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polymerase chain reaction (27) 27
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thiopurines (26) 26
adverse drug-reactions (25) 25
biochemical-properties (25) 25
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azathioprine-induced myelosuppression (24) 24
medicine, general & internal (24) 24
risk factors (24) 24
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cancer (22) 22
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1. Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT∗3 alleles
by Urbančič, Dunja and Šmid, Alenka and Stocco, Gabriele and Decorti, Giuliana and Mlinarič-Raščan, Irena and Karas Kuželički, Nataša
Pharmacogenomics, ISSN 1462-2416, 11/2018, Volume 19, Issue 17, pp. 1311 - 1322
thiopurine S-methyltransferase | lymphoblastoid cell lines | TPMT activity | TPMT | acute lymphoblastic leukemia | variable number of tandem repeats | genetic polymorphisms | inflammatory bowel disease | VNTR | linkage disequilibrium
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2. The analysis of the association of the polymorphic variants of the TPMT, COMT, and ABCC3 genes with the development of hearing disorders induced by the cisplatin treatment
by Mironovich, O.L and Bliznetz, E.A and Garbaruk, E.S and Belogurova, M.B and Subora, N.V and Varfolomeeva, S.R and Kachanov, D.Y.U and Shamanskaya, T.V and Markova, T.G and Polyakov, A.V
Vestnik Otorinolaringologii, ISSN 0042-4668, 2018, Volume 83, Issue 4, pp. 60 - 66
ABCC3 | TPMT | COMT | Ototoxicirty | Cisplatin
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3. Full Text Assessment of methods for predicting the effects of PTEN and TPMT protein variants
by Pejaver, Vikas and Babbi, Giulia and Casadio, Rita and Folkman, Lukas and Katsonis, Panagiotis and Kundu, Kunal and Lichtarge, Olivier and Martelli, Pier Luigi and Miller, Maximilian and Moult, John and Pal, Lipika R and Savojardo, Castrense and Yin, Yizhou and Zhou, Yaoqi and Radivojac, Predrag and Bromberg, Yana
Human Mutation, ISSN 1059-7794, 09/2019, Volume 40, Issue 9, pp. 1495 - 1506
Thermodynamic stability is a fundamental property shared by all proteins. Changes in stability due to mutation are a widespread molecular mechanism in genetic... 
variant stability profiling | phosphatase and tensin homolog, PTEN | VAMP‐seq | thiopurine S‐methyl transferase, TPMT | CAGI | MUTAGENESIS | TPMT | PTEN | STABILITY CHANGES | MISSENSE VARIANT | phosphatase and tensin homolog | thiopurine S-methyl transferase | PATHOGENICITY | THERMODYNAMICS | SEQUENCE | MUTATION | GENETICS & HEREDITY | VAMP-seq | BINDING | WEB SERVER | Proteins | Phosphatases | Analysis | Genomics | Methods | Genomes | Mutation | PTEN protein | Computer applications
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4. Full Text Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: A worldwide survey of experts
by Roblin, Xavier and Oussalah, Abderrahim and Chevaux, Jean‐Baptiste and Sparrow, Miles and Peyrin‐Biroulet, Laurent
Inflammatory Bowel Diseases, ISSN 1078-0998, 12/2011, Volume 17, Issue 12, pp. 2480 - 2487
Background: We performed a worldwide survey to evaluate the extent to which gastroenterologists who are experts in the field of inflammatory bowel diseases... 
6‐methylmercaptopurine ribonucleotides (6‐MMP) | mercaptopurine | thiopurines | inflammatory bowel diseases (IBD) | 6‐thioguanine nucleotides (6‐TGN) | azathioprine | survey | thiopurine S‐methyltransferase (TPMT) | thiopurine S-methyltransferase (TPMT) | 6-thioguanine nucleotides (6-TGN) | 6-methylmercaptopurine ribonucleotides (6-MMP) | CROHNS-DISEASE | TPMT | ULCERATIVE-COLITIS | METHYLTRANSFERASE ACTIVITY | 6-MERCAPTOPURINE | ALLOPURINOL | TRIAL | AZATHIOPRINE THERAPY | GASTROENTEROLOGY & HEPATOLOGY | Inflammatory Bowel Diseases - drug therapy | Azathioprine - administration & dosage | Genetic Testing | Cross-Sectional Studies | Global Health | Humans | Biomarkers - analysis | Inflammatory Bowel Diseases - diagnosis | Mercaptopurine - administration & dosage | Methyltransferases - genetics | Genotype | Practice Patterns, Physicians | Phenotype | Gastroenterology | Inflammatory Bowel Diseases - genetics | Surveys and Questionnaires | Mercaptopurine - analogs & derivatives | Inflammatory bowel diseases | Inventories | Metabolites | Intestine | ribonucleotides | Thiopurine S-methyltransferase | Nucleotides | Genotypes | Public health
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5. Genetic predictors of azathioprine toxicity and clinical response in patients with inflammatory bowel disease
by Al-Judaibi, B and Schwarz, U.I and Huda, N and Dresser, G.K and Gregor, J.C and Ponich, T and Chande, N and Mosli, M and Kim, R.B
Journal of Population Therapeutics and Clinical Pharmacology, ISSN 1710-6222, 02/2016, Volume 23, Issue 1, pp. e26 - e36
Inflammatory bowel disease | GSTM1 | TPMT | Azathioprine | ITPA
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6. Full Text Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden
by Zimdahl Kahlin, Anna and Helander, Sara and Skoglund, Karin and Söderkvist, Peter and Mårtensson, Lars-Göran and Appell, Malin Lindqvist
Biochemical Pharmacology, ISSN 0006-2952, 06/2019, Volume 164, pp. 263 - 272
Thiopurines are widely used in the treatment of leukemia and inflammatory bowel diseases. Thiopurine metabolism varies among individuals because of differences... 
Individualization | Pharmacogenetics | TPMT | Genotyping | Thiopurine | Gastrointestinal diseases | Transferases | Leukemia | Physiological aspects | Genetic research | Genetic aspects | Cells
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7. Full Text Development of duplex-crossed allele-specific PCR targeting of TPMT3B and 3C using crossed allele-specific blockers to eliminate non-specific amplification
by Qu, Xue-Mei and Zhao, Na and Mo, Qin-Yun and Yao, Pu and Su, Ning and Wei, Kun and Wang, Liu and Huang, Jun-Fu and Huang, Qing and Ren, Xiao-Dong and Ren, Sai and Fu, Wei-Ling
Analytical Biochemistry, ISSN 0003-2697, 06/2019, Volume 575, pp. 54 - 62
Prospective testing for variants in the thiopurine -methyltransferase (TPMT) is considered a key process in the development of thiopurine therapy. This testing... 
Allele-specific PCR | Ethnic Chinese | Thiopurines | TPMT genes | Genotypes | Medical colleges
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8. Full Text Thiopurine S-methyltransferase assay by HPLC in acute lymphoblastic leukemia patients and a healthy Iranian population
by Mozafari, Sima and Einollahi, Nahid and Shahgholi, Elham and Vardasbi, Safoura and Golestani, Abolfazl
Acta Medica Iranica, ISSN 0044-6025, 2018, Volume 56, Issue 5, pp. 301 - 307
Thiopurine s-methyltransferase (TPMT) plays a key role in the metabolism of the drug; 6-MP in children with acute lymphoblastic leukemia (ALL). The wild-type... 
ALL | 6-MP | TPMT | HPLC | 6-MMP | Enzymes | Leukemia
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9. Full Text Individualized Therapy: Role of Thiopurine S-Methyltransferase Protein and Genetic Variants
by Pavlović, Sonja and Zukić, Branka
Journal of Medical Biochemistry, ISSN 1452-8258, 7/2010, Volume 29, Issue 3, pp. 150 - 156
Thiopurine S-methyltransferase (TPMT: EC 2.1.1.67) is an enzyme that metabolizes immunosuppressive thiopurine medications, used in the treatment of autoimmune... 
TPMT allozyme | VNTR u promotoru gena za TPMT | TPMT gene polymorphisms | VNTR in TPMT gene promoter | polimorfizmi u genu za TPMT | alozimi TPMT | pharmacogenetics | farmakogenetika | POPULATION | TPMT | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYMORPHISM | TANDEM REPEAT | ACTIVITY PHENOTYPE | VARIABLE NUMBER | ACUTE LYMPHOBLASTIC-LEUKEMIA | PROMOTER REGION | ALLOZYME DEGRADATION
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10. Full Text Azathioprine/6-mercaptopurinetoxicity: The role of the TPMT gene
by Katsanos, K.H and Tsianos, Epameinondas V
Annals of Gastroenterology, ISSN 1108-7471, 2007, Volume 20, Issue 4, pp. 251 - 264
Inflammatory bowel disease | Prevalence | Single nucleotide polymorphism | Toxicity | AZA/6-MP | TPMT gene
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11. Full Text American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease
by Feuerstein, Joseph D and Nguyen, Geoffrey C and Kupfer, Sonia S and Falck-Ytter, Yngve and Singh, Siddharth and Gerson, Lauren and Hirano, Ikuo and Rubenstein, Joel H and Smalley, Walter E and Stollman, Neil and Sultan, Shahnaz and Vege, Santhi S and Wani, Sachin B and Weinberg, David and Yang, Yu-Xiao and Amer Gastroenterological Assoc and American Gastroenterological Association Institute Clinical Guidelines Committee
Gastroenterology, ISSN 0016-5085, 09/2017, Volume 153, Issue 3, pp. 827 - 834
RCT | TPMT | CBC | 6-TGN | IBD | TNF | inflammatory bowel disease | relative risk | 6-thioguanine | complete blood count | randomized controlled trial | thiopurine methyltransferase | Grading of Recommendations Assessment, Development and Evaluation | tumor necrosis factor | GRADE | confidence interval | AGA | TDM | American Gastroenterological Association | therapeutic drug monitoring | ANTIBODIES | IMPROVE OUTCOMES | INFLIXIMAB TROUGH LEVELS | COST | CROHNS-DISEASE | ADALIMUMAB | AZATHIOPRINE | GASTROENTEROLOGY & HEPATOLOGY | FAILURE | REMISSION | Health aspects | Continuing medical education | Gastrointestinal diseases
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12. Full Text Characterisation of novel defective thiopurine S-methyltransferase allelic variants
by Garat, A and Cauffiez, C and Renault, N and Lo-Guidice, J.M and Allorge, D and Chevalier, D and Houdret, N and Chavatte, P and Loriot, M.A and Gala, J.L and Broly, F
Biochemical Pharmacology, ISSN 0006-2952, 2008, Volume 76, Issue 3, pp. 404 - 415
Human thiopurine -methyltransferase (TPMT, EC 2.1.1.67) is a key enzyme in the detoxification of thiopurine drugs widely used in the treatment of various... 
Thiopurine drugs | Molecular modeling | HPLC | TPMT genetic polymorphism | Heterologous expression | GENETIC-POLYMORPHISM | ENZYME-ACTIVITY | TPMT | AZATHIOPRINE | heterologous expression | TANDEM REPEAT | IDENTIFICATION | DEFICIENCY | thiopurine drugs | molecular modeling | CATALYTIC ACTIVITY | TPMT-ASTERISK-3A | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | Saccharomyces cerevisiae - genetics | Humans | Methyltransferases - genetics | Molecular Sequence Data | Crystallography, X-Ray | Mutation, Missense | Leukocytes - enzymology | 5' Flanking Region - genetics | Base Sequence | Amino Acid Sequence | Methyltransferases - chemistry | European Continental Ancestry Group - genetics | Mutagenesis, Site-Directed | Purines - pharmacokinetics | Models, Molecular | Genotype | Reverse Transcriptase Polymerase Chain Reaction | Polymorphism, Genetic | DNA - genetics | Sequence Alignment | Animals | Alleles | Saccharomyces cerevisiae - enzymology | Inactivation, Metabolic - genetics | Leukocytes - metabolism | Amino Acid Substitution | Index Medicus
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13. Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT3 alleles
by Urbancic, D and Smid, A and Stocco, G and Decorti, G and Mlinaric-Rascan, I and Kuzelicki, NK
PHARMACOGENOMICS, ISSN 1462-2416, 11/2018, Volume 19, Issue 17, pp. 1311 - 1322
Aim: SNPs in the gene for TPMT exemplify one of the most successful translations of pharmacogenomics into clinical practice. This study explains the... 
thiopurine S-methyltransferase | POPULATION | TPMT | THIOPURINE METHYLTRANSFERASE GENE | AZATHIOPRINE | 6-THIOGUANINE NUCLEOTIDE LEVELS | POLYMORPHISM | genetic polymorphisms | inflammatory bowel disease | lymphoblastoid cell lines | TPMT activity | acute lymphoblastic leukemia | PHENOTYPE CORRELATION | PEDIATRIC-PATIENTS | PHARMACOLOGY & PHARMACY | PHARMACOGENETICS | variable number of tandem repeats | INHERITANCE | VNTR | LYMPHOBLASTIC-LEUKEMIA | linkage disequilibrium
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14. Full Text Nonlinear H∞ Filtering Based on Tensor Product Model Transformation
by Gong, Hengheng and Yu, Yin and Zheng, Lini and Wang, Binglei and Li, Zhen and Fernando, Tyrone and Iu, Herbert H. C and Liao, Xiaozhong and Liu, Xiangdong
IEEE Transactions on Circuits and Systems II: Express Briefs, ISSN 1549-7747, 7/2019, pp. 1 - 1
The nonlinear H∞ filter design is always a desirable solution for nonlinear systems with noise of non-Gaussian or unknown distribution. This paper proposes a... 
polytopic linearization | Nonlinear system | H∞ filtering | tensor product model transformation (TPMT)
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15. Full Text Oral azathioprine for recalcitrant pediatric atopic dermatitis: Clinical response and thiopurine monitoring
by Caufield, Maura, BA and Tom, Wynnis L., MD
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2012, Volume 68, Issue 1, pp. 29 - 35
Background Azathioprine is prescribed as a corticosteroid-sparing agent for many inflammatory conditions, including refractory atopic dermatitis (AD). There... 
Dermatology | thiopurine methyltransferase | thiopurine metabolites | eczema | atopic dermatitis | azathioprine | monitoring | pediatric | EFFICACY | METHYLTRANSFERASE ACTIVITY | VARIANT | CHILDREN | DERMATOLOGY | TPMT-ASTERISK-28 | TRIAL | INFLAMMATORY-BOWEL-DISEASE | TPMT DEFICIENCY | DOUBLE-BLIND | Mercaptopurine - blood | Severity of Illness Index | Guanine Nucleotides - blood | Azathioprine - therapeutic use | Dermatitis, Atopic - genetics | Azathioprine - metabolism | Prospective Studies | Thionucleotides - blood | Administration, Oral | Dermatitis, Atopic - enzymology | Humans | Immunosuppressive Agents - therapeutic use | Child, Preschool | Male | Methyltransferases - blood | Dermatitis, Atopic - drug therapy | Adolescent | Immunosuppressive Agents - metabolism | Female | Immunosuppressive Agents - adverse effects | Azathioprine - adverse effects | Child | Mercaptopurine - analogs & derivatives | Pediatrics | Medical colleges | Children | Azathioprine | Atopic dermatitis | Health aspects
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16. Full Text Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing
by Relling, MV and Gardner, EE and Sandborn, WJ and Schmiegelow, K and Pui, C‐H and Yee, SW and Stein, CM and Carrillo, M and Evans, WE and Klein, TE and Clinical Pharmacogenetics Implementation Consortium
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 03/2011, Volume 89, Issue 3, pp. 387 - 391
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co‐dominant inheritance, with ethnic differences in the frequency of occurrence of variant... 
6-MERCAPTOPURINE | S-METHYLTRANSFERASE | GENETIC-POLYMORPHISM | THERAPY | MERCAPTOPURINE METABOLISM | TPMT | ACUTE LYMPHOBLASTIC-LEUKEMIA | AZATHIOPRINE | PHARMACOLOGY & PHARMACY | TOXICITY | DEFICIENCY | Azathioprine - administration & dosage | Azathioprine - metabolism | Humans | Methyltransferases - metabolism | Mercaptopurine - administration & dosage | Mercaptopurine - adverse effects | Methyltransferases - genetics | Thioguanine - metabolism | Genotype | Antimetabolites, Antineoplastic - administration & dosage | Thioguanine - adverse effects | Dose-Response Relationship, Drug | Thioguanine - administration & dosage | Antimetabolites, Antineoplastic - adverse effects | Mercaptopurine - metabolism | Immunosuppressive Agents - metabolism | Immunosuppressive Agents - adverse effects | Azathioprine - adverse effects | Antimetabolites, Antineoplastic - metabolism | Immunosuppressive Agents - administration & dosage | Genetic aspects | Dosage and administration | Methyltransferases | Azathioprine | Thioguanine | Mercaptopurine | Index Medicus | Abridged Index Medicus
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17. Full Text Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate
by Rieger, Hannah and Schmidt, Patrik and Schaeffeler, Elke and Abe, Manabu and Schiffhauer, Mira and Schwab, Matthias and von Ahsen, Nicolas and Zurek, Gabriela and Kirchherr, Hartmut and Shipkova, Maria and Wieland, Eberhard
Clinical Chemistry and Laboratory Medicine (CCLM), ISSN 1434-6621, 04/2018, Volume 56, Issue 5, pp. 803 - 809
Background: Variation in metabolism, toxicity and therapeutic efficacy of thiopurine drugs is largely influenced by genetic polymorphisms in the thiopurine... 
6-MP | drug therapy | whole-blood | phenotype-genotype concordance | thiopurine | hematocrit | thiopurine methyltransferase (TPMT) | genetic polymorphism | HPLC | pharmacogenetics | POPULATION | ENZYME-ACTIVITY | TPMT | VARIANTS | DRUG-INTERACTIONS | PHENOTYPE | AZATHIOPRINE | ISOLATED HUMAN ERYTHROCYTES | MERCAPTOPURINE | MEDICAL LABORATORY TECHNOLOGY | Phenotype | Humans | Methyltransferases - metabolism | Mercaptopurine - metabolism | Methyltransferases - genetics | Substrate Specificity | Genotype | Chromatography, High Pressure Liquid | Healthy Volunteers | Methyltransferases - blood | Mercaptopurine - analogs & derivatives | Mercaptopurine - chemistry | Index Medicus
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18. Full Text Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine
by Lee, Mi-Na and Kang, Ben and Choi, So Yoon and Kim, Mi Jin and Woo, Sook Young and Kim, Jong-Won and Choe, Yon Ho and Lee, Soo-Youn
Inflammatory Bowel Diseases, ISSN 1078-0998, 08/2015, Volume 21, Issue 12, pp. 2897 - 2908
Background:Thiopurine-related toxicity results in discontinuation of therapy in up to 30% of patients with inflammatory bowel disease. Although thiopurine... 
azathioprine | TPMT | polymorphisms | inflammatory bowel disease | pediatric | MESSENGER-RNA EXPRESSION | THIOPURINE-INDUCED LEUKOPENIA | METABOLITE CONCENTRATIONS | TPMT ACTIVITY | METHYLTRANSFERASE GENOTYPE | HUMAN NORMAL LYMPHOCYTES | INFLAMMATORY-BOWEL-DISEASE | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | COLORECTAL-CANCER PATIENTS | ACUTE LYMPHOBLASTIC-LEUKEMIA | GASTROENTEROLOGY & HEPATOLOGY | Crohn Disease - genetics | Guanine Nucleotides - blood | Azathioprine - pharmacokinetics | Humans | Immunosuppressive Agents - pharmacokinetics | Colitis, Ulcerative - genetics | Methyltransferases - genetics | Male | Dose-Response Relationship, Drug | Inflammatory Bowel Diseases - genetics | Leukopenia - chemically induced | Female | Retrospective Studies | Colitis, Ulcerative - drug therapy | Inflammatory Bowel Diseases - drug therapy | Thionucleotides - blood | Genotype | Inflammatory Bowel Diseases - blood | Colitis, Ulcerative - blood | Polymorphism, Genetic - drug effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Crohn Disease - blood | Crohn Disease - drug therapy | Adolescent | Mesalamine - therapeutic use | Immunosuppressive Agents - adverse effects | Azathioprine - adverse effects | Index Medicus
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19. Full Text Pharmacogenomics of Cisplatin‐Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research
by Drögemöller, Britt I and Wright, Galen E.B and Lo, Cody and Le, Tan and Brooks, Beth and Bhavsar, Amit P and Rassekh, Shahrad R and Ross, Colin J.D and Carleton, Bruce C
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 08/2019, Volume 106, Issue 2, pp. 350 - 359
Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin‐induced ototoxicity ( CIO ). Substantial research has been... 
DIABETES-MELLITUS | CHILDHOOD-CANCER | WFS1 GENE | RISK-FACTORS | SENSORINEURAL HEARING-LOSS | VARIANTS | TPMT | COMT GENETIC-VARIATION | WOLFRAM-SYNDROME | PHARMACOLOGY & PHARMACY | CHILDREN
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