Annual Review of Immunology, ISSN 0732-0582, 2005, Volume 23, Issue 1, pp. 161 - 196
Our views regarding the origins and functions of splenic marginal zone B cells have changed considerably over the past few years. Perspectives regarding the...
B cell receptor | Notch2 | Follicular B cells | Transitional B cells | B1B CELLS | follicular B cells | transitional B cells | KAPPA-B | T-CELL | IMMUNOLOGY | HEAT-STABLE ANTIGEN(HI) | LYMPHOTOXIN-BETA-RECEPTOR | SPLEEN DENDRITIC CELLS | POSITIVE SELECTION | IMMUNE-RESPONSES | IN-VIVO | SPLENIC WHITE PULP | Adaptation, Physiological | Spleen - immunology | Signal Transduction | B-Lymphocyte Subsets - cytology | Microcirculation - anatomy & histology | Spleen - cytology | Receptors, Antigen, B-Cell - metabolism | Immunity, Innate | Models, Immunological | Animals | Spleen - blood supply | B-Lymphocyte Subsets - immunology | Cell Differentiation | Mice
B cell receptor | Notch2 | Follicular B cells | Transitional B cells | B1B CELLS | follicular B cells | transitional B cells | KAPPA-B | T-CELL | IMMUNOLOGY | HEAT-STABLE ANTIGEN(HI) | LYMPHOTOXIN-BETA-RECEPTOR | SPLEEN DENDRITIC CELLS | POSITIVE SELECTION | IMMUNE-RESPONSES | IN-VIVO | SPLENIC WHITE PULP | Adaptation, Physiological | Spleen - immunology | Signal Transduction | B-Lymphocyte Subsets - cytology | Microcirculation - anatomy & histology | Spleen - cytology | Receptors, Antigen, B-Cell - metabolism | Immunity, Innate | Models, Immunological | Animals | Spleen - blood supply | B-Lymphocyte Subsets - immunology | Cell Differentiation | Mice
Journal Article
AMERICAN JOURNAL OF TRANSPLANTATION, ISSN 1600-6135, 05/2014, Volume 14, Issue 5, pp. 1173 - 1182
Phase III clinical studies have shown that kidney transplant (KT) recipients treated with the costimulation blocker belatacept exhibited a better renal...
ANTIBODIES | SURGERY | BAFF | transitional B cells | kidney transplantation | PHASE-III | BENEFIT-EXT | IDENTIFICATION | PLASMA-CELLS | TRANSPLANTATION | BAFF-R | REJECTION | ACCEPTANCE | belatacept | CTLA-4-Ig | EXPRESSION | CYCLOSPORINE
ANTIBODIES | SURGERY | BAFF | transitional B cells | kidney transplantation | PHASE-III | BENEFIT-EXT | IDENTIFICATION | PLASMA-CELLS | TRANSPLANTATION | BAFF-R | REJECTION | ACCEPTANCE | belatacept | CTLA-4-Ig | EXPRESSION | CYCLOSPORINE
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 08/2019, Volume 102, pp. 150 - 158
Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at...
TLR9 | Interferon | Systemic lupus erythematosus | CD19 | Transitional B cells | ACTIVATION | TOLERANCE CHECKPOINTS | IMMUNOLOGY | GENOME | RESPONSES | SYSTEMS | SELECTION | AUTOANTIBODY PRODUCTION | SELF-TOLERANCE | Lupus | Autoimmunity | Autoantibodies | Analysis | African Americans | Bone marrow | Transplantation | B cells | Biological response modifiers
TLR9 | Interferon | Systemic lupus erythematosus | CD19 | Transitional B cells | ACTIVATION | TOLERANCE CHECKPOINTS | IMMUNOLOGY | GENOME | RESPONSES | SYSTEMS | SELECTION | AUTOANTIBODY PRODUCTION | SELF-TOLERANCE | Lupus | Autoimmunity | Autoantibodies | Analysis | African Americans | Bone marrow | Transplantation | B cells | Biological response modifiers
Journal Article
American Journal of Reproductive Immunology, ISSN 1046-7408, 05/2019, Volume 81, Issue 5, pp. e13102 - n/a
Problem The immunophenotype of B cells at the maternal‐fetal interface (decidua) in labor at term and preterm labor is poorly understood. Method of study...
funisitis | plasmablasts | transitional B cells | B1 B cells | placental inflammation | pregnancy | naïve B cells | chronic chorioamnionitis | memory B cells | IMMUNE-RESPONSE | AMNIOTIC-FLUID INFECTION | IMMUNOLOGY | CD8(+) T-CELLS | PREMATURE RUPTURE | REPRODUCTIVE BIOLOGY | BACTERIAL-COLONIZATION | TOLL-LIKE RECEPTORS | naive B cells | INTRAAMNIOTIC INFLAMMATION | CLINICAL-SIGNIFICANCE | INTACT MEMBRANES | Flow cytometry | Placenta | Chorioamnionitis | Lymphocytes B | Fetuses | Decidua | Gestational age
funisitis | plasmablasts | transitional B cells | B1 B cells | placental inflammation | pregnancy | naïve B cells | chronic chorioamnionitis | memory B cells | IMMUNE-RESPONSE | AMNIOTIC-FLUID INFECTION | IMMUNOLOGY | CD8(+) T-CELLS | PREMATURE RUPTURE | REPRODUCTIVE BIOLOGY | BACTERIAL-COLONIZATION | TOLL-LIKE RECEPTORS | naive B cells | INTRAAMNIOTIC INFLAMMATION | CLINICAL-SIGNIFICANCE | INTACT MEMBRANES | Flow cytometry | Placenta | Chorioamnionitis | Lymphocytes B | Fetuses | Decidua | Gestational age
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2016, Volume 137, Issue 5, pp. 1577 - 1584.e10
CD24 CD38 transitional B cells represent cells at a key stage in their developmental pathway. In addition, these B cells have been widely ascribed regulatory...
chronic inflammatory diseases | autoimmunity | Transitional B cells | immune regulation | Life Sciences | Immunology
chronic inflammatory diseases | autoimmunity | Transitional B cells | immune regulation | Life Sciences | Immunology
Journal Article
AIDS, ISSN 0269-9370, 09/2016, Volume 30, Issue 14, pp. 2169 - 2177
OBJECTIVE:The frequency of immature transitional B cells is increased in blood of HIV-1-infected individuals. We investigated whether HIV-1 infection affects...
CXCR4 | Chemokine receptor | Immature transitional B cells | HIV-1 infection | CD10 | INFECTIOUS DISEASES | ACTIVATION | CXCR4 EXPRESSION | LYMPH-NODES | BONE-MARROW | TRAFFICKING | RECEPTOR | IMMUNOLOGY | MATURATION | immature transitional B cells | chemokine receptor | INDIVIDUALS | VIROLOGY | ACTIVE ANTIRETROVIRAL THERAPY | DIFFERENTIATION | Anti-Retroviral Agents - therapeutic use | Cross-Sectional Studies | Humans | Middle Aged | Immunophenotyping | Male | Young Adult | HIV Infections - immunology | HIV-1 - immunology | HIV Infections - pathology | Precursor Cells, B-Lymphoid - pathology | Staining and Labeling | Aged, 80 and over | Adult | Female | HIV Infections - drug therapy | Aged | Cell Differentiation | Cell Movement
CXCR4 | Chemokine receptor | Immature transitional B cells | HIV-1 infection | CD10 | INFECTIOUS DISEASES | ACTIVATION | CXCR4 EXPRESSION | LYMPH-NODES | BONE-MARROW | TRAFFICKING | RECEPTOR | IMMUNOLOGY | MATURATION | immature transitional B cells | chemokine receptor | INDIVIDUALS | VIROLOGY | ACTIVE ANTIRETROVIRAL THERAPY | DIFFERENTIATION | Anti-Retroviral Agents - therapeutic use | Cross-Sectional Studies | Humans | Middle Aged | Immunophenotyping | Male | Young Adult | HIV Infections - immunology | HIV-1 - immunology | HIV Infections - pathology | Precursor Cells, B-Lymphoid - pathology | Staining and Labeling | Aged, 80 and over | Adult | Female | HIV Infections - drug therapy | Aged | Cell Differentiation | Cell Movement
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 04/2018, Volume 9, p. 909
Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased...
IgA | B regulatory cells | B cells | CpG | Selective IgA deficiency | T cell-independent B cell responses | T cells | Transitional B cells | ANTIBODIES | ACTIVATION | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | selective IgA deficiency | GENERATION | T-CELLS | Immune response | Research | Immunoglobulin A
IgA | B regulatory cells | B cells | CpG | Selective IgA deficiency | T cell-independent B cell responses | T cells | Transitional B cells | ANTIBODIES | ACTIVATION | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | selective IgA deficiency | GENERATION | T-CELLS | Immune response | Research | Immunoglobulin A
Journal Article
Cellular and Molecular Immunology, ISSN 1672-7681, 03/2018, Volume 16, Issue 4, pp. 1 - 13
A hallmark of systemic lupus erythematosus (SLE) is the breaking of B-cell tolerance with the generation of high-affinity autoantibodies; however, the...
interleukin 6 | apoptosis | Systemic lupus erythematosus | transitional B cells | type I interferons | POPULATION | ACTIVATION | EFFICACY | LYMPHOCYTE STIMULATOR | ALPHA | MONOCLONAL-ANTIBODY | PERIPHERAL-BLOOD | IMMUNOLOGY | INTERLEUKIN-6 | PLASMACYTOID DENDRITIC CELLS | EXPRESSION
interleukin 6 | apoptosis | Systemic lupus erythematosus | transitional B cells | type I interferons | POPULATION | ACTIVATION | EFFICACY | LYMPHOCYTE STIMULATOR | ALPHA | MONOCLONAL-ANTIBODY | PERIPHERAL-BLOOD | IMMUNOLOGY | INTERLEUKIN-6 | PLASMACYTOID DENDRITIC CELLS | EXPRESSION
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 08/2018, Volume 9, p. 1806
Developing B cells undergo defined maturation steps in the bone marrow and in the spleen. The timing and the factors that control these differentiation steps...
Ig-a | MerCreMer | Cre/loxP | Imb-1 mouse | B cell activating factor | B cell development | Tamoxifen | Transitional B cells | transitional B cells | Ig-alpha | CRE RECOMBINASE | KAPPA-B | IMMUNOLOGY | MARGINAL-ZONE | CUTTING EDGE | BAFF-R | LYMPHOCYTE DEVELOPMENT | ANTIGEN-RECEPTOR | PERIPHERAL DELETION | imb-1 mouse | tamoxifen | T-CELLS | Rats | Physiological aspects | Research | B cells | Cell development (Biology) | Rattus | Ig-α
Ig-a | MerCreMer | Cre/loxP | Imb-1 mouse | B cell activating factor | B cell development | Tamoxifen | Transitional B cells | transitional B cells | Ig-alpha | CRE RECOMBINASE | KAPPA-B | IMMUNOLOGY | MARGINAL-ZONE | CUTTING EDGE | BAFF-R | LYMPHOCYTE DEVELOPMENT | ANTIGEN-RECEPTOR | PERIPHERAL DELETION | imb-1 mouse | tamoxifen | T-CELLS | Rats | Physiological aspects | Research | B cells | Cell development (Biology) | Rattus | Ig-α
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 05/2016, Volume 137, Issue 5, pp. 1577 - 1577
Background: CD24(high)CD38(high) transitional B cells represent cells at a key stage in their developmental pathway. In addition, these B cells have been...
chronic inflammatory diseases | MOUSE | SUBSETS | POPULATIONS | PERIPHERAL-BLOOD | IMMUNOLOGY | IDENTIFICATION | COMPARTMENT | Transitional B cells | immune regulation | autoimmunity | MEMORY | ALLERGY | ANERGY | T-CELLS | Humans | Middle Aged | Sjogren's Syndrome - immunology | Male | Precursor Cells, B-Lymphoid - immunology | Kidney Transplantation | HIV Infections - immunology | ADP-ribosyl Cyclase 1 - immunology | Lupus Erythematosus, Systemic - immunology | Aged, 80 and over | Adult | Female | Aged | Graft Rejection - immunology | Membrane Glycoproteins - immunology | Arthritis, Rheumatoid - immunology | CD24 Antigen - immunology | Cytokines - immunology | Life Sciences | Immunology
chronic inflammatory diseases | MOUSE | SUBSETS | POPULATIONS | PERIPHERAL-BLOOD | IMMUNOLOGY | IDENTIFICATION | COMPARTMENT | Transitional B cells | immune regulation | autoimmunity | MEMORY | ALLERGY | ANERGY | T-CELLS | Humans | Middle Aged | Sjogren's Syndrome - immunology | Male | Precursor Cells, B-Lymphoid - immunology | Kidney Transplantation | HIV Infections - immunology | ADP-ribosyl Cyclase 1 - immunology | Lupus Erythematosus, Systemic - immunology | Aged, 80 and over | Adult | Female | Aged | Graft Rejection - immunology | Membrane Glycoproteins - immunology | Arthritis, Rheumatoid - immunology | CD24 Antigen - immunology | Cytokines - immunology | Life Sciences | Immunology
Journal Article
Clinical Immunology, ISSN 1521-6616, 2014, Volume 151, Issue 2, pp. 127 - 135
Abstract The chief therapeutic mechanism of fingolimod in multiple sclerosis (MS) is considered to be sequestration of pathogenic lymphocytes into secondary...
Allergy and Immunology | Multiple sclerosis | B cells | Fingolimod | CD80 | Transitional B cells | Cytokine | PROFILES | PROTEIN | SUBSETS | DEPLETION | PERIPHERAL-BLOOD | IMMUNOLOGY | FTY720 | RITUXIMAB | Transitional 8 cells | MEMORY T-CELLS | B7-1 Antigen - blood | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Tumor Necrosis Factor-alpha - blood | Interleukin-10 - blood | Male | Case-Control Studies | Chemotaxis, Leukocyte - physiology | Inflammation - metabolism | Chemotaxis, Leukocyte - drug effects | Propylene Glycols - therapeutic use | Adult | B-Lymphocyte Subsets - immunology | Female | Multiple Sclerosis - metabolism | B-Lymphocyte Subsets - drug effects | B-Lymphocyte Subsets - physiology | Fingolimod Hydrochloride | Inflammation - immunology | Receptors, CCR7 - blood | Sphingosine - analogs & derivatives | Multiple Sclerosis - immunology | Sphingosine - therapeutic use | Multiple Sclerosis - drug therapy | Care and treatment | Analysis
Allergy and Immunology | Multiple sclerosis | B cells | Fingolimod | CD80 | Transitional B cells | Cytokine | PROFILES | PROTEIN | SUBSETS | DEPLETION | PERIPHERAL-BLOOD | IMMUNOLOGY | FTY720 | RITUXIMAB | Transitional 8 cells | MEMORY T-CELLS | B7-1 Antigen - blood | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Tumor Necrosis Factor-alpha - blood | Interleukin-10 - blood | Male | Case-Control Studies | Chemotaxis, Leukocyte - physiology | Inflammation - metabolism | Chemotaxis, Leukocyte - drug effects | Propylene Glycols - therapeutic use | Adult | B-Lymphocyte Subsets - immunology | Female | Multiple Sclerosis - metabolism | B-Lymphocyte Subsets - drug effects | B-Lymphocyte Subsets - physiology | Fingolimod Hydrochloride | Inflammation - immunology | Receptors, CCR7 - blood | Sphingosine - analogs & derivatives | Multiple Sclerosis - immunology | Sphingosine - therapeutic use | Multiple Sclerosis - drug therapy | Care and treatment | Analysis
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 06/2019, Volume 10
Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the...
type I IFNs | TLR7 | transitional B cells | RNP | SLE | autoantibodies
type I IFNs | TLR7 | transitional B cells | RNP | SLE | autoantibodies
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 05/2014, Volume 14, Issue 5, pp. 1173 - 1182
Phase III clinical studies have shown that kidney transplant (KT) recipients treated with the costimulation blocker belatacept exhibited a better renal...
BAFF | BAFF‐R | belatacept | transitional B cells | CTLA‐4‐Ig | kidney transplantation | BAFF-R | CTLA-4-Ig | Prognosis | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Precursor Cells, B-Lymphoid - metabolism | Graft Rejection - metabolism | Male | Transplant Recipients | Clinical Trials, Phase III as Topic | Flow Cytometry | Abatacept | Immunoconjugates - therapeutic use | Female | B-Cell Activation Factor Receptor - genetics | Real-Time Polymerase Chain Reaction | Graft Rejection - drug therapy | Kidney Failure, Chronic - surgery | RNA, Messenger - genetics | Cells, Cultured | Kidney Transplantation | Reverse Transcriptase Polymerase Chain Reaction | B-Cell Activation Factor Receptor - metabolism | B-Cell Activating Factor - metabolism | B-Cell Activating Factor - genetics | Precursor Cells, B-Lymphoid - cytology | Graft Rejection - immunology | Clinical Trials, Phase II as Topic | Cohort Studies
BAFF | BAFF‐R | belatacept | transitional B cells | CTLA‐4‐Ig | kidney transplantation | BAFF-R | CTLA-4-Ig | Prognosis | Follow-Up Studies | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Precursor Cells, B-Lymphoid - metabolism | Graft Rejection - metabolism | Male | Transplant Recipients | Clinical Trials, Phase III as Topic | Flow Cytometry | Abatacept | Immunoconjugates - therapeutic use | Female | B-Cell Activation Factor Receptor - genetics | Real-Time Polymerase Chain Reaction | Graft Rejection - drug therapy | Kidney Failure, Chronic - surgery | RNA, Messenger - genetics | Cells, Cultured | Kidney Transplantation | Reverse Transcriptase Polymerase Chain Reaction | B-Cell Activation Factor Receptor - metabolism | B-Cell Activating Factor - metabolism | B-Cell Activating Factor - genetics | Precursor Cells, B-Lymphoid - cytology | Graft Rejection - immunology | Clinical Trials, Phase II as Topic | Cohort Studies
Journal Article