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Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1590 - 1601
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2011, Volume 108, Issue 40, pp. 16663 - 16668
Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid... 
Embigin | EMMPRIN | Lactate transport | Cancer metabolism | Warburg effect | IMMUNOGLOBULIN SUPERFAMILY | MONOCARBOXYLATE TRANSPORTER 4 | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | lactate transport | PLASMA-MEMBRANE | CANCER | cancer metabolism | PYRUVATE-KINASE | CARBONIC-ANHYDRASE IX | NA+/H+ ANTIPORT | INHIBITORS | CELL-METABOLISM | Immunohistochemistry | Humans | DNA Primers - genetics | Glycolysis - drug effects | Oxygen Consumption - physiology | Protein Subunits - metabolism | Uracil - pharmacology | Monocarboxylic Acid Transporters - antagonists & inhibitors | Monocarboxylic Acid Transporters - metabolism | Flow Cytometry | Basigin - genetics | Cell Transformation, Neoplastic - genetics | Symporters - antagonists & inhibitors | Muscle Proteins - metabolism | Protein Subunits - genetics | Lactic Acid - metabolism | Gene Silencing | Thiophenes - pharmacology | Gene Knockout Techniques | Symporters - metabolism | Muscle Proteins - genetics | Symporters - genetics | Fluorescent Antibody Technique | Basigin - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Transformation, Neoplastic - drug effects | Monocarboxylic Acid Transporters - genetics | Uracil - analogs & derivatives | Protein Subunits | Cell Proliferation | Lactic Acid | Oxygen Consumption | DNA Primers | Life Sciences | Muscle Proteins | Monocarboxylic Acid Transporters | Thiophenes | Cell Transformation, Neoplastic | Symporters | Glycolysis | Development Biology | Antigens, CD147 | Uracil | Biological Sciences
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2013, Volume 12, Issue 9, pp. 1371 - 1384
Here, we interrogated head and neck cancer (HNSCC) specimens (n = 12) to examine if different metabolic compartments (oxidative vs. glycolytic) co-exist in... 
stem cells | head and neck cancer | mitochondria | glycolysis | OXPHOS | TOMM20 | tumor recurrence | monocarboxylate transporters (MCT) | MCT4 | MCT1 | tumor stroma | metabolic symbiosis | oxidative stress | Oxidative stress | Tumor stroma | Monocarboxylate transporters (MCT) | Metabolic symbiosis | Mitochondria | Tumor recurrence | Stem cells | Glycolysis | Head and neck cancer | FDG-PET | MITOCHONDRIAL METABOLISM | CELL BIOLOGY | BREAST-CANCER | CYTOCHROME-C-OXIDASE | POSITRON-EMISSION-TOMOGRAPHY | PROGNOSTIC-FACTOR | AEROBIC GLYCOLYSIS | SQUAMOUS-CELL CARCINOMA | HYDROGEN-PEROXIDE | Cell Proliferation | Epithelial Cells - metabolism | Oxidative Stress | Humans | Ketone Bodies - metabolism | Middle Aged | Male | Head and Neck Neoplasms - metabolism | Neoplasm Recurrence, Local - pathology | Monocarboxylic Acid Transporters - metabolism | Neoplastic Stem Cells - metabolism | Muscle Proteins - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Membrane Transport Proteins - metabolism | Cell Differentiation | Fibroblasts - metabolism | Neoplasm Recurrence, Local - metabolism | Lactic Acid - metabolism | Kaplan-Meier Estimate | Oxidative Phosphorylation | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Mitochondria - metabolism | Fibroblasts - pathology | Symporters - metabolism | Head and Neck Neoplasms - pathology | Aged | Neoplasm Staging | Report
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 14, pp. 9030 - 9037
The monocarboxylate transporter MCT4 mediates lactic acid efflux from most tissues that are dependent on glycolysis for their ATP production. Here we... 
SKELETAL-MUSCLE | PROTEIN | RAT MUSCLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN MONOCARBOXYLATE TRANSPORTER | GENE-EXPRESSION | INDUCTION | INDUCIBLE FACTOR-1 | CD147 | LACTIC-ACID EFFLUX | FAMILY
Journal Article
Cancer Research, ISSN 0008-5472, 02/2014, Volume 74, Issue 3, pp. 908 - 920
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33418
Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue... 
OXYGEN | AUTOCRINE LOOP | METABOLISM | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | AEROBIC GLYCOLYSIS | GENE-EXPRESSION | GROWTH-FACTOR | HIF-1-ALPHA | CANCER | HYPOXIA-INDUCIBLE FACTOR-1 | Immunohistochemistry | RNA, Small Interfering - genetics | Enzyme-Linked Immunosorbent Assay | Endothelial Cells - metabolism | Humans | Lactic Acid - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Hypoxia-Inducible Factor 1 - metabolism | Blotting, Western | Cell Movement - physiology | Symporters - metabolism | Fibroblast Growth Factors - metabolism | Monocarboxylic Acid Transporters - metabolism | Animals | Analysis of Variance | RNA Interference | Luciferases | Polymerase Chain Reaction | Nuclear Magnetic Resonance, Biomolecular | Mice | Neovascularization, Pathologic - metabolism | Lactic Acid - pharmacology | Endothelial Cells - physiology | Physiological aspects | Fibroblast growth factors | Vascular endothelial growth factor | Tumors | Endothelium | Fibroblast growth factor | Hypoxia-inducible factor 1 | Nuclear magnetic resonance--NMR | Leukocyte migration | Activation | Angiogenesis | Rodents | Oxidation | Inhibition | Vascular endothelial growth factor receptor 2 | Hypoxia-inducible factors | Fibroblast growth factor 2 | Tumor cells | Metabolism | Endothelial cells | Microscopy | Nitric oxide | Glycolysis | Hypoxia | Lactic acid | Transporter | Cell migration | Cancer | Nuclear magnetic resonance | NMR
Journal Article
Journal Article
EMBO reports, ISSN 1469-221X, 12/2017, Volume 18, Issue 12, pp. 2172 - 2185
Journal Article
FASEB Journal, ISSN 0892-6638, 06/2017, Volume 31, Issue 6, pp. 2562 - 2575
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e105038
Introduction: Monocarboxylate transporters (MCTs) 1-4 are lactate transporters crucial for cancers cells adaption to upregulated glycolysis. Herein, we aimed... 
SQUAMOUS-CELL | LUNG-CANCER | COEXPRESSION | METABOLISM | MULTIDISCIPLINARY SCIENCES | LACTATE | CARCINOMAS | TUMOR-CELLS | STROMAL CELLS | HYPOXIA | EXPRESSION | Immunohistochemistry | Prognosis | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - pathology | Male | Biomarkers, Tumor | Monocarboxylic Acid Transporters - metabolism | Muscle Proteins - metabolism | Aged, 80 and over | Female | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Non-Small-Cell Lung - surgery | Risk Factors | Stromal Cells - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Symporters - metabolism | Muscle Proteins - genetics | Symporters - genetics | Cell Line, Tumor | Lung Neoplasms - surgery | Aged | Monocarboxylic Acid Transporters - genetics | Neoplasm Staging | Lung cancer | Homeostasis | Oncology | Biology | Cancer therapies | Proteins | Ethics | Angiogenesis | Compartments | Oxidation | Medical research | Cell survival | Non-small cell lung carcinoma | Radiation therapy | Metabolism | Survival | Medicine | Pathology | Hospitals | Biopsy | Stromal cells | Glycolysis | Hypoxia | Lactic acid | Clinical medicine | Cancer | Tumors | VDP | Klinisk medisinske fag: 750 | Onkologi: 762 | Oncology: 762 | Medisinske Fag: 700 | Clinical medical disciplines: 750 | Medical disciplines: 700
Journal Article