X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (282) 282
humans (220) 220
trex1 (171) 171
exonuclease trex1 (142) 142
aicardi-goutieres-syndrome (127) 127
mutations (107) 107
animals (95) 95
immunology (92) 92
exodeoxyribonucleases - genetics (82) 82
phosphoproteins - genetics (81) 81
systemic-lupus-erythematosus (76) 76
interferon (71) 71
dna (69) 69
mutation (68) 68
lupus (66) 66
autoimmunity (65) 65
mice (65) 65
aicardi-goutieres syndrome (63) 63
male (60) 60
dna exonuclease trex1 (59) 59
familial chilblain lupus (58) 58
samhd1 (57) 57
female (56) 56
systemic lupus erythematosus (56) 56
autoimmune-disease (53) 53
article (48) 48
autoimmune diseases of the nervous system - genetics (47) 47
nervous system malformations - genetics (46) 46
biochemistry & molecular biology (42) 42
disease (42) 42
rheumatology (42) 42
exodeoxyribonucleases - metabolism (41) 41
genetic aspects (40) 40
autoimmune diseases (38) 38
clinical neurology (38) 38
deoxyribonucleic acid--dna (38) 38
research (38) 38
aicardi-goutières syndrome (37) 37
gene (37) 37
phosphoproteins - metabolism (37) 37
genetics & heredity (35) 35
innate immune-response (35) 35
phenotype (34) 34
abridged index medicus (33) 33
interferon-alpha (31) 31
lupus erythematosus, systemic - genetics (31) 31
biological response modifiers (30) 30
cell biology (30) 30
proteins (30) 30
activation (28) 28
genes (28) 28
immunity, innate (28) 28
cyclic gmp-amp (27) 27
cytosolic dna (27) 27
interferon type i - immunology (26) 26
mice, knockout (26) 26
cells (25) 25
dendritic cells (24) 24
expression (24) 24
genetics (24) 24
lupus erythematosus, systemic - immunology (24) 24
mediated cell-death (24) 24
adult (23) 23
child (23) 23
child, preschool (23) 23
rna (23) 23
toll-like receptors (23) 23
autoimmune diseases - immunology (22) 22
dna damage (22) 22
genetic predisposition to disease (22) 22
health aspects (22) 22
i interferon (22) 22
inflammation (22) 22
signal transduction (22) 22
cgas (21) 21
erythematosus (21) 21
infection (21) 21
innate immunity (21) 21
nucleic acids (21) 21
pediatrics (21) 21
adolescent (20) 20
gene expression (20) 20
immune system (20) 20
multidisciplinary sciences (20) 20
type i interferon (20) 20
autoimmune diseases of the nervous system - immunology (19) 19
dna - metabolism (19) 19
infant (19) 19
nervous system malformations - immunology (19) 19
neurosciences (19) 19
mutation - genetics (18) 18
plasmacytoid dendritic cells (18) 18
protein (18) 18
ribonuclease h - genetics (18) 18
sam domain and hd domain-containing protein 1 (18) 18
sting (18) 18
cell line (17) 17
development and progression (17) 17
escherichia-coli (17) 17
medicine, research & experimental (17) 17
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Neuropathology & Experimental Neurology, ISSN 0022-3069, 02/2019, Volume 78, Issue 2, pp. 181 - 186
Abstract Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an autosomal-dominant disorder involving the cerebral, retinal, renal, and other systemic... 
Pseudotumor | Immunohis-tochemistry | Retinal vasculopathy with cerebral leukodystrophy (RVCL) | Hereditary small vessel disease | HERNS | TREX1 | Immunohistochemistry | DNA | PATHOLOGY | EXONUCLEASE TREX1 | NEUROSCIENCES | CLINICAL NEUROLOGY
Journal Article
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 07/2017, Volume 69, Issue 7, pp. 1495 - 1501
Objective. Gain-of-function mutations in TMEM173, encoding the stimulator of interferon (IFN) genes (STING) protein, underlie a novel type I interferonopathy... 
IMMUNITY | TBK1 | IKK-EPSILON | TREX1 | DISEASE | MUTATIONS | RHEUMATOLOGY | VASCULOPATHY | RUXOLITINIB
Journal Article
Genes and Immunity, ISSN 1466-4879, 06/2011, Volume 12, Issue 4, pp. 270 - 279
Journal Article
by Wu, JJ and Chen, YJ and Dobbs, N and Sakai, T and Liou, J and Miner, JJ and Yan, N
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2019, Volume 216, Issue 4, pp. 867 - 883
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic... 
SYNTHASE | MEDICINE, RESEARCH & EXPERIMENTAL | CYCLIC GMP-AMP | TREX1 | KINASE | CGAS | INNATE IMMUNE SENSOR | IMMUNOLOGY
Journal Article
AMERICAN JOURNAL OF KIDNEY DISEASES, ISSN 0272-6386, 12/2018, Volume 72, Issue 6, pp. 895 - 899
Renal thrombotic microangiopathy (TMA) involves diverse causes and clinical presentations. Genetic determinants causing alternate pathway complement... 
LUPUS | AICARDI-GOUTIERES SYNDROME | DNA EXONUCLEASE TREX1 | UROLOGY & NEPHROLOGY | RETINOPATHY | RETINAL VASCULOPATHY | NEPHROPATHY | HEREDITARY ENDOTHELIOPATHY
Journal Article
NEUROLOGY, ISSN 0028-3878, 01/2016, Volume 86, Issue 1, pp. 15 - 16
In 1984, 2 pediatric neurologists, Jean Aicardi and Francoise Goutieres, published their seminal case report of 8 patients (from 5 families) with a devastating... 
TREX1 | GOUTIERES-SYNDROME | MUTATIONS | FAMILIAL ENCEPHALOPATHY | CLINICAL NEUROLOGY
Journal Article
Cytokine & Growth Factor Reviews, ISSN 1359-6101, 04/2019
Journal Article
Cytokine, ISSN 1043-4666, 07/2019, pp. 154781 - 154781
Genetic variants of the three-prime repair exonuclease 1 (TREX1) -an exonuclease involved in DNA repair and degradation- have been previously found to increase... 
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 06/2019, Volume 100, pp. 84 - 94
TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including... 
Lupus | Autoimmune disorder | Trex1 mutation | cGAS | Innate immunity | IFN-signature | DNA sensor
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2017, Volume 41, Issue 18, pp. 9718 - 9723
The 3'-5' exonuclease plays key roles in maintaining genome stability; therefore, the detection of 3'-5' exonuclease activity is very important for disease... 
NANOPARTICLES | ASSAY | METALLIZATION | TREX1 | STRATEGY | POLYMERASE | APTAMER | CHEMISTRY, MULTIDISCIPLINARY | VIRUS TYPE-1 | MESSENGER-RNA DETECTION | LIVING CELLS
Journal Article
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 09/2015, Volume 15, Issue 9, pp. 529 - 544
Nucleic acid sensing by innate receptors initiates immune defences against viruses and other pathogens. A hallmark of this response is the release of... 
PLASMACYTOID DENDRITIC CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CYCLIC GMP-AMP | DOUBLE-STRANDED-RNA | SMALL-MOLECULE INHIBITORS | DNA EXONUCLEASE TREX1 | ACTIVATE B-CELLS | TOLL-LIKE RECEPTORS | OF-FUNCTION MUTATIONS | IMMUNOLOGY | IFN-ALPHA PRODUCTION
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2012, Volume 44, Issue 11, pp. 1243 - 1248
Journal Article
Journal Article