X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (34570) 34570
Book Review (5255) 5255
Publication (4748) 4748
Book Chapter (751) 751
Conference Proceeding (335) 335
Dissertation (125) 125
Book / eBook (24) 24
Government Document (15) 15
Magazine Article (15) 15
Paper (9) 9
Reference (7) 7
Web Resource (5) 5
Data Set (4) 4
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (27831) 27831
humans (17266) 17266
animals (13307) 13307
biochemistry & molecular biology (9991) 9991
cell biology (5948) 5948
mutation (5450) 5450
cystic fibrosis transmembrane conductance regulator - genetics (5429) 5429
proteins (5382) 5382
cystic fibrosis (5188) 5188
molecular sequence data (5156) 5156
transmembrane conductance regulator (5088) 5088
amino acid sequence (4931) 4931
mice (4419) 4419
male (3984) 3984
female (3772) 3772
cystic fibrosis - genetics (3500) 3500
biophysics (3393) 3393
cell line (3137) 3137
expression (3045) 3045
transmembrane domain (3042) 3042
research (2987) 2987
cystic fibrosis transmembrane conductance regulator - metabolism (2967) 2967
analysis (2824) 2824
models, molecular (2713) 2713
signal transduction (2583) 2583
physiology (2577) 2577
cftr (2496) 2496
transmembrane protein (2475) 2475
biochemistry (2445) 2445
cystic fibrosis transmembrane conductance regulator (2433) 2433
multidisciplinary sciences (2412) 2412
cells (2386) 2386
identification (2352) 2352
membrane proteins - metabolism (2343) 2343
membrane proteins - genetics (2313) 2313
article (2295) 2295
protein structure, tertiary (2295) 2295
research article (2279) 2279
protein binding (2201) 2201
membrane proteins (2185) 2185
cell membrane - metabolism (2100) 2100
physiological aspects (2088) 2088
cystic-fibrosis (2084) 2084
gene expression (2043) 2043
protein conformation (2038) 2038
genetics & heredity (2007) 2007
biology (1972) 1972
respiratory system (1887) 1887
rats (1830) 1830
base sequence (1826) 1826
medicine (1820) 1820
genetic aspects (1810) 1810
adult (1798) 1798
protein (1772) 1772
binding sites (1769) 1769
cells, cultured (1763) 1763
gene (1757) 1757
membranes (1750) 1750
activation (1736) 1736
membrane proteins - chemistry (1689) 1689
protein structure, secondary (1621) 1621
transmembrane proteins (1609) 1609
science (1600) 1600
phosphorylation (1568) 1568
immunology (1560) 1560
endoplasmic-reticulum (1496) 1496
pharmacology & pharmacy (1484) 1484
cystic fibrosis - metabolism (1402) 1402
transfection (1386) 1386
kinetics (1342) 1342
protein folding (1328) 1328
phenotype (1304) 1304
ligands (1299) 1299
mutations (1287) 1287
crystal-structure (1285) 1285
escherichia-coli (1280) 1280
genes (1280) 1280
transport (1280) 1280
neurosciences (1277) 1277
models, biological (1257) 1257
binding (1209) 1209
abridged index medicus (1203) 1203
virology (1198) 1198
transmembrane (1197) 1197
peptides (1177) 1177
life sciences (1146) 1146
medicine, research & experimental (1133) 1133
endoplasmic reticulum - metabolism (1125) 1125
microbiology (1102) 1102
lipids (1100) 1100
sequence homology, amino acid (1093) 1093
amino acids (1080) 1080
genotype (1070) 1070
protein transport (1060) 1060
chlorides - metabolism (1059) 1059
child (1034) 1034
mutagenesis, site-directed (1033) 1033
transmembrane domains (1010) 1010
apoptosis (998) 998
genetics (990) 990
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (11) 11
Online Resources - Online (5) 5
Collection Dvlpm't (Acquisitions) - Vendor file (2) 2
UofT at Mississauga - Stacks (2) 2
UofT at Scarborough - Stacks (2) 2
Chemistry (A D Allen) - Stacks (1) 1
Physics - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (34720) 34720
French (196) 196
Chinese (114) 114
German (88) 88
Japanese (84) 84
Spanish (70) 70
Russian (47) 47
Polish (24) 24
Korean (16) 16
Portuguese (16) 16
Italian (7) 7
Dutch (4) 4
Czech (3) 3
Hebrew (3) 3
Serbian (3) 3
Swedish (3) 3
Croatian (2) 2
Hungarian (2) 2
Persian (2) 2
Turkish (2) 2
Ukrainian (2) 2
Arabic (1) 1
Bulgarian (1) 1
Danish (1) 1
Icelandic (1) 1
Lithuanian (1) 1
Norwegian (1) 1
Romanian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1997, Computational neuroscience., ISBN 9780262181747, xvi, 395
Book
Protein Science, ISSN 0961-8368, 12/2002, Volume 11, Issue 12, pp. 2774 - 2791
Methods that predict membrane helices have become increasingly useful in the context of analyzing entire proteomes, as well as in everyday sequence analysis.... 
acetyl‐amino‐acid amides (Fauchere and Pliska 1983) | Av‐Cid, normalized average hydrophobicity scale (Cid 1992) | PSI‐BLAST, position‐specific iterated database search (Altschul et al. 1997) | TrEMBL, translation of the EMBL‐nucleotide database coding DNA to protein sequences (Bairoch and Apweiler 2000) | TopPred2, hydrophobicity‐based membrane helix prediction (von Heijne 1992; Cserzö et al. 1997) | BIG, nonidentical merger of SWISS‐PROT (Bairoch and Apweiler 2000) and TrEMBL (Bairoch and Apweiler 2000) and PDB (Berman et al. 2000) | PHDhtm, profile‐based neural network prediction of transmembrane helices (Rost 1996; Rost et al. 1996b) | Eisenberg, normalized consensus hydrophobicity scale (Eisenberg et al. 1984) | TM, transmembrane | MEMSAT, dynamic‐programming based prediction of transmembrane helices (Jones et al. 1994) | PDB, Protein Data Bank of experimentally determined 3D structures of proteins (Bernstein et al. 1977; Berman et al. 2000) | A‐Cid, normalized hydrophobicity scale for α‐proteins (Cid 1992) | GES, hydrophobicity property (Engelman et al. 1986; Prabhakaran 1990) | MaxHom, dynamic programming algorithm for conservation weight‐based multiple sequence alignment (Sander and Schneider 1991) | EM, Solvation free energy (Eisenberg and McLachlan 1986) | bioinformatics | SignalP, signal peptide prediction (Nielsen et al. 1997a) | Ben‐Tal, hydrophobicity scale representing the free energy of transferring an amino acid from water into the center of the hydrocarbon region of a lipid bilayer (Kessel and Ben‐Tal 2002) | TMHMM, transmembrane prediction using cyclic hidden Markov models (Sonnhammer et al. 1998; Krogh et al. 2001) | computational biology | Roseman, solvation‐corrected side‐chain hydropathy (Roseman 1988) | KD, Kyte–Doolittle hydropathy index (Kyte and Doolittle 1982) | PHDpsihtm, divergent profile (PSI‐BLAST)‐based neural network prediction 2002 | Radzicka, transfer free energy from 1‐octanol to water (Radzicka and Wolfenden 1988) | Sweet, optimal matching hydrophobicity (Sweet and Eisenberg 1983) | HMM, hidden Markov model | Fauchere, hydrophobic parameter π from the partitioning of | SWISS‐PROT, database of protein sequences (Bairoch and Apweiler 2000) | TMAP, alignment‐based prediction of transmembrane helices (Persson and Argos 1996) | Wolfenden, hydration potential (Wolfenden et al. 1981) | BLAST, fast sequence alignment method (Altschul and Gish 1996) | Levitt, hydrophobic parameter (Levitt 1976) | multiple alignments, predicting transmembrane helices | proteomes | Lawson, transfer free energy (Lawson et al. 1984) | WW, Wimley–White hydrophobicity scale‐based method (Wimley et al. 1996a,b; White and Wimley 1999; White 2001) | Nakashima, normalized composition of membrane proteins (Nakashima et al. 1990) | SOSUI, hydrophobicity‐ and amphiphilicity‐based transmembrane helix prediction (Hirokawa et al. 1998) | Bull‐Breese, Bull‐Breese hydrophobicity scale (Bull 1974) | SPLIT, transmembrane helix prediction (Juretic et al. 1998) | EVA, server automatically evaluating structure prediction methods (Eyrich et al. 2001a,b) | comparing genomes | TMpred, prediction of transmembrane helices (Hofmann and Stoffel 1993) | Heijne, transfer free energy to lipophilic phase (von Heijne and Blomberg 1979) | TMH, transmembrane helix | HMMTOP, hidden Markov model predicting transmembrane helices (Tusnady and Simon 1998) | Sequence analysis | protein structure prediction | DSSP, program assigning secondary structure (Kabsch and Sander 1983) | META‐PP, internet service allowing access to a variety of bioinformatics tools through one single interface (Eyrich and Rost 2000) | Hopp‐Woods, Hopp‐Woods hydrophilicity value (Hopp and Woods 1981) | Protein structure prediction | Multiple alignments, predicting transmembrane helices | Proteomes | Bioinformatics | Comparing genomes | Computational biology | PROTEIN SECONDARY STRUCTURE | predicting transmembrane helices | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | multiple alignments | ACID SIDE-CHAINS | TOPOLOGY PREDICTION | INTEGRAL MEMBRANE-PROTEINS | BACTERIAL OUTER-MEMBRANE | SARCOPLASMIC-RETICULUM CA2+-ATPASE | STRUCTURAL CLASSIFICATION | sequence analysis | C-TERMINAL DOMAIN | MITOCHONDRIAL PROTEINS | Computational Biology - methods | Algorithms | Animals | Membrane Proteins - chemistry | Protein Structure, Secondary | Sensitivity and Specificity | Models, Molecular | Software | Protein Folding | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2017, Volume 377, Issue 21, pp. 2024 - 2035
Approximately 5% of patients with cystic fibrosis express one allele with some retained CFTR function. In a prospective trial, tezacaftor–ivacaftor had a... 
POPULATION | REGULATOR | MEDICINE, GENERAL & INTERNAL | LUMACAFTOR | EFFICACY | SAFETY | PHENOTYPE | AGED 6-11 YEARS | RANDOMIZED CONTROLLED-TRIAL | F508DEL-CFTR | G551D-CFTR MUTATION | Forced Expiratory Volume - drug effects | Cystic Fibrosis - physiopathology | Humans | Male | Aminophenols - therapeutic use | Quinolones - pharmacology | Aminophenols - adverse effects | Aminophenols - pharmacology | Young Adult | Quinolones - adverse effects | Quinolones - therapeutic use | Cystic Fibrosis Transmembrane Conductance Regulator - pharmacology | Adult | Benzodioxoles - adverse effects | Female | Indoles - pharmacology | Benzodioxoles - therapeutic use | Child | Double-Blind Method | Cross-Over Studies | Cystic Fibrosis Transmembrane Conductance Regulator - therapeutic use | Indoles - adverse effects | Cystic Fibrosis - genetics | Cystic Fibrosis Transmembrane Conductance Regulator - adverse effects | Adolescent | Quality of Life | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Heterozygote | Indoles - therapeutic use | Mutation | Benzodioxoles - pharmacology | Cystic Fibrosis - drug therapy | Drug Combinations | Proteins | Clonal deletion | Clinical trials | Heterozygotes | Cystic fibrosis | Cystic fibrosis transmembrane conductance regulator | Gene deletion | Drug therapy | Patients | Pharmaceuticals | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 2013, Volume 19, Issue 7, pp. 939 - 945
Journal Article
Thorax, ISSN 0040-6376, 01/2012, Volume 67, Issue 1, pp. 12 - 18
Journal Article
2007, Biological and medical physics, biomedical engineering, ISBN 9780387333236, xiv, 658
Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells,... 
Ion channels | Biophysics | Biology, life sciences | Biomedical Engineering | Biophysics/Biomedical Physics | Biotechnology | Neurosciences | Animal Biochemistry | Neurobiology | Physics
Book
Journal of Molecular Biology, ISSN 0022-2836, 2010, Volume 396, Issue 2, pp. 406 - 430
Journal Article