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tpmt (212) 212
science & technology (196) 196
life sciences & biomedicine (193) 193
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methyltransferases - genetics (122) 122
azathioprine (111) 111
pharmacogenetics (109) 109
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6-mercaptopurine (61) 61
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methyltransferases - metabolism (58) 58
thiopurine methyltransferase (58) 58
polymorphism, genetic (52) 52
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thiopurine s-methyltransferase (51) 51
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azathioprine - therapeutic use (32) 32
genetic aspects (31) 31
enzymes (29) 29
gastroenterology & hepatology (29) 29
thiopurine (29) 29
aged (28) 28
pharmacogenomics (28) 28
tpmt activity (28) 28
gene frequency (27) 27
inflammatory bowel diseases - drug therapy (27) 27
mercaptopurine - therapeutic use (27) 27
polymorphism (27) 27
acute lymphoblastic leukemia (26) 26
genetics & heredity (26) 26
mercaptopurine (26) 26
mutation (26) 26
toxicity (26) 26
crohn's disease (25) 25
immunosuppressive agents - therapeutic use (24) 24
metabolites (23) 23
young adult (23) 23
immunosuppressive agents - adverse effects (21) 21
leukemia (21) 21
oncology (21) 21
pharmacology (21) 21
transferases (21) 21
genetic variation (20) 20
methyltransferases - blood (20) 20
pediatrics (20) 20
retrospective studies (20) 20
analysis (19) 19
ulcerative colitis (19) 19
child, preschool (18) 18
erythrocytes - enzymology (18) 18
genetic polymorphism (18) 18
medical laboratory technology (18) 18
polymorphism, single nucleotide (18) 18
precursor cell lymphoblastic leukemia-lymphoma - genetics (18) 18
thioguanine (18) 18
drug therapy (17) 17
mercaptopurine - adverse effects (17) 17
nudt15 (17) 17
physiological aspects (17) 17
research (17) 17
thiopurines (17) 17
treatment outcome (17) 17
6-mp (16) 16
6-thioguanine (16) 16
biotechnology & applied microbiology (16) 16
crohn disease - drug therapy (16) 16
drugs (16) 16
health aspects (16) 16
mercaptopurine - metabolism (16) 16
polymerase chain reaction (16) 16
pyrophosphatases - genetics (16) 16
risk factors (16) 16
toxicology (16) 16
animals (15) 15
azathioprine - administration & dosage (15) 15
biochemistry & molecular biology (15) 15
dose-response relationship, drug (15) 15
genotyping (15) 15
hematology (15) 15
tpmt gene (15) 15
genotype & phenotype (14) 14
heterozygote (14) 14
precursor cell lymphoblastic leukemia-lymphoma - drug therapy (14) 14
abridged index medicus (13) 13
genetic polymorphisms (13) 13
genetic research (13) 13
genetics (13) 13
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ugt1a1 (13) 13
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1. Full Text Assessment of methods for predicting the effects of PTEN and TPMT protein variants
by Pejaver, Vikas and Babbi, Giulia and Casadio, Rita and Folkman, Lukas and Katsonis, Panagiotis and Kundu, Kunal and Lichtarge, Olivier and Martelli, Pier Luigi and Miller, Maximilian and Moult, John and Pal, Lipika R and Savojardo, Castrense and Yin, Yizhou and Zhou, Yaoqi and Radivojac, Predrag and Bromberg, Yana
Human mutation, ISSN 1059-7794, 09/2019, Volume 40, Issue 9, pp. 1495 - 1506
variant stability profiling | phosphatase and tensin homolog, PTEN | VAMP‐seq | thiopurine S‐methyl transferase, TPMT | CAGI | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Methyltransferases - chemistry | PTEN Phosphohydrolase - genetics | Computational Biology - methods | Humans | Methyltransferases - genetics | High-Throughput Nucleotide Sequencing | Mutation | Protein Stability | PTEN Phosphohydrolase - chemistry | Proteins | Phosphatases | Analysis | Genomics | Methods | Genomes | PTEN protein | Computer applications | Index Medicus | TPMT | Phosphatase and tensin homolog | PTEN | Thiopurine S-methyl transferase | VAMP-seq
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2. Full Text Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review
by Loit, Evelin and Tricco, Andrea C and Tsouros, Sophia and Sears, Margaret and Ansari, Mohammed T and Booth, Ronald A
Clinical biochemistry, ISSN 0009-9120, 2011, Volume 44, Issue 10, pp. 751 - 757
Thiopurine S-methyltransferase | Stability | TPMT | Analytic variability | Life Sciences & Biomedicine | Medical Laboratory Technology | Science & Technology | Biological and medical sciences | Investigative techniques, diagnostic techniques (general aspects) | Medical sciences | Mercaptopurine - pharmacology | Thioguanine - pharmacology | Purines - pharmacology | Humans | Methyltransferases - metabolism | Aging - drug effects | Hematocrit | Mercaptopurine - adverse effects | Azathioprine - pharmacology | Enzyme Stability - drug effects | Sex Characteristics | Methyltransferases - analysis | Prescription Drugs - adverse effects | Thioguanine - adverse effects | Prescription Drugs - pharmacology | Purines - adverse effects | Azathioprine - adverse effects | Health Care Surveys | Index Medicus
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3. Full Text American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease
by Feuerstein, Joseph D and Nguyen, Geoffrey C and Kupfer, Sonia S and Falck-Ytter, Yngve and Singh, Siddharth and Gerson, Lauren and Hirano, Ikuo and Nguyen, Geoffrey C and Rubenstein, Joel H and Smalley, Walter E and Stollman, Neil and Sultan, Shahnaz and Vege, Santhi S and Wani, Sachin B and Weinberg, David and Yang, Yu-Xiao and American Gastroenterological Association Institute Clinical Guidelines Committee and Amer Gastroenterological Assoc
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2017, Volume 153, Issue 3, pp. 827 - 834
RCT | TPMT | CBC | 6-TGN | IBD | TNF | inflammatory bowel disease | relative risk | 6-thioguanine | complete blood count | randomized controlled trial | thiopurine methyltransferase | Grading of Recommendations Assessment, Development and Evaluation | tumor necrosis factor | GRADE | confidence interval | AGA | TDM | American Gastroenterological Association | therapeutic drug monitoring | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Health aspects | Continuing medical education | Gastrointestinal diseases | Index Medicus | Abridged Index Medicus
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4. Full Text Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia
by Burgueno-Rodriguez, Gabriela and Mendez, Yessika and Olano, Natalia and Dabezies, Agustin and Bertoni, Bernardo and Souto, Jorge and Castillo, Luis and da Luz, Julio and Soler, Ana Maria
Frontiers in pharmacology, ISSN 1663-9812, 11/2020, Volume 11, pp. 594262 - 594262
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Genetic aspects | Acute lymphocytic leukemia | 6-MP | TPMT-VNTR | TPMT | NUDT15 | Acute Lymphoblastic Leukemia | Pharmacogenomics
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5. Full Text ALL-051: The Influence of Thiopurine Methyltransferase Gene Polymorphism on Egyptian Children with Acute Lymphoblastic Leukaemia
by Adly, Amira and Tantawy, Azza and El-Ghoroury, Eman and Mostafa, Mai and Ebeid, Fatma
Clinical lymphoma, myeloma and leukemia, ISSN 2152-2650, 09/2020, Volume 20, pp. S160 - S160
ALL | thiopurine methyltransferase gene polymorphism | Egyptian children | TPMT | acute lymphoblastic leukemia
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6. Full Text NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series
by Devasia, Anup J and Illangeswaran, Raveen Stephen Stallon and Raj, Infencia Xavier and George, Biju and Balasubramanian, Poonkuzhali
Drug metabolism and personalized therapy, ISSN 2363-8907, 08/2020, Volume 35, Issue 4
azathioprine | polymorphism | thiopurine methyltransferase (TPMT) | NUDT15
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7. Full Text Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update
by Relling, Mary V and Schwab, Matthias and Whirl‐Carrillo, Michelle and Suarez‐Kurtz, Guilherme and Pui, Ching‐Hon and Stein, Charles M and Moyer, Ann M and Evans, William E and Klein, Teri E and Antillon‐Klussmann, Federico Guillermo and Caudle, Kelly E and Kato, Motohiro and Yeoh, Allen E.J and Schmiegelow, Kjeld and Yang, Jun J
Clinical pharmacology and therapeutics, ISSN 0009-9236, 05/2019, Volume 105, Issue 5, pp. 1095 - 1105
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Azathioprine - administration & dosage | Pharmacogenetics | Antimetabolites, Antineoplastic - pharmacokinetics | Azathioprine - pharmacokinetics | Humans | Mercaptopurine - administration & dosage | Methyltransferases - genetics | Pyrophosphatases - genetics | Pharmacogenomic Testing | Antimetabolites, Antineoplastic - administration & dosage | Dose-Response Relationship, Drug | Drug Dosage Calculations | Thioguanine - administration & dosage | Thioguanine - pharmacokinetics | Inactivation, Metabolic - genetics | Mercaptopurine - pharmacokinetics | Index Medicus | Abridged Index Medicus | TPMT | mercaptopurine | thiopurine | thioguanine | genetic testing | CPIC | azathioprine | NUDT15 | pharmacogenetics
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8. Full Text Thiopurine S-methyltransferase assay by HPLC in acute lymphoblastic leukemia patients and a healthy Iranian population
by Mozafari, Sima and Einollahi, Nahid and Shahgholi, Elham and Vardasbi, Safoura and Golestani, Abolfazl
Acta medica Iranica, ISSN 0044-6025, 2018, Volume 56, Issue 5, pp. 301 - 307
ALL | 6-MP | TPMT | HPLC | 6-MMP | Enzymes | Leukemia
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9. Full Text Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden
by Zimdahl Kahlin, Anna and Helander, Sara and Skoglund, Karin and Söderkvist, Peter and Mårtensson, Lars-Göran and Appell, Malin Lindqvist
Biochemical pharmacology, ISSN 0006-2952, 06/2019, Volume 164, pp. 263 - 272
Individualization | Pharmacogenetics | TPMT | Genotyping | Thiopurine | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmacogenetics - methods | Humans | Methyltransferases - metabolism | Middle Aged | Methyltransferases - genetics | Genetic Association Studies - methods | Genotype | Male | Sweden - epidemiology | Purine-Pyrimidine Metabolism, Inborn Errors - diagnosis | Phenotype | Drug Hypersensitivity - epidemiology | Drug Hypersensitivity - genetics | Purine-Pyrimidine Metabolism, Inborn Errors - genetics | Drug Hypersensitivity - diagnosis | Polymorphism, Single Nucleotide - genetics | Adult | Female | Purine-Pyrimidine Metabolism, Inborn Errors - epidemiology | Gastrointestinal diseases | Transferases | Leukemia | Physiological aspects | Genetic research | Genetic aspects | Cells | Index Medicus
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10. Full Text Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study
by Clemens, Eva and Broer, Linda and Langer, Thorsten and Uitterlinden, Ane G and de Vries, Anica C. H and van Grotel, Martine and Pluijm, Saskia F. M and Binder, Harald and Byrne, Julianne and Broeder, Eline van Dulmen-den and Crocco, Marco and Grabow, Desiree and Kaatsch, Peter and Kaiser, Melanie and Kenborg, Line and Winther, Jeanette F and Rechnitzer, Catherine and Hasle, Henrik and Kepak, Tomas and van der Kooi, Anne-Lotte F and Kremer, Leontien C and Kruseova, Jarmila and Kuehni, Claudia E and van der Pal, Heleen and Parfitt, Ross and Deuster, Dirk and Matulat, Peter and Spix, Claudia and Tillmanns, Amelie and Tissing, Wim J. E and Maier, Lara and Zehnhoff-Dinnesen, Antoinette and Zolk, Oliver and van den Heuvel-eibrink, Marry M
The pharmacogenomics journal, ISSN 1470-269X, 04/2020, Volume 20, Issue 2, pp. 294 - 305
CHILDHOOD-CANCER | REPLICATION | VARIANTS | TPMT | ACYP2 | COMT | SURVIVORS | PLATINUM CHEMOTHERAPY | INDUCED HEARING-LOSS | CHILDREN
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11. Full Text Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis
by Vinayaga-Pavan, Mathena and Frampton, Matthew and Pontikos, Nikolas and Levine, Adam P and Smith, Phillip J and Jonasson, Jon G and Björnsson, Einar S and Segal, Anthony W and Smith, Andrew M
Inflammatory bowel diseases, ISSN 1078-0998, 01/2019, Volume 25, Issue 2, pp. 317 - 327
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Iceland - epidemiology | Cell Cycle - genetics | Prognosis | Follow-Up Studies | Colitis, Ulcerative - metabolism | Humans | Middle Aged | Biomarkers - analysis | Colitis, Ulcerative - genetics | Transcriptome | Male | Colitis, Ulcerative - pathology | Gene Expression Profiling | Colitis, Ulcerative - epidemiology | Whole Exome Sequencing - methods | Case-Control Studies | Colon - metabolism | Young Adult | Adult | Colon - physiopathology | Female | Aged | Mutation | Index Medicus | microarray | rectum | TPMT | Original Basic Science | inflammatory bowel disease
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12. Full Text The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia
by Wahlund, Martina and Nilsson, Anna and Kahlin, Anna Zimdahl and Broliden, Kristina and Myrberg, Ida Hed and Appell, Malin Lindqvist and Berggren, Anna
The Journal of pediatrics, ISSN 0022-3476, 01/2020, Volume 216, pp. 150 - 157.e1
neutropenia | 6-MP | febrile neutropenia | TPMT | NUDT15 | ITPA | Life Sciences & Biomedicine | Pediatrics | Science & Technology | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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13. Azathioprine/6-mercaptopurinetoxicity: The role of the TPMT gene
by Katsanos, K.H and Tsianos, Epameinondas V
Annals of gastroenterology, ISSN 1108-7471, 2007, Volume 20, Issue 4, pp. 251 - 264
Inflammatory bowel disease | Prevalence | Single nucleotide polymorphism | Toxicity | AZA/6-MP | TPMT gene
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14. Full Text American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases
by Vande Casteele, Niels and Herfarth, Hans and Katz, Jeffry and Falck-Ytter, Yngve and Singh, Siddharth
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 09/2017, Volume 153, Issue 3, pp. 835 - 857.e6
CRP | RCT | 6-MP | C-reactive protein | TPMT | CBC | IBD | TNF | 6-methylmercaptopurine | 6-MMP | ulcerative colitis | AGA | TDM | therapeutic drug monitoring | AZA | azathioprine | 6-TGN | Crohn's disease | homogenous mobility shift assay | RIA | ECLIA | Grading of Recommendations Assessment, Development, and Evaluation | inflammatory bowel disease | relative risk | 6-thioguanine | complete blood count | randomized controlled trial | anti-drug antibody | thiopurine methyltransferase | HMSA | electrochemiluminescence immunoassay | radioimmunoassay | 6-mercaptopurine | tumor necrosis factor | enzyme-linked immunosorbent assay | GRADE | ADAb | confidence interval | American Gastroenterological Association | ELISA | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Inflammatory Bowel Diseases - drug therapy | Body Weight | Azathioprine - pharmacokinetics | Humans | Immunosuppressive Agents - pharmacokinetics | Immunosuppressive Agents - therapeutic use | Antibodies, Monoclonal - pharmacokinetics | Antibodies, Monoclonal - therapeutic use | Drug Monitoring - methods | Azathioprine - blood | Methyltransferases - blood | Antibodies, Monoclonal - blood | Immunosuppressive Agents - blood | Thionucleosides - therapeutic use | Thionucleosides - pharmacokinetics | Thionucleosides - blood | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Continuing medical education | Biological products | Health aspects | Gastrointestinal diseases | Index Medicus | Abridged Index Medicus
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