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mediated apoptosis (6) 6
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receptors, tnf-related apoptosis-inducing ligand (6) 6
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CURRENT OPINION IN PHARMACOLOGY, ISSN 1471-4892, 08/2004, Volume 4, Issue 4, pp. 333 - 339
Unlike conventional cancer therapeutics, death receptor ligands trigger tumor cell apoptosis independently of the p53 tumor suppressor gene, which frequently... 
TRAIL/APO2L-INDUCED APOPTOSIS | APOPTOSIS-INDUCING LIGAND | CHEMOTHERAPEUTIC-AGENTS | DECOY RECEPTORS | IN-VIVO | PHARMACOLOGY & PHARMACY | TRAIL-INDUCED APOPTOSIS | MEDIATED APOPTOSIS | DEFICIENT MICE | ANTITUMOR-ACTIVITY | UP-REGULATION
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2015, Volume 16, Issue 16, pp. 6991 - 6996
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 08/2019, Volume 234, Issue 8, pp. 13510 - 13524
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 7, pp. 5546 - 5557
Discovery of the molecular targets of traditional medicine and its chemical footprints can validate the use of such medicine. In the present report, we... 
LUNG-CANCER | LEUKEMIC HL-60 CELLS | COLON-CANCER CELLS | TRAIL/APO2L-INDUCED APOPTOSIS | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | DOWN-REGULATION | MEDIATED APOPTOSIS | ANTITUMOR-ACTIVITY | IONIZING-RADIATION | Neoplasm Transplantation | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Tumor Necrosis Factor Decoy Receptors - agonists | Tumor Necrosis Factor Decoy Receptors - genetics | Apoptosis - drug effects | Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists | Colorectal Neoplasms - genetics | Humans | Cell Survival - genetics | Apoptosis - genetics | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Tumor Suppressor Protein p53 - genetics | MAP Kinase Kinase 4 - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | TNF-Related Apoptosis-Inducing Ligand - agonists | Colorectal Neoplasms - drug therapy | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Colorectal Neoplasms - metabolism | Caco-2 Cells | Antineoplastic Agents, Phytogenic - agonists | Cell Survival - drug effects | Tumor Suppressor Protein p53 - metabolism | Up-Regulation - genetics | Down-Regulation - drug effects | Xenograft Model Antitumor Assays - methods | Down-Regulation - genetics | Triterpenes - agonists | Tumor Necrosis Factor Decoy Receptors - metabolism | Drug Synergism | Up-Regulation - drug effects | Animals | Mice, Nude | MAP Kinase Kinase 4 - genetics | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Index Medicus | Molecular Bases of Disease | Cancer Therapy | Reactive Oxygen Species (ROS) | JNK | Cytokine | Apoptosis
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 01/2019, Volume 20, Issue 3, p. 525
Journal Article
CANCER CHEMOTHERAPY AND PHARMACOLOGY, ISSN 0344-5704, 06/2005, Volume 55, Issue 6, pp. 531 - 540
Ginsenoside Rh2 (Rh2), a purified ginseng saponin, has been shown to have antiproliferative effects in certain cancer cell types. However, the molecular... 
CANCER-CELLS | TRAIL/APO2L-INDUCED APOPTOSIS | cyclin | TRAIL | SK-HEP-1 CELLS | apoptosis | TRAIL-RI | C6BU-1 CELLS | caspase | pRb2/p130 | ONCOLOGY | ginsenoside Rh2 | PHARMACOLOGY & PHARMACY | MELANOMA-CELLS | RETINOBLASTOMA GENE FAMILY | DEATH RECEPTOR DR4 | EXPRESSION | CYCLE
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2005, Volume 11, Issue 8, pp. 3075 - 3083
Purpose: We have recently shown that combination of tumor necrosis factor α–related apoptosis-inducing ligand (TRAIL) with anticancer drugs induced an... 
Bcl-2 | tumor cells | GSH | hepatocytes | TRAIL/5-FU | CANCER-CELLS | OXIDATIVE STRESS | TRAIL/APO2L-INDUCED APOPTOSIS | BUTHIONINE SULFOXIMINE | ONCOLOGY | RESISTANCE | DEATH | LIGAND | ACTIVATED PROTEIN-KINASES | ANTITUMOR-ACTIVITY | CYTOTOXICITY
Journal Article
Oncology Reports, ISSN 1021-335X, 02/2016, Volume 35, Issue 2, pp. 1020 - 1026
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent anticancer agent possessing the ability to induce apoptosis in various cancer... 
TRAIL-induced apoptosis | Bcl-2 | c-FLIP | hispolon | ERK | death receptor | C-FLIP | Bcl | Hispolon | Death receptor | TRAIL/APO2L-INDUCED APOPTOSIS | PROTEIN | DOWN-REGULATION | XIAP | INDUCTION | ONCOLOGY | RESISTANCE | CASPASE-8 | INHIBITOR | EXPRESSION | MAP Kinase Signaling System - physiology | Apoptosis - drug effects | Humans | Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis | Catechols - isolation & purification | TNF-Related Apoptosis-Inducing Ligand - pharmacology | CCAAT-Enhancer-Binding Proteins - biosynthesis | Caspases - biosynthesis | Apoptosis Regulatory Proteins - genetics | Catechols - pharmacology | Polysaccharides - chemistry | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | CCAAT-Enhancer-Binding Proteins - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Apoptosis Regulatory Proteins - biosynthesis | Caspases - genetics | Neoplasm Proteins - biosynthesis | Plant Extracts | Down-Regulation | Up-Regulation - drug effects | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Line, Tumor | Signal Transduction - physiology | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Usage | Care and treatment | Innovations | Health aspects | Basidiomycota | Apoptosis | Cancer | Immunoglobulins | Colorectal cancer | Metastasis | Radiation therapy | Kinases | Cancer therapies | Studies | Proteins | Chemotherapy | Penicillin | Tumor necrosis factor-TNF | Ligands | Index Medicus
Journal Article
Journal Article
Neurochemistry International, ISSN 0197-0186, 2009, Volume 55, Issue 6, pp. 423 - 430
Embelin has been reported to exhibit therapeutic activity in cancer. In this study glioblastoma cells and human astrocytes were treated with Embelin, tumor... 
Glioma | Embelin | TRAIL/Apo2L | c-FLIP | CANCER CELLS | PROTEASOMAL DEGRADATION | SURVIVIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGAND-INDUCED APOPTOSIS | DEATH | CELECOXIB | NEUROSCIENCES | SIGNALING COMPLEX | GLIOBLASTOMAS | DR5 UP-REGULATION | Apoptosis - drug effects | Humans | Brain Neoplasms - physiopathology | RNA, Messenger - metabolism | Apoptosis Regulatory Proteins - drug effects | Brain Neoplasms - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Glioma - metabolism | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Protein Isoforms - metabolism | TNF-Related Apoptosis-Inducing Ligand - agonists | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Gene Expression Regulation, Neoplastic - physiology | RNA, Messenger - drug effects | Cell Line | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | CASP8 and FADD-Like Apoptosis Regulating Protein - antagonists & inhibitors | Brain Neoplasms - drug therapy | Down-Regulation - drug effects | Apoptosis Regulatory Proteins - metabolism | Benzoquinones - pharmacology | Down-Regulation - physiology | Drug Synergism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Apoptosis - physiology | Glioma - physiopathology | Glioma - drug therapy | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Proteins | Care and treatment | Cell research | Messenger RNA | Gliomas | Oncology, Experimental | Research | Cancer | Apoptosis | Index Medicus
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2008, Volume 33, Issue 2, pp. 243 - 249
Journal Article
Journal Article