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1. Full Text Trial Sequential Analysis in systematic reviews with meta-analysis
by Wetterslev, Jørn and Jakobsen, Janus Christian and Gluud, Christian
BMC Medical Research Methodology, ISSN 1471-2288, 03/2017, Volume 17, Issue 1, pp. 39 - 18
Background: Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large... 
Heterogeneity | Interim analysis | Sample size | Random-effects model | Diversity | Fixed-effect model | Group sequential analysis | Information size | Trial sequential analysis | Meta-analysis | DESIGN | RANDOMIZED-TRIALS | GUIDELINES | POWER | TEMPERATURE MANAGEMENT | NONCARDIAC SURGERY | CLINICAL-TRIALS | HEALTH CARE SCIENCES & SERVICES | ERROR | MONITORING BOUNDARIES | Meta-Analysis as Topic | Sample Size | Research Design | Humans | Randomized Controlled Trials as Topic | Confidence intervals | Intervention | Hypotheses | Surgery | Mortality | Clinical trials
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2. Full Text Interpreting trial sequential analysis
by Chai‐Adisaksopha, Chatree and Thorlund, Kristian and Iorio, Alfonso
Transfusion, ISSN 0041-1132, 12/2016, Volume 56, Issue 12, pp. 2918 - 2922
RANDOMIZED CONTROLLED-TRIALS | METAANALYSIS | HEMATOLOGY | SIZE
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3. Full Text Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
by Brok, Jesper and Thorlund, Kristian and Gluud, Christian and Wetterslev, Jørn
Journal of Clinical Epidemiology, ISSN 0895-4356, 2008, Volume 61, Issue 8, pp. 763 - 769
Abstract Objectives To evaluate meta-analyses with trial sequential analysis (TSA). TSA adjusts for random error risk and provides the required number of... 
Internal Medicine | Heterogeneity | Information size | Random error | Trial sequential analysis | Sample size | Meta-analysis | REVIEWS | trial sequential analysis | DESIGN | RANDOMIZED-TRIALS | meta-analysis | information size | heterogeneity | DISCREPANCIES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | BOUNDARIES | CLINICAL-TRIALS | HEALTH CARE SCIENCES & SERVICES | EMPIRICAL-EVIDENCE | sample size | random error | METHODOLOGICAL QUALITY | Data Interpretation, Statistical | Meta-Analysis as Topic | Sample Size | Review Literature as Topic | Humans | Research Design - standards | False Positive Reactions | Infant, Newborn | Randomized Controlled Trials as Topic | Studies | Intervention | Respiratory distress syndrome | Bias | Risk assessment | Nitric oxide | Statistical methods | Boundaries | Estimates
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4. Full Text Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
by Wetterslev, Jørn and Thorlund, Kristian and Brok, Jesper and Gluud, Christian
Journal of Clinical Epidemiology, ISSN 0895-4356, 2008, Volume 61, Issue 1, pp. 64 - 75
Abstract Background and Objective Cumulative meta-analyses are prone to produce spurious P < 0.05 because of repeated testing of significance as trial data... 
Internal Medicine | Heterogeneity | Sample size | Trial sequential monitoring boundaries | Type II error | Information size | Type I error | Cumulative meta-analysis | Meta-analysis | RANDOMIZED CONTROLLED-TRIALS | DESIGN | QUALITY | LIMITATIONS | MYOCARDIAL-INFARCTION | type II error | meta-analysis | ANTIOXIDANT SUPPLEMENTS | information size | type I error | heterogeneity | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | BOUNDARIES | NONCARDIAC SURGERY | CLINICAL-TRIALS | EMPIRICAL-EVIDENCE | trial sequential monitoring boundaries | cumulative meta-analysis | sample size | Infant Care - methods | Data Interpretation, Statistical | Meta-Analysis as Topic | Sample Size | Randomized Controlled Trials as Topic - methods | Humans | Infant, Newborn, Diseases - therapy | Evidence-Based Medicine | Infant, Newborn | Studies | Intervention | Boundaries | Bias
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5. Full Text Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis
by Holst, Lars B and Petersen, Marie W and Haase, Nicolai and Perner, Anders and Wetterslev, Jørn
BMJ : British Medical Journal, ISSN 0959-8138, 3/2015, Volume 350, Issue mar24 9, pp. h1354 - h1354
Objective To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions.Design Systematic review... 
RESEARCH | REQUIREMENTS | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | PEDIATRIC CARDIAC-SURGERY | MYOCARDIAL-INFARCTION | PREMATURE-INFANTS | RISK | PRETERM INFANTS | HEMOGLOBIN THRESHOLD | CLINICAL-PRACTICE | CARE | Erythrocyte Transfusion - adverse effects | Erythrocyte Transfusion - mortality | Humans | Models, Statistical | Erythrocyte Transfusion - methods | Odds Ratio | Randomized Controlled Trials as Topic
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6. Full Text Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis
by Volbeda, M and Wetterslev, J and Gluud, C and Zijlstra, J. G and van der Horst, I. C. C and Keus, F
INTENSIVE CARE MEDICINE, ISSN 0342-4642, 07/2015, Volume 41, Issue 7, pp. 1220 - 1234
Glucocorticosteroids (steroids) are widely used for sepsis patients. However, the potential benefits and harms of both high and low dose steroids remain... 
Pediatrics | Pain Medicine | Emergency Medicine | Pneumology/Respiratory System | Medicine & Public Health | Intensive / Critical Care Medicine | Sepsis | Trial sequential analysis | Anesthesiology | Steroids | Meta-analysis | COMMUNITY-ACQUIRED PNEUMONIA | DEXAMETHASONE | METHYLPREDNISOLONE | SEPTIC SHOCK PATIENTS | DOUBLE-BLIND | STEROID-THERAPY | LOW-DOSE HYDROCORTISONE | CORTICOSTEROIDS | MONITORING BOUNDARIES | CLINICAL-SIGNIFICANCE | CRITICAL CARE MEDICINE | Sepsis - drug therapy | Glucocorticoids - therapeutic use | Humans | Randomized Controlled Trials as Topic | Sepsis - mortality | Dosage and administration | Corticosteroids | Drug therapy | Systematic Review
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7. Full Text Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
by Hemmingsen, Bianca and Lund, Søren S and Gluud, Christian and Vaag, Allan and Almdal, Thomas and Hemmingsen, Christina and Wetterslev, Jørn
BMJ, ISSN 0959-8138, 11/2011, Volume 343, Issue 7834, pp. 1136 - 1136
Objective To assess the effect of targeting intensive glycaemic control versus conventional glycaemic control on all cause mortality and cardiovascular... 
RESEARCH | Sequential analysis | Mortality | Clinical trials | Experimentation | Type 2 diabetes mellitus | Diabetes | GLYCATED HEMOGLOBIN | 10-YEAR FOLLOW-UP | MEDICINE, GENERAL & INTERNAL | COST-EFFECTIVENESS | ACUTE CORONARY EVENTS | MYOCARDIAL-INFARCTION | MULTIFACTORIAL INTERVENTION | MICROVASCULAR COMPLICATIONS | METABOLIC-CONTROL | BLOOD-GLUCOSE CONTROL | INSULIN THERAPY | Risk Assessment | Glycated Hemoglobin A - metabolism | Humans | Risk Factors | Diabetes Mellitus, Type 2 - prevention & control | Diabetic Angiopathies - mortality | Blood Glucose | Diabetic Angiopathies - blood | Randomized Controlled Trials as Topic | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - mortality | Cardiovascular Diseases - blood | Cardiovascular Diseases - mortality
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8. Full Text Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis
by Uthman, Olalekan A and van der Windt, Danielle A and Jordan, Joanne L and Dziedzic, Krysia S and Healey, Emma L and Peat, George M and Foster, Nadine E
BMJ : British Medical Journal, ISSN 0959-8138, 9/2013, Volume 347, Issue 7928, pp. 14 - 14
Objective To determine whether there is sufficient evidence to conclude that exercise interventions are more effective than no exercise control and to compare... 
RESEARCH | Sequential analysis | Medical research | Exercise | Knee osteoarthritis | Meta analysis | Experimentation | Lower extremity | Osteoarthritis | LAND-BASED EXERCISE | MEDICINE, GENERAL & INTERNAL | TAI-CHI | OLDER-ADULTS | PHYSICAL-ACTIVITY | RANDOMIZED CONTROLLED-TRIAL | QUALITY-OF-LIFE | AQUATIC EXERCISE | KNEE OSTEOARTHRITIS | META-REGRESSION | EVIDENCE-BASED RECOMMENDATIONS | Exercise Therapy - methods | Osteoarthritis, Knee - rehabilitation | Osteoarthritis, Hip - rehabilitation | Humans | Randomized Controlled Trials as Topic
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9. Full Text Determining optimal trial size using sequential analysis
by Taylor, Paul Geoffrey and Lee, Kwee-Yum and Landeo, Raul and O'Meara, Damien Michael and Millett, Emma
Journal of Sports Sciences, ISSN 0264-0414, 02/2015, Volume 33, Issue 3, pp. 300 - 308
When characterising typical human movement profiles, the optimal number of trials analysed for each participant should ensure a stable mean. Sequential... 
mean stability | overarm throw | sequential analysis | kinematic profile | trial size | SPORT SCIENCES | NUMBER | REACTION FORCE VARIABLES | RELIABILITY | PARAMETERS | ACHIEVE PERFORMANCE STABILITY | Young Adult | Biomechanical Phenomena | Data Interpretation, Statistical | Movement | Humans | Adolescent | Arm - physiology | Adult | Female | Male | Research Design
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10. Full Text Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis
by Bolland, Mark J and Grey, Andrew and Avenell, Alison
The Lancet Diabetes & Endocrinology, ISSN 2213-8587, 11/2018, Volume 6, Issue 11, pp. 847 - 858
The effects of vitamin D on fractures, falls, and bone mineral density are uncertain, particularly for high vitamin D doses. We aimed to determine the effect... 
CALCIUM SUPPLEMENTATION | NON-VERTEBRAL FRACTURES | BONE-MINERAL DENSITY | MUSCLE STRENGTH | DWELLING OLDER-ADULTS | ENDOCRINOLOGY & METABOLISM | PHYSICAL FUNCTION | ELDERLY-WOMEN | RANDOMIZED CONTROLLED-TRIAL | DOUBLE-BLIND RCT | POSTMENOPAUSAL WOMEN | Bone Density - drug effects | Accidental Falls - prevention & control | Humans | Treatment Outcome | Vitamin D - therapeutic use | Dietary Supplements | Fractures, Bone - prevention & control | Musculoskeletal diseases | Calcifediol | Control | Alfacalcidol | Vitamin D | Health aspects
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11. Full Text More Versus Less Intensive Blood Pressure–Lowering Strategy: Cumulative Evidence and Trial Sequential Analysis
by Verdecchia, Paolo and Angeli, Fabio and Gentile, Giorgio and Reboldi, Gianpaolo
Hypertension, ISSN 0194-911X, 09/2016, Volume 68, Issue 3, pp. 642 - 653
Several randomized trials compared a more versus less intensive blood pressure–lowering strategy on the risk of major cardiovascular events and death.... 
KIDNEY-DISEASE | TARGET | blood pressure | heart failure | METAANALYSIS | myocardial infarction | stroke | HYPERTENSIVE PATIENTS | SPRINT | CHRONIC RENAL-DISEASE | PERIPHERAL VASCULAR DISEASE | OUTCOMES | hypertension | PROGRESSION | ANTIHYPERTENSIVE TREATMENT | MONITORING BOUNDARIES | Myocardial Infarction - mortality | Prospective Studies | Outcome Assessment (Health Care) | Humans | Middle Aged | Heart Failure - physiopathology | Hypertension - drug therapy | Male | Stroke - physiopathology | Dose-Response Relationship, Drug | Female | Myocardial Infarction - physiopathology | Stroke - mortality | Hypertension - diagnosis | Heart Failure - etiology | Myocardial Infarction - etiology | Blood Pressure Determination | Heart Failure - mortality | Drug Administration Schedule | Risk Assessment | Antihypertensive Agents - therapeutic use | Evidence-Based Medicine | Randomized Controlled Trials as Topic | Stroke - etiology | Survival Analysis | Hypertension - complications | Aged
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12. Full Text Regional citrate versus heparin anticoagulation for continuous renal replacement therapy in critically ill patients: A meta-analysis with trial sequential analysis of randomized controlled trials
by Liu, Chao and Mao, Zhi and Kang, Hongjun and Hu, Jie and Zhou, Feihu
Critical Care, ISSN 1364-8535, 2016, Volume 20, Issue 1, p. 144
Background: Regional citrate or heparin is often prescribed as an anticoagulant for continuous renal replacement therapy (CRRT). However, their efficacy and... 
Regional citrate | Anticoagulation | Trial sequential analysis | Heparin | Continuous renal replacement therapy | Meta-analysis | SURVIVAL | ACUTE KIDNEY INJURY | EFFICACY | CONTINUOUS VENOVENOUS HEMOFILTRATION | SAFETY | HEMODIALYSIS | DEGRANULATION | SYSTEMIC HEPARIN | CIRCUIT | PATENCY | CRITICAL CARE MEDICINE | Humans | Middle Aged | Renal Replacement Therapy - methods | Anticoagulants - therapeutic use | Heparin - therapeutic use | Treatment Outcome | Citric Acid - therapeutic use | Citric Acid - pharmacology | Randomized Controlled Trials as Topic | Anticoagulants - pharmacology | China | Adult | Heparin - pharmacology | Clinical trials | Usage | Care and treatment | Research | Acute renal failure
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