaccine Research
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6. Full Text Enhancement of cytokine‐driven NK cell IFN‐γ production after vaccination of HCMV infected Africans
by Darboe, Alansana and Danso, Ebrima and Clarke, Ed and Umesi, Ama and Touray, Ebrima and Wegmuller, Rita and Moore, Sophie E and Riley, Eleanor M and Goodier, Martin R
European Journal of Immunology, ISSN 0014-2980, 06/2017, Volume 47, Issue 6, pp. 1040 - 1050
Human cytomegalovirus (HCMV) infection drives the phenotypic and functional differentiation of NK cells, thereby influencing the responses of these cells after... 
DTPiP vaccine | NK cells | NKG2C | Influenza vaccine | Vaccination | NATURAL-KILLER-CELLS | ACTIVATION | RECEPTOR | IL-2 | IMMUNOLOGY | RESPONSES | HUMAN CYTOMEGALOVIRUS-INFECTION | DISEASE | DIFFERENTIATION | EXPRESSION | T-CELLS | Africa - epidemiology | Cytomegalovirus Infections - ethnology | Influenza Vaccines - administration & dosage | Interleukin-18 - immunology | Vaccine Potency | Humans | Middle Aged | Child, Preschool | Male | Cytomegalovirus Infections - immunology | Diphtheria Toxoid - immunology | Vaccines, Combined - administration & dosage | Vaccines, Combined - immunology | Young Adult | Immunization, Secondary | Interleukins - immunology | Lysosomal-Associated Membrane Protein 1 - immunology | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Adult | Female | Child | Interleukin-12 - pharmacology | Interleukin-2 Receptor alpha Subunit - immunology | Poliovirus Vaccines - administration & dosage | Tetanus Toxoid - administration & dosage | Cytomegalovirus - immunology | Influenza Vaccines - pharmacology | Diphtheria Toxoid - administration & dosage | Influenza Vaccines - immunology | Interferon-gamma - immunology | Adolescent | Interleukin-12 - immunology | Aged | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Poliovirus Vaccines - immunology | Tetanus Toxoid - immunology | Interferon-gamma - biosynthesis | Antigens | Immunization | Populations | Cytokines | Differentiation (biology) | Interleukin 12 | Stimulation | Exposure | Infections | Vaccines | Diphtheria | Interleukin 18 | Exploitation | Pertussis | NKG2 antigen | Cell activation | Influenza | CD25 antigen | Tetanus | Natural killer cells | In vitro methods and tests | Clinical | Immunity to infection
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7. Full Text Defining the optimal formulation and schedule of a candidate toxoid vaccine against Clostridium difficile infection: A randomized Phase 2 clinical trial
by de Bruyn, Guy and Saleh, Jamshid and Workman, David and Pollak, Richard and Elinoff, Victor and Fraser, Neil J and Lefebvre, Gigi and Martens, Mark and Mills, Richard E and Nathan, Richard and Trevino, Miguel and van Cleeff, Martin and Foglia, Ginamarie and Ozol-Godfrey, Ayca and Patel, Dhaval M and Pietrobon, Patricia J and Gesser, Richard and H-030-012 Clinical Investigator Study Team
Vaccine, ISSN 0264-410X, 2016, Volume 34, Issue 19, pp. 2170 - 2178
Abstract Background Clostridium difficile , a major cause of nosocomial and antibiotic-associated diarrhea, carries a significant disease and cost burden. This... 
Allergy and Immunology | Vaccine | Formulation | Schedule | Clostridium difficile | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Humans | Middle Aged | Toxoids - adverse effects | Bacterial Vaccines - adverse effects | Clostridium Infections - prevention & control | Seroconversion | Toxoids - administration & dosage | Toxoids - immunology | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Adult | Immunization Schedule | Aged | Antibodies, Bacterial - blood | Clinical trials | Diarrhea | Product development | Vaccines | Health aspects | Communicable diseases | Antigens | Medical research | Aluminum hydroxide | Medicine, Experimental | Rankings | Enzymes | Hepatitis | Laboratories | Toxins | Nosocomial infections
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8. Full Text Clinical Study of New Tetravalent (Type A, B, E, and F) Botulinum Toxoid Vaccine Derived from M Toxin in Japan
by Torii, Yasushi and Sugimoto, Nakaba and Kohda, Tomoko and Kozaki, Shunji and Morokuma, Kazunori and Horikawa, Yoshikane and Ginnaga, Akihiro and Yamamoto, Akihiko and Takahashi, Motohide
Japanese Journal of Infectious Diseases, ISSN 1344-6304, 2017, Volume 70, Issue 4, pp. 423 - 429
Botulinum toxin is the most poisonous substance known, and is believed to be a highly lethal as a biological weapon; researchers of the toxin are exposed to... 
clinical study | neutralizing antibody | botulinum toxoid vaccine | quality control tests | Botulinum toxoid vaccine | Neutralizing antibody | Clinical study | Quality control tests | WEAPON | INFECTIOUS DISEASES | CLOSTRIDIUM-BOTULINUM | Guinea Pigs | Antitoxins - blood | Enzyme-Linked Immunosorbent Assay | Humans | Japan | Middle Aged | Toxoids - adverse effects | Bacterial Vaccines - adverse effects | Male | Treatment Outcome | Healthy Volunteers | Bacterial Vaccines - isolation & purification | Toxoids - administration & dosage | Toxoids - immunology | Young Adult | Botulinum Toxins - immunology | Animals | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Adult | Female | Mice | Toxoids - isolation & purification | Botulism - prevention & control | Ethics | Immunogenicity | Biological warfare | Botulinum Toxin Type A | Quality control | Vaccines | Tetanus | Botulinum toxin | Guidelines
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9. Full Text Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
by Mitchell, Duane A and Batich, Kristen A and Gunn, Michael D and Huang, Min-Nung and Sanchez-Perez, Luis and Nair, Smita K and Congdon, Kendra L and Reap, Elizabeth A and Archer, Gary E and Desjardins, Annick and Friedman, Allan H and Friedman, Henry S and Herndon Ii, James E and Coan, April and McLendon, Roger E and Reardon, David A and Vredenburgh, James J and Bigner, Darell D and Sampson, John H
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7543, pp. 366 - 369
After stimulation, dendritic cells(DCs) mature andmigrate to draining lymph nodes to induce immune responses(1). As such, autologous DCs generated ex vivo have... 
MALIGNANT GLIOMA | RESPONSES | IMMUNITY | MULTIDISCIPLINARY SCIENCES | HUMAN CYTOMEGALOVIRUS | VACCINATION | PERIPHERAL-BLOOD | MELANOMA-CELLS | MIP-1-ALPHA | TUMORS | T-CELLS | Phosphoproteins - immunology | Immunotherapy - methods | Viral Matrix Proteins - genetics | Chemokine CCL3 - immunology | Dendritic Cells - immunology | Humans | Substrate Specificity | Phosphoproteins - chemistry | CD4-Positive T-Lymphocytes - immunology | Cancer Vaccines - therapeutic use | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Tetanus Toxoid - pharmacology | Antigens, Neoplasm - immunology | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Tetanus Toxoid - therapeutic use | Survival Rate | Treatment Outcome | Lymph Nodes - immunology | Phosphoproteins - genetics | Lymph Nodes - cytology | Tetanus Toxoid - administration & dosage | Glioblastoma - therapy | Cancer Vaccines - immunology | Cell Movement - drug effects | Animals | Glioblastoma - immunology | Viral Matrix Proteins - chemistry | Glioblastoma - pathology | Dendritic Cells - cytology | Mice | Viral Matrix Proteins - immunology | Glioblastoma - drug therapy | CD4-Positive T-Lymphocytes - drug effects | Medical research | Dendritic cells | Physiological aspects | Medicine, Experimental | Vaccines | Research | Glioblastoma multiforme | Immunization | Lymphocytes | Medical prognosis | Clinical trials | Tetanus | Chemokines
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10. Full Text Serum vaccine antibody concentrations in adolescents exposed to perfluorinated compounds
by Grandjean, Philippe and Heilmann, Carsten and Weihe, Pal and Nielsen, Flemming and Mogensen, Ulla B and Budtz-Jørgensen, Esben
Environmental Health Perspectives, ISSN 0091-6765, 07/2017, Volume 125, Issue 7, p. 077018
BACKGROUND: Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concentrations of specific antibodies against... 
ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PERFLUOROOCTANESULFONATE | PRENATAL EXPOSURE | IMMUNOTOXICITY | EARLY-CHILDHOOD | RISK | TOXICOLOGY | HEALTH | LIFE | Environmental Monitoring | Prospective Studies | Sulfonic Acids - blood | Humans | Male | Diphtheria Toxoid - immunology | Environmental Exposure | Environmental Pollutants - blood | Tetanus Toxoid - administration & dosage | Fluorocarbons - blood | Diphtheria Toxoid - administration & dosage | Adolescent | Denmark | Female | Antibodies, Bacterial - blood | Child | Tetanus Toxoid - immunology | Perfluorocarbons | Vaccination | Water pollution | Immunotoxicology | Research | Children | Health aspects | Adolescence | Statistical analysis | Immunotoxicity | Antibodies | Emergency medical care | Exposure | Vaccines | Regression analysis | Diphtheria | Epidemiology | Alkylation | Subgroups | Studies | Perfluoro compounds | Tetanus | Adolescents | Emergency medical services | Age
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11. Full Text Microneedle-based transcutaneous immunisation in mice with n-trimethyl chitosan adjuvanted diphtheria toxoid formulations
by Bal, Suzanne M and Ding, Zhi and Kersten, Gideon F. A and Jiskoot, Wim and Bouwstra, Joke A
Pharmaceutical Research, ISSN 0724-8741, 09/2010, Volume 27, Issue 9, pp. 1837 - 1847
Purpose The purpose of this study was to gain insight into the delivery and immunogenicity of N-trimethyl chitosan (TMC) adjuvanted diphtheria toxoid (DT)... 
microneedles | nanoparticles | transcutaneous immunisation | diphtheria toxoid | trimethyl chitosan (TMC) | HUMAN SKIN | DRUG-DELIVERY | INFLUENZA | EPICUTANEOUS IMMUNIZATION | CHEMISTRY, MULTIDISCIPLINARY | EPIDERMAL LANGERHANS CELLS | HEALTHY-ADULTS | IMMUNE-RESPONSES | IN-VIVO | PHARMACOLOGY & PHARMACY | LANGERIN(+) DENDRITIC CELLS | Immunoglobulin G - blood | Skin - metabolism | Cercopithecus aethiops | Administration, Cutaneous | Diphtheria Toxoid - immunology | Equipment Design | Drug Carriers - chemistry | Vaccination - methods | Chemical Phenomena | Female | Needles | Adjuvants, Pharmaceutic - chemistry | Vero Cells | Injections, Intradermal | Diphtheria Toxoid - pharmacokinetics | Mice, Hairless | Microscopy, Confocal | Diphtheria Toxoid - administration & dosage | Animals | Chitosan - chemistry | Diphtheria Toxoid - chemistry | Vaccination - instrumentation | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Drugs | Virus diseases | Drug delivery systems | Biological products | Vaccination | Immunoglobulin G | Ophthalmology | Diphtheria | Vehicles | Nanoparticles | Immunization | Pharmacology | Microscopy | Rodents | Research Paper
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12. Full Text Induction of potential protective immunity against enterotoxemia in calves by single or multiple recombinant Clostridium perfringens toxoids
by Jiang, Zhigang and De, Yanyan and Chang, Jitao and Wang, Fang and Yu, Li
Microbiology and Immunology, ISSN 0385-5600, 11/2014, Volume 58, Issue 11, pp. 621 - 627
Cattle enterotoxemia caused by Clostridium perfringens toxins is a noncontagious, sporadic, and fatal disease characterized by sudden death. Strategies for... 
neutralizing antibody | enterotoxemia | recombinant toxoid | calf | Clostridium perfringens | Recombinant toxoid | Enterotoxemia | Neutralizing antibody | Calf | VACCINE | CATTLE | ALPHA-TOXIN | MICROBIOLOGY | NEONATAL CALVES | IMMUNOLOGY | EPSILON-TOXIN | IMMUNIZATION | PURIFICATION | MICE | Cattle Diseases - prevention & control | Clostridium Infections - veterinary | Gene Expression | Antitoxins - blood | Immunoglobulin G - blood | Recombinant Proteins - genetics | Clostridium Infections - prevention & control | Enterotoxemia - prevention & control | Recombinant Proteins - administration & dosage | Toxoids - administration & dosage | Toxoids - immunology | Recombinant Proteins - isolation & purification | Animals | Recombinant Proteins - immunology | Cattle | Clostridium perfringens - genetics | Escherichia coli - genetics | Toxoids - genetics | Female | Toxoids - isolation & purification | Clostridium perfringens - immunology | Antibodies, Bacterial - blood | Antibodies, Neutralizing - blood | Biological products | Gram-positive bacteria | Medical research | Vaccines
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13. Full Text A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile
by Donald, Robert G. K and Flint, Mike and Kalyan, Narender and Johnson, Erik and Witko, Susan E and Kotash, Cheryl and Zhao, Ping and Megati, Shakuntala and Yurgelonis, Irina and Lee, Phillip Kwok and Matsuka, Yury V and Severina, Elena and Deatly, Anne and Sidhu, Mini and Jansen, Kathrin U and Minton, Nigel P and Anderson, Annaliesa S
Microbiology (United Kingdom), ISSN 1350-0872, 07/2013, Volume 159, Issue 7, pp. 1254 - 1266
The Clostridium difficile toxins A and B are primarily responsible for symptoms of C. difficile associated disease and are prime targets for vaccine... 
SYSTEM | TOXIN-B | FIDAXOMICIN | HAMSTERS | MICROBIOLOGY | PORE FORMATION | INFECTION | CLOSTRON | CLEAVAGE | INTESTINAL EPITHELIAL-CELLS | INSIGHTS | Bacterial Vaccines - genetics | Clostridium difficile - immunology | Humans | Clostridium difficile - genetics | Enterocolitis, Pseudomembranous - microbiology | Vaccines, Synthetic - immunology | Toxoids - administration & dosage | Toxoids - immunology | Clostridium Infections - microbiology | Enterocolitis, Pseudomembranous - immunology | Bacterial Toxins - genetics | Enterocolitis, Pseudomembranous - prevention & control | Cell Line | Cricetinae | Vaccines, Synthetic - genetics | Bacterial Proteins - genetics | Clostridium Infections - prevention & control | Clostridium Infections - immunology | Enterotoxins - genetics | Animals | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Toxoids - genetics | Antibodies, Bacterial - immunology | Mutation | Vaccines, Synthetic - administration & dosage | Biological products industry | Usage | Product development | Research | Bacterial vaccines | Clostridium difficile | Index Medicus | Synthetic Biology | Standard
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