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1994, ISBN 0120342456, Volume 45., xvi, 459
Book
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
Aim/Hypothesis: Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is... 
3T3-L1 ADIPOCYTES | SUBCUTANEOUS FAT-CELLS | BETA-ADRENERGIC STIMULATION | WEIGHT-REDUCTION | TISSUE | ENDOCRINOLOGY & METABOLISM | UPPER-BODY OBESITY | PPAR-GAMMA | SKELETAL-MUSCLE METABOLISM | TNF-ALPHA | LIPOPROTEIN-LIPASE | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 05/2018, Volume 122, Issue 18, pp. 4802 - 4812
Lipases exhibit a unique process during the catalysis of the hydrolysis of triglyceride substrates called interfacial activation. Surfactants are used as... 
BROAD SUBSTRATE SCOPE | ACTIVATION | LABORATORY EVOLUTION | CANDIDA-RUGOSA | ORGANIC-SOLVENTS | CRYSTAL-STRUCTURE | MOLECULAR-DYNAMICS METHOD | CHEMISTRY, PHYSICAL | THERMOMYCES HUMICOLA LANUGINOSA | IONIC LIQUIDS | CATALYTIC SERINE
Journal Article
Journal Article
Plant Cell, ISSN 1040-4651, 10/2014, Volume 26, Issue 10, pp. 4119 - 4134
Triacylglycerol (TAG) metabolism is a key aspect of intracellular lipid homeostasis in yeast and mammals, but its role in vegetative tissues of plants remains... 
DIACYLGLYCEROL ACYLTRANSFERASE | CONTACT SITES | SHORT-CHAIN | CHLOROPLAST INNER ENVELOPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPID-SYNTHESIS | CARRIER PROTEIN | PLANT SCIENCES | CELL BIOLOGY | OIL CATABOLISM | METABOLISM | ENDOPLASMIC-RETICULUM | PHOSPHATIDIC-ACID | Homeostasis | Acyltransferases - metabolism | Acyltransferases - genetics | Arabidopsis Proteins - metabolism | Lipid Droplets - ultrastructure | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | beta-Glucosidase - genetics | Plants, Genetically Modified | Gene Expression Regulation, Plant | ATP-Binding Cassette Transporters - metabolism | beta-Glucosidase - metabolism | Membrane Transport Proteins - metabolism | Carboxylic Ester Hydrolases - genetics | Lipid Droplets - metabolism | Fatty Acids - metabolism | Microscopy, Electron, Transmission | Arabidopsis Proteins - genetics | Oxidation-Reduction | Lipase - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Peroxisomes - metabolism | Arabidopsis - metabolism | Triglycerides - metabolism | Arabidopsis - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Models, Biological | Membrane Lipids - metabolism | Mutation | Microscopy, Fluorescence | Plant Leaves - ultrastructure | Carboxylic Ester Hydrolases - metabolism | Lipase - genetics
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2019, Volume 120, Issue 8, pp. 13706 - 13716
Journal Article
Journal Article