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International Journal of Molecular Sciences, ISSN 1661-6596, 09/2015, Volume 16, Issue 9, pp. 21775 - 21790
Blood-retinal barrier (BRB) breakdown is one of the primary causes of diabetic retinopathy (DR). The pro-inflammatory factor interleukin-1 (IL-1) was reported... 
TR-iBRB2 cells | Oxidative stress | Nitrosative stress | Tetramethylpyrazine | DIABETIC-RETINOPATHY | SIGNALING PATHWAYS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER BREAKDOWN | CHEMISTRY, MULTIDISCIPLINARY | CYTOCHROME-C | tetramethylpyrazine | nitrosative stress | NITRIC-OXIDE | GROWTH-FACTOR | LEUKOCYTE ADHESION | NF-KAPPA-B | EXPRESSION | oxidative stress | Interleukin-1beta - pharmacology | Phosphorylation | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | NF-kappa B - metabolism | Protein Transport - drug effects | Blood-Retinal Barrier - drug effects | Cell Nucleus - metabolism | Interleukin-1beta - metabolism | Protective Agents - pharmacology | Cell Line | Endothelial Cells - metabolism | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Cell Adhesion - drug effects | Blood-Retinal Barrier - metabolism | Gene Expression Regulation - drug effects | Nitrates - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Intercellular Adhesion Molecule-1 - genetics | Leukocytes - drug effects | Oxidative Stress - drug effects | Pyrazines - pharmacology | Leukocytes - metabolism | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Synthase Type II - metabolism
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