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FEBS JOURNAL, ISSN 1742-464X, 07/2015, Volume 282, Issue 13, pp. 2512 - 2526
We have analyzed the natural evolution of transaminase structure and sequence between an -transaminase serine-pyruvate aminotransferase and an -transaminase... 
SUBSTRATE-SPECIFICITY | AMINO-ALCOHOLS | TRANSKETOLASE | OMEGA-TRANSAMINASE | PYRUVATE TRANSAMINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | substrate specificity | aminotransferase | transaminase | biocatalysis | directed evolution | CHIRAL AMINES | Molecular biology | Enzymes | Mutation
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2008, Volume 350, Issue 16, pp. 2631 - 2638
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 01/2018, Volume 200, Issue 2
Sinorhizobium meliloti is a Gram-negative alphaproteobacterium that can enter into a symbiotic relationship with Medicago sativa and Medicago truncatula.... 
Symbiosis | Phosphates | Pentose phosphate | Auxotrophy | Transketolase | Acidification | Amino acids | Alfalfa | Iron | Metabolism | Carbon | Mutants | Erythritol | Proteins | Genotype & phenotype | Transaldolase | Metabolites | Ribose | Pentose | Pentose phosphate pathway | Mutation | Gram-negative bacteria | Galactose | Sinorhizobium meliloti
Journal Article
American Journal of Human Genetics, ISSN 0002-9297, 12/2012, Volume 91, Issue 6, pp. 1082 - 1087
Abnormalities in metabolite profiles are valuable indicators of underlying pathologic conditions at the molecular level. However, their interpretation relies... 
Enzymes | Nonsense mutation | Therapeutic applications | Transketolase | biomarkers | L-lysine | Methionine | mRNA | Metabolism | dehydrogenase | aciduria | Heterozygosity | Missense mutation | Metabolites | Decarboxylation | Fibroblasts
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 47, p. E11043
Multiple mutations are typically required to significantly improve protein stability or aggregation kinetics. However, when several substitutions are made in a... 
Dynamic structural analysis | Systems stability | Protein engineering | Recombination | Deactivation | Computer simulation | Transketolase | Molecular dynamics | Epistasis | Agglomeration | Inactivation | Thermal stability | Free energy | Proteins | Domains | Engineering | E coli | Correlation analysis | Dynamic stability | Molecular chemistry | Mutation | Kinetics
Journal Article
Journal Article
MOLECULAR MEDICINE REPORTS, ISSN 1791-2997, 05/2019, Volume 19, Issue 5, pp. 4484 - 4490
Charcot-Marie-Tooth (CMT) disease is a group of motor and sensory neuropathies with a high degree of pathological and genetic heterogenicity. The present study... 
SWISS-MODEL | MEDICINE, RESEARCH & EXPERIMENTAL | mutation | dehydrogenase E1 and transketolase domain containing 1 gene | ONCOLOGY | Charcot-Marie-Tooth disease | TRAFFICKING | gap junction protein beta 1 gene
Journal Article
Yeast, ISSN 0749-503X, 07/2009, Volume 26, Issue 7, pp. 371 - 382
Journal Article
ChemBioChem, ISSN 1439-4227, 08/2017, Volume 18, Issue 15, pp. 1482 - 1486
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 41212
Flexible sites are potential targets for engineering the stability of enzymes. Nevertheless, the success rate of the rigidifying flexible sites (RFS) strategy... 
ESCHERICHIA-COLI TRANSKETOLASE | STRUCTURAL STABILITY | SUBSTRATE | MULTIDISCIPLINARY SCIENCES | ALIPHATIC ALDEHYDE | DENATURATION | AROMATICS | POTENTIALS | MUTATIONS | PROTEINS | DIRECTED EVOLUTION | Enzymes | Statistical analysis | Transketolase | Computer applications | Mutation | Protein-tyrosine kinase | Thermal stability
Journal Article