X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (582) 582
traf6 (563) 563
traf6 protein (413) 413
humans (380) 380
animals (368) 368
signal transduction (324) 324
activation (293) 293
tnf receptor-associated factor 6 - metabolism (271) 271
mice (263) 263
nf-kappa-b (253) 253
inflammation (243) 243
cell biology (233) 233
proteins (228) 228
biochemistry & molecular biology (219) 219
immunology (189) 189
ubiquitination (187) 187
gene expression (177) 177
expression (162) 162
kinases (157) 157
toll-like receptors (156) 156
cytokines (154) 154
nf-kappa b - metabolism (153) 153
tnf receptor-associated factor 6 - genetics (150) 150
phosphorylation (148) 148
apoptosis (140) 140
nf-κb protein (135) 135
ubiquitin (130) 130
multidisciplinary sciences (121) 121
cell line (120) 120
article (116) 116
tumor necrosis factor (116) 116
research article (106) 106
innate immunity (103) 103
male (103) 103
nf-κb (103) 103
rodents (101) 101
tumor necrosis factor-tnf (101) 101
medicine (98) 98
signaling (98) 98
macrophages (96) 96
cancer (95) 95
science (95) 95
cells (94) 94
protein (93) 93
analysis (91) 91
immune response (86) 86
kinase (84) 84
oncology (83) 83
immune system (81) 81
cells, cultured (79) 79
protein binding (78) 78
biology (77) 77
myd88 protein (77) 77
nf-kappa b (75) 75
health aspects (73) 73
female (72) 72
pathway (71) 71
tak1 (70) 70
hek293 cells (68) 68
research (68) 68
genetic aspects (62) 62
irak protein (62) 62
lipopolysaccharides (62) 62
interferon (60) 60
medicine, research & experimental (60) 60
gene expression regulation (59) 59
micrornas (59) 59
pathways (59) 59
receptors (59) 59
genes (57) 57
rna (57) 57
tlr4 protein (57) 57
transcription factors (57) 57
mice, inbred c57bl (56) 56
microrna (56) 56
receptor (56) 56
mice, knockout (55) 55
tumors (55) 55
amino acid sequence (54) 54
infections (54) 54
inhibition (54) 54
tumor necrosis factor receptors (54) 54
autophagy (53) 53
immunity (53) 53
mirna (52) 52
tumor necrosis factor-α (51) 51
cell proliferation (49) 49
differentiation (49) 49
interleukin 6 (49) 49
micrornas - genetics (49) 49
disease (48) 48
identification (48) 48
cell line, tumor (47) 47
defective interleukin-1 (47) 47
map kinase kinase kinases - metabolism (47) 47
complex (46) 46
infection (46) 46
map kinase (46) 46
molecular sequence data (46) 46
mutation (46) 46
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 251 - 266
Polyubiquitin chains of different topologies regulate diverse cellular processes. K48- and K63-linked chains, the two most abundant chain types, regulate... 
NF-κB | CYLD | AQUA | proteomics | Lys63 | inflammation | TRAF6 | HUWE1 | Lys48 | ACTIVATION | COMPLEX | INHIBITION | SPECIFICITY | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYLD USP | DEGRADATION | POLYUBIQUITIN CHAIN | MECHANISMS | LIGASE | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Interleukin-1beta - pharmacology | Deubiquitinating Enzyme CYLD | Humans | Ubiquitin - metabolism | Substrate Specificity | NF-kappa B - metabolism | NF-kappa B - chemistry | Polyubiquitin - genetics | Ubiquitination | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Lysine - metabolism | Protein Interaction Domains and Motifs | Osteoblasts - cytology | TNF Receptor-Associated Factor 6 - genetics | Binding Sites | Polyubiquitin - chemistry | Polyubiquitin - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Tumor Suppressor Proteins - metabolism | Signal Transduction | Osteoblasts - drug effects | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Sequence Alignment | NF-kappa B - genetics | Protein Conformation, beta-Strand | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e78439
Neuroinflammation mediated by the activated microglia is suggested to play a pivotal role in the pathogenesis of hypoxic brain injury; however, the underlying... 
MURINE BV-2 CELLS | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | RECEPTOR | NEURAL PROGENITOR CELLS | RAT-BRAIN | DIFFERENTIATION | INFLAMMATORY RESPONSE | EXPRESSION | AMEBOID MICROGLIA | INNATE IMMUNITY | Amyloid Precursor Protein Secretases - genetics | Microglia - metabolism | Transcription Factor HES-1 | Homeodomain Proteins - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Hypoxia - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Microglia - pathology | Membrane Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Animals, Newborn | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Dipeptides - pharmacology | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Rats | Toll-Like Receptor 4 - genetics | Receptor, Notch1 - metabolism | Toll-Like Receptor 4 - metabolism | Homeodomain Proteins - genetics | Amyloid Precursor Protein Secretases - metabolism | Hypoxia - genetics | Animals | NF-kappa B - genetics | Hypoxia - pathology | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Cell Hypoxia - genetics | Receptor, Notch1 - genetics | Myeloid Differentiation Factor 88 - metabolism | Brain | Mental disorders | Laboratories | Pathogenesis | Crosstalk | Activation | Neurogenesis | Signal transduction | Embryology | Head injuries | Pathways | Rodents | Cerebrum | Toll-like receptors | Microglial cells | Inhibition | Pretreatment | Casualties | Translocation | NF-κB protein | Adenosine | TRAF6 protein | Cytokines | Histology | Exposure | Inflammation | TLR4 protein | Gene expression | Microglia | Medicine | Studies | Signaling | Brain research | DELTA protein | Stem cells | MyD88 protein | Hypoxia | Ligands | Brain damage | Notch protein | Brain injury | Secretase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 421 - 437
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex... 
Ubiquitination | Catalysis | Ubiquitin ligase | Structure | ubiquitin ligase | INDUCED CELL-DEATH | ANDROGEN RECEPTOR TRANSACTIVATION | KAPPA-B ACTIVATION | LINEAR POLYUBIQUITIN CHAINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | catalysis | CHAIN ASSEMBLY COMPLEX | AMYOTROPHIC-LATERAL-SCLEROSIS | ALPHA-SYNUCLEIN | structure | ubiquitination | RING-FINGER PROTEINS | CONJUGATING ENZYME | FAMILIAL PARKINSONS-DISEASE | Animals | DNA Repair | Humans | Ubiquitin-Protein Ligases - metabolism | Protein Conformation | Membrane Proteins - metabolism | Enzyme Activation | Ubiquitin-Protein Ligases - chemistry | Protein Interaction Maps | RNA - metabolism | HECT, homologous with E6-associated protein C-terminus | Ubl, ubiquitin-like | IBR, InBetweenRING | ANKIB1, ankyrin repeat- and IBR domain-containing 1 | SH3, Src homology 3 | Eps15, epidermal growth factor receptor pathway substrate 15 | UBA, ubiquitin-associated | RWD, RING finger and WD repeat-containing | CCCP, carbonyl cyanide m-chlorophenylhydrazone | CRL, Cul-RING-ligase | TOMM70A, translocase of outer mitochondrial membrane 70 homologue A | NF-κB, nuclear factor κB | NZF, Npl4 ZNF | cIAP2, cellular inhibitor of apoptosis 2 | MIRO, mitochondrial Rho GTPase | TRAF6, tumour-necrosis-factor-receptor-associated factor 6 | NEMO, NF-κB essential modulator | MDM2, murine double minute 2 | TRIAD, two RING fingers and a DRIL (double RING finger linked) | HOIP, HOIL-1-interacting protein | BRcat, benign-catalytic | SHARPIN, SHANK-associated RH domain interactor | Review | RING1-BRcat-Rcat | Parc, parkin-like cytoplasmic p53-binding protein | SUMO, small ubiquitin-related modifier | LUBAC, linear ubiquitin chain assembly complex | HOIL-1, haem-oxidized IRP2 ubiquitin ligase 1 | RNF, RING finger protein | CPH, Cul7, Parc and HERC2 proteins | HDAC, histone deacetylase | RBR, RING-BetweenRING-RING | Cdk5, cyclin-dependent kinase 5 | SILAC, stable isotope labelling by amino acids in cell culture | RanBP2, RAN-binding protein 2 | FANCL, Fanconi anaemia, complementation group L | PINK1, PTEN-induced putative kinase 1 | PKC, protein kinase C | CK1, casein kinase 1 | NEDD, neural-precursor-cell-expressed developmentally down-regulated | ZNF, zinc finger | UBE2L, ubiquitin-conjugating enzyme E2L | UIM, ubiquitin-interacting motif | Cul, cullin | Rcat, required-for-catalysis
Journal Article
Hepatology, ISSN 0270-9139, 01/2019, Volume 69, Issue 1, pp. 34 - 50
Hepatitis C virus (HCV) is highly efficient in establishing a chronic infection, having evolved multiple strategies to suppress the host antiviral responses.... 
INTERFERON RESPONSE | MAVS | ACTIVATE | REPLICATION | NLRX1 | BLOCKS | KINASE | TOLL-LIKE RECEPTORS | CLEAVAGE | GASTROENTEROLOGY & HEPATOLOGY | INNATE IMMUNITY | Proteins | Hepatitis | Mitochondria | TRAF6 protein | Chronic infection | Infections | Interferon | Hepatitis C
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1937 - 1952
Lipopolysaccharide (LPS)-induced activation of TLR4 (toll-like receptor 4) is followed by a subsequent overwhelming inflammatory response, a hallmark of the... 
ACTB, actin, beta | MYD88, myeloid differentiation primary response 88 | PELI3 | CHX, cycloheximide | BECN1, Beclin 1, autophagy related | TICAM1, toll-like receptor adaptor molecule 1 | LPS | RIPK1, receptor (TNFRSF)-interacting serine-threonine kinase 1 | TUBB, tubulin, beta class I | PRRs, pattern recognition receptors | UBB, ubiquitin B | IRAKs, interleukin-1 receptor-associated kinases | HBSS, Hank's balanced salt solution | ATG7, autophagy-related 7 | MAP1LC3B, microtubule-associated protein 1 light chain 3 beta | TLRs, toll-like receptors | Baf A1, bafilomycin A | WT, wildtype | autophagy | TNF, tumor necrosis factor | MAPK14, mitogen-activated protein kinase 14 | NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MAPK1/3, mitogen-activated protein kinase 1/3 | Epoxo, epoxomycin | TRAF6, TNF receptor-associated factor 6, E3 ubiquitin protein ligase | IL1B, interleukin 1, beta | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | TABs, TGF-beta activated kinase 1/MAP3K7 binding protein 1/2/3 | Wortm, wortmannin | 1 | PELI3, pellino E3 ubiquitin protein ligase family member 3 | MAPK8/9, mitogen-activated protein kinase 8/9 | SQSTM1, sequestosome 1 | NFE2L2, nuclear factor, erythroid 2-like 2 | NLRP3, NLR family, pyrin domain containing 3 | LAMP2, lysosomal-associated membrane protein 2 | LPS, lipopolysaccharide | MAP3K14, mitogen-activated protein kinase kinase kinase 14 | MΦ, macrophages | Rapa, rapamycin | SQSTM1 | TBK1, TANK-binding kinase 1 | Torin2 | MAP3K7, mitogen-activated protein kinase kinase kinase 7 | Autophagy | TOLL-LIKE-RECEPTORS | ACTIVATION | BECLIN 1 | RECOGNITION | SELECTIVE AUTOPHAGY | CELL BIOLOGY | UBIQUITINATION | IL-1-BETA PRODUCTION | INFLAMMASOME | SCAFFOLD PROTEINS | INNATE IMMUNITY | Cell Line | Cytokines - metabolism | Signal Transduction | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Lipopolysaccharides - metabolism | Inflammation | Immunity, Innate | RNA, Messenger - metabolism | Toll-Like Receptor 4 - metabolism | Point Mutation | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Sepsis - metabolism | Mice | Naphthyridines - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal Article
Journal Article
by Ben, JJ and Jiang, B and Wang, DD and Liu, QL and Zhang, YJ and Qi, Y and Tong, X and Chen, LL and Liu, XZ and Zhang, Y and Zhu, XD and Li, XY and Zhang, HW and Bai, H and Yang, Q and Ma, JQ and Wiemer, EAC and Xu, Y and Chen, Q
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1801 - 15
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35051
Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson's disease (PD). Although large gene deletions have been... 
PROTEIN | OXIDATIVE DAMAGE | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL-FUNCTION | PROTEASOME | DOPAMINERGIC-NEURONS | ALPHA-SYNUCLEIN | DYSFUNCTION | STRESS | LEWY BODIES | Oncogene Proteins - genetics | Cell Fractionation | Cell Proliferation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Substantia Nigra - metabolism | RNA, Ribosomal - genetics | Lewy Bodies - genetics | Cell Nucleolus - metabolism | Parkinson Disease - metabolism | Lewy Bodies - metabolism | TNF Receptor-Associated Factor 6 - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Cell Nucleolus - genetics | Oncogene Proteins - metabolism | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | Parkinson Disease - genetics | Transcription Factors - genetics | Proteasome Endopeptidase Complex - genetics | Transcription Factors - metabolism | Protein Deglycase DJ-1 | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Proteasome Endopeptidase Complex - metabolism | Genetic aspects | Biosynthesis | RNA | Ligases | Tumor necrosis factor receptors | Brain | Neurosciences | Parkinson's disease | Yeast | Neuropathology | Parkinsons disease | Neurobiology | Neuroblastoma cells | Recruitment | Proteins | Nucleoli | Signal transduction | Missense mutation | Neurodegeneration | Protein folding | Evolution | Physiology | Life sciences | Trends | Stress response | Localization | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Movement disorders | TRAF6 protein | Neurodegenerative diseases | rRNA | MAP kinase | JNK protein | Lewy bodies | PARK7 protein | Molecular modelling | Aggregates | Tumor necrosis factor | Quality control | Mutation | Alzheimers disease | Endoplasmic reticulum | Cytoplasm | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article