X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
traak (91) 91
index medicus (83) 83
animals (57) 57
humans (41) 41
potassium channels (38) 38
potassium channels, tandem pore domain - metabolism (35) 35
trek-1 (31) 31
biochemistry & molecular biology (28) 28
activation (26) 26
potassium channels, tandem pore domain - genetics (24) 24
crystal-structure (23) 23
polyunsaturated fatty-acids (23) 23
neurosciences (22) 22
mice (21) 21
potassium channel (20) 20
potassium channels - metabolism (20) 20
k+ channels (19) 19
rats (19) 19
patch-clamp techniques (18) 18
cells (17) 17
cell biology (16) 16
ion channels (16) 16
k+ channel (16) 16
potassium channels, tandem pore domain - chemistry (16) 16
trek-2 (16) 16
domain k+ channels (15) 15
pharmacology & pharmacy (15) 15
physiology (15) 15
potassium channels - genetics (15) 15
arachidonic-acid (14) 14
article (14) 14
male (14) 14
inhibition (13) 13
multidisciplinary sciences (13) 13
neurons (13) 13
cells, cultured (12) 12
cloning (12) 12
electrophysiology (12) 12
proteins (12) 12
biology (11) 11
expression (11) 11
functional expression (11) 11
potassium (11) 11
potassium channels, tandem pore domain (11) 11
protein structure, tertiary (11) 11
hydrogen-ion concentration (10) 10
immunohistochemistry (10) 10
k-2p channels (10) 10
mechanism (10) 10
mice, inbred c57bl (10) 10
pain (10) 10
physiological aspects (10) 10
trek (10) 10
arachidonic acid (9) 9
biophysics (9) 9
channel (9) 9
channels (9) 9
family (9) 9
potassium channels - chemistry (9) 9
xenopus (9) 9
amino acid sequence (8) 8
apoptosis (8) 8
cell line (8) 8
ion channel gating (8) 8
ion channel gating - physiology (8) 8
life sciences (8) 8
lysophospholipids (8) 8
mechanotransduction (8) 8
models, molecular (8) 8
modulation (8) 8
mutation (8) 8
pore (8) 8
potassium channels, tandem pore domain - physiology (8) 8
task-1 (8) 8
trp channels (8) 8
arachidonic acid - pharmacology (7) 7
cos cells (7) 7
domain potassium channels (7) 7
gene expression (7) 7
hek293 cells (7) 7
localization (7) 7
molecular dynamics simulation (7) 7
neuroprotection (7) 7
potassium channels - physiology (7) 7
reverse transcriptase polymerase chain reaction (7) 7
temperature (7) 7
traak k+ channel (7) 7
alternative translation initiation (6) 6
binding sites (6) 6
chemistry, medicinal (6) 6
fatty-acids (6) 6
female (6) 6
human activities (6) 6
ion channel (6) 6
ion channels - metabolism (6) 6
k2p channel (6) 6
lipids (6) 6
medicine, research & experimental (6) 6
membrane potentials - drug effects (6) 6
models, biological (6) 6
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 06/2019, Volume 95, Issue 6, pp. 652 - 660
Cloxyquin has been reported as a specific activator of TRESK [TWIK-related spinal cord K+ channel (also known as K(2P)18.1)] background potassium channel. In... 
TREK-2 | K-2P CHANNELS | ACID | FUNCTIONAL HETERODIMERS | TRAAK | PHARMACOLOGY & PHARMACY | CURRENTS | K+ CHANNELS | SENSORY NEURONS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2016, Volume 59, Issue 11, pp. 5149 - 5157
Potassium (K+) channels are membrane proteins expressed in most living cells that selectively control the flow of K+ ions. More than 80 genes encode the K+... 
DEPRESSION | PERCEPTION | ACTIVATION | CHEMISTRY, MEDICINAL | K-2P CHANNELS | INHIBITION | GATING MECHANISM | TRAAK | NEUROPROTECTIVE AGENT RILUZOLE | GENERAL-ANESTHESIA | MODULATION | Chemical Sciences
Journal Article
European Journal of Anaesthesiology, ISSN 0265-0215, 05/2019, Volume 36, Issue 5, pp. 342 - 350
BACKGROUNDNeuropathic pain following surgery could be a useful model for the study of the genetic mechanisms of peripheral neuropathic pain. OBJECTIVEThe aim... 
TRAAK | ANESTHESIOLOGY | NEURECTOMY | TREK-1 | INGUINAL NEURALGIA | Pain, Postoperative | Genetic aspects | Neuralgia | Risk factors
Journal Article
Cell Reports, ISSN 2211-1247, 11/2016, Volume 17, Issue 7, pp. 1739 - 1746
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 08/2013, Volume 8, Issue 8, pp. 1841 - 1851
K-2P (KCNK) potassium channels generate "leak" potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation,... 
YEAST | TREK-1 | INHIBITION | POTASSIUM CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE | TRAAK | BLOCK | DOMAIN K+ CHANNELS | SACCHAROMYCES-CEREVISIAE | SELECTIVITY
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 07/2017, Volume 174, Issue 13, pp. 2102 - 2113
Background and PurposeCloxyquin (5-cloroquinolin-8-ol) has been described as an activator of TRESK (K(2P)18.1, TWIK-related spinal cord K+ channel) background... 
TREK-2 | CONCISE GUIDE | CRYSTAL-STRUCTURE | PHARMACOLOGY | FUNCTIONAL HETERODIMERS | TRAAK | PHARMACOLOGY & PHARMACY | 5-CHLOROQUINOLIN-8-OL | K+ CHANNEL | DOCKING SITE | SENSORY NEURONS
Journal Article
Science, ISSN 0036-8075, 03/2015, Volume 347, Issue 6227, pp. 1256 - 1259
Journal Article
BMC Ophthalmology, ISSN 1471-2415, 11/2017, Volume 17, Issue 1, pp. 210 - 210
Background: Age-related macular degeneration (AMD) causes the dysfunction of the retinal pigment epithelial (RPE) cells. In this study, we examined the effects... 
ARPE-19 cells | AMD | channel | apoptosis | TRAAK K | Riluzole | OXIDATIVE STRESS | RAT | TRAAK K2P channel | OPHTHALMOLOGY | DOMAIN K+ CHANNELS | Macular degeneration | Analysis | Physiological aspects | Influence | Models | Genetic aspects | Retinal pigment epithelium | Apoptosis | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 12/2015, Volume 4, Issue 2015
Piezo1 ion channels mediate the conversion of mechanical forces into electrical signals and are critical for responsiveness to touch in metazoans. The apparent... 
ADHESION | MECHANOSENSITIVE CHANNEL | CURVATURE | BIOLOGY | ARCHITECTURE | TRAAK | MUTATIONS | MSCL | PATCH-CLAMPED MEMBRANES | STRAIN | Cell Line | Mechanical Phenomena | Ion Channels - metabolism | Cell Membrane - physiology | Humans | Physiological aspects | Mechanical properties | Cell membranes | Ion channels | Proteins | Neurosciences | Microscopy | Physiology | Mechanical stimuli | Mutation | Protocol | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2016, Volume 113, Issue 15, pp. 4200 - 4205
Journal Article
Cell Reports, ISSN 2211-1247, 03/2012, Volume 1, Issue 3, pp. 241 - 250
How renal epithelial cells respond to increased pressure and the link with kidney disease states remain poorly understood. knockout or expression of a PC2... 
filamin A | TREK | mechanotransduction | cysts | TRAAK K2P channels | apoptosis | polycystins | TRP channels
Journal Article
by Woo, J and Jun, YK and Zhang, YH and Nam, JH and Shin, DH and Kim, SJ
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, ISSN 0031-6768, 02/2018, Volume 470, Issue 2, pp. 327 - 337
TWIK-related two-pore domain K+ channels (TREKs) are regulated by intracellular pH (pH(i)) and Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P-2). Previously,... 
PHYSIOLOGY | PI(4,5)P-2 | KINASE | TRAAK | FATTY-ACIDS | CURRENTS | PHOSPHOINOSITIDES | Intracellular pH | DOMAIN POTASSIUM CHANNELS | TREK-2 | PAIN | Two-pore K+ channel | REGULATIONS | ATP | PIP2
Journal Article
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 3, pp. 701 - 708
Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways regulating their activity remain poorly understood. TMEM150C was proposed to... 
trigeminal ganglia | Tentonin3 | TREK-1 | mechano-transduction | Piezo2 | Piezo1 | mechano-receptor | TMEM150C | K2P2.1 | mechano-sensitivity | PERCEPTION | XEROCYTOSIS | MEMBRANE | MECHANOSENSITIVITY | TRAAK | PIEZO1 | TOUCH | K+ CHANNELS | MECHANOTRANSDUCTION | CELL BIOLOGY
Journal Article
International journal of ophthalmology, ISSN 2222-3959, 2019, Volume 12, Issue 8, pp. 1243 - 1249
To investigate the expression of TWIK-related arachidonic acid-stimulated K channel (TRAAK) in retinal degeneration mice (rd1) and further evaluate how TRAAK... 
riluzole | TRAAK | OPHTHALMOLOGY | apoptosis | ARACHIDONIC-ACID | ION CHANNELS | photoreceptor cell
Journal Article
by Zhang, XT and Xu, Z and Shi, KP and Guo, DL and Li, H and Wang, L and Zhu, XB
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, ISSN 2222-3959, 06/2019, Volume 12, Issue 6, pp. 924 - 929
AIM: To examine the expression of Twik-related K+ channel 1 (TREK-1), Twik-related K+ channel 2 (TREK-2), and Twik-related arachidonic acid-stimulated K+... 
arachidonic acid | GANGLION | retinal degeneration | TREK-TRAAK channels | OPHTHALMOLOGY | retinal ganglion cells | MECHANISMS | K+ CHANNEL | DEGENERATION
Journal Article
International Journal of Ophthalmology, ISSN 2222-3959, 06/2019, Volume 12, Issue 6, pp. 924 - 929
AIMTo examine the expression of Twik-related K+ channel 1 (TREK-1), Twik-related K+ channel 2 (TREK-2), and Twik-related arachidonic acid-stimulated K+ channel... 
arachidonic acid | retinal degeneration | retinal ganglion cells | TREK-TRAAK channels
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2004, Volume 25, Issue 11, pp. 601 - 608
Two-pore-domain K (K ) channels are a diverse and highly regulated superfamily of channels that are thought to provide baseline regulation of membrane... 
NITROUS-OXIDE | AMINO-ACID | POTASSIUM CHANNELS | VOLATILE ANESTHETICS | TRAAK | POLYUNSATURATED FATTY-ACIDS | PHARMACOLOGY & PHARMACY | DOMAIN K+ CHANNELS | GATED ION CHANNELS | RECEPTORS | MOLECULAR-BASIS
Journal Article
Scientific reports, ISSN 2045-2322, 08/2019, Volume 9, Issue 1, pp. 12394 - 13
A better understanding of the gating of TREK two pore domain potassium (K2P) channels and their activation by compounds such as the negatively charged... 
OPENER | ACTIVATION | K-2P CHANNELS | MECHANISM | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | TRAAK | TRESK | IDENTIFICATION | POTASSIUM CHANNEL | FAMILY | Pain | Phenylalanine | Channel gating | Mutation | Potassium channels | Gating | Conformation | Index Medicus
Journal Article