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by Yan, CY and Wan, RX and Bai, R and Huang, GXY and Shi, YG
SCIENCE, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 904 - 911
Pre-messenger RNA (pre-mRNA) splicing is carried out by the spliceosome, which undergoes an intricate assembly and activation process. Here, we report an... 
METAL-ION CATALYSIS | 3-DIMENSIONAL STRUCTURE | GROUP-II INTRON | U4/U6.U5 TRI-SNRNP | MESSENGER-RNA | SMALL NUCLEAR-RNA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | G-PATCH PROTEIN | CRYO-EM STRUCTURE
Journal Article
by Wan, RX and Yan, CY and Bai, R and Huang, GXY and Shi, YG
SCIENCE, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 895 - 904
Each cycle of pre-messenger RNA splicing, carried out by the spliceosome, comprises two sequential transesterification reactions, which result in the removal... 
METAL-ION CATALYSIS | 3-DIMENSIONAL STRUCTURE | 2ND STEP | U4/U6.U5 TRI-SNRNP | SMALL NUCLEAR-RNA | ACTIVE-SITE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ELECTRON-MICROSCOPY | 19 COMPLEX | CRYO-EM STRUCTURE
Journal Article
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 318 - 323
Spliceosome rearrangements facilitated by RNA helicase PRP16 before catalytic step two of splicing are poorly understood. Here we report a 3D cryo-electron... 
2ND STEP | ANGSTROM RESOLUTION | I SPLICEOSOME | U4/U6.U5 TRI-SNRNP | ELECTRON CRYOMICROSCOPY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | CATALYTIC CORE | SACCHAROMYCES-CEREVISIAE | PRE-MESSENGER-RNA | Spliceosomes - chemistry | Humans | Cell Cycle Proteins - ultrastructure | RNA Splicing Factors - chemistry | RNA, Messenger - metabolism | RNA Splicing Factors - metabolism | Cell Cycle Proteins - chemistry | Spliceosomes - metabolism | RNA Splicing | Ribonucleoproteins, Small Nuclear - ultrastructure | Base Sequence | Protein Domains | Ribonucleoproteins, Small Nuclear - chemistry | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Biocatalysis | Introns - genetics | Movement | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Exons - genetics | Spliceosomes - ultrastructure | RNA Stability | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA-Binding Proteins - ultrastructure | RNA Splicing Factors - ultrastructure | Ribonuclease H - chemistry | Adenosine - metabolism | Saccharomyces cerevisiae - enzymology | RNA, Messenger - chemistry | DEAD-box RNA Helicases - ultrastructure | RNA-Binding Proteins - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Ribonuclease H - metabolism | Genetic research | Genetic engineering | Research | Methods | RNA splicing | Proteins | Yeast | Catalysis | Molecular structure | Microscopy | Ribonucleic acid--RNA | Index Medicus
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2017, Volume 45, Issue 8, pp. 4866 - 4880
Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical re-arrangements of the spliceosome. Here, we report USP15,... 
SISTER-CHROMATID COHESION | RECYCLING FACTOR SART3 | COMPLEX | RNA | STRUCTURAL BASIS | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEUBIQUITYLATING ENZYME | RIG-I | TRI-SNRNP | CELL-CYCLE PROGRESSION | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 12/2017, Volume 171, Issue 7, pp. 1589 - 1598.e8
Journal Article
Science, ISSN 0036-8075, 09/2016, Volume 353, Issue 6306, pp. 1399 - 1405
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 537, Issue 7619, pp. 197 - 201
Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification reactions via a lariat-intron intermediate. Here we present the 3.8 angstrom... 
U4/U6.U5 TRI-SNRNP | IN-VITRO | ELECTRON CRYOMICROSCOPY | ACTIVE-SITE | CRYSTAL-STRUCTURE | CONFORMATIONAL REARRANGEMENT | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | U6 SNRNA | PRE-MESSENGER-RNA | CATALYTIC ACTIVATION | RNA Precursors - chemistry | RNA Helicases - metabolism | Spliceosomes - chemistry | RNA, Fungal - ultrastructure | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | Saccharomyces cerevisiae - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | RNA, Small Nuclear - genetics | Base Sequence | RNA Precursors - metabolism | RNA, Fungal - genetics | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Introns - genetics | RNA Splice Sites - genetics | RNA, Fungal - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Exons - genetics | Magnesium - metabolism | Nuclear Proteins - metabolism | Spliceosomes - ultrastructure | Esterification | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Base Pairing | Saccharomyces cerevisiae Proteins - metabolism | Adenosine - metabolism | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Genetic aspects | Spliceosomes | Structure | Brewer's yeast | Methods | RNA splicing | Proteins | Enzymes | Molecular structure | Microscopy | Catalysis | Ribonucleic acid--RNA | Binding sites | Index Medicus
Journal Article
CELL, ISSN 0092-8674, 01/2018, Volume 172, Issue 3, pp. 454 - 454
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2016, Volume 138, Issue 24, pp. 7532 - 7535
The total synthesis of the spliceosome inhibitor thailanstatin A has been achieved in a longest linear sequence of nine steps from readily available starting... 
MICHAEL REACTION | SPLICEOSTATIN | CATALYSIS | U4/U6.U5 TRI-SNRNP | FR901464 | MECHANISM | BURKHOLDERIA SP | ALDEHYDES | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | PRE-MESSENGER-RNA | Research | Chemical properties | Chemical synthesis | Hydrogenation | Statins | Index Medicus
Journal Article
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 05/2018, Volume 83, Issue 9, pp. 5187 - 5198
Thailanstatin A has been isolated recently from the fermentation broth of B. thailandensis MSMB43. We describe here an enantioselective convergent synthesis of... 
U4/U6.U5 TRI-SNRNP | PLADIENOLIDE B | FR901464 | ANALOGS | SPLICEOSOME | TRANSCRIPTION | CHEMISTRY, ORGANIC | BURKHOLDERIA SP | SUBSTANCES | DERIVATIVES | PRE-MESSENGER-RNA | Pyrans - chemical synthesis | RNA Splicing - drug effects | Chemistry Techniques, Synthetic | Esters - chemistry | Pyrans - chemistry | Stereoisomerism | Pyrans - pharmacology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 06/2018, Volume 360, Issue 6396, pp. 1423 - 1429
Journal Article