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Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 09/2017, Volume 8, Issue 9, pp. 1980 - 1994
Medulloblastoma is one of the most prevalent brain tumors in children. Aberrant hedgehog (Hh) pathway signaling is thought to be involved in the initiation and... 
cancer therapy | Smoothened | medulloblastoma | GPCR | scaffold hopping | antagonist | hedgehog signaling pathway | CHEMISTRY, MEDICINAL | RECEPTOR ANTAGONISTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CANCER | NEUROSCIENCES | DISCOVERY | SMALL-MOLECULE INHIBITORS | RESISTANCE | DEPENDENT MALIGNANCIES | HEDGEHOG-SIGNALING PATHWAY | METABOLIC STABILITY | MEDULLOBLASTOMA | NIH 3T3 Cells | Neoplasm Transplantation | Cricetulus | Pyridines - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Anilides - chemistry | Transcriptional Regulator ERG - metabolism | Pyridines - pharmacokinetics | Male | Anilides - pharmacokinetics | Structure-Activity Relationship | Smoothened Receptor - metabolism | Patched-1 Receptor - genetics | Antineoplastic Agents - adverse effects | Drug Design | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Smoothened Receptor - antagonists & inhibitors | Cerebellar Neoplasms - metabolism | CHO Cells | Cerebellar Neoplasms - drug therapy | Mice, Transgenic | Medulloblastoma - metabolism | Pyrimidines - pharmacology | Random Allocation | Mice, SCID | Rats, Sprague-Dawley | Mice, Inbred ICR | Patched-1 Receptor - deficiency | Animals | Dogs | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Mice | Transcriptional Regulator ERG - genetics | Medulloblastoma - drug therapy
Journal Article
2008, ISBN 9780387736082, xii, 425
The regulation of gene transcription by neuronal activity is evident in many neuronal processes, ranging from neural development and refinement of neuronal... 
Neuroplasticity | Neural transmission | Regulation | Genetic transcription | Neurology | Neurosciences | Biomedicine | Neurobiology
Book
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2005, Volume 48, Issue 8, pp. 2972 - 2984
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 07/2017, Volume 42, Issue 7, pp. 531 - 542
Journal Article