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Molecular cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 251 - 266
NF-κB | CYLD | AQUA | proteomics | Lys63 | inflammation | TRAF6 | HUWE1 | Lys48 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Adaptor Proteins, Signal Transducing - chemistry | Interleukin-1beta - pharmacology | Deubiquitinating Enzyme CYLD | Humans | Ubiquitin - metabolism | Substrate Specificity | NF-kappa B - metabolism | NF-kappa B - chemistry | Polyubiquitin - genetics | Ubiquitination | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Lysine - metabolism | Protein Interaction Domains and Motifs | Osteoblasts - cytology | TNF Receptor-Associated Factor 6 - genetics | Binding Sites | Polyubiquitin - chemistry | Polyubiquitin - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Tumor Suppressor Proteins - metabolism | Signal Transduction | Osteoblasts - drug effects | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Sequence Alignment | NF-kappa B - genetics | Protein Conformation, beta-Strand | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 01/2019, Volume 69, Issue 1, pp. 34 - 50
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Adaptor Proteins, Signal Transducing - physiology | Signal Transduction | Humans | Neoplasm Proteins - physiology | Cells, Cultured | Hepatitis C, Chronic - virology | Mitochondrial Proteins - physiology | Hepacivirus - physiology | Viral Nonstructural Proteins - physiology | Proteins | Hepatitis | Mitochondria | TRAF6 protein | Chronic infection | Infections | Interferon | Hepatitis C | Index Medicus
Journal Article
Biochemical journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 421 - 437
Ubiquitination | Catalysis | Ubiquitin ligase | Structure | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Animals | DNA Repair | Humans | Ubiquitin-Protein Ligases - metabolism | Protein Conformation | Membrane Proteins - metabolism | Enzyme Activation | Ubiquitin-Protein Ligases - chemistry | Protein Interaction Maps | RNA - metabolism | Index Medicus | ubiquitin ligase | HECT, homologous with E6-associated protein C-terminus | Ubl, ubiquitin-like | IBR, InBetweenRING | ANKIB1, ankyrin repeat- and IBR domain-containing 1 | catalysis | SH3, Src homology 3 | Eps15, epidermal growth factor receptor pathway substrate 15 | UBA, ubiquitin-associated | RWD, RING finger and WD repeat-containing | CCCP, carbonyl cyanide m-chlorophenylhydrazone | CRL, Cul-RING-ligase | TOMM70A, translocase of outer mitochondrial membrane 70 homologue A | NF-κB, nuclear factor κB | NZF, Npl4 ZNF | cIAP2, cellular inhibitor of apoptosis 2 | MIRO, mitochondrial Rho GTPase | TRAF6, tumour-necrosis-factor-receptor-associated factor 6 | NEMO, NF-κB essential modulator | MDM2, murine double minute 2 | TRIAD, two RING fingers and a DRIL (double RING finger linked) | HOIP, HOIL-1-interacting protein | BRcat, benign-catalytic | SHARPIN, SHANK-associated RH domain interactor | Review | RING1-BRcat-Rcat | Parc, parkin-like cytoplasmic p53-binding protein | SUMO, small ubiquitin-related modifier | LUBAC, linear ubiquitin chain assembly complex | HOIL-1, haem-oxidized IRP2 ubiquitin ligase 1 | RNF, RING finger protein | CPH, Cul7, Parc and HERC2 proteins | HDAC, histone deacetylase | RBR, RING-BetweenRING-RING | Cdk5, cyclin-dependent kinase 5 | SILAC, stable isotope labelling by amino acids in cell culture | RanBP2, RAN-binding protein 2 | FANCL, Fanconi anaemia, complementation group L | PINK1, PTEN-induced putative kinase 1 | PKC, protein kinase C | structure | CK1, casein kinase 1 | NEDD, neural-precursor-cell-expressed developmentally down-regulated | ubiquitination | ZNF, zinc finger | UBE2L, ubiquitin-conjugating enzyme E2L | UIM, ubiquitin-interacting motif | Cul, cullin | Rcat, required-for-catalysis
Journal Article
The EMBO journal, ISSN 0261-4189, 10/2001, Volume 20, Issue 20, pp. 5678 - 5691
LMP1 | signal transduction | p38 MAPK | TRADD | TRAF6 | Signal transduction | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cytoskeletal Proteins | MAP Kinase Signaling System - physiology | Phosphorylation | Humans | Structure-Activity Relationship | TNF Receptor-Associated Factor 1 | Kidney | TNF Receptor-Associated Factor 2 | MAP Kinase Kinase 6 | Enzyme Induction - drug effects | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases | Tyrosine - chemistry | Fibroblasts - metabolism | Carrier Proteins - physiology | Cell Line | Gene Targeting | Proteins - physiology | LIM Domain Proteins | Herpesvirus 4, Human - physiology | Mitogen-Activated Protein Kinases - biosynthesis | Intracellular Signaling Peptides and Proteins | Amino Acid Motifs | Macromolecular Substances | Proteins - genetics | Adaptor Proteins, Signal Transducing | TNF Receptor-Associated Factor 6 | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinases - physiology | Models, Biological | NF-kappa B - physiology | Mitogen-Activated Protein Kinases - genetics | Protein Processing, Post-Translational | HeLa Cells | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Cell Transformation, Viral | Microscopy, Fluorescence | mitogen-activated protein kinase | TRAF2 protein | TRAF6 protein | latent membrane protein 1 | TRADD protein | LMP1 protein | JAK3 protein | Jak3 kinase | Epstein-Barr virus | p38 protein | JNK1 protein | Index Medicus
Journal Article
The EMBO journal, ISSN 0261-4189, 04/2000, Volume 19, Issue 7, pp. 1576 - 1586
IL‐1–TRAF6 pathway | NF‐κB activation | ζPKC | p62 | IL1-TRAF6 pathway | NF-κB activation | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | NF-B protein | TRAF2 protein | TRAF6 protein | RIP protein | IKKb protein | TRAF5 protein | p62 protein | protein kinase C-interacting protein | IL-1–TRAF6 pathway | NF–κB activation
Journal Article
Nature cell biology, ISSN 1465-7392, 02/2019, Volume 21, Issue 2, pp. 214 - 225
Life Sciences & Biomedicine | Science & Technology | Cell Biology | NIH 3T3 Cells | Humans | Lung Neoplasms - metabolism | Protein Methyltransferases - genetics | Transplantation, Heterologous | Carcinogenesis - metabolism | Protein Methyltransferases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Ubiquitination | HEK293 Cells | Female | Lysine - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Lung Neoplasms - genetics | A549 Cells | Carcinoma, Non-Small-Cell Lung - genetics | Histone-Lysine N-Methyltransferase | Carcinogenesis - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Mice, Knockout | Lysine - genetics | Animals | Mice, Nude | Mice | Mice, Inbred BALB C | Methylation | Methyltransferases | Oncology, Experimental | Physiological aspects | Research | Ubiquitin-proteasome system | Protein kinases | Health aspects | Carcinogenesis | Cancer | Cell proliferation | Phosphorylation | Cell survival | TRAF6 protein | Threonine | Non-small cell lung carcinoma | AKT protein | Lung carcinoma | Cell membranes | Metabolism | Kinases | Recruitment | Cell activation | Skp2 protein | Protein-serine/threonine kinase | Tumorigenesis | Growth factors | Ubiquitin-protein ligase | Tumors | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1937 - 1952
ACTB, actin, beta | MYD88, myeloid differentiation primary response 88 | PELI3 | CHX, cycloheximide | BECN1, Beclin 1, autophagy related | TICAM1, toll-like receptor adaptor molecule 1 | LPS | RIPK1, receptor (TNFRSF)-interacting serine-threonine kinase 1 | TUBB, tubulin, beta class I | PRRs, pattern recognition receptors | UBB, ubiquitin B | IRAKs, interleukin-1 receptor-associated kinases | HBSS, Hank's balanced salt solution | ATG7, autophagy-related 7 | MAP1LC3B, microtubule-associated protein 1 light chain 3 beta | TLRs, toll-like receptors | Baf A1, bafilomycin A | WT, wildtype | autophagy | TNF, tumor necrosis factor | MAPK14, mitogen-activated protein kinase 14 | NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MAPK1/3, mitogen-activated protein kinase 1/3 | Epoxo, epoxomycin | TRAF6, TNF receptor-associated factor 6, E3 ubiquitin protein ligase | IL1B, interleukin 1, beta | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | TABs, TGF-beta activated kinase 1/MAP3K7 binding protein 1/2/3 | Wortm, wortmannin | PELI3, pellino E3 ubiquitin protein ligase family member 3 | MAPK8/9, mitogen-activated protein kinase 8/9 | SQSTM1, sequestosome 1 | NFE2L2, nuclear factor, erythroid 2-like 2 | NLRP3, NLR family, pyrin domain containing 3 | LAMP2, lysosomal-associated membrane protein 2 | LPS, lipopolysaccharide | MAP3K14, mitogen-activated protein kinase kinase kinase 14 | MΦ, macrophages | Rapa, rapamycin | SQSTM1 | TBK1, TANK-binding kinase 1 | Torin2 | MAP3K7, mitogen-activated protein kinase kinase kinase 7 | Autophagy | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Cytokines - metabolism | Signal Transduction | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Lipopolysaccharides - metabolism | Inflammation | Immunity, Innate | RNA, Messenger - metabolism | Toll-Like Receptor 4 - metabolism | Point Mutation | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Sepsis - metabolism | Mice | Naphthyridines - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article