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Nature structural & molecular biology, ISSN 1545-9993, 06/2019, Volume 26, Issue 6, pp. 501 - 509
The drug-like molecule PF-06446846 (PF846) binds the human ribosome and selectively blocks the translation of a small number of proteins by an unknown... 
Polypeptides | Research | Ribosomes | Peptidyl transferases | Proteins | Translocation | rRNA 28S | Translation | Translation elongation | Chains | Translation termination | mRNA | Stalling | Elongation | Transfer RNA
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 143, Issue 3, pp. 379 - 389
The selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control process with important consequences for human disease. From... 
MEDIATED DECAY | SURVEILLANCE MACHINERY | GAG-POL JUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERMINATION CODONS | MURINE LEUKEMIA-VIRUS | READ-THROUGH | EXON JUNCTION COMPLEX | SACCHAROMYCES-CEREVISIAE | TRANSLATION TERMINATION | MAMMALIAN-CELLS | CELL BIOLOGY
Journal Article
ELIFE, ISSN 2050-084X, 07/2016, Volume 5
Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize... 
ELONGATION-FACTOR TU | AMINOACYL-TRANSFER-RNA | ACID STARVATION | CRYSTAL-STRUCTURE | ESCHERICHIA-COLI | BIOLOGY | CODON-RECOGNITION | TRANSLATION TERMINATION | 70S RIBOSOME | GTP HYDROLYSIS | GUANOSINE TETRAPHOSPHATE
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 40, pp. 26171 - 26182
The earliest step in the mRNA degradation process is deadenylation, a progressive shortening of the mRNA poly(A) tail by deadenylases. The question of when... 
Poly(A) tail | Translation termination | ERF3 | MYC | MRNA deadenylation
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 02/2018, Volume 46, Issue 4, pp. 1945 - 1957
Abstract Intracellular levels of reactive oxygen species (ROS) increase as a consequence of oxidative stress and represent a major source of damage to... 
MESSENGER-RNA | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDYL TRANSFERASE CENTER | ATOMIC MUTAGENESIS | BOND FORMATION | BASE-PAIRING PROPERTIES | REVERSE TRANSCRIPTASES | NASCENT PEPTIDE | PROTEIN-SYNTHESIS | TRANSLATION TERMINATION | Index Medicus | Nucleic Acid Enzymes
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 2009, Volume 15, Issue 9, pp. 430 - 438
Nonsense mutations that generate premature translation–termination codons (PTCs) are responsible for approximately one- third of human genetic diseases. PTCs... 
Pathology | Nonsense | Premature translation-termination codons (PTCs) | Mutation | Epilepsy | GABAA receptor subunits
Journal Article
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4
Stop codon recognition is a crucial event during translation termination and is performed by class I release factors (RF1 and RF2 in bacterial cells). Recent... 
TRANSLOCATION | MESSENGER-RNA | POLYPEPTIDE RELEASE | MULTIDISCIPLINARY SCIENCES | TRANSLATION TERMINATION | BINDING | RIBOSOME | RF2
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 03/2014, Volume 42, Issue 5, pp. 3409 - 3418
Eukaryotic translation termination results from the complex functional interplay between two release factors, eRF1 and eRF3, in which GTP hydrolysis by eRF3... 
MOLECULAR-DYNAMICS | EUKARYOTIC TRANSLATION TERMINATION | AMINOACYL-TRANSFER-RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFER-RNA HYDROLYSIS | STOP CODON RECOGNITION | CRYO-EM STRUCTURE | SACCHAROMYCES-CEREVISIAE | GTP HYDROLYSIS | RELEASE FACTOR ERF1
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 9260 - 11
Modes of evolution of stop codons in protein-coding genes, especially the conservation of UAA, have been debated for many years. We reconstructed the evolution... 
BACTERIA | RELEASE FACTORS RF1 | GENOMES | INITIATION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | PATTERNS | TRANSLATION TERMINATION | EFFICIENCY | UGA | ABUNDANCE | Eukaryotes | Prokaryotes | Positive selection | Evolution | Translation termination | Evolutionary genetics | Stop codon | Genomes | Codons
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2019, Volume 75, Issue 4, pp. 835 - 848.e8
Mitochondrial dysfunction and proteostasis failure frequently coexist as hallmarks of neurodegenerative disease. How these pathologies are related is not well... 
MISTERMINATE | RQC | PINK1/Parkin | CAT-tailing | neurodegeneration | ribosome stalling | translation termination | proteostasis | mitochondrial stress | Parkinson’s disease | Proteins | Medical research | Medical colleges | Nervous system diseases | Neurosciences | Codon | Analysis | Stem cells | Medicine, Experimental | Amino acids | Genetic translation | Index Medicus
Journal Article