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Cell death & disease, ISSN 2041-4889, 09/2017, Volume 8, Issue 9, pp. e3037 - e3037
.... Ribosomal protein s5 (RPS5) has been identified as a target of M19 and regulates PI3K/Akt, NF-kappa B and MAPKs pathways in osteoclastogenesis... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mesenchymal Stromal Cells - cytology | RANK Ligand - pharmacology | Macrophage Colony-Stimulating Factor - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Mesenchymal Stromal Cells - drug effects | NF-kappa B - antagonists & inhibitors | Osteoclasts - pathology | Signal Transduction | Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Mesenchymal Stromal Cells - metabolism | Osteoporosis, Postmenopausal - genetics | Bone Density Conservation Agents - chemical synthesis | Ribosomal Proteins - agonists | Osteoporosis, Postmenopausal - drug therapy | Bone Density Conservation Agents - pharmacology | Mitogen-Activated Protein Kinases - genetics | Mice | Ovariectomy - adverse effects | Alkaloids - chemical synthesis | Osteoporosis, Postmenopausal - pathology | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Ribosomal Proteins - metabolism | Bone Marrow Cells - drug effects | Female | Benzopyrans - pharmacology | Osteogenesis - genetics | Osteoporosis, Postmenopausal - etiology | Alkaloids - pharmacology | Bone Marrow Cells - cytology | Ribosomal Proteins - genetics | Osteogenesis - drug effects | Gene Expression Regulation | Osteoclasts - metabolism | Phosphatidylinositol 3-Kinases - genetics | Bone Density - drug effects | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | NF-kappa B - genetics | RANK Ligand - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - agonists | Acetates - pharmacology | Primary Cell Culture | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism | Mesenchyme | Ovariectomy | Ribosomal protein S5 | Menopause | Macrophage colony-stimulating factor | Stem cell transplantation | AKT protein | Post-menopause | 1-Phosphatidylinositol 3-kinase | Osteoclastogenesis | Osteoporosis | Allografts | Cellular biology | Bioactive compounds | Stem cells | Bone marrow | Hormone replacement therapy | Bone density | TRANCE protein | Bone loss | Public health | Osteogenesis | Adipogenesis | Index Medicus | Original
Journal Article
PloS one, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102797 - e102797
... (OPG, a decoy receptor of the receptor activator of NF-kappaB ligand (RANKL)), it significantly enhanced that of secreted Frizzled-related protein 4... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Diabetes Mellitus - genetics | Gene Expression - genetics | Methyl-CpG-Binding Protein 2 - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Methyl-CpG-Binding Protein 2 - genetics | Pyruvaldehyde - metabolism | Wnt Proteins - genetics | Epigenomics - methods | Receptor Activator of Nuclear Factor-kappa B - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Oxidative Stress - genetics | Diabetes Mellitus - metabolism | Mesenchymal Stromal Cells - metabolism | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | DNA Methylation - genetics | Signal Transduction - genetics | beta Catenin - metabolism | Down-Regulation - genetics | beta Catenin - genetics | Bone Diseases, Metabolic - metabolism | Animals | Epigenesis, Genetic - genetics | Receptor Activator of Nuclear Factor-kappa B - genetics | Mice | Bone Diseases, Metabolic - genetics | Oxidative stress | Bisulfite | Frizzled-related protein | Wnt protein | Frizzled protein | Genes | DNA damage | Inactivation | Osteoblasts | Gene sequencing | Osteoprotegerin | Proteins | Osteoporosis | β-catenin | Demethylation | Biomedical materials | Methyl-CpG binding protein | Rodents | DNA methylation | Bone marrow | Aging | Biocompatibility | Physiology | TRANCE protein | Deoxyribonucleic acid--DNA | Osteopenia | University graduates | CpG islands | NF-κB protein | Deactivation | Complications | Legal medicine | Diabetes mellitus | Stroma | Gene expression | Medicine | Pathology | Signaling | Deoxyguanosine | Sodium | MeCP2 protein | Derepression | Epigenetics | Biomarkers | Diabetes | Pyruvaldehyde | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
by Meng, S and Zhang, L and Tang, Y and Tu, Q and Zheng, L and Yu, L and Murray, D and Cheng, J and Kim, S.H and Zhou, X and Chen, J
Journal of dental research, ISSN 1544-0591, 05/2014, Volume 93, Issue 7, pp. 657 - 662
BET proteins are a group of epigenetic regulators controlling transcription through reading acetylated histone tails and recruiting transcription complexes... 
Epigenetics | Osteoclasts | BRD4 protein | Experimental animal models | Periodontitis | Anti-inflammatory agents | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Interleukin-1beta - drug effects | Transcription Factor AP-1 - drug effects | Toll-Like Receptor 2 - antagonists & inhibitors | Alveolar Bone Loss - prevention & control | Cathepsin K - drug effects | Tartrate-Resistant Acid Phosphatase | Promoter Regions, Genetic - drug effects | Lipopolysaccharides - adverse effects | RANK Ligand - drug effects | Proto-Oncogene Proteins c-ets - drug effects | Cell Differentiation | Toll-Like Receptor 4 - antagonists & inhibitors | Acid Phosphatase - drug effects | Transcription Factors - therapeutic use | Cell Line | Proto-Oncogene Proteins c-fos - drug effects | Nuclear Proteins - therapeutic use | Periodontitis - prevention & control | NFATC Transcription Factors - drug effects | Animals | Tumor Necrosis Factor-alpha - drug effects | Isoenzymes - drug effects | Mice | Osteoclasts - drug effects | NF-kappa B - drug effects | Phosphorylation | Chromatin | Immunoprecipitation | Disease | Transcription | Laboratories | Calcineurin | Inflammatory diseases | Lipopolysaccharides | Interleukin 6 | Proteins | Toll-like receptors | Bacteria | Tumor necrosis factor-TNF | TRANCE protein | Bone loss | c-Fos protein | NF-κB protein | Medical research | Cathepsin K | Cytokines | Therapeutic applications | Alveolar bone | Inflammation | RNA polymerase | Tumor necrosis factor-α | Gene expression | Nuclear transport | Polymerase chain reaction | Lymphocytes B | TLR2 protein | Acid phosphatase (tartrate-resistant) | Index Medicus | Dentistry | experimental animal models | periodontitis | osteoclasts | anti-inflammatory agents | Research Reports | epigenetics
Journal Article
Journal Article
Molecular and cellular biochemistry, ISSN 0300-8177, 4/2012, Volume 363, Issue 1, pp. 179 - 190
Bone-morphogenetic proteins (BMPs) play an important role in development and many cellular processes... 
Life Sciences | Biochemistry, general | BMP4 | MMP-1 | Medical Biochemistry | Oncology | CXCR4 | Breast cancer | Cardiology | Metastases | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | RANK Ligand - metabolism | Bone Morphogenetic Protein 4 - genetics | Coculture Techniques | Humans | Gene Expression Regulation, Neoplastic | RNA, Messenger - metabolism | Bone Morphogenetic Protein 4 - metabolism | Activin Receptors - genetics | Breast Neoplasms - metabolism | Transfection | RNA Interference | Time Factors | HEK293 Cells | Female | Receptors, CXCR4 - genetics | Matrix Metalloproteinase 1 - genetics | Neoplasm Invasiveness | Smad Proteins - genetics | Receptors, CXCR4 - metabolism | Carrier Proteins - genetics | Phenotype | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Osteoprotegerin - metabolism | Matrix Metalloproteinase 1 - metabolism | Osteoblasts - metabolism | Cell Movement | Development and progression | Bone morphogenetic proteins | RNA | Bone density | Cell adhesion & migration | Bone morphogenetic protein 4 | Bone remodelling | Antagonists | mRNA | Matrix metalloproteinase | Noggin protein | Tumor cell lines | CXCR4 protein | Osteoprotegerin | Signal transduction | Development | Microenvironments | TRANCE protein | CXC chemokine receptors | Cell migration | Interstitial collagenase | Index Medicus
Journal Article
Journal Article
The FASEB journal, ISSN 0892-6638, 09/2017, Volume 31, Issue 9, pp. 4011 - 4022
ABSTRACT Kelch‐like ECH‐associated protein 1 (Keap1) binds to nuclear factor E2 p45... 
IRF‐8 | MafB | Blimp1 | Nrf2 | oxidative stress | Oxidative stress | IRF-8 | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | MafB Transcription Factor - metabolism | Osteogenesis - physiology | RANK Ligand - metabolism | Interferon Regulatory Factors - metabolism | Macrophages | Kelch-Like ECH-Associated Protein 1 - genetics | NF-E2-Related Factor 2 - genetics | Nuclear Proteins - genetics | Osteogenesis - genetics | Animals, Newborn | MafB Transcription Factor - genetics | Down-Regulation | NFATC Transcription Factors - metabolism | Osteoblasts - physiology | Gene Expression Regulation - physiology | Interferon Regulatory Factors - genetics | Nuclear Proteins - metabolism | Kelch-Like ECH-Associated Protein 1 - metabolism | Mitochondria - metabolism | Transcription Factors - genetics | Mice, Knockout | RANK Ligand - genetics | Transcription Factors - metabolism | Animals | NF-E2-Related Factor 2 - metabolism | Mice | NFATC Transcription Factors - genetics | Transcription factors | Activation | NF-AT protein | Talus | Proteins | Antioxidants | Bone growth | Mitochondria | Biomedical materials | Lymphocytes | Rodents | Down-regulation | Biocompatibility | TRANCE protein | Bone loss | NF-κB protein | Abnormalities | Protein deficiency | Gene expression | Osteoclastogenesis | Signaling | Calcaneus | Osteoclasts | Interferon | Osteogenesis | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0181782 - e0181782
Bruton's tyrosine kinase (BTK) regulates critical signal transduction pathways involved in the pathobiology of rheumatoid arthritis (RA) and other autoimmune... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Arthritis, Experimental - drug therapy | Osteoclasts - pathology | Leukocytes, Mononuclear - drug effects | Humans | Arthritis, Experimental - immunology | Protein-Tyrosine Kinases - immunology | Arthritis, Experimental - pathology | RANK Ligand - immunology | B-Lymphocytes - drug effects | Leukocytes, Mononuclear - pathology | Animals | B-Lymphocytes - immunology | Osteoclasts - immunology | Protein Kinase Inhibitors - therapeutic use | Antibody Formation - drug effects | Leukocytes, Mononuclear - immunology | Female | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | B-Lymphocytes - pathology | Osteoclasts - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Care and treatment | Rheumatoid arthritis | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects | Phosphotransferases | Cell proliferation | Animal models | Sjogren's syndrome | Disease | Disorders | Clinical trials | Leukocytes (mononuclear) | Biology | Arthritis | Signal transduction | Biomedical materials | CTLA-4 protein | Pathways | Etanercept | Rodents | Peripheral blood mononuclear cells | Tumor necrosis factor-TNF | Biocompatibility | Chief executive officers | Inhibition | Methotrexate | TRANCE protein | Protein-tyrosine kinase | Tyrosine | Medical research | Immunoglobulins | Effectiveness | Cytokines | Research & development--R&D | Pharmacology | Bruton's tyrosine kinase | Osteoclastogenesis | Generic drugs | Fc receptors | Inhibitors | Lymphocytes B | Tumor necrosis factor | Collagen | Autoimmune diseases | In vitro methods and tests | Index Medicus | Research & development | R&D
Journal Article