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Revue Neurologique, ISSN 0035-3787, 04/2019, Volume 175, pp. S124 - S124
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2017, Volume 36, Issue 13, pp. 1837 - 1853
Genetic variants in the triggering receptor expressed on myeloid cells 2 ( TREM 2) increase the risk for several neurodegenerative diseases including... 
neurodegeneration | TREM | frontotemporal dementia | regulated intramembrane proteolysis | neuroinflammation | TREM2 | NASU-HAKOLA-DISEASE | FLUID SOLUBLE TREM2 | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | APOLIPOPROTEIN-E | CELL BIOLOGY | TRANSLOCATOR PROTEIN | IN-VIVO | MYELOID CELLS-2 TREM2 | GAMMA-SECRETASE | Immunohistochemistry | Humans | Mutant Proteins - genetics | Positron-Emission Tomography | Mutation, Missense | Gene Knock-In Techniques | Membrane Glycoproteins - genetics | Magnetic Resonance Imaging | Animals | Microglia - physiology | Perfusion | Brain - pathology | Glucose - metabolism | Mice | Receptors, Immunologic - genetics | Disease Models, Animal | Frontotemporal Dementia - pathology | Neuroimaging | Brain | Editing | Risk | Stimulation | Genomes | Glucose | Macrophages | Blood | Phagocytes | Glucose metabolism | Alterations | Missense mutation | Cerebral blood flow | Rodents | Dementia disorders | Alzheimer's disease | Age | CRISPR | Myeloid cells | Medical imaging | Neurodegenerative diseases | Positron emission | Metabolism | Patients | Blood flow | Microglia | Neurological diseases | Magnetic resonance imaging | Emissions control | Resonance | Mutation | Frontotemporal dementia | Alzheimers disease | Positron emission tomography | Dementia | Index Medicus | Neuroscience | Molecular Biology of Disease
Journal Article
Neurological Research, ISSN 0161-6412, 10/2014, Volume 36, Issue 10, pp. 894 - 896
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 07/2019
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2015, Volume 11, Issue 12, pp. 1407 - 1416
Journal Article
Neuroscience Letters, ISSN 0304-3940, 11/2018, Volume 686, pp. 10 - 16
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a potential and novel biomarker of neuroinflammation implicated in the onset and... 
Inflammation | Alzheimer’s disease | Soluble TREM2 | Meta-analysis
Journal Article
Journal Article
Neurobiology of aging, ISSN 0197-4580, 8/2015, Volume 36, Issue 8, pp. 2443.e21 - 2443.e26
Over twenty risk loci have been identified for late onset Alzheimer’s disease (LOAD), most of which display relatively small effect sizes. Recently, a rare... 
rare variants | LOAD | TREM2
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Elevated risk of developing Alzheimer’s disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to... 
TREM2 | metabolism | immunity | Alzheimer’s disease | microglia
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 12/2016, Volume 11, Issue 1
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 10/2017, Volume 9, Issue 10, pp. 1356 - 1365
Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 ( TREM 2) support an essential function of microglia... 
neurodegeneration | phagocytosis | TREM | regulated intramembrane proteolysis | Alzheimer's disease | TREM2 | MEDICINE, RESEARCH & EXPERIMENTAL | MICROGLIAL RESPONSE | FLUID SOLUBLE TREM2 | INTRAMEMBRANE PROTEOLYSIS | GOLGI-APPARATUS | AMYLOID PRECURSOR PROTEIN | APOLIPOPROTEIN-E | DISEASE | BETA-PROTEIN | MYELOID CELLS-2 TREM2 | GAMMA-SECRETASE | Amyloid Precursor Protein Secretases - genetics | Membrane Glycoproteins - metabolism | ADAM10 Protein - genetics | Humans | ADAM10 Protein - metabolism | Histidine - metabolism | Mutation, Missense | Phagocytosis - genetics | ADAM17 Protein - metabolism | Sequence Analysis, Protein | HEK293 Cells | Cell Membrane - metabolism | Membrane Proteins - metabolism | Membrane Proteins - genetics | Phagocytosis - physiology | THP-1 Cells | Immunity, Innate | Serine - metabolism | Membrane Glycoproteins - genetics | Microglia | ADAM17 Protein - genetics | Amyloid Precursor Protein Secretases - metabolism | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Histidine | Proteases | Proteolysis | Mass spectrometry | Immunoglobulins | Myeloid cells | Neurodegenerative diseases | Serine | Mass spectroscopy | Innate immunity | Cell surface | Phagocytes | Missense mutation | Coding | Mutation | Alzheimers disease | Endoplasmic reticulum | Phagocytosis | Index Medicus | Neuroscience | Immunology | Report | Reports | Genetics, Gene Therapy & Genetic Disease
Journal Article
Neurobiology of aging, ISSN 0197-4580, 05/2019
The triggering receptor expressed on myeloid cells 2 (TREM2) gene has been reported to increase the risk of Alzheimer's disease (AD). The soluble TREM2 protein... 
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 05/2016, Volume 8, Issue 5, pp. 466 - 476
Journal Article
Neurobiology of aging, ISSN 0197-4580, 6/2016, Volume 42, pp. 132 - 141
Mutations in TREM2, which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β (Aβ), are... 
TREM2 | proliferation | inflammation | microglia | TREML2
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2016, Volume 48, pp. 222.e9 - 222.e15
Abstract We aimed to identify new candidate genes potentially involved in early onset Alzheimer’s disease (EOAD). Exome sequencing was conducted on 45 EOAD... 
Neurology | Internal Medicine | exome sequencing | TREM2 | TYROBP | burden test | Alzheimer’s disease
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2019
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) are associated with both behavioral variant frontotemporal lobar degeneration and... 
Early-onset dementia | TREM2 | Frontotemporal dementia | Nasu-Hakola disease | Leukoencephalopathy
Journal Article