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Annual Review of Biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 265 - 290
Transcription factor IIH (TFIIH) is a multiprotein complex involved in both transcription and DNA repair, revealing a striking functional link between these... 
human diseases | transcription | cell cycle | DNA repair | TFIIH | Human diseases | Transcription | Cell cycle | RNA-POLYMERASE-II | CARBOXY-TERMINAL DOMAIN | CDK-ACTIVATING KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COCKAYNE-SYNDROME | PREINITIATION COMPLEX | GENERAL TRANSCRIPTION | XERODERMA-PIGMENTOSUM | STRUCTURAL BASIS | XPD MUTATIONS | DNA-REPAIR | Cell Cycle - genetics | Transcription, Genetic - drug effects | Trichothiodystrophy Syndromes - genetics | Phenylenediamines - therapeutic use | Xeroderma Pigmentosum - genetics | Xeroderma Pigmentosum - metabolism | Transcription Factor TFIIH - antagonists & inhibitors | Humans | Trichothiodystrophy Syndromes - pathology | Molecular Targeted Therapy | Protein Subunits - metabolism | Transcription Factor TFIIH - genetics | Cell Cycle Proteins - antagonists & inhibitors | Xeroderma Pigmentosum - pathology | Cell Cycle Proteins - genetics | Trichothiodystrophy Syndromes - metabolism | Xeroderma Pigmentosum - drug therapy | Spironolactone - therapeutic use | Protein Subunits - genetics | Chromosome Segregation | DNA Repair - drug effects | Cell Cycle Proteins - metabolism | Models, Molecular | DNA - metabolism | DNA - genetics | Trichothiodystrophy Syndromes - drug therapy | Pyrimidines - therapeutic use | Transcription Factor TFIIH - metabolism | Protein Subunits - antagonists & inhibitors | DNA Damage | Mutation | Cell Cycle - drug effects | Genetic transcription | Observations | Genetic regulation
Journal Article
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7680, pp. 389 - 393
DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair... 
RESISTANCE | CUE DOMAIN | TRICHOTHIODYSTROPHY | MULTIDISCIPLINARY SCIENCES | ALKYLATION DAMAGE | LIGASE | Trichothiodystrophy Syndromes - genetics | Alkylating Agents - pharmacology | Humans | Ubiquitin - metabolism | Endoplasmic Reticulum - metabolism | RNA Polymerase II - metabolism | Trichothiodystrophy Syndromes - pathology | Alkylation | DNA Adducts - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Splicing | Ubiquitination | Genes, X-Linked | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase - metabolism | Trichothiodystrophy Syndromes - metabolism | Polyubiquitin - metabolism | Amino Acid Sequence | Signal Transduction | DNA Adducts - chemistry | Models, Molecular | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | AlkB Enzymes - metabolism | DNA Helicases - metabolism | DNA Repair | Kinetics | Ubiquitin | Genetic research | Genetic aspects | Cellular signal transduction | Research | DNA repair | DNA damage | Trichothiodystrophy | Cytotoxicity | Nucleotides | DNA-directed RNA polymerase | Proteins | Coupling (molecular) | Signal transduction | Pathways | Rodents | Cell cycle | Lesions | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Elongation | Biodegradation | Enzymes | Splicing | Dealkylation | Alkylating agents | Crosslinking | Ribonucleic acid--RNA | Polymerase | Signaling | Chemotherapy | Damage detection | Mutation | RNA polymerase II | Cancer | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 03/2017, Volume 169, Issue 1, pp. 132 - 147.e16
The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue... 
Senescence | IL6 | apoptosis | FOXO4 | aging | chemotherapy | cell-penetrating peptide | TP53 | tissue homeostasis | LMNB1 | REPAIR SYNDROME TRICHOTHIODYSTROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORKHEAD BOX O | DNA-DAMAGE | MOUSE MODEL | TRANSCRIPTION | INFLAMMATORY CYTOKINE SECRETION | PEPTIDE INHIBITOR | HUMAN FIBROBLASTS | CELLULAR SENESCENCE | CANCER | CELL BIOLOGY | Kidney - physiology | Antibiotics, Antineoplastic - pharmacology | Humans | Aging - drug effects | Antibiotics, Antineoplastic - adverse effects | Cellular Senescence - drug effects | Male | Cell-Penetrating Peptides - pharmacology | Liver - drug effects | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - chemistry | Female | Inclusion Bodies - metabolism | Doxorubicin - administration & dosage | Cell Line | Kidney - drug effects | Cell Survival | Tumor Suppressor Protein p53 - metabolism | Inclusion Bodies - drug effects | Aging - pathology | Antibiotics, Antineoplastic - administration & dosage | Animals | Trichothiodystrophy Syndromes - drug therapy | Inclusion Bodies - pathology | Liver - physiology | Fibroblasts - cytology | Mice | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Apoptosis | Medical colleges | Anthracyclines | Peptides | Radiation | Homeostasis | Tumor proteins | Molecular biology | Health aspects | Cells | Chemotherapy | Liver | Cancer
Journal Article
Journal Article
Journal Article
Journal Article
Photochemistry and Photobiology, ISSN 0031-8655, 03/2015, Volume 91, Issue 2, pp. 254 - 264
Ultraviolet (UV) radiation from sunlight is a major etiologic factor for skin cancer, the most prevalent cancer in the United States, as well as premature skin... 
RNA-POLYMERASE-II | CYCLOBUTANE PYRIMIDINE DIMERS | BIOPHYSICS | XERODERMA-PIGMENTOSUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | GROUP-C PROTEIN | THYMINE DIMER BYPASS | COCKAYNE-SYNDROME | PIGMENTOSUM GROUP-A | ULTRAVIOLET-RADIATION | NUCLEOTIDE EXCISION-REPAIR | Trichothiodystrophy Syndromes - genetics | Xeroderma Pigmentosum - genetics | Xeroderma Pigmentosum - metabolism | Humans | DNA Repair Enzymes - genetics | Cockayne Syndrome - etiology | RNA Polymerase II - metabolism | Trichothiodystrophy Syndromes - pathology | Carcinogenesis - metabolism | Cockayne Syndrome - pathology | DNA-Binding Proteins - metabolism | Xeroderma Pigmentosum - etiology | Xeroderma Pigmentosum - pathology | Aging - genetics | DNA Repair Enzymes - metabolism | Trichothiodystrophy Syndromes - metabolism | Skin Neoplasms - pathology | Signal Transduction | Cockayne Syndrome - metabolism | Carcinogenesis - genetics | Gene Expression Regulation | Aging - radiation effects | DNA-Binding Proteins - genetics | Ultraviolet Rays - adverse effects | Skin Neoplasms - metabolism | Carcinogenesis - pathology | Trichothiodystrophy Syndromes - etiology | DNA Repair | Skin Neoplasms - genetics | Cockayne Syndrome - genetics | RNA Polymerase II - genetics | Skin Neoplasms - etiology | Aging - metabolism | DNA repair | DNA damage | DNA
Journal Article