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PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175329
Teriparatide [human parathyroid hormone (1-34)], which exerts an anabolic effect on bone, is used for the treatment of osteoporosis in patients who are at a high risk for fracture... 
HUMAN PARATHYROID HORMONE(1-34) | MARROW FIBROSIS | OVARIECTOMIZED CYNOMOLGUS MONKEYS | VERTEBRAL FRACTURES | THINNER CORTICES | DISTAL RADIUS | MULTIDISCIPLINARY SCIENCES | TURNOVER MARKERS | POSTMENOPAUSAL WOMEN | FIBROUS DYSPLASIA | MECHANICAL-PROPERTIES | Osteogenesis - physiology | X-Ray Microtomography | Bone and Bones - drug effects | Dose-Response Relationship, Drug | Collagen - drug effects | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Biomechanical Phenomena - drug effects | Bone Resorption - metabolism | Female | Models, Animal | Bone Resorption - chemically induced | Porosity - drug effects | Imaging, Three-Dimensional | Bone and Bones - cytology | Rabbits | Bone Density Conservation Agents - adverse effects | Drug Administration Schedule | Teriparatide - administration & dosage | Teriparatide - blood | Osteogenesis - drug effects | Bone Density Conservation Agents - administration & dosage | Microscopy, Interference | Bone Density Conservation Agents - blood | Collagen - metabolism | Animals | Bone Resorption - pathology | Teriparatide - adverse effects | Microscopy, Fluorescence | Adaptations | Animal models | Spine | Bone (trabecular) | Bisphosphonates | Clinical outcomes | Bone resorption | Proteins | Osteoporosis | Alendronic acid | Bone growth | Computed tomography | Fibrous dysplasia | Bone marrow | Bone dysplasia | Tunneling | Skeleton | Bone density | Bone loss | Bone (cortical) | Drug therapy | Bone strength | Drug dosages | Age | Bone remodelling | Rats | Risk reduction | Endocrine therapy | Pharmacology | Frost | Bone turnover | Metabolism | Bone mass | Fractures | Osteodystrophy | Mice | Bone mineral density | Mutation | Porosity | Pharmacokinetics | Risk management | Kidney transplantation | Bone (cancellous)
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e92368
.... Germ-free mice have increased bone mass associated with reduced bone resorption indicating that the GM also regulates bone mass. Ovariectomy (ovx... 
C-REACTIVE PROTEIN | TRABECULAR BONE | WOMEN | MINERAL DENSITY | IMMUNE-SYSTEM | MULTIDISCIPLINARY SCIENCES | ESTROGEN-RECEPTOR-ALPHA | OSTEOPROTEGERIN | GUT MICROBIOTA | TNF-ALPHA | T-CELLS | Bone and Bones - pathology | Ovariectomy - adverse effects | T-Lymphocytes, Regulatory - metabolism | RANK Ligand - metabolism | Body Weight - drug effects | Bone and Bones - drug effects | Lactobacillus - drug effects | Bone Marrow - metabolism | Bone and Bones - metabolism | Inflammation Mediators - metabolism | Female | Minerals - metabolism | Bone Marrow - drug effects | Bone Resorption - etiology | Bone Resorption - blood | Cytokines - metabolism | Mice, Inbred C57BL | Bone Resorption - drug therapy | Biomarkers - blood | Probiotics - pharmacology | Lactobacillus - metabolism | Bone Resorption - prevention & control | Organ Size - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Bone Marrow - pathology | Probiotics - therapeutic use | Mice | Osteoprotegerin - metabolism | Transforming Growth Factor beta - metabolism | Probiotics | Ovariectomy | Microbiota (Symbiotic organisms) | Physiological aspects | Bones | T cells | Density | Drinking water | Calcium | Lymphocytes T | Genomes | Arthritis | Immune status | Osteoprotegerin | Bone resorption | Osteoporosis | Microorganisms | Biomedical materials | Microbiota | Lymphocytes | Bone marrow | Bacteria | Tumor necrosis factor-TNF | Biocompatibility | Bone density | Bone loss | Bone (cortical) | Bone composition | Food | Immune system | Calcium (urinary) | Excretion | Gnotobiotics | Cytokines | Nutrition | Immunoregulation | Rheumatology | Inflammation | Tumor necrosis factor-α | IL-1β | Metabolism | Gene expression | Bone mineral content | Medicine | Serum levels | Osteoclastogenesis | Bone mass | Antibiotics | Womens health | Ligands | Endokrinologi och diabetes | Endocrinology and Diabetes
Journal Article
Journal of bone and mineral research, ISSN 0884-0431, 2017, Volume 32, Issue 11, pp. 2239 - 2247
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177416
To improve the safe use of allograft bone, decellularization techniques may be utilized to produce acellular scaffolds... 
CORTICAL BONE | MATRIX | WOMEN | SITE | ALLOGRAFT | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | OSTEOGENIC DIFFERENTIATION | POTENTIAL IMPLICATIONS | MESENCHYMAL STEM-CELLS | GROWTH-FACTOR-I | Cell Proliferation | Age Factors | Humans | Middle Aged | Transcriptome | Culture Media, Conditioned - pharmacology | Male | Tissue Scaffolds | Cell Differentiation - genetics | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Aged, 80 and over | Adult | Female | Mesenchymal Stem Cells - metabolism | Osteogenesis - genetics | Bone Density | Bone Regeneration | Radiography | Cell Differentiation - drug effects | Bone Transplantation | Biomarkers | Aged | Tissue Donors | Culture Media, Conditioned - metabolism | Bones | Bone-grafting | Growth | Health aspects | Patient outcomes | Osseointegration | Health services | Carbon dioxide | Bone (trabecular) | Bone surgery | Blood | Proteins | Osteoporosis | Pore size | Bone growth | Surgery | Topography | Bone marrow | Aging | Bone (cortical) | Bone matrix | Bone composition | Autografts | Longevity | Bone healing | Bioavailability | Metabolism | Insulin | Chemicals | Studies | Immunogenicity | Quality control | Stem cells | Osteoarthritis | Endocrinology | Age composition | Bone (cancellous) | Adherent cells | Osteoprogenitor cells | Animal models | Calcium | Biology | Arthritis | Insulin-like growth factors | Engineering | Allografts | Rodents | Extracellular matrix | Bone loss | Age | Immune response | Bone morphogenetic protein 2 | Tissue engineering | Complications | Bioassays | Feasibility studies | Hip | Medicine | Skin & tissue grafts | Porosity | Bone morphogenetic protein 9
Journal Article
Journal of bone and mineral research, ISSN 0884-0431, 2017, Volume 32, Issue 10, pp. 2010 - 2021
...; the reversibility of the bone lost at the weight-bearing bone sites is not established, although it is suspected to take longer than the mission length... 
MICROGRAVITY | Radius/anatomy & histology | Tibia/anatomy & histology | Cortical Bone/anatomy & histology | Humans | Middle Aged | Bone Density/physiology | Tomography, X-Ray Computed | Endocrinology, Diabetes and Metabolism | SPACEFLIGHT | Space Flight | BONE HR-pQCT | PERIOSTIN | Journal Article | Walking | Biomechanical Phenomena | BONE RECOVERY | Orthopedics and Sports Medicine | Cancellous Bone/anatomy & histology | Adult | Biomarkers/blood | Weight-Bearing | BONE HR‐pQCT | VIVO HR-PQCT | QUANTITATIVE COMPUTED-TOMOGRAPHY | MINERAL DENSITY | ESTIMATED STRENGTH | LONG-DURATION SPACEFLIGHT | DISTAL RADIUS | MICROARCHITECTURE | ENDOCRINOLOGY & METABOLISM | POSTMENOPAUSAL WOMEN | BED REST | AGE | Cancellous Bone - physiopathology | Bone Density - physiology | Tibia - physiology | Radius - physiology | Cortical Bone - physiopathology | Tibia - diagnostic imaging | Tibia - anatomy & histology | Biomarkers - blood | Radius - anatomy & histology | Cortical Bone - anatomy & histology | Cancellous Bone - diagnostic imaging | Cancellous Bone - anatomy & histology | Cortical Bone - diagnostic imaging | Radius - diagnostic imaging | Osteoporosis | Analysis | Bones | Astronauts | Porosity | Density | Space stations | Radius | SOST protein | Space flight | Weightlessness | Bone (trabecular) | Bone resorption | Bone growth | Bone mass | Multinational space ventures | Computed tomography | Tibia | Bone density | Bone (cortical)
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e95144
Adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from impaired bone resorption... 
OSTEOCLASTOGENESIS | OSTEOPONTIN | DEFECTS | CHONDROCYTES | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | PLATE | Osteopontin - blood | Osteopontin - genetics | Osteopontin - deficiency | Male | Insulin-Like Growth Factor I - genetics | Mice, 129 Strain | Growth Plate - growth & development | Behavior, Animal | Hedgehog Proteins - genetics | Bone Resorption - genetics | Gene Expression Regulation, Developmental | Female | Tibia - growth & development | Tibia - metabolism | Femur - growth & development | Osteogenesis - genetics | Animals, Newborn | Femur - metabolism | Growth Plate - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Osteoclasts - metabolism | Mice, Knockout | Animals | Bone Development - genetics | Osteoblasts - metabolism | Bones | Growth | Density | Analysis | Neonates | Femur | Insulin-like growth factor I | Bone sialoprotein | Insulin-like growth factors | Birth | Bone (trabecular) | Accumulation | Bone resorption | Cartilage | Genotype & phenotype | Reproductive behavior | Biomedical materials | Bone growth | Mineralization | Tibia | Rodents | Sutures | Biocompatibility | Bone (cortical) | Bone (endochondral) | Genotypes | Cbfa-1 protein | Heredity | Bone turnover | Gene expression | Mutants | Childbirth & labor | Bone mass | Hedgehog protein | Skull | Bone mineral density | Adults | Mice | Bone (long) | Osteogenesis | Life Sciences
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 12/2018, Volume 33, Issue 12, pp. 2165 - 2176
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e34647
.... The GC related disruption of bone marrow microcirculation and increased adipogenesis contribute to GIO development... 
TRABECULAR BONE | CELLS | GLUCOCORTICOIDS | HISTOMORPHOMETRY | MULTIDISCIPLINARY SCIENCES | OSTEOBLASTS | BEAGLE | DIFFERENTIATION | EXPRESSION | OSTEONECROSIS | MILTIORRHIZA | Neovascularization, Physiologic - drug effects | Gene Expression - drug effects | Adipogenesis - drug effects | Benzofurans - administration & dosage | Male | Adipocytes - drug effects | PPAR gamma - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Bone and Bones - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Osteoporosis - metabolism | Bone and Bones - metabolism | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Differentiation | Bone Morphogenetic Proteins - genetics | PPAR gamma - genetics | Prednisone - administration & dosage | Benzofurans - therapeutic use | Osteoporosis - chemically induced | Prednisone - adverse effects | Osteoporosis - prevention & control | Osteoblasts - drug effects | Osteogenesis - drug effects | Stromal Cells - metabolism | Bone and Bones - blood supply | Intercellular Signaling Peptides and Proteins - genetics | Rats | Rats, Sprague-Dawley | beta Catenin - metabolism | beta Catenin - genetics | Animals | Adipocytes - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Osteoporosis | Corticosteroids | Bones | Prednisone | Cell differentiation | Density | Steroids | Oxidative stress | Transcription factors | Glucocorticoids | Laboratories | Differentiation (biology) | Stimulation | Adipocytes | Inflammatory diseases | β-catenin | Angiogenesis | Bone histomorphometry | Biomedical materials | Bone growth | Ischemia | Rodents | Bone marrow | Biocompatibility | Inhibition | Bone loss | Bone strength | Osteopenia | Adipogenesis | Cbfa-1 protein | Research & development--R&D | Medical treatment | Pharmacology | Gene expression | Medicine | Studies | Herbal medicine | Osteoblastogenesis | Bone mass | Acids | Stem cells | Dilation | Bone mineral density | In vivo methods and tests | Dkk1 protein | Osteogenesis | Bone (cancellous) | Apoptosis | Herbal medicines | Guanylate cyclase | Osteoblasts | adipogenesis | stromal cells | Bone morphogenetic proteins | Differentiation | Research & development | R&D
Journal Article
BioMed research international, ISSN 2314-6133, 12/2017, Volume 2017, pp. 3905216 - 10
Rationale. Radium-223-Dichloride (Ra-223) is an alpha-emitter, used to treat bone metastases... 
MEDICINE, RESEARCH & EXPERIMENTAL | RADIUM-223 DICHLORIDE | EFFICACY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DOUBLE-BLIND | PATTERNS | SEEKING | TOXICITY | PHASE-3 | PLANAR | DOCETAXEL | CHEMOTHERAPY | Blood Platelets - radiation effects | Leukocytes - pathology | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - radiotherapy | Bone Marrow Diseases - etiology | Cancellous Bone - metabolism | Hemoglobins - radiation effects | Tumor Burden - radiation effects | Humans | Middle Aged | Bone Neoplasms - secondary | Hemoglobinuria, Paroxysmal - radiotherapy | Hemoglobinuria, Paroxysmal - etiology | Male | Bone Marrow - radiation effects | Hemoglobinuria, Paroxysmal - pathology | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Leukocytes - radiation effects | Anemia, Aplastic - etiology | Neoplasm Invasiveness - pathology | Anemia, Aplastic - radiotherapy | Bone Marrow - metabolism | Aged, 80 and over | Cancellous Bone - pathology | Anemia, Aplastic - pathology | Prostatic Neoplasms - pathology | Radium - administration & dosage | Cancellous Bone - radiation effects | Radioisotopes - adverse effects | Hemoglobins - metabolism | Radium - adverse effects | Bone Marrow Diseases - pathology | Bone Neoplasms - radiotherapy | Bone Marrow - pathology | Radioisotopes - administration & dosage | Bone Marrow Diseases - radiotherapy | Aged | Prostatic Neoplasms - complications | Care and treatment | Cancer patients | Algorithms | Hemoglobin | Metastasis | Health aspects | Prostate cancer | Patient compliance | Cancer | Nuclear medicine | Correlation | Toxicity | Bone tumors | Leukocytes | Bone (trabecular) | Cancer therapies | Metastases | Mathematical analysis | Bone marrow | Emitters | Failure | Radium | Radiation therapy | Metabolism | Patients | Single photon emission computed tomography | White blood cells | Bone cancer | Computer applications | Bone (long) | Platelets | Prostate
Journal Article