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Journal Article
Cell (Cambridge), ISSN 0092-8674, 02/2009, Volume 136, Issue 4, pp. 669 - 687
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12853 - 12858
.... Here, we report the discovery of (R)-PFI-2—a first-in-class, potent ($K_i^{app}$ = 0.33 nM), selective, and cell-active inhibitor of the methyltransferase activity of human SETD7... 
Enzymes | Transcriptional regulatory elements | Genes | Cell lines | Histones | Gene expression regulation | Kinetics | Methylation | Inhibitory concentration 50 | Chemicals | Chemical biology | Epigenetics | Chemical probe | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Methyltransferases - metabolism | Structure-Activity Relationship | Phosphoproteins - metabolism | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | MCF-7 Cells | Tetrahydroisoquinolines - chemistry | Enzyme Inhibitors - chemistry | Epigenesis, Genetic - drug effects | Protein Structure, Tertiary | Tetrahydroisoquinolines - pharmacology | Histone-Lysine N-Methyltransferase - genetics | Sulfonamides - chemistry | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | Sulfonamides - pharmacology | Pyrrolidines - chemistry | Methyltransferases - antagonists & inhibitors | Histone-Lysine N-Methyltransferase - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Adaptor Proteins, Signal Transducing - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Protein research | Research | Methyltransferases | Lysine | Health aspects | Protein-protein interactions | Proteins | Cells | Substrates | Proteomics | Index Medicus | chemical probe | Biological Sciences | chemical biology | epigenetics
Journal Article
RNA (Cambridge), ISSN 1355-8382, 12/2010, Volume 17, Issue 2, pp. 312 - 326
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 05/2010, Volume 328, Issue 5986, pp. 1694 - 1698
Journal Article