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Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 559 - 573
Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that... 
co-transporter (NCC) | Cl | Blood pressure/hypertension | K | Ion homoeostasis | Signal transduction | Na | co-transporter 1 (NKCC1) | Protein kinase | γ-aminobutyric acid (GABA) | 2Cl | co-transporter 2 (KCC2) | co-transporter 3 (KCC3) | SALT TRANSPORT | CELL-VOLUME | signal transduction | CATION-CHLORIDE COTRANSPORTERS | ION-TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | blood pressure/hypertension | ion homoeostasis | HYPOKALEMIC ALKALOSIS | K+-Cl- co-transporter 3 (KCC3) | Na+-K+-2Cl(-) co-transporter 1 (NKCC1) | K+-Cl- co-transporter 2 (KCC2) | protein kinase | BLOOD-PRESSURE | PROTEIN-KINASES | BARTTERS-SYNDROME | Na+-Cl- co-transporter (NCC) | ALANINE-RICH KINASE | MOLECULAR PHYSIOLOGY | gamma-aminobutyric acid (GABA) | Potassium - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Signal Transduction | Humans | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - metabolism | Symporters - metabolism | Transcription Factors - metabolism | Protein Isoforms - metabolism | Chlorides - metabolism | Symporters - antagonists & inhibitors | Phosphopeptides - metabolism | Protein Isoforms - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | N[K]CC, Na+–K+ ion co-transporter | HEK, human embryonic kidney | TTBS, Tris-buffered saline containing Tween 20 | HRP, horseradish peroxidase | ES, embryonic stem | Na+–Cl− co-transporter (NCC) | CCT, conserved C-terminal | NCC, Na+–Cl− co-transporter | Na+–K+–2Cl− co-transporter 1 (NKCC1) | OSR1, oxidative stress-responsive kinase 1 | CCC, cation–Cl− co-transporter | K+–Cl− co-transporter 3 (KCC3) | KCC, K+–Cl− co-transporter | blood pressure | ERK1, extracellular-signal-regulated kinase 1 | SLC12, solute carrier family 12 | LDS, lithium dodecyl sulfate | NKCC, Na+–K+–2Cl− co-transporter | SPAK, SPS1-related proline | NTD, N-terminal cytoplasmic domain | WNK, WNK lysine-deficient protein kinase | CTD, C-terminal cytoplasmic domain | hypertension | XIC, extracted ion chromatogram | K+–Cl− co-transporter 2 (KCC2) | alanine-rich kinase
Journal Article
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 12/2012, Volume 464, Issue 6, pp. 601 - 611
Acquiring a mechanistic understanding of the processes underlying the renal clearance of drug molecules in man has been hampered by a lack of robust in vitro... 
Biomedicine | Proximal tubule cells | Human Physiology | Drug transporters | PHYSIOLOGY | MEMBRANE | INTESTINE | ORGANIC ANION TRANSPORTERS | HUMAN KIDNEY | P-CRESYL SULFATE | UREMIC TOXIN | PROTEIN MRP | MOLECULAR-CLONING | GLYCOPROTEIN | MULTIDRUG-RESISTANCE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Epithelial Cells - metabolism | Kidney Cortex - metabolism | Humans | Neoplasm Proteins - metabolism | Monocarboxylic Acid Transporters - metabolism | ATP-Binding Cassette Transporters - genetics | Biological Transport | Monocarboxylic Acid Transporters - biosynthesis | Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Neoplasm Proteins - genetics | Cell Line | Kidney Cortex - cytology | Kidney Tubules, Proximal - cytology | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | Symporters - metabolism | ATP-Binding Cassette Transporters - biosynthesis | Membrane Transport Proteins - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - biosynthesis | Symporters - genetics | Kidney Tubules, Proximal - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Monocarboxylic Acid Transporters - genetics | Symporters - biosynthesis | ATP Binding Cassette Transporter, Sub-Family B - genetics | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2008, Volume 155, Issue 2, pp. 423 - 438
Abstract Nutrient transporters and ABC efflux pumps at the blood–brain barrier are major determinants of drug penetration into the brain. Immunohistochemical... 
Neurology | abluminal | cerebral microvessels | luminal | ABC transporter | choroid plexus | NEUROSCIENCES | P-GLYCOPROTEIN ABCB1 | MICROVESSEL ENDOTHELIUM | AMINO-ACID TRANSPORTER | ABLUMINAL MEMBRANE | GLUCOSE-TRANSPORTER | RESISTANCE-ASSOCIATED PROTEIN-1 | CENTRAL-NERVOUS-SYSTEM | CAPILLARY ENDOTHELIAL-CELLS | CHOROID-PLEXUS | MULTIDRUG TRANSPORTERS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Ependyma - blood supply | Cerebrovascular Circulation - physiology | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Choroid Plexus - metabolism | Glucose Transporter Type 1 - metabolism | Male | Gene Expression Profiling | Choroid Plexus - ultrastructure | Blood-Brain Barrier - ultrastructure | Microcirculation - physiology | Choroid Plexus - blood supply | Monocarboxylic Acid Transporters - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | ATP-Binding Cassette Transporters - metabolism | Blood-Brain Barrier - physiology | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Cell Line | Biotinylation | Rats | Ependyma - metabolism | Large Neutral Amino Acid-Transporter 1 - genetics | Kidney - cytology | Rats, Sprague-Dawley | Blotting, Western | Symporters - metabolism | Animals | Glucose Transporter Type 1 - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Symporters - genetics | Microcirculation - ultrastructure | Monocarboxylic Acid Transporters - genetics | Multidrug Resistance-Associated Proteins - metabolism | Ependyma - ultrastructure | Phosphates | Glucose metabolism | Brain | Fluorescein | Biotin | Glucose | Drug resistance | Intermediate filament proteins | Dextrose | Protein binding | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1133 - 1142
RATIONALE:High-density lipoprotein (HDL) is a heterogeneous population of particles. Differences in the capacities of HDL subfractions to remove cellular... 
foam cells | HDL | ATP-binding cassette transporters | macrophages | cholesterol, HDL | ATP binding cassette transporter 1 | Cholesterol | cholesterol-efflux regulatory protein | ABCA1 | CARDIAC & CARDIOVASCULAR SYSTEMS | APOA-I | HIGH-DENSITY-LIPOPROTEIN | TANGIER DISEASE | EFFLUX | MESSENGER-RNA | CASSETTE TRANSPORTER A1 | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ABCG1 | APOLIPOPROTEIN-A-I | Lipoproteins - deficiency | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Cricetulus | Humans | Lipoproteins, HDL - metabolism | ATP-Binding Cassette Transporters - physiology | Recombinant Fusion Proteins - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP Binding Cassette Transporter 1 - physiology | Biological Transport | Foam Cells - metabolism | Lipoproteins, HDL2 - metabolism | CHO Cells | Cell Line | Cricetinae | Tangier Disease - enzymology | Tangier Disease - genetics | Cholesterol, HDL - metabolism | Mice, Inbred C57BL | Gene Silencing | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Lipoproteins - physiology | Mice, Knockout | Particle Size | Macrophages - metabolism | Animals | ATP Binding Cassette Transporter 1 - deficiency | ATP Binding Cassette Transporter 1 - antagonists & inhibitors | Mice | ATP Binding Cassette Transporter 1 - genetics | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | Index Medicus | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 02/2013, Volume 10, Issue 2, pp. 650 - 663
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 325 - 337
Mutations in the WNK with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | Cl | 2Cl | Coiled-coil domain | Osmotic stress | KINASE-ACTIVITY | SPAK | coiled-coil domain | Na+/K+/2Cl(-) co-transporter 1 (NKCC1) | signal transduction | PHOSPHORYLATION | PROTEIN-KINASE | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein kinase | BLOOD-PRESSURE | osmotic stress | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | MUTATIONS | PC12 CELLS | HYPERTENSION | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Transcription Factors - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | Protein Isoforms | HEK293 Cells | Embryonic Stem Cells | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | CCD, coiled-coil domain | PI3K, phosphoinositide 3-kinase | WNK, with no lysine (K) kinase | 2Cl− co-transporter | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | ES, embryonic stem | DMEM, Dulbecco's modified Eagle's medium | CCT, conserved C-terminal | GST, glutathione transferase | HEK-293, human embryonic kidney 293 | 2Cl− co-transporter 1 (NKCC1) | Cl− co-transporter | NKCC, Na+ | SPAK, SPS1-related proline | Cl− co-transporter (NCC) | OSR, oxidative stress-responsive kinase | LRRK2, leucine-repeat-rich kinase 2 | CATCHtide, cation chloride co-transporter peptide substrate | Na+ | NCC, Na+ | MAPK, mitogen-activated protein kinase | alanine-rich kinase
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2017, Volume 19, Issue 9, pp. 1322 - 1326
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4740 - 4763
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 561 - 564
Journal Article